Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFN6_LEIMA

TriTrypDb:

LmjF.35.4100 , LMJLV39_350048900 , LMJSD75_350048300

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFN6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.633
CLV_C14_Caspase3-7	230	234	PF00656	0.637
CLV_NRD_NRD_1	222	224	PF00675	0.664
CLV_NRD_NRD_1	311	313	PF00675	0.563
CLV_NRD_NRD_1	330	332	PF00675	0.590
CLV_PCSK_FUR_1	220	224	PF00082	0.519
CLV_PCSK_FUR_1	309	313	PF00082	0.608
CLV_PCSK_KEX2_1	109	111	PF00082	0.550
CLV_PCSK_KEX2_1	222	224	PF00082	0.647
CLV_PCSK_KEX2_1	262	264	PF00082	0.514
CLV_PCSK_KEX2_1	311	313	PF00082	0.545
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.622
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.572
CLV_PCSK_PC7_1	307	313	PF00082	0.531
CLV_PCSK_SKI1_1	201	205	PF00082	0.498
CLV_PCSK_SKI1_1	311	315	PF00082	0.570
CLV_PCSK_SKI1_1	335	339	PF00082	0.492
CLV_PCSK_SKI1_1	53	57	PF00082	0.523
DEG_APCC_DBOX_1	262	270	PF00400	0.602
DEG_APCC_DBOX_1	52	60	PF00400	0.530
DEG_Nend_UBRbox_1	1	4	PF02207	0.713
DOC_CYCLIN_RxL_1	258	268	PF00134	0.603
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.541
DOC_MAPK_gen_1	109	117	PF00069	0.585
DOC_MAPK_gen_1	218	226	PF00069	0.688
DOC_MAPK_gen_1	48	56	PF00069	0.621
DOC_MAPK_MEF2A_6	109	116	PF00069	0.512
DOC_MAPK_MEF2A_6	48	56	PF00069	0.621
DOC_MAPK_MEF2A_6	68	76	PF00069	0.297
DOC_MAPK_MEF2A_6	95	103	PF00069	0.557
DOC_PP4_FxxP_1	148	151	PF00568	0.543
DOC_PP4_FxxP_1	402	405	PF00568	0.672
DOC_USP7_MATH_1	183	187	PF00917	0.604
DOC_USP7_MATH_1	225	229	PF00917	0.695
DOC_USP7_MATH_1	232	236	PF00917	0.695
DOC_USP7_MATH_1	333	337	PF00917	0.637
DOC_USP7_MATH_1	87	91	PF00917	0.634
DOC_USP7_UBL2_3	258	262	PF12436	0.613
DOC_USP7_UBL2_3	44	48	PF12436	0.535
DOC_WW_Pin1_4	325	330	PF00397	0.526
LIG_14-3-3_CanoR_1	386	392	PF00244	0.588
LIG_14-3-3_CanoR_1	417	422	PF00244	0.664
LIG_14-3-3_CanoR_1	77	85	PF00244	0.530
LIG_Actin_WH2_2	39	55	PF00022	0.645
LIG_APCC_ABBA_1	291	296	PF00400	0.638
LIG_BRCT_BRCA1_1	144	148	PF00533	0.573
LIG_BRCT_BRCA1_1	198	202	PF00533	0.545
LIG_BRCT_BRCA1_1	89	93	PF00533	0.628
LIG_BRCT_BRCA1_2	89	95	PF00533	0.670
LIG_deltaCOP1_diTrp_1	67	75	PF00928	0.508
LIG_FHA_1	168	174	PF00498	0.586
LIG_FHA_1	179	185	PF00498	0.454
LIG_FHA_1	254	260	PF00498	0.552
LIG_FHA_1	38	44	PF00498	0.519
LIG_FHA_1	5	11	PF00498	0.686
LIG_FHA_1	81	87	PF00498	0.618
LIG_FHA_2	126	132	PF00498	0.636
LIG_FHA_2	153	159	PF00498	0.566
LIG_FHA_2	202	208	PF00498	0.504
LIG_FHA_2	228	234	PF00498	0.718
LIG_FHA_2	319	325	PF00498	0.468
LIG_FHA_2	393	399	PF00498	0.718
LIG_LIR_Apic_2	145	151	PF02991	0.564
LIG_LIR_Gen_1	155	165	PF02991	0.519
LIG_LIR_Gen_1	336	346	PF02991	0.446
LIG_LIR_Gen_1	369	380	PF02991	0.640
LIG_LIR_Gen_1	67	76	PF02991	0.517
LIG_LIR_Nem_3	144	150	PF02991	0.615
LIG_LIR_Nem_3	155	160	PF02991	0.515
LIG_LIR_Nem_3	199	205	PF02991	0.557
LIG_LIR_Nem_3	336	341	PF02991	0.498
LIG_LIR_Nem_3	369	375	PF02991	0.637
LIG_LIR_Nem_3	416	421	PF02991	0.689
LIG_LIR_Nem_3	67	72	PF02991	0.498
LIG_LYPXL_S_1	293	297	PF13949	0.505
LIG_LYPXL_yS_3	205	208	PF13949	0.516
LIG_LYPXL_yS_3	294	297	PF13949	0.491
LIG_NRBOX	286	292	PF00104	0.499
LIG_PDZ_Class_1	417	422	PF00595	0.727
LIG_Pex14_1	69	73	PF04695	0.483
LIG_Pex14_2	346	350	PF04695	0.521
