SAC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AFP7_LEIMA

TriTrypDb:

LmjF.35.4200 , LMJLV39_350050000 , LMJSD75_350049400

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.706
CLV_C14_Caspase3-7	497	501	PF00656	0.683
CLV_NRD_NRD_1	342	344	PF00675	0.597
CLV_NRD_NRD_1	4	6	PF00675	0.662
CLV_PCSK_KEX2_1	4	6	PF00082	0.662
CLV_PCSK_SKI1_1	113	117	PF00082	0.558
CLV_PCSK_SKI1_1	311	315	PF00082	0.608
CLV_PCSK_SKI1_1	327	331	PF00082	0.504
CLV_PCSK_SKI1_1	376	380	PF00082	0.694
CLV_PCSK_SKI1_1	38	42	PF00082	0.641
CLV_PCSK_SKI1_1	460	464	PF00082	0.688
CLV_PCSK_SKI1_1	5	9	PF00082	0.609
DEG_APCC_DBOX_1	310	318	PF00400	0.587
DEG_Nend_UBRbox_3	1	3	PF02207	0.661
DEG_SCF_FBW7_1	265	271	PF00400	0.664
DEG_SCF_FBW7_1	492	499	PF00400	0.732
DEG_SCF_FBW7_2	403	410	PF00400	0.658
DOC_CKS1_1	265	270	PF01111	0.668
DOC_CKS1_1	402	407	PF01111	0.667
DOC_PP1_RVXF_1	10	17	PF00149	0.541
DOC_PP2B_LxvP_1	601	604	PF13499	0.642
DOC_PP4_FxxP_1	402	405	PF00568	0.673
DOC_SPAK_OSR1_1	400	404	PF12202	0.624
DOC_USP7_MATH_1	451	455	PF00917	0.747
DOC_USP7_MATH_1	480	484	PF00917	0.675
DOC_USP7_MATH_1	496	500	PF00917	0.583
DOC_USP7_MATH_1	556	560	PF00917	0.583
DOC_USP7_MATH_1	573	577	PF00917	0.506
DOC_USP7_MATH_1	616	620	PF00917	0.716
DOC_USP7_MATH_1	90	94	PF00917	0.585
DOC_USP7_MATH_2	605	611	PF00917	0.647
DOC_WW_Pin1_4	264	269	PF00397	0.649
DOC_WW_Pin1_4	376	381	PF00397	0.778
DOC_WW_Pin1_4	401	406	PF00397	0.671
DOC_WW_Pin1_4	490	495	PF00397	0.829
DOC_WW_Pin1_4	500	505	PF00397	0.676
DOC_WW_Pin1_4	521	526	PF00397	0.626
DOC_WW_Pin1_4	568	573	PF00397	0.626
LIG_14-3-3_CanoR_1	277	283	PF00244	0.617
LIG_14-3-3_CanoR_1	343	347	PF00244	0.657
LIG_14-3-3_CanoR_1	460	469	PF00244	0.675
LIG_14-3-3_CanoR_1	528	532	PF00244	0.778
LIG_14-3-3_CanoR_1	582	589	PF00244	0.596
LIG_14-3-3_CanoR_1	84	89	PF00244	0.555
LIG_14-3-3_CanoR_1	94	101	PF00244	0.461
LIG_APCC_ABBA_1	597	602	PF00400	0.597
LIG_BIR_III_4	6	10	PF00653	0.540
LIG_Clathr_ClatBox_1	314	318	PF01394	0.620
LIG_deltaCOP1_diTrp_1	645	653	PF00928	0.570
LIG_EH_1	465	469	PF12763	0.608
LIG_FHA_1	115	121	PF00498	0.583
LIG_FHA_1	29	35	PF00498	0.618
LIG_FHA_1	292	298	PF00498	0.669
LIG_FHA_1	392	398	PF00498	0.606
LIG_FHA_1	569	575	PF00498	0.619
LIG_FHA_1	613	619	PF00498	0.655
LIG_FHA_2	230	236	PF00498	0.679
LIG_FHA_2	495	501	PF00498	0.734
LIG_LIR_Gen_1	333	341	PF02991	0.674
LIG_LIR_Gen_1	472	482	PF02991	0.648
LIG_LIR_Gen_1	510	519	PF02991	0.675
LIG_LIR_LC3C_4	145	150	PF02991	0.512
LIG_LIR_Nem_3	21	27	PF02991	0.643
LIG_LIR_Nem_3	333	339	PF02991	0.672
LIG_LIR_Nem_3	472	477	PF02991	0.690
LIG_LIR_Nem_3	510	516	PF02991	0.679
LIG_LIR_Nem_3	555	560	PF02991	0.686
LIG_PDZ_Class_1	660	665	PF00595	0.574
LIG_Pex14_1	171	175	PF04695	0.609
LIG_Pex14_2	207	211	PF04695	0.708
LIG_Pex14_2	474	478	PF04695	0.639
LIG_PTB_Apo_2	463	470	PF02174	0.608
LIG_SH2_CRK	24	28	PF00017	0.604
LIG_SH2_STAP1	306	310	PF00017	0.528
LIG_SH2_STAP1	557	561	PF00017	0.551
LIG_SH2_STAT5	103	106	PF00017	0.600
LIG_SH2_STAT5	111	114	PF00017	0.532
LIG_SH2_STAT5	175	178	PF00017	0.622
LIG_SH2_STAT5	515	518	PF00017	0.672
LIG_SH2_STAT5	560	563	PF00017	0.570
LIG_SH2_STAT5	626	629	PF00017	0.613
LIG_SH3_3	117	123	PF00018	0.659
LIG_SH3_3	162	168	PF00018	0.653
LIG_SH3_3	220	226	PF00018	0.662
LIG_SH3_3	259	265	PF00018	0.719
LIG_SH3_3	528	534	PF00018	0.649
