Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFN9_LEIMA

TriTrypDb:

LmjF.35.4125 , LMJLV39_350049200 , LMJSD75_350048600

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFN9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.710
CLV_C14_Caspase3-7	506	510	PF00656	0.594
CLV_C14_Caspase3-7	521	525	PF00656	0.704
CLV_NRD_NRD_1	172	174	PF00675	0.721
CLV_NRD_NRD_1	204	206	PF00675	0.807
CLV_NRD_NRD_1	240	242	PF00675	0.816
CLV_NRD_NRD_1	432	434	PF00675	0.712
CLV_NRD_NRD_1	436	438	PF00675	0.710
CLV_NRD_NRD_1	66	68	PF00675	0.733
CLV_PCSK_KEX2_1	172	174	PF00082	0.721
CLV_PCSK_KEX2_1	204	206	PF00082	0.807
CLV_PCSK_KEX2_1	240	242	PF00082	0.816
CLV_PCSK_KEX2_1	290	292	PF00082	0.653
CLV_PCSK_KEX2_1	490	492	PF00082	0.749
CLV_PCSK_KEX2_1	66	68	PF00082	0.733
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.709
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.730
CLV_PCSK_SKI1_1	205	209	PF00082	0.703
CLV_PCSK_SKI1_1	342	346	PF00082	0.688
CLV_PCSK_SKI1_1	70	74	PF00082	0.707
DEG_SCF_FBW7_1	303	308	PF00400	0.583
DEG_SCF_FBW7_2	43	50	PF00400	0.752
DEG_SPOP_SBC_1	104	108	PF00917	0.743
DEG_SPOP_SBC_1	56	60	PF00917	0.812
DOC_CKS1_1	139	144	PF01111	0.777
DOC_CKS1_1	197	202	PF01111	0.711
DOC_PP4_FxxP_1	527	530	PF00568	0.674
DOC_USP7_MATH_1	180	184	PF00917	0.699
DOC_USP7_MATH_1	248	252	PF00917	0.791
DOC_USP7_MATH_1	28	32	PF00917	0.715
DOC_USP7_MATH_1	427	431	PF00917	0.705
DOC_USP7_MATH_1	495	499	PF00917	0.686
DOC_USP7_MATH_1	504	508	PF00917	0.722
DOC_USP7_MATH_1	512	516	PF00917	0.578
DOC_USP7_MATH_1	57	61	PF00917	0.787
DOC_USP7_UBL2_3	434	438	PF12436	0.807
DOC_WW_Pin1_4	138	143	PF00397	0.753
DOC_WW_Pin1_4	196	201	PF00397	0.719
DOC_WW_Pin1_4	235	240	PF00397	0.671
DOC_WW_Pin1_4	299	304	PF00397	0.791
DOC_WW_Pin1_4	322	327	PF00397	0.712
DOC_WW_Pin1_4	349	354	PF00397	0.733
DOC_WW_Pin1_4	41	46	PF00397	0.757
DOC_WW_Pin1_4	484	489	PF00397	0.647
DOC_WW_Pin1_4	526	531	PF00397	0.627
DOC_WW_Pin1_4	536	541	PF00397	0.597
DOC_WW_Pin1_4	567	572	PF00397	0.669
LIG_14-3-3_CanoR_1	12	17	PF00244	0.732
LIG_14-3-3_CanoR_1	204	213	PF00244	0.807
LIG_14-3-3_CanoR_1	226	230	PF00244	0.589
LIG_14-3-3_CanoR_1	247	253	PF00244	0.751
LIG_14-3-3_CanoR_1	256	261	PF00244	0.650
LIG_14-3-3_CanoR_1	278	288	PF00244	0.752
LIG_14-3-3_CanoR_1	348	353	PF00244	0.794
LIG_14-3-3_CanoR_1	37	45	PF00244	0.734
LIG_14-3-3_CanoR_1	433	439	PF00244	0.692
LIG_14-3-3_CanoR_1	491	497	PF00244	0.817
LIG_14-3-3_CanoR_1	502	511	PF00244	0.721
LIG_14-3-3_CanoR_1	54	64	PF00244	0.715
LIG_14-3-3_CanoR_1	564	570	PF00244	0.700
LIG_14-3-3_CanoR_1	583	587	PF00244	0.779
LIG_14-3-3_CanoR_1	66	70	PF00244	0.672
LIG_14-3-3_CanoR_1	79	85	PF00244	0.682
LIG_BIR_II_1	1	5	PF00653	0.830
LIG_BRCT_BRCA1_1	465	469	PF00533	0.672
LIG_CtBP_PxDLS_1	464	468	PF00389	0.550
LIG_EVH1_2	452	456	PF00568	0.769
LIG_FHA_1	105	111	PF00498	0.746
LIG_FHA_1	118	124	PF00498	0.528
LIG_FHA_1	149	155	PF00498	0.660
