Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AFP8_LEIMA

TriTrypDb:

LmjF.35.4210 , LMJLV39_350050100 , LMJSD75_350049500

Length:

701

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.759
CLV_C14_Caspase3-7	198	202	PF00656	0.778
CLV_C14_Caspase3-7	428	432	PF00656	0.640
CLV_NRD_NRD_1	238	240	PF00675	0.798
CLV_NRD_NRD_1	282	284	PF00675	0.680
CLV_NRD_NRD_1	445	447	PF00675	0.600
CLV_NRD_NRD_1	514	516	PF00675	0.763
CLV_NRD_NRD_1	654	656	PF00675	0.794
CLV_NRD_NRD_1	87	89	PF00675	0.806
CLV_PCSK_KEX2_1	219	221	PF00082	0.657
CLV_PCSK_KEX2_1	238	240	PF00082	0.528
CLV_PCSK_KEX2_1	282	284	PF00082	0.680
CLV_PCSK_KEX2_1	445	447	PF00082	0.643
CLV_PCSK_KEX2_1	654	656	PF00082	0.794
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.657
CLV_PCSK_SKI1_1	140	144	PF00082	0.776
CLV_PCSK_SKI1_1	228	232	PF00082	0.747
CLV_PCSK_SKI1_1	325	329	PF00082	0.601
CLV_PCSK_SKI1_1	524	528	PF00082	0.794
CLV_PCSK_SKI1_1	635	639	PF00082	0.772
CLV_PCSK_SKI1_1	8	12	PF00082	0.617
DEG_APCC_DBOX_1	514	522	PF00400	0.765
DEG_SCF_FBW7_1	295	300	PF00400	0.619
DEG_SPOP_SBC_1	305	309	PF00917	0.797
DEG_SPOP_SBC_1	456	460	PF00917	0.616
DEG_SPOP_SBC_1	562	566	PF00917	0.788
DOC_CDC14_PxL_1	479	487	PF14671	0.739
DOC_CDC14_PxL_1	645	653	PF14671	0.609
DOC_CKS1_1	1	6	PF01111	0.762
DOC_CKS1_1	590	595	PF01111	0.593
DOC_MAPK_DCC_7	503	512	PF00069	0.608
DOC_MAPK_gen_1	409	416	PF00069	0.658
DOC_MAPK_MEF2A_6	605	614	PF00069	0.763
DOC_MAPK_RevD_3	640	655	PF00069	0.608
DOC_PP2B_LxvP_1	666	669	PF13499	0.780
DOC_USP7_MATH_1	142	146	PF00917	0.699
DOC_USP7_MATH_1	158	162	PF00917	0.540
DOC_USP7_MATH_1	176	180	PF00917	0.537
DOC_USP7_MATH_1	245	249	PF00917	0.745
DOC_USP7_MATH_1	305	309	PF00917	0.762
DOC_USP7_MATH_1	418	422	PF00917	0.789
DOC_USP7_MATH_1	43	47	PF00917	0.777
DOC_USP7_MATH_1	433	437	PF00917	0.563
DOC_USP7_MATH_1	438	442	PF00917	0.497
DOC_USP7_MATH_1	457	461	PF00917	0.791
DOC_USP7_MATH_1	689	693	PF00917	0.636
DOC_USP7_MATH_1	82	86	PF00917	0.617
DOC_USP7_UBL2_3	629	633	PF12436	0.589
DOC_WW_Pin1_4	192	197	PF00397	0.595
DOC_WW_Pin1_4	23	28	PF00397	0.740
DOC_WW_Pin1_4	293	298	PF00397	0.713
DOC_WW_Pin1_4	301	306	PF00397	0.707
DOC_WW_Pin1_4	316	321	PF00397	0.602
DOC_WW_Pin1_4	338	343	PF00397	0.789
DOC_WW_Pin1_4	371	376	PF00397	0.775
DOC_WW_Pin1_4	379	384	PF00397	0.683
DOC_WW_Pin1_4	39	44	PF00397	0.594
DOC_WW_Pin1_4	447	452	PF00397	0.744
DOC_WW_Pin1_4	535	540	PF00397	0.791
DOC_WW_Pin1_4	589	594	PF00397	0.592
