CULLIN_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2009), putative

Species:

Leishmania major

UniProt:

E9AFP3_LEIMA

TriTrypDb:

LmjF.35.4160 , LMJLV39_350049600 , LMJSD75_350049000

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFP3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	237	241	PF00656	0.302
CLV_C14_Caspase3-7	278	282	PF00656	0.376
CLV_C14_Caspase3-7	443	447	PF00656	0.302
CLV_C14_Caspase3-7	453	457	PF00656	0.302
CLV_C14_Caspase3-7	62	66	PF00656	0.302
CLV_NRD_NRD_1	10	12	PF00675	0.696
CLV_NRD_NRD_1	123	125	PF00675	0.302
CLV_NRD_NRD_1	307	309	PF00675	0.362
CLV_NRD_NRD_1	44	46	PF00675	0.302
CLV_NRD_NRD_1	96	98	PF00675	0.438
CLV_PCSK_FUR_1	8	12	PF00082	0.669
CLV_PCSK_KEX2_1	10	12	PF00082	0.663
CLV_PCSK_KEX2_1	123	125	PF00082	0.302
CLV_PCSK_KEX2_1	428	430	PF00082	0.375
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.375
CLV_PCSK_SKI1_1	154	158	PF00082	0.302
CLV_PCSK_SKI1_1	199	203	PF00082	0.359
CLV_PCSK_SKI1_1	215	219	PF00082	0.377
CLV_PCSK_SKI1_1	429	433	PF00082	0.309
CLV_PCSK_SKI1_1	75	79	PF00082	0.326
CLV_PCSK_SKI1_1	81	85	PF00082	0.276
DOC_CKS1_1	262	267	PF01111	0.369
DOC_CYCLIN_RxL_1	71	82	PF00134	0.447
DOC_MAPK_DCC_7	185	195	PF00069	0.321
DOC_MAPK_gen_1	45	56	PF00069	0.414
DOC_MAPK_gen_1	470	479	PF00069	0.302
DOC_MAPK_gen_1	71	80	PF00069	0.298
DOC_PP2B_LxvP_1	26	29	PF13499	0.512
DOC_USP7_MATH_1	147	151	PF00917	0.447
DOC_USP7_MATH_1	280	284	PF00917	0.426
DOC_WW_Pin1_4	106	111	PF00397	0.298
DOC_WW_Pin1_4	188	193	PF00397	0.302
DOC_WW_Pin1_4	261	266	PF00397	0.305
LIG_14-3-3_CanoR_1	284	291	PF00244	0.375
LIG_14-3-3_CanoR_1	458	465	PF00244	0.288
LIG_14-3-3_CanoR_1	97	103	PF00244	0.369
LIG_CtBP_PxDLS_1	93	98	PF00389	0.447
LIG_EH1_1	174	182	PF00400	0.414
LIG_FHA_1	133	139	PF00498	0.302
LIG_FHA_1	59	65	PF00498	0.302
LIG_FHA_1	82	88	PF00498	0.289
LIG_FHA_2	355	361	PF00498	0.302
LIG_GBD_Chelix_1	79	87	PF00786	0.321
LIG_LIR_Gen_1	135	144	PF02991	0.287
LIG_LIR_Gen_1	21	31	PF02991	0.403
LIG_LIR_Gen_1	481	490	PF02991	0.414
LIG_LIR_LC3C_4	76	80	PF02991	0.398
LIG_LIR_Nem_3	105	111	PF02991	0.294
LIG_LIR_Nem_3	135	140	PF02991	0.299
LIG_LIR_Nem_3	21	26	PF02991	0.445
LIG_LIR_Nem_3	385	390	PF02991	0.319
LIG_LIR_Nem_3	473	478	PF02991	0.399
LIG_LIR_Nem_3	481	486	PF02991	0.367
LIG_LYPXL_S_1	474	478	PF13949	0.302
LIG_NRBOX	254	260	PF00104	0.321
LIG_PCNA_yPIPBox_3	41	55	PF02747	0.344
LIG_Pex14_2	436	440	PF04695	0.302
LIG_Pex14_2	474	478	PF04695	0.302
LIG_Rb_LxCxE_1	264	283	PF01857	0.330
LIG_REV1ctd_RIR_1	433	441	PF16727	0.302
LIG_SH2_CRK	387	391	PF00017	0.321
LIG_SH2_PTP2	293	296	PF00017	0.369
LIG_SH2_STAP1	328	332	PF00017	0.335
LIG_SH2_STAP1	60	64	PF00017	0.302
LIG_SH2_STAT3	142	145	PF00017	0.302
LIG_SH2_STAT5	137	140	PF00017	0.296
LIG_SH2_STAT5	171	174	PF00017	0.302
LIG_SH2_STAT5	262	265	PF00017	0.368
LIG_SH2_STAT5	293	296	PF00017	0.303
LIG_SH2_STAT5	416	419	PF00017	0.363
LIG_SH2_STAT5	60	63	PF00017	0.302
