Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AFP1_LEIMA

TriTrypDb:

LmjF.35.4140 , LMJLV39_350049400 , LMJSD75_350048800

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AFP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFP1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.426
CLV_NRD_NRD_1	158	160	PF00675	0.382
CLV_NRD_NRD_1	214	216	PF00675	0.472
CLV_NRD_NRD_1	219	221	PF00675	0.463
CLV_PCSK_KEX2_1	142	144	PF00082	0.426
CLV_PCSK_KEX2_1	158	160	PF00082	0.382
CLV_PCSK_KEX2_1	214	216	PF00082	0.469
CLV_PCSK_SKI1_1	158	162	PF00082	0.388
CLV_PCSK_SKI1_1	214	218	PF00082	0.462
CLV_PCSK_SKI1_1	60	64	PF00082	0.329
CLV_PCSK_SKI1_1	89	93	PF00082	0.325
DEG_APCC_DBOX_1	228	236	PF00400	0.656
DEG_Nend_Nbox_1	1	3	PF02207	0.403
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.596
DOC_MAPK_gen_1	142	149	PF00069	0.567
DOC_MAPK_gen_1	200	208	PF00069	0.684
DOC_MAPK_gen_1	60	68	PF00069	0.410
DOC_MAPK_MEF2A_6	142	149	PF00069	0.547
DOC_MAPK_MEF2A_6	200	208	PF00069	0.539
DOC_MAPK_MEF2A_6	50	59	PF00069	0.664
DOC_MAPK_MEF2A_6	60	68	PF00069	0.440
DOC_PP1_RVXF_1	87	93	PF00149	0.385
DOC_PP2B_LxvP_1	111	114	PF13499	0.526
DOC_PP2B_LxvP_1	97	100	PF13499	0.607
DOC_USP7_MATH_1	243	247	PF00917	0.767
DOC_USP7_MATH_1	36	40	PF00917	0.684
DOC_WW_Pin1_4	122	127	PF00397	0.670
DOC_WW_Pin1_4	39	44	PF00397	0.694
LIG_14-3-3_CanoR_1	134	139	PF00244	0.589
LIG_14-3-3_CanoR_1	223	232	PF00244	0.656
LIG_14-3-3_CanoR_1	29	34	PF00244	0.694
LIG_14-3-3_CanoR_1	50	56	PF00244	0.654
LIG_APCC_ABBA_1	82	87	PF00400	0.325
LIG_BRCT_BRCA1_1	171	175	PF00533	0.575
LIG_deltaCOP1_diTrp_1	80	85	PF00928	0.308
LIG_FHA_1	126	132	PF00498	0.676
LIG_FHA_1	133	139	PF00498	0.714
LIG_FHA_1	208	214	PF00498	0.619
LIG_FHA_1	29	35	PF00498	0.710
LIG_FHA_1	52	58	PF00498	0.570
LIG_FHA_1	68	74	PF00498	0.270
LIG_FHA_2	51	57	PF00498	0.617
LIG_GBD_Chelix_1	8	16	PF00786	0.246
LIG_LIR_Apic_2	95	101	PF02991	0.520
LIG_LIR_Gen_1	106	116	PF02991	0.591
LIG_LIR_Nem_3	106	111	PF02991	0.592
LIG_LIR_Nem_3	80	85	PF02991	0.266
LIG_Pex14_1	81	85	PF04695	0.367
LIG_RPA_C_Fungi	162	174	PF08784	0.367
LIG_SH2_CRK	108	112	PF00017	0.395
LIG_SH2_CRK	94	98	PF00017	0.363
LIG_SH2_PTP2	98	101	PF00017	0.368
LIG_SH2_SRC	98	101	PF00017	0.465
LIG_SH2_STAP1	108	112	PF00017	0.395
LIG_SH2_STAP1	94	98	PF00017	0.363
LIG_SH2_STAT5	15	18	PF00017	0.385
LIG_SH2_STAT5	94	97	PF00017	0.370
LIG_SH2_STAT5	98	101	PF00017	0.531
LIG_SUMO_SIM_par_1	6	11	PF11976	0.367
LIG_SUMO_SIM_par_1	64	70	PF11976	0.385
LIG_TRAF2_1	103	106	PF00917	0.521
MOD_CDK_SPxxK_3	122	129	PF00069	0.549
MOD_CK1_1	125	131	PF00069	0.580
MOD_CK1_1	192	198	PF00069	0.510
MOD_CK1_1	245	251	PF00069	0.619
MOD_CK1_1	39	45	PF00069	0.693
MOD_CK2_1	50	56	PF00069	0.528
MOD_GlcNHglycan	189	192	PF01048	0.643
MOD_GlcNHglycan	194	197	PF01048	0.612
MOD_GlcNHglycan	226	229	PF01048	0.645
MOD_GlcNHglycan	37	41	PF01048	0.631
MOD_NEK2_1	1	6	PF00069	0.560
MOD_NEK2_1	208	213	PF00069	0.567
MOD_NEK2_1	67	72	PF00069	0.340
MOD_NEK2_1	8	13	PF00069	0.289
MOD_NEK2_1	92	97	PF00069	0.332
MOD_PIKK_1	208	214	PF00454	0.406
MOD_PKA_2	187	193	PF00069	0.663
MOD_PKA_2	28	34	PF00069	0.596
MOD_Plk_1	243	249	PF00069	0.720
MOD_Plk_4	134	140	PF00069	0.478
MOD_Plk_4	29	35	PF00069	0.629
MOD_Plk_4	72	78	PF00069	0.401
MOD_Plk_4	8	14	PF00069	0.315
MOD_Plk_4	92	98	PF00069	0.162
MOD_ProDKin_1	122	128	PF00069	0.589
MOD_ProDKin_1	39	45	PF00069	0.628
TRG_DiLeu_BaEn_1	3	8	PF01217	0.411
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.495
TRG_DiLeu_LyEn_5	3	8	PF01217	0.411
TRG_ENDOCYTIC_2	108	111	PF00928	0.406
TRG_ENDOCYTIC_2	15	18	PF00928	0.306
TRG_ENDOCYTIC_2	20	23	PF00928	0.275
TRG_ENDOCYTIC_2	94	97	PF00928	0.377
TRG_ER_diArg_1	141	143	PF00400	0.526
TRG_ER_diArg_1	158	160	PF00400	0.476
TRG_ER_diArg_1	213	215	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X0	Leptomonas seymouri	59%	82%
A0A1X0P530	Trypanosomatidae	27%	100%
A0A3Q8IIP6	Leishmania donovani	85%	83%
A0A422NK66	Trypanosoma rangeli	32%	100%
A4HN86	Leishmania braziliensis	63%	84%
A4IBV4	Leishmania infantum	86%	83%
E9B6U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	83%