LIG_SH2_GRB2like	376	379	PF00017	0.694
LIG_SH2_STAP1	143	147	PF00017	0.688
LIG_SH2_STAP1	376	380	PF00017	0.659
LIG_SH2_STAP1	415	419	PF00017	0.686
LIG_SH2_STAT5	136	139	PF00017	0.540
LIG_SH2_STAT5	23	26	PF00017	0.613
LIG_SH2_STAT5	301	304	PF00017	0.530
LIG_SH2_STAT5	418	421	PF00017	0.725
LIG_SH2_STAT5	73	76	PF00017	0.500
LIG_SH3_2	330	335	PF14604	0.552
LIG_SH3_3	119	125	PF00018	0.529
LIG_SH3_3	274	280	PF00018	0.519
LIG_SH3_3	302	308	PF00018	0.495
LIG_SH3_3	323	329	PF00018	0.593
LIG_SUMO_SIM_anti_2	321	328	PF11976	0.469
LIG_SUMO_SIM_par_1	180	186	PF11976	0.540
LIG_SUMO_SIM_par_1	207	212	PF11976	0.622
LIG_TRAF2_1	128	131	PF00917	0.493
LIG_TRAF2_1	240	243	PF00917	0.665
LIG_TRAF2_1	363	366	PF00917	0.704
LIG_UBA3_1	384	392	PF00899	0.551
LIG_WRC_WIRS_1	251	256	PF05994	0.626
LIG_WRC_WIRS_1	388	393	PF05994	0.609
LIG_WRC_WIRS_1	5	10	PF05994	0.725
LIG_WW_3	328	332	PF00397	0.568
MOD_CDC14_SPxK_1	328	331	PF00782	0.565
MOD_CDK_SPxK_1	325	331	PF00069	0.533
MOD_CDK_SPxxK_3	325	332	PF00069	0.539
MOD_CK1_1	135	141	PF00069	0.665
MOD_CK1_1	228	234	PF00069	0.657
MOD_CK1_1	368	374	PF00069	0.705
MOD_CK2_1	125	131	PF00069	0.485
MOD_CK2_1	13	19	PF00069	0.721
MOD_CK2_1	152	158	PF00069	0.526
MOD_CK2_1	201	207	PF00069	0.505
MOD_CK2_1	333	339	PF00069	0.522
MOD_Cter_Amidation	95	98	PF01082	0.625
MOD_GlcNHglycan	15	18	PF01048	0.755
MOD_GlcNHglycan	152	155	PF01048	0.680
MOD_GlcNHglycan	176	179	PF01048	0.444
MOD_GlcNHglycan	227	230	PF01048	0.670
MOD_GSK3_1	174	181	PF00069	0.556
MOD_GSK3_1	197	204	PF00069	0.497
MOD_GSK3_1	224	231	PF00069	0.721
MOD_GSK3_1	314	321	PF00069	0.513
MOD_GSK3_1	76	83	PF00069	0.593
MOD_N-GLC_1	13	18	PF02516	0.630
MOD_N-GLC_1	87	92	PF02516	0.677
MOD_NEK2_1	137	142	PF00069	0.688
MOD_NEK2_1	197	202	PF00069	0.622
MOD_NEK2_1	224	229	PF00069	0.594
MOD_NEK2_1	37	42	PF00069	0.680
MOD_NEK2_2	333	338	PF00069	0.559
MOD_NEK2_2	387	392	PF00069	0.668
MOD_PIKK_1	152	158	PF00454	0.599
MOD_PIKK_1	209	215	PF00454	0.607
MOD_PIKK_1	318	324	PF00454	0.497
MOD_PIKK_1	357	363	PF00454	0.664
MOD_PIKK_1	37	43	PF00454	0.677
MOD_PKA_2	197	203	PF00069	0.510
MOD_PKA_2	76	82	PF00069	0.509
MOD_Plk_1	333	339	PF00069	0.635
MOD_Plk_4	132	138	PF00069	0.660
MOD_Plk_4	333	339	PF00069	0.620
MOD_Plk_4	368	374	PF00069	0.627
MOD_ProDKin_1	325	331	PF00069	0.533
MOD_SUMO_rev_2	102	111	PF00179	0.614
MOD_SUMO_rev_2	377	385	PF00179	0.572
TRG_DiLeu_BaEn_1	286	291	PF01217	0.541
TRG_DiLeu_BaEn_2	70	76	PF01217	0.500
TRG_ENDOCYTIC_2	205	208	PF00928	0.516
TRG_ENDOCYTIC_2	294	297	PF00928	0.482
TRG_ENDOCYTIC_2	73	76	PF00928	0.500
TRG_ER_diArg_1	220	223	PF00400	0.710
TRG_ER_diArg_1	29	32	PF00400	0.722
TRG_ER_diArg_1	307	310	PF00400	0.543
TRG_ER_diArg_1	311	313	PF00400	0.572
TRG_ER_diArg_1	51	54	PF00400	0.615
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.697

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR9	Leptomonas seymouri	69%	90%
A0A0S4J059	Bodo saltans	44%	94%
A0A1X0P5E2	Trypanosomatidae	54%	93%
A0A3S7X9S4	Leishmania donovani	95%	100%
A4HN81	Leishmania braziliensis	86%	100%
A4IBU9	Leishmania infantum	94%	100%
C9ZYR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	92%
E9B6T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BCS7	Trypanosoma cruzi	54%	93%