Putative Bardet-Biedl syndrome 1 protein (BBS1-like protein 1)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bardet-biedl syndrome 1 protein

Species:

Leishmania major

UniProt:

E9AFP5_LEIMA

TriTrypDb:

LmjF.35.4180 , LMJLV39_350049800 , LMJSD75_350049200

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0005930	axoneme	2	2
GO:0012506	vesicle membrane	4	2
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0030662	coated vesicle membrane	5	2
GO:0030665	clathrin-coated vesicle membrane	6	2
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0032991	protein-containing complex	1	12
GO:0034464	BBSome	2	12
GO:0036064	ciliary basal body	3	2
GO:0060170	ciliary membrane	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098590	plasma membrane region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFP5

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	2
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006826	iron ion transport	8	2
GO:0006897	endocytosis	5	2
GO:0006907	pinocytosis	6	2
GO:0006996	organelle organization	4	12
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	12
GO:0016192	vesicle-mediated transport	4	2
GO:0022607	cellular component assembly	4	12
GO:0030001	metal ion transport	6	2
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0033572	transferrin transport	5	2
GO:0044782	cilium organization	5	12
GO:0045184	establishment of protein localization	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0060271	cilium assembly	6	12
GO:0061512	protein localization to cilium	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0070925	organelle assembly	5	12
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12
GO:1905515	non-motile cilium assembly	7	12