DOC_WW_Pin1_4	659	664	PF00397	0.795
DOC_WW_Pin1_4	676	681	PF00397	0.516
DOC_WW_Pin1_4	685	690	PF00397	0.654
LIG_14-3-3_CanoR_1	181	188	PF00244	0.746
LIG_14-3-3_CanoR_1	323	328	PF00244	0.692
LIG_14-3-3_CanoR_1	332	336	PF00244	0.595
LIG_14-3-3_CanoR_1	355	361	PF00244	0.789
LIG_14-3-3_CanoR_1	411	415	PF00244	0.786
LIG_14-3-3_CanoR_1	44	48	PF00244	0.745
LIG_14-3-3_CanoR_1	445	451	PF00244	0.750
LIG_14-3-3_CanoR_1	470	476	PF00244	0.799
LIG_14-3-3_CanoR_1	484	492	PF00244	0.510
LIG_14-3-3_CanoR_1	515	519	PF00244	0.675
LIG_14-3-3_CanoR_1	625	629	PF00244	0.686
LIG_Actin_WH2_2	621	637	PF00022	0.768
LIG_APCC_ABBA_1	104	109	PF00400	0.668
LIG_BIR_II_1	1	5	PF00653	0.779
LIG_BIR_III_4	250	254	PF00653	0.609
LIG_CtBP_PxDLS_1	663	667	PF00389	0.786
LIG_FHA_1	1	7	PF00498	0.762
LIG_FHA_1	123	129	PF00498	0.618
LIG_FHA_1	141	147	PF00498	0.714
LIG_FHA_1	209	215	PF00498	0.612
LIG_FHA_1	244	250	PF00498	0.798
LIG_FHA_1	294	300	PF00498	0.761
LIG_FHA_1	447	453	PF00498	0.723
LIG_FHA_1	456	462	PF00498	0.782
LIG_FHA_1	557	563	PF00498	0.651
LIG_FHA_1	590	596	PF00498	0.654
LIG_FHA_1	619	625	PF00498	0.769
LIG_FHA_1	72	78	PF00498	0.761
LIG_FHA_1	99	105	PF00498	0.787
LIG_FHA_2	343	349	PF00498	0.801
LIG_FHA_2	536	542	PF00498	0.749
LIG_LIR_Nem_3	322	327	PF02991	0.780
LIG_PCNA_yPIPBox_3	32	44	PF02747	0.614
LIG_Pex14_2	47	51	PF04695	0.728
LIG_PTAP_UEV_1	314	319	PF05743	0.655
LIG_SH2_CRK	590	594	PF00017	0.593
LIG_SH2_CRK	683	687	PF00017	0.610
LIG_SH2_NCK_1	132	136	PF00017	0.725
LIG_SH2_NCK_1	683	687	PF00017	0.610
LIG_SH2_STAT3	59	62	PF00017	0.748
LIG_SH2_STAT5	590	593	PF00017	0.769
LIG_SH3_1	84	90	PF00018	0.747
LIG_SH3_3	133	139	PF00018	0.766
LIG_SH3_3	144	150	PF00018	0.600
LIG_SH3_3	24	30	PF00018	0.730
LIG_SH3_3	246	252	PF00018	0.640
LIG_SH3_3	283	289	PF00018	0.797
LIG_SH3_3	312	318	PF00018	0.666
LIG_SH3_3	372	378	PF00018	0.773
LIG_SH3_3	380	386	PF00018	0.667
LIG_SH3_3	432	438	PF00018	0.775
LIG_SH3_3	491	497	PF00018	0.682
LIG_SH3_3	611	617	PF00018	0.762
LIG_SH3_3	674	680	PF00018	0.763
LIG_SH3_3	683	689	PF00018	0.654
LIG_SH3_3	84	90	PF00018	0.747
LIG_SUMO_SIM_anti_2	265	274	PF11976	0.608
LIG_SUMO_SIM_anti_2	549	555	PF11976	0.797
LIG_SUMO_SIM_par_1	558	567	PF11976	0.608
LIG_SUMO_SIM_par_1	577	582	PF11976	0.499
LIG_SUMO_SIM_par_1	662	667	PF11976	0.788
LIG_TRAF2_1	543	546	PF00917	0.645
LIG_WW_3	667	671	PF00397	0.784
MOD_CDC14_SPxK_1	341	344	PF00782	0.792
MOD_CDC14_SPxK_1	346	349	PF00782	0.728