LIG_SUMO_SIM_anti_2	542	548	PF11976	0.623
LIG_SUMO_SIM_par_1	312	318	PF11976	0.524
LIG_SUMO_SIM_par_1	539	544	PF11976	0.585
LIG_TRAF2_1	206	209	PF00917	0.702
LIG_TRAF2_1	604	607	PF00917	0.580
LIG_TYR_ITIM	22	27	PF00017	0.596
LIG_UBA3_1	314	320	PF00899	0.625
LIG_WRC_WIRS_1	136	141	PF05994	0.643
LIG_WRC_WIRS_1	85	90	PF05994	0.608
LIG_WW_1	273	276	PF00397	0.689
MOD_CDK_SPK_2	500	505	PF00069	0.673
MOD_CDK_SPxK_1	492	498	PF00069	0.679
MOD_CDK_SPxxK_3	521	528	PF00069	0.632
MOD_CK1_1	347	353	PF00069	0.801
MOD_CK1_1	422	428	PF00069	0.681
MOD_CK1_1	48	54	PF00069	0.683
MOD_CK1_1	518	524	PF00069	0.672
MOD_CK1_1	576	582	PF00069	0.621
MOD_CK1_1	93	99	PF00069	0.574
MOD_CK2_1	94	100	PF00069	0.579
MOD_GlcNHglycan	142	145	PF01048	0.651
MOD_GlcNHglycan	307	311	PF01048	0.563
MOD_GlcNHglycan	360	363	PF01048	0.748
MOD_GlcNHglycan	440	443	PF01048	0.684
MOD_GlcNHglycan	445	448	PF01048	0.654
MOD_GlcNHglycan	482	485	PF01048	0.726
MOD_GlcNHglycan	578	581	PF01048	0.695
MOD_GlcNHglycan	584	587	PF01048	0.600
MOD_GlcNHglycan	609	612	PF01048	0.710
MOD_GlcNHglycan	96	99	PF01048	0.596
MOD_GSK3_1	114	121	PF00069	0.477
MOD_GSK3_1	260	267	PF00069	0.709
MOD_GSK3_1	363	370	PF00069	0.733
MOD_GSK3_1	387	394	PF00069	0.713
MOD_GSK3_1	486	493	PF00069	0.707
MOD_GSK3_1	494	501	PF00069	0.669
MOD_GSK3_1	514	521	PF00069	0.739
MOD_GSK3_1	541	548	PF00069	0.579
MOD_GSK3_1	562	569	PF00069	0.632
MOD_GSK3_1	612	619	PF00069	0.734
MOD_GSK3_1	90	97	PF00069	0.621
MOD_GSK3_1	99	106	PF00069	0.503
MOD_LATS_1	92	98	PF00433	0.589
MOD_N-GLC_1	126	131	PF02516	0.605
MOD_N-GLC_1	363	368	PF02516	0.672
MOD_N-GLC_1	376	381	PF02516	0.602
MOD_N-GLC_1	414	419	PF02516	0.709
MOD_N-GLC_2	419	421	PF02516	0.625
MOD_NEK2_1	278	283	PF00069	0.562
MOD_NEK2_1	339	344	PF00069	0.653
MOD_NEK2_1	478	483	PF00069	0.730
MOD_NEK2_1	545	550	PF00069	0.553
MOD_NEK2_1	561	566	PF00069	0.467
MOD_NEK2_2	534	539	PF00069	0.657
MOD_PIKK_1	218	224	PF00454	0.673
MOD_PIKK_1	28	34	PF00454	0.562
MOD_PIKK_1	344	350	PF00454	0.694
MOD_PIKK_1	467	473	PF00454	0.666
MOD_PKA_2	342	348	PF00069	0.656
MOD_PKA_2	438	444	PF00069	0.653
MOD_PKA_2	527	533	PF00069	0.702
MOD_PKA_2	93	99	PF00069	0.536
MOD_Plk_1	18	24	PF00069	0.584
MOD_Plk_1	414	420	PF00069	0.622
MOD_Plk_1	45	51	PF00069	0.684
MOD_Plk_1	541	547	PF00069	0.575
MOD_Plk_1	99	105	PF00069	0.521
MOD_Plk_4	135	141	PF00069	0.645
MOD_Plk_4	419	425	PF00069	0.623
MOD_Plk_4	541	547	PF00069	0.581
MOD_Plk_4	556	562	PF00069	0.460
MOD_Plk_4	573	579	PF00069	0.501
MOD_Plk_4	99	105	PF00069	0.542
MOD_ProDKin_1	264	270	PF00069	0.651
MOD_ProDKin_1	376	382	PF00069	0.776
MOD_ProDKin_1	401	407	PF00069	0.669
MOD_ProDKin_1	490	496	PF00069	0.826
MOD_ProDKin_1	500	506	PF00069	0.673
MOD_ProDKin_1	521	527	PF00069	0.628
MOD_ProDKin_1	568	574	PF00069	0.621
MOD_SUMO_rev_2	288	295	PF00179	0.726
TRG_DiLeu_BaEn_1	208	213	PF01217	0.645
TRG_DiLeu_BaEn_4	183	189	PF01217	0.659
TRG_ENDOCYTIC_2	24	27	PF00928	0.608
TRG_ENDOCYTIC_2	336	339	PF00928	0.675
TRG_ENDOCYTIC_2	560	563	PF00928	0.616
TRG_ER_diArg_1	3	5	PF00400	0.677
TRG_NES_CRM1_1	592	607	PF08389	0.644
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.688
TRG_Pf-PMV_PEXEL_1	505	510	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4IBW0	Leishmania infantum	79%	100%
E9B6V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	93%