5'-deoxynucleotidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HD domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AFN7_LEIMA

TriTrypDb:

LmjF.35.4110 , LMJLV39_350049000 , LMJSD75_350048400

Length:

205

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFN7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002953	5'-deoxynucleotidase activity	6	11
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	65	69	PF00082	0.292
CLV_PCSK_SKI1_1	91	95	PF00082	0.366
DEG_APCC_DBOX_1	47	55	PF00400	0.296
DOC_MAPK_gen_1	63	71	PF00069	0.233
DOC_USP7_MATH_1	101	105	PF00917	0.311
DOC_USP7_MATH_1	57	61	PF00917	0.312
DOC_USP7_UBL2_3	91	95	PF12436	0.366
DOC_WW_Pin1_4	109	114	PF00397	0.314
DOC_WW_Pin1_4	35	40	PF00397	0.407
DOC_WW_Pin1_4	81	86	PF00397	0.233
LIG_14-3-3_CanoR_1	22	32	PF00244	0.182
LIG_14-3-3_CanoR_1	48	52	PF00244	0.317
LIG_Actin_WH2_2	10	26	PF00022	0.346
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_FHA_2	182	188	PF00498	0.446
LIG_HCF-1_HBM_1	44	47	PF13415	0.233
LIG_LIR_Nem_3	123	128	PF02991	0.252
LIG_LIR_Nem_3	188	194	PF02991	0.432
LIG_PDZ_Class_1	200	205	PF00595	0.334
LIG_REV1ctd_RIR_1	164	172	PF16727	0.381
LIG_SH2_NCK_1	154	158	PF00017	0.347
LIG_SH2_STAP1	182	186	PF00017	0.395
LIG_SH2_STAT3	128	131	PF00017	0.233
LIG_SH2_STAT5	191	194	PF00017	0.414
LIG_UBA3_1	79	88	PF00899	0.276
LIG_WRC_WIRS_1	13	18	PF05994	0.393
LIG_WRC_WIRS_1	163	168	PF05994	0.354
MOD_CDK_SPxxK_3	81	88	PF00069	0.312
MOD_CK1_1	112	118	PF00069	0.306
MOD_CK1_1	153	159	PF00069	0.298
MOD_CK1_1	38	44	PF00069	0.254
MOD_CK2_1	181	187	PF00069	0.443
MOD_GlcNHglycan	155	158	PF01048	0.264
MOD_GlcNHglycan	168	171	PF01048	0.368
MOD_GSK3_1	108	115	PF00069	0.365
MOD_GSK3_1	12	19	PF00069	0.383
MOD_GSK3_1	162	169	PF00069	0.361
MOD_GSK3_1	181	188	PF00069	0.316
MOD_N-GLC_1	113	118	PF02516	0.232
MOD_NEK2_1	1	6	PF00069	0.590
MOD_NEK2_1	108	113	PF00069	0.366
MOD_NEK2_1	16	21	PF00069	0.252
MOD_NEK2_1	166	171	PF00069	0.477
MOD_NEK2_1	185	190	PF00069	0.315
MOD_NEK2_1	23	28	PF00069	0.276
MOD_PIKK_1	96	102	PF00454	0.390
MOD_PKA_2	47	53	PF00069	0.316
MOD_Plk_1	113	119	PF00069	0.318
MOD_Plk_1	57	63	PF00069	0.260
MOD_Plk_4	162	168	PF00069	0.359
MOD_Plk_4	181	187	PF00069	0.389
MOD_Plk_4	47	53	PF00069	0.356
MOD_Plk_4	75	81	PF00069	0.233
MOD_ProDKin_1	109	115	PF00069	0.314
MOD_ProDKin_1	35	41	PF00069	0.407
MOD_ProDKin_1	81	87	PF00069	0.233
TRG_ENDOCYTIC_2	182	185	PF00928	0.354
TRG_NES_CRM1_1	44	58	PF08389	0.312
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.329
TRG_PTS2	1	36	PF00400	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX92	Leptomonas seymouri	78%	100%
A0A0S4J0X2	Bodo saltans	60%	100%
A0A1X0P6J6	Trypanosomatidae	60%	100%
A0A3Q8IQ15	Leishmania donovani	95%	100%
A0A3R7MHB3	Trypanosoma rangeli	60%	100%
A4HN82	Leishmania braziliensis	87%	100%
A4IBV0	Leishmania infantum	95%	100%
C9ZYR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9B6U0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P38331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	86%
P53144	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	95%
P87242	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
Q0P565	Bos taurus	44%	100%
Q1LUI2	Danio rerio	39%	100%
Q3SXD3	Mus musculus	44%	100%
Q54FK1	Dictyostelium discoideum	39%	100%
Q66L17	Xenopus laevis	44%	100%
Q7Z4H3	Homo sapiens	44%	100%