Molecular functions
Term	Name	Level	Count
GO:0001664	G protein-coupled receptor binding	4	2
GO:0005102	signaling receptor binding	3	2
GO:0005113	patched binding	4	2
GO:0005119	smoothened binding	5	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043130	ubiquitin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.413
CLV_C14_Caspase3-7	84	88	PF00656	0.337
CLV_NRD_NRD_1	431	433	PF00675	0.434
CLV_PCSK_KEX2_1	55	57	PF00082	0.305
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.341
CLV_PCSK_SKI1_1	205	209	PF00082	0.365
CLV_PCSK_SKI1_1	230	234	PF00082	0.388
CLV_PCSK_SKI1_1	516	520	PF00082	0.407
CLV_PCSK_SKI1_1	55	59	PF00082	0.243
DEG_APCC_DBOX_1	21	29	PF00400	0.258
DEG_SCF_TRCP1_1	151	157	PF00400	0.308
DEG_SPOP_SBC_1	154	158	PF00917	0.264
DOC_CDC14_PxL_1	533	541	PF14671	0.337
DOC_CKS1_1	165	170	PF01111	0.218
DOC_CKS1_1	234	239	PF01111	0.308
DOC_MAPK_DCC_7	113	121	PF00069	0.248
DOC_MAPK_DCC_7	177	186	PF00069	0.308
DOC_MAPK_gen_1	305	314	PF00069	0.345
DOC_MAPK_gen_1	369	379	PF00069	0.299
DOC_MAPK_MEF2A_6	113	121	PF00069	0.266
DOC_MAPK_MEF2A_6	177	186	PF00069	0.388
DOC_MAPK_MEF2A_6	372	381	PF00069	0.293
DOC_PP1_RVXF_1	514	520	PF00149	0.446
DOC_PP4_FxxP_1	114	117	PF00568	0.302
DOC_PP4_FxxP_1	534	537	PF00568	0.402
DOC_PP4_FxxP_1	72	75	PF00568	0.337
DOC_PP4_FxxP_1	89	92	PF00568	0.337
DOC_PP4_MxPP_1	115	118	PF00568	0.388
DOC_SPAK_OSR1_1	113	117	PF12202	0.302
DOC_USP7_MATH_1	123	127	PF00917	0.358
DOC_USP7_MATH_1	196	200	PF00917	0.404
DOC_USP7_MATH_1	425	429	PF00917	0.430
DOC_USP7_MATH_1	462	466	PF00917	0.462
DOC_USP7_MATH_1	481	485	PF00917	0.329
DOC_USP7_MATH_1	51	55	PF00917	0.318
DOC_USP7_MATH_1	61	65	PF00917	0.341
DOC_USP7_MATH_1	77	81	PF00917	0.206
DOC_WW_Pin1_4	164	169	PF00397	0.407
DOC_WW_Pin1_4	233	238	PF00397	0.341
DOC_WW_Pin1_4	571	576	PF00397	0.524
LIG_14-3-3_CanoR_1	177	182	PF00244	0.403
LIG_14-3-3_CanoR_1	369	379	PF00244	0.458
LIG_14-3-3_CanoR_1	450	458	PF00244	0.343
LIG_Actin_WH2_2	434	452	PF00022	0.443
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BIR_III_2	277	281	PF00653	0.409
LIG_BIR_III_4	87	91	PF00653	0.177
LIG_BRCT_BRCA1_1	420	424	PF00533	0.523
LIG_Clathr_ClatBox_1	183	187	PF01394	0.388
LIG_deltaCOP1_diTrp_1	14	21	PF00928	0.304
LIG_FHA_1	132	138	PF00498	0.318
LIG_FHA_1	158	164	PF00498	0.263
LIG_FHA_1	35	41	PF00498	0.325
LIG_FHA_2	136	142	PF00498	0.348
LIG_FHA_2	165	171	PF00498	0.374
LIG_FHA_2	321	327	PF00498	0.368
LIG_FHA_2	550	556	PF00498	0.438
LIG_FHA_2	577	583	PF00498	0.495
LIG_LIR_Apic_2	524	530	PF02991	0.497
LIG_LIR_Apic_2	87	92	PF02991	0.374
LIG_LIR_Gen_1	126	137	PF02991	0.325
LIG_LIR_Gen_1	213	224	PF02991	0.236
LIG_LIR_Gen_1	437	446	PF02991	0.472
LIG_LIR_Gen_1	45	51	PF02991	0.395
LIG_LIR_Gen_1	98	105	PF02991	0.406
LIG_LIR_LC3C_4	385	388	PF02991	0.296
LIG_LIR_Nem_3	126	132	PF02991	0.263
LIG_LIR_Nem_3	14	19	PF02991	0.384
LIG_LIR_Nem_3	213	219	PF02991	0.229
LIG_LIR_Nem_3	247	253	PF02991	0.284
LIG_LIR_Nem_3	298	304	PF02991	0.300
LIG_LIR_Nem_3	356	362	PF02991	0.345
LIG_LIR_Nem_3	437	442	PF02991	0.483
LIG_LIR_Nem_3	45	49	PF02991	0.273
LIG_MYND_1	537	541	PF01753	0.338
LIG_NRBOX	145	151	PF00104	0.388
LIG_NRBOX	160	166	PF00104	0.388
LIG_PCNA_yPIPBox_3	106	115	PF02747	0.308
LIG_Pex14_1	17	21	PF04695	0.243
LIG_SH2_CRK	250	254	PF00017	0.243
LIG_SH2_CRK	286	290	PF00017	0.326
LIG_SH2_CRK	359	363	PF00017	0.332
LIG_SH2_CRK	46	50	PF00017	0.262
LIG_SH2_CRK	527	531	PF00017	0.396
LIG_SH2_GRB2like	301	304	PF00017	0.368
LIG_SH2_STAT5	101	104	PF00017	0.380
LIG_SH2_STAT5	218	221	PF00017	0.263
LIG_SH2_STAT5	347	350	PF00017	0.332
LIG_SH2_STAT5	457	460	PF00017	0.366
LIG_SH2_STAT5	527	530	PF00017	0.457
LIG_SH3_3	114	120	PF00018	0.340
LIG_SH3_3	228	234	PF00018	0.266
LIG_SH3_3	270	276	PF00018	0.426
LIG_SH3_3	309	315	PF00018	0.336