LIG_FHA_1	339	345	PF00498	0.787
LIG_FHA_1	434	440	PF00498	0.770
LIG_FHA_1	575	581	PF00498	0.692
LIG_FHA_2	571	577	PF00498	0.688
LIG_LIR_Apic_2	524	530	PF02991	0.675
LIG_LIR_Gen_1	311	317	PF02991	0.708
LIG_LIR_Gen_1	46	56	PF02991	0.775
LIG_LIR_Gen_1	573	580	PF02991	0.672
LIG_LIR_Nem_3	311	316	PF02991	0.776
LIG_LIR_Nem_3	46	51	PF02991	0.775
LIG_LIR_Nem_3	573	578	PF02991	0.709
LIG_PDZ_Class_2	583	588	PF00595	0.780
LIG_Pex14_2	527	531	PF04695	0.676
LIG_PTAP_UEV_1	306	311	PF05743	0.701
LIG_SH2_CRK	313	317	PF00017	0.711
LIG_SH2_NCK_1	231	235	PF00017	0.563
LIG_SH2_NCK_1	249	253	PF00017	0.809
LIG_SH2_NCK_1	313	317	PF00017	0.711
LIG_SH2_STAP1	231	235	PF00017	0.563
LIG_SH2_STAP1	313	317	PF00017	0.711
LIG_SH3_2	236	241	PF14604	0.703
LIG_SH3_2	485	490	PF14604	0.712
LIG_SH3_3	111	117	PF00018	0.779
LIG_SH3_3	136	142	PF00018	0.654
LIG_SH3_3	174	180	PF00018	0.718
LIG_SH3_3	233	239	PF00018	0.680
LIG_SH3_3	269	275	PF00018	0.808
LIG_SH3_3	304	310	PF00018	0.681
LIG_SH3_3	443	449	PF00018	0.653
LIG_SH3_3	482	488	PF00018	0.628
LIG_SH3_3	550	556	PF00018	0.726
LIG_SH3_4	73	80	PF00018	0.667
LIG_SH3_CIN85_PxpxPR_1	176	181	PF14604	0.619
LIG_SH3_CIN85_PxpxPR_1	445	450	PF14604	0.588
LIG_SUMO_SIM_par_1	576	581	PF11976	0.689
MOD_CDC14_SPxK_1	238	241	PF00782	0.811
MOD_CDC14_SPxK_1	487	490	PF00782	0.710
MOD_CDK_SPK_2	235	240	PF00069	0.800
MOD_CDK_SPK_2	349	354	PF00069	0.826
MOD_CDK_SPK_2	567	572	PF00069	0.696
MOD_CDK_SPxK_1	235	241	PF00069	0.803
MOD_CDK_SPxK_1	484	490	PF00069	0.712
MOD_CDK_SPxxK_3	484	491	PF00069	0.713
MOD_CDK_SPxxK_3	526	533	PF00069	0.711
MOD_CK1_1	102	108	PF00069	0.717
MOD_CK1_1	124	130	PF00069	0.792
MOD_CK1_1	135	141	PF00069	0.562
MOD_CK1_1	149	155	PF00069	0.709
MOD_CK1_1	15	21	PF00069	0.660
MOD_CK1_1	156	162	PF00069	0.636
MOD_CK1_1	183	189	PF00069	0.687
MOD_CK1_1	225	231	PF00069	0.569
MOD_CK1_1	255	261	PF00069	0.640
MOD_CK1_1	294	300	PF00069	0.663
MOD_CK1_1	301	307	PF00069	0.659
MOD_CK1_1	338	344	PF00069	0.730
MOD_CK1_1	432	438	PF00069	0.609
MOD_CK1_1	468	474	PF00069	0.668
MOD_CK1_1	476	482	PF00069	0.676
MOD_CK1_1	538	544	PF00069	0.709
MOD_CK1_1	570	576	PF00069	0.690
MOD_CK1_1	60	66	PF00069	0.824
MOD_CK2_1	91	97	PF00069	0.707
MOD_Cter_Amidation	288	291	PF01082	0.608
MOD_GlcNHglycan	125	129	PF01048	0.702
MOD_GlcNHglycan	134	137	PF01048	0.795
MOD_GlcNHglycan	216	219	PF01048	0.677
MOD_GlcNHglycan	244	247	PF01048	0.787
MOD_GlcNHglycan	250	253	PF01048	0.643
MOD_GlcNHglycan	293	296	PF01048	0.656
MOD_GlcNHglycan	30	33	PF01048	0.660
MOD_GlcNHglycan	320	323	PF01048	0.633
MOD_GlcNHglycan	354	357	PF01048	0.763
MOD_GlcNHglycan	382	385	PF01048	0.818
MOD_GlcNHglycan	395	398	PF01048	0.721
MOD_GlcNHglycan	421	424	PF01048	0.711
MOD_GlcNHglycan	475	478	PF01048	0.773
MOD_GlcNHglycan	497	500	PF01048	0.668
MOD_GlcNHglycan	506	509	PF01048	0.699
MOD_GlcNHglycan	580	583	PF01048	0.670
MOD_GlcNHglycan	93	96	PF01048	0.693
MOD_GSK3_1	117	124	PF00069	0.700
