TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFN3_LEIMA

TriTrypDb:

LmjF.35.4070 , LMJLV39_350048600 , LMJSD75_350048000

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0000152	nuclear ubiquitin ligase complex	3	2
GO:0005680	anaphase-promoting complex	4	2
GO:0005737	cytoplasm	2	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

E9AFN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFN3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0007088	regulation of mitotic nuclear division	6	2
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	5	2
GO:0007346	regulation of mitotic cell cycle	5	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0010564	regulation of cell cycle process	5	2
GO:0010638	positive regulation of organelle organization	6	2
GO:0010965	regulation of mitotic sister chromatid separation	6	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0022402	cell cycle process	2	2
GO:0030071	regulation of mitotic metaphase/anaphase transition	7	2
GO:0030163	protein catabolic process	4	2
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0033043	regulation of organelle organization	5	2
GO:0033044	regulation of chromosome organization	6	2
GO:0033045	regulation of sister chromatid segregation	5	2
GO:0036211	protein modification process	4	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0044770	cell cycle phase transition	3	2
GO:0044772	mitotic cell cycle phase transition	4	2
GO:0044784	metaphase/anaphase transition of cell cycle	4	2
GO:0045787	positive regulation of cell cycle	5	2
GO:0045840	positive regulation of mitotic nuclear division	7	2
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	8	2
GO:0045931	positive regulation of mitotic cell cycle	6	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051130	positive regulation of cellular component organization	5	2
GO:0051301	cell division	2	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0051726	regulation of cell cycle	4	2
GO:0051783	regulation of nuclear division	6	2
GO:0051785	positive regulation of nuclear division	7	2
GO:0051983	regulation of chromosome segregation	4	2
GO:0065007	biological regulation	1	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0090068	positive regulation of cell cycle process	6	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901970	positive regulation of mitotic sister chromatid separation	7	2
GO:1901987	regulation of cell cycle phase transition	6	2
GO:1901989	positive regulation of cell cycle phase transition	7	2
GO:1901990	regulation of mitotic cell cycle phase transition	6	2
GO:1901992	positive regulation of mitotic cell cycle phase transition	7	2
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	6	2
GO:1902101	positive regulation of metaphase/anaphase transition of cell cycle	7	2
GO:1903047	mitotic cell cycle process	3	2
GO:1905818	regulation of chromosome separation	5	2
GO:1905820	positive regulation of chromosome separation	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.323
CLV_C14_Caspase3-7	266	270	PF00656	0.442
CLV_C14_Caspase3-7	274	278	PF00656	0.408
CLV_NRD_NRD_1	106	108	PF00675	0.372
CLV_NRD_NRD_1	183	185	PF00675	0.374
CLV_NRD_NRD_1	247	249	PF00675	0.347
CLV_NRD_NRD_1	257	259	PF00675	0.380
CLV_PCSK_FUR_1	244	248	PF00082	0.310
CLV_PCSK_KEX2_1	183	185	PF00082	0.358
CLV_PCSK_KEX2_1	246	248	PF00082	0.344
CLV_PCSK_KEX2_1	257	259	PF00082	0.366
CLV_PCSK_SKI1_1	109	113	PF00082	0.415
CLV_PCSK_SKI1_1	260	264	PF00082	0.344