MOD_CDC14_SPxK_1	688	691	PF00782	0.600
MOD_CDK_SPK_2	374	379	PF00069	0.604
MOD_CDK_SPK_2	39	44	PF00069	0.786
MOD_CDK_SPK_2	535	540	PF00069	0.773
MOD_CDK_SPxK_1	338	344	PF00069	0.790
MOD_CDK_SPxK_1	664	670	PF00069	0.785
MOD_CDK_SPxK_1	685	691	PF00069	0.605
MOD_CDK_SPxxK_3	306	313	PF00069	0.697
MOD_CDK_SPxxK_3	316	323	PF00069	0.618
MOD_CK1_1	108	114	PF00069	0.672
MOD_CK1_1	169	175	PF00069	0.627
MOD_CK1_1	179	185	PF00069	0.589
MOD_CK1_1	195	201	PF00069	0.768
MOD_CK1_1	2	8	PF00069	0.783
MOD_CK1_1	218	224	PF00069	0.682
MOD_CK1_1	304	310	PF00069	0.762
MOD_CK1_1	316	322	PF00069	0.644
MOD_CK1_1	331	337	PF00069	0.557
MOD_CK1_1	356	362	PF00069	0.784
MOD_CK1_1	374	380	PF00069	0.525
MOD_CK1_1	394	400	PF00069	0.517
MOD_CK1_1	42	48	PF00069	0.743
MOD_CK1_1	561	567	PF00069	0.731
MOD_CK1_1	618	624	PF00069	0.765
MOD_CK1_1	657	663	PF00069	0.794
MOD_CK1_1	75	81	PF00069	0.811
MOD_CK1_1	9	15	PF00069	0.679
MOD_CK2_1	174	180	PF00069	0.791
MOD_CK2_1	342	348	PF00069	0.796
MOD_CK2_1	60	66	PF00069	0.620
MOD_GlcNHglycan	118	121	PF01048	0.793
MOD_GlcNHglycan	133	136	PF01048	0.581
MOD_GlcNHglycan	176	179	PF01048	0.795
MOD_GlcNHglycan	184	187	PF01048	0.805
MOD_GlcNHglycan	201	204	PF01048	0.532
MOD_GlcNHglycan	239	242	PF01048	0.764
MOD_GlcNHglycan	315	318	PF01048	0.788
MOD_GlcNHglycan	354	358	PF01048	0.759
MOD_GlcNHglycan	395	399	PF01048	0.792
MOD_GlcNHglycan	464	467	PF01048	0.764
MOD_GlcNHglycan	485	488	PF01048	0.622
MOD_GlcNHglycan	569	572	PF01048	0.785
MOD_GlcNHglycan	621	624	PF01048	0.769
MOD_GlcNHglycan	630	633	PF01048	0.631
MOD_GlcNHglycan	659	662	PF01048	0.797
MOD_GlcNHglycan	695	698	PF01048	0.755
MOD_GlcNHglycan	8	11	PF01048	0.727
MOD_GSK3_1	165	172	PF00069	0.797
MOD_GSK3_1	182	189	PF00069	0.525
MOD_GSK3_1	191	198	PF00069	0.724
MOD_GSK3_1	2	9	PF00069	0.763
MOD_GSK3_1	210	217	PF00069	0.559
MOD_GSK3_1	218	225	PF00069	0.688
MOD_GSK3_1	237	244	PF00069	0.561
MOD_GSK3_1	293	300	PF00069	0.709
MOD_GSK3_1	301	308	PF00069	0.705
MOD_GSK3_1	309	316	PF00069	0.644
MOD_GSK3_1	319	326	PF00069	0.549
MOD_GSK3_1	338	345	PF00069	0.605
MOD_GSK3_1	384	391	PF00069	0.745
MOD_GSK3_1	39	46	PF00069	0.773
MOD_GSK3_1	419	426	PF00069	0.741
MOD_GSK3_1	447	454	PF00069	0.740
MOD_GSK3_1	462	469	PF00069	0.607
MOD_GSK3_1	558	565	PF00069	0.755
MOD_GSK3_1	615	622	PF00069	0.763
MOD_GSK3_1	624	631	PF00069	0.642
MOD_GSK3_1	650	657	PF00069	0.660
MOD_GSK3_1	672	679	PF00069	0.770
MOD_GSK3_1	68	75	PF00069	0.768
MOD_GSK3_1	681	688	PF00069	0.653
