Polyadenylate-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

polyadenylate-binding protein 2

Species:

Leishmania major

UniProt:

E9AFP0_LEIMA

TriTrypDb:

LmjF.35.4130 , LMJLV39_350049300 , LMJSD75_350048700

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	2
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	12
GO:0005829	cytosol	2	2
GO:0010494	cytoplasmic stress granule	5	2
GO:0032991	protein-containing complex	1	2
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2

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Expansion

Sequence features

E9AFP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFP0

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0005488	binding	1	12
GO:0005515	protein binding	2	2
GO:0008143	poly(A) binding	7	2
GO:0008187	poly-pyrimidine tract binding	6	2
GO:0008266	poly(U) RNA binding	7	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.548
CLV_C14_Caspase3-7	575	579	PF00656	0.551
CLV_NRD_NRD_1	277	279	PF00675	0.541
CLV_NRD_NRD_1	366	368	PF00675	0.509
CLV_NRD_NRD_1	371	373	PF00675	0.509
CLV_NRD_NRD_1	90	92	PF00675	0.498
CLV_PCSK_FUR_1	275	279	PF00082	0.532
CLV_PCSK_KEX2_1	277	279	PF00082	0.539
CLV_PCSK_KEX2_1	371	373	PF00082	0.517
CLV_PCSK_KEX2_1	89	91	PF00082	0.500

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A9	Leptomonas seymouri	90%	100%
A0A0S4IKZ4	Bodo saltans	57%	100%
A0A0S4JPT3	Bodo saltans	38%	100%
A0A1X0P4T3	Trypanosomatidae	37%	100%
A0A1X0P525	Trypanosomatidae	66%	100%
A0A3Q8IF40	Leishmania donovani	37%	100%
A0A3Q8IGR8	Leishmania donovani	36%	100%
A0A3Q8IMW2	Leishmania donovani	99%	100%
A0A3R7NAH9	Trypanosoma rangeli	36%	100%
A0A422NK82	Trypanosoma rangeli	66%	100%

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