LIG_SH3_3	477	483	PF00018	0.558
LIG_SH3_3	538	544	PF00018	0.432
LIG_SH3_3	578	584	PF00018	0.415
LIG_SUMO_SIM_anti_2	160	167	PF11976	0.314
LIG_SUMO_SIM_anti_2	206	213	PF11976	0.286
LIG_SUMO_SIM_par_1	206	213	PF11976	0.286
LIG_SUMO_SIM_par_1	288	295	PF11976	0.291
LIG_SUMO_SIM_par_1	335	340	PF11976	0.410
LIG_SUMO_SIM_par_1	562	568	PF11976	0.509
LIG_SUMO_SIM_par_1	579	585	PF11976	0.290
LIG_SUMO_SIM_par_1	92	98	PF11976	0.337
LIG_TRAF2_1	138	141	PF00917	0.242
LIG_TRAF2_1	167	170	PF00917	0.370
LIG_TYR_ITIM	248	253	PF00017	0.277
LIG_TYR_ITIM	299	304	PF00017	0.302
LIG_TYR_ITIM	357	362	PF00017	0.465
LIG_WRC_WIRS_1	78	83	PF05994	0.302
MOD_CDK_SPxxK_3	164	171	PF00069	0.301
MOD_CDK_SPxxK_3	571	578	PF00069	0.395
MOD_CK1_1	157	163	PF00069	0.243
MOD_CK1_1	319	325	PF00069	0.430
MOD_CK1_1	465	471	PF00069	0.599
MOD_CK1_1	76	82	PF00069	0.317
MOD_CK2_1	135	141	PF00069	0.278
MOD_CK2_1	149	155	PF00069	0.274
MOD_CK2_1	164	170	PF00069	0.354
MOD_CK2_1	196	202	PF00069	0.391
MOD_CK2_1	337	343	PF00069	0.414
MOD_CK2_1	425	431	PF00069	0.479
MOD_CK2_1	549	555	PF00069	0.421
MOD_Cter_Amidation	305	308	PF01082	0.359
MOD_GlcNHglycan	1	4	PF01048	0.774
MOD_GlcNHglycan	125	128	PF01048	0.337
MOD_GlcNHglycan	151	154	PF01048	0.416
MOD_GlcNHglycan	318	321	PF01048	0.406
MOD_GlcNHglycan	75	78	PF01048	0.282
MOD_GSK3_1	131	138	PF00069	0.295
MOD_GSK3_1	145	152	PF00069	0.299
MOD_GSK3_1	153	160	PF00069	0.261
MOD_GSK3_1	173	180	PF00069	0.355
MOD_GSK3_1	291	298	PF00069	0.298
MOD_GSK3_1	316	323	PF00069	0.313
MOD_GSK3_1	395	402	PF00069	0.363
MOD_GSK3_1	419	426	PF00069	0.530
MOD_GSK3_1	535	542	PF00069	0.390
MOD_GSK3_1	565	572	PF00069	0.372
MOD_GSK3_1	73	80	PF00069	0.304
MOD_N-GLC_1	324	329	PF02516	0.407
MOD_N-GLC_1	382	387	PF02516	0.303
MOD_N-GLC_1	395	400	PF02516	0.388
MOD_N-GLC_1	462	467	PF02516	0.567
MOD_N-GLC_1	471	476	PF02516	0.577
MOD_NEK2_1	104	109	PF00069	0.266
MOD_NEK2_1	149	154	PF00069	0.415
MOD_NEK2_1	397	402	PF00069	0.543
MOD_NEK2_1	449	454	PF00069	0.372
MOD_NEK2_1	576	581	PF00069	0.453
MOD_NEK2_2	77	82	PF00069	0.302
MOD_PIKK_1	347	353	PF00454	0.367
MOD_PIKK_1	423	429	PF00454	0.573
MOD_PIKK_1	444	450	PF00454	0.469
MOD_PIKK_1	471	477	PF00454	0.464
MOD_PK_1	177	183	PF00069	0.264
MOD_PK_1	260	266	PF00069	0.337
MOD_PK_1	308	314	PF00069	0.411
MOD_PKA_2	449	455	PF00069	0.442
MOD_Plk_1	324	330	PF00069	0.302
MOD_Plk_1	444	450	PF00069	0.417
MOD_Plk_2-3	135	141	PF00069	0.289
MOD_Plk_4	145	151	PF00069	0.424
MOD_Plk_4	308	314	PF00069	0.368
MOD_Plk_4	382	388	PF00069	0.314
MOD_Plk_4	419	425	PF00069	0.422
MOD_Plk_4	535	541	PF00069	0.349
MOD_Plk_4	77	83	PF00069	0.346
MOD_ProDKin_1	164	170	PF00069	0.407
MOD_ProDKin_1	233	239	PF00069	0.341
MOD_ProDKin_1	571	577	PF00069	0.516
TRG_DiLeu_BaEn_1	331	336	PF01217	0.461
TRG_DiLeu_BaEn_3	169	175	PF01217	0.314
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.388
TRG_ENDOCYTIC_2	101	104	PF00928	0.304
TRG_ENDOCYTIC_2	112	115	PF00928	0.401
TRG_ENDOCYTIC_2	250	253	PF00928	0.291
TRG_ENDOCYTIC_2	286	289	PF00928	0.343
TRG_ENDOCYTIC_2	301	304	PF00928	0.291
TRG_ENDOCYTIC_2	359	362	PF00928	0.335
TRG_ENDOCYTIC_2	439	442	PF00928	0.492
TRG_ENDOCYTIC_2	457	460	PF00928	0.265
TRG_ENDOCYTIC_2	46	49	PF00928	0.266
TRG_Pf-PMV_PEXEL_1	578	582	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJK5	Leptomonas seymouri	74%	100%
A0A0S4KEX6	Bodo saltans	41%	97%
A0A1X0P534	Trypanosomatidae	48%	97%
A0A3Q8IVI7	Leishmania donovani	95%	100%
A0A3R7KG84	Trypanosoma rangeli	48%	100%
A4HN90	Leishmania braziliensis	84%	99%
A4IBV8	Leishmania infantum	95%	100%
C9ZYQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
E9B6U8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q3V3N7	Mus musculus	32%	100%
Q8NFJ9	Homo sapiens	32%	100%
Q9NEZ7	Caenorhabditis elegans	23%	100%
V5DUI8	Trypanosoma cruzi	48%	100%