MOD_GSK3_1	12	19	PF00069	0.723
MOD_GSK3_1	131	138	PF00069	0.686
MOD_GSK3_1	149	156	PF00069	0.698
MOD_GSK3_1	157	164	PF00069	0.635
MOD_GSK3_1	180	187	PF00069	0.694
MOD_GSK3_1	208	215	PF00069	0.659
MOD_GSK3_1	218	225	PF00069	0.588
MOD_GSK3_1	248	255	PF00069	0.706
MOD_GSK3_1	291	298	PF00069	0.710
MOD_GSK3_1	299	306	PF00069	0.720
MOD_GSK3_1	318	325	PF00069	0.780
MOD_GSK3_1	344	351	PF00069	0.752
MOD_GSK3_1	37	44	PF00069	0.704
MOD_GSK3_1	391	398	PF00069	0.802
MOD_GSK3_1	399	406	PF00069	0.678
MOD_GSK3_1	429	436	PF00069	0.733
MOD_GSK3_1	491	498	PF00069	0.683
MOD_GSK3_1	547	554	PF00069	0.656
MOD_GSK3_1	55	62	PF00069	0.695
MOD_GSK3_1	563	570	PF00069	0.686
MOD_GSK3_1	574	581	PF00069	0.682
MOD_GSK3_1	98	105	PF00069	0.694
MOD_N-GLC_1	147	152	PF02516	0.819
MOD_N-GLC_1	16	21	PF02516	0.723
MOD_N-GLC_1	205	210	PF02516	0.575
MOD_N-GLC_1	391	396	PF02516	0.737
MOD_NEK2_1	146	151	PF00069	0.742
MOD_NEK2_1	279	284	PF00069	0.741
MOD_NEK2_1	344	349	PF00069	0.728
MOD_NEK2_1	395	400	PF00069	0.707
MOD_NEK2_1	456	461	PF00069	0.711
MOD_NEK2_1	578	583	PF00069	0.667
MOD_PIKK_1	16	22	PF00454	0.700
MOD_PIKK_1	180	186	PF00454	0.696
MOD_PIKK_1	218	224	PF00454	0.783
MOD_PIKK_1	368	374	PF00454	0.722
MOD_PIKK_1	73	79	PF00454	0.731
MOD_PK_1	12	18	PF00069	0.702
MOD_PK_1	256	262	PF00069	0.699
MOD_PK_1	518	524	PF00069	0.686
MOD_PKA_1	433	439	PF00069	0.809
MOD_PKA_1	490	496	PF00069	0.716
MOD_PKA_2	161	167	PF00069	0.770
MOD_PKA_2	180	186	PF00069	0.696
MOD_PKA_2	225	231	PF00069	0.552
MOD_PKA_2	255	261	PF00069	0.679
MOD_PKA_2	38	44	PF00069	0.709
MOD_PKA_2	402	408	PF00069	0.754
MOD_PKA_2	432	438	PF00069	0.632
MOD_PKA_2	490	496	PF00069	0.819
MOD_PKA_2	517	523	PF00069	0.705
MOD_PKA_2	563	569	PF00069	0.707
MOD_PKA_2	582	588	PF00069	0.677
MOD_PKA_2	65	71	PF00069	0.792
MOD_Plk_1	391	397	PF00069	0.738
MOD_Plk_4	208	214	PF00069	0.692
MOD_Plk_4	225	231	PF00069	0.465
MOD_Plk_4	80	86	PF00069	0.663
MOD_ProDKin_1	138	144	PF00069	0.756
MOD_ProDKin_1	196	202	PF00069	0.714
MOD_ProDKin_1	235	241	PF00069	0.675
MOD_ProDKin_1	299	305	PF00069	0.786
MOD_ProDKin_1	322	328	PF00069	0.711
MOD_ProDKin_1	349	355	PF00069	0.733
MOD_ProDKin_1	41	47	PF00069	0.752
MOD_ProDKin_1	484	490	PF00069	0.647
MOD_ProDKin_1	526	532	PF00069	0.623
MOD_ProDKin_1	536	542	PF00069	0.599
MOD_ProDKin_1	567	573	PF00069	0.669
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.683
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.686
TRG_ENDOCYTIC_2	313	316	PF00928	0.716
TRG_ER_diArg_1	11	14	PF00400	0.715
TRG_ER_diArg_1	203	205	PF00400	0.802
TRG_ER_diArg_1	239	241	PF00400	0.801
TRG_ER_diArg_1	36	39	PF00400	0.644
TRG_ER_diArg_1	362	365	PF00400	0.786

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3V4	Leptomonas seymouri	38%	100%
A0A3S7X9W4	Leishmania donovani	89%	100%
A4HN84	Leishmania braziliensis	62%	100%
A4IBV2	Leishmania infantum	88%	100%
E9B6U2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%