DEG_Nend_UBRbox_2	1	3	PF02207	0.366
DOC_CYCLIN_RxL_1	147	157	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	299	305	PF00134	0.457
DOC_MAPK_DCC_7	297	307	PF00069	0.467
DOC_MAPK_gen_1	254	264	PF00069	0.321
DOC_MAPK_MEF2A_6	257	265	PF00069	0.340
DOC_USP7_MATH_1	178	182	PF00917	0.349
DOC_USP7_UBL2_3	108	112	PF12436	0.301
DOC_USP7_UBL2_3	90	94	PF12436	0.350
DOC_WW_Pin1_4	30	35	PF00397	0.281
LIG_14-3-3_CanoR_1	169	175	PF00244	0.368
LIG_Clathr_ClatBox_1	210	214	PF01394	0.381
LIG_EH1_1	95	103	PF00400	0.436
LIG_eIF4E_1	96	102	PF01652	0.441
LIG_FHA_1	1	7	PF00498	0.474
LIG_FHA_1	187	193	PF00498	0.357
LIG_FHA_2	112	118	PF00498	0.383
LIG_HCF-1_HBM_1	300	303	PF13415	0.471
LIG_IBAR_NPY_1	232	234	PF08397	0.329
LIG_LIR_Gen_1	217	226	PF02991	0.421
LIG_LIR_Gen_1	41	51	PF02991	0.309
LIG_LIR_Nem_3	217	222	PF02991	0.304
LIG_LIR_Nem_3	24	28	PF02991	0.271
LIG_LIR_Nem_3	41	46	PF02991	0.255
LIG_LYPXL_SIV_4	95	103	PF13949	0.436
LIG_NRBOX	205	211	PF00104	0.300
LIG_PDZ_Class_3	333	338	PF00595	0.636
LIG_Rb_LxCxE_1	84	100	PF01857	0.436
LIG_RPA_C_Fungi	242	254	PF08784	0.233
LIG_SH2_GRB2like	76	79	PF00017	0.281
LIG_SH2_NCK_1	249	253	PF00017	0.327
LIG_SH2_NCK_1	92	96	PF00017	0.428
LIG_SH2_SRC	249	252	PF00017	0.305
LIG_SH2_SRC	43	46	PF00017	0.341
LIG_SH2_SRC	96	99	PF00017	0.393
LIG_SH2_STAP1	200	204	PF00017	0.366
LIG_SH2_STAP1	249	253	PF00017	0.370
LIG_SH2_STAP1	26	30	PF00017	0.306
LIG_SH2_STAP1	43	47	PF00017	0.247
LIG_SH2_STAP1	50	54	PF00017	0.340
LIG_SH2_STAP1	92	96	PF00017	0.391
LIG_SH2_STAT5	130	133	PF00017	0.383
LIG_SH2_STAT5	234	237	PF00017	0.297
LIG_SH2_STAT5	73	76	PF00017	0.294
LIG_SUMO_SIM_par_1	261	266	PF11976	0.460
LIG_SUMO_SIM_par_1	303	309	PF11976	0.461
LIG_TRAF2_1	114	117	PF00917	0.458
LIG_TYR_ITIM	74	79	PF00017	0.299
MOD_CK2_1	111	117	PF00069	0.390
MOD_CK2_1	199	205	PF00069	0.391
MOD_GlcNHglycan	11	14	PF01048	0.306
MOD_GlcNHglycan	241	244	PF01048	0.317
MOD_GlcNHglycan	265	268	PF01048	0.437
MOD_GSK3_1	111	118	PF00069	0.366
MOD_GSK3_1	164	171	PF00069	0.343
MOD_NEK2_1	111	116	PF00069	0.366
MOD_NEK2_1	164	169	PF00069	0.338
MOD_NEK2_1	239	244	PF00069	0.326
MOD_NEK2_1	263	268	PF00069	0.416
MOD_NEK2_1	9	14	PF00069	0.296
MOD_NEK2_2	178	183	PF00069	0.348
MOD_PIKK_1	168	174	PF00454	0.350
MOD_PKA_2	168	174	PF00069	0.353
MOD_Plk_1	268	274	PF00069	0.572
MOD_Plk_4	97	103	PF00069	0.443
MOD_ProDKin_1	30	36	PF00069	0.281
MOD_SUMO_rev_2	195	204	PF00179	0.450
TRG_DiLeu_BaEn_1	205	210	PF01217	0.302
TRG_DiLeu_BaEn_1	97	102	PF01217	0.305
TRG_DiLeu_BaEn_2	216	222	PF01217	0.348
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.282
TRG_DiLeu_LyEn_5	205	210	PF01217	0.317
TRG_ENDOCYTIC_2	234	237	PF00928	0.337
TRG_ENDOCYTIC_2	43	46	PF00928	0.247
TRG_ENDOCYTIC_2	76	79	PF00928	0.279
TRG_ER_diArg_1	182	184	PF00400	0.355
TRG_ER_diArg_1	244	247	PF00400	0.348
TRG_ER_diArg_1	256	258	PF00400	0.368
TRG_NLS_MonoCore_2	106	111	PF00514	0.381
TRG_NLS_MonoExtC_3	107	112	PF00514	0.410
TRG_NLS_MonoExtN_4	107	113	PF00514	0.390
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVL1	Leptomonas seymouri	88%	99%
A0A0S4J0K8	Bodo saltans	58%	100%
A0A1X0P5Y3	Trypanosomatidae	63%	98%
A0A3Q8IJE6	Leishmania donovani	96%	100%
A0A3R7LYN1	Trypanosoma rangeli	65%	100%
A4HN78	Leishmania braziliensis	91%	100%
A4IBU6	Leishmania infantum	95%	100%
C8V3W6	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	88%
C9ZYR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	98%
E9B6T6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BXX3	Trypanosoma cruzi	64%	100%