MOD_GSK3_1	689	696	PF00069	0.527
MOD_N-GLC_1	222	227	PF02516	0.592
MOD_N-GLC_1	405	410	PF02516	0.745
MOD_N-GLC_1	446	451	PF02516	0.640
MOD_N-GLC_1	649	654	PF02516	0.641
MOD_N-GLC_1	68	73	PF02516	0.760
MOD_NEK2_1	166	171	PF00069	0.744
MOD_NEK2_1	214	219	PF00069	0.625
MOD_NEK2_1	237	242	PF00069	0.625
MOD_NEK2_1	328	333	PF00069	0.591
MOD_PIKK_1	170	176	PF00454	0.799
MOD_PIKK_1	564	570	PF00454	0.778
MOD_PK_1	323	329	PF00069	0.690
MOD_PK_1	60	66	PF00069	0.620
MOD_PKA_1	219	225	PF00069	0.786
MOD_PKA_1	282	288	PF00069	0.673
MOD_PKA_1	445	451	PF00069	0.641
MOD_PKA_1	654	660	PF00069	0.792
MOD_PKA_2	219	225	PF00069	0.786
MOD_PKA_2	237	243	PF00069	0.544
MOD_PKA_2	275	281	PF00069	0.646
MOD_PKA_2	282	288	PF00069	0.635
MOD_PKA_2	331	337	PF00069	0.595
MOD_PKA_2	410	416	PF00069	0.789
MOD_PKA_2	43	49	PF00069	0.742
MOD_PKA_2	445	451	PF00069	0.803
MOD_PKA_2	469	475	PF00069	0.801
MOD_PKA_2	483	489	PF00069	0.508
MOD_PKA_2	514	520	PF00069	0.677
MOD_PKA_2	556	562	PF00069	0.609
MOD_PKA_2	615	621	PF00069	0.764
MOD_PKA_2	624	630	PF00069	0.642
MOD_PKA_2	654	660	PF00069	0.792
MOD_Plk_1	179	185	PF00069	0.616
MOD_Plk_1	228	234	PF00069	0.763
MOD_Plk_4	451	457	PF00069	0.785
MOD_Plk_4	60	66	PF00069	0.620
MOD_Plk_4	615	621	PF00069	0.764
MOD_Plk_4	681	687	PF00069	0.605
MOD_ProDKin_1	192	198	PF00069	0.596
MOD_ProDKin_1	23	29	PF00069	0.741
MOD_ProDKin_1	293	299	PF00069	0.713
MOD_ProDKin_1	301	307	PF00069	0.707
MOD_ProDKin_1	316	322	PF00069	0.601
MOD_ProDKin_1	338	344	PF00069	0.790
MOD_ProDKin_1	371	377	PF00069	0.774
MOD_ProDKin_1	379	385	PF00069	0.675
MOD_ProDKin_1	39	45	PF00069	0.593
MOD_ProDKin_1	447	453	PF00069	0.747
MOD_ProDKin_1	535	541	PF00069	0.792
MOD_ProDKin_1	589	595	PF00069	0.593
MOD_ProDKin_1	659	665	PF00069	0.793
MOD_ProDKin_1	676	682	PF00069	0.518
MOD_ProDKin_1	685	691	PF00069	0.652
MOD_SUMO_rev_2	631	640	PF00179	0.725
TRG_DiLeu_BaEn_1	265	270	PF01217	0.603
TRG_DiLeu_BaLyEn_6	412	417	PF01217	0.610
TRG_ENDOCYTIC_2	683	686	PF00928	0.610
TRG_ER_diArg_1	237	239	PF00400	0.803
TRG_ER_diArg_1	281	283	PF00400	0.630
TRG_ER_diArg_1	444	446	PF00400	0.599
TRG_ER_diArg_1	548	551	PF00400	0.633
TRG_ER_diArg_1	654	656	PF00400	0.787
TRG_Pf-PMV_PEXEL_1	126	131	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.783

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X9X6	Leishmania donovani	79%	94%
A4IBW1	Leishmania infantum	79%	94%
E9B6V1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	94%