LIG_SUMO_SIM_anti_2	228	235	PF11976	0.414
LIG_SUMO_SIM_anti_2	76	82	PF11976	0.414
LIG_SUMO_SIM_par_1	76	82	PF11976	0.414
LIG_TRAF2_1	357	360	PF00917	0.375
LIG_UBA3_1	255	260	PF00899	0.321
LIG_UBA3_1	90	98	PF00899	0.303
LIG_WRC_WIRS_1	483	488	PF05994	0.302
MOD_CK1_1	283	289	PF00069	0.273
MOD_CK1_1	481	487	PF00069	0.414
MOD_CK1_1	58	64	PF00069	0.302
MOD_CK2_1	264	270	PF00069	0.356
MOD_CK2_1	312	318	PF00069	0.302
MOD_CK2_1	354	360	PF00069	0.302
MOD_GlcNHglycan	441	445	PF01048	0.302
MOD_GlcNHglycan	460	463	PF01048	0.273
MOD_GlcNHglycan	480	483	PF01048	0.116
MOD_GlcNHglycan	65	68	PF01048	0.416
MOD_GSK3_1	266	273	PF00069	0.384
MOD_GSK3_1	478	485	PF00069	0.414
MOD_GSK3_1	81	88	PF00069	0.315
MOD_N-GLC_2	203	205	PF02516	0.414
MOD_N-GLC_2	305	307	PF02516	0.302
MOD_N-GLC_2	464	466	PF02516	0.302
MOD_NEK2_1	181	186	PF00069	0.365
MOD_NEK2_1	312	317	PF00069	0.431
MOD_NEK2_1	330	335	PF00069	0.208
MOD_NEK2_1	440	445	PF00069	0.294
MOD_NEK2_1	478	483	PF00069	0.414
MOD_NEK2_1	56	61	PF00069	0.414
MOD_PKA_2	283	289	PF00069	0.302
MOD_PKA_2	330	336	PF00069	0.302
MOD_PKA_2	457	463	PF00069	0.302
MOD_Plk_1	13	19	PF00069	0.618
MOD_Plk_1	269	275	PF00069	0.323
MOD_Plk_4	298	304	PF00069	0.295
MOD_Plk_4	98	104	PF00069	0.369
MOD_ProDKin_1	106	112	PF00069	0.298
MOD_ProDKin_1	188	194	PF00069	0.302
MOD_ProDKin_1	261	267	PF00069	0.305
TRG_DiLeu_BaEn_1	21	26	PF01217	0.465
TRG_DiLeu_BaEn_4	21	27	PF01217	0.548
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.414
TRG_ENDOCYTIC_2	125	128	PF00928	0.286
TRG_ENDOCYTIC_2	137	140	PF00928	0.286
TRG_ENDOCYTIC_2	23	26	PF00928	0.379
TRG_ENDOCYTIC_2	293	296	PF00928	0.303
TRG_ENDOCYTIC_2	387	390	PF00928	0.319
TRG_ENDOCYTIC_2	475	478	PF00928	0.302
TRG_ER_diArg_1	123	125	PF00400	0.303
TRG_ER_diArg_1	38	41	PF00400	0.213
TRG_ER_diArg_1	8	11	PF00400	0.707
TRG_ER_FFAT_2	257	267	PF00635	0.369
TRG_NES_CRM1_1	82	95	PF08389	0.375
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P579	Leptomonas seymouri	31%	100%
A0A0N1IK28	Leptomonas seymouri	82%	100%
A0A0S4JK69	Bodo saltans	32%	98%
A0A1X0P4E6	Trypanosomatidae	30%	100%
A0A1X0P522	Trypanosomatidae	66%	100%
A0A3R7KQ87	Trypanosoma rangeli	30%	100%
A0A3S7X9T8	Leishmania donovani	99%	100%
A0A3S7XBA3	Leishmania donovani	30%	100%
A0A422NK56	Trypanosoma rangeli	64%	100%
A4HN88	Leishmania braziliensis	92%	100%
A4HPM5	Leishmania braziliensis	31%	100%
A4IBV6	Leishmania infantum	98%	100%
A4ID40	Leishmania infantum	30%	100%
C9ZYQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
D0A8J1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ATD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B6U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q10301	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q4Q160	Leishmania major	31%	100%
Q54BM8	Dictyostelium discoideum	39%	73%
Q9USN2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
V5BS87	Trypanosoma cruzi	32%	98%
V5C2P9	Trypanosoma cruzi	65%	100%