EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulatory subunit of type II PKA R-subunit, putative

Species:

Leishmania major

UniProt:

E9AFN2_LEIMA

TriTrypDb:

LmjF.35.4060 , LMJLV39_350048500 , LMJSD75_350047900

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFN2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0005509	calcium ion binding	5	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.414
CLV_NRD_NRD_1	109	111	PF00675	0.414
CLV_PCSK_KEX2_1	109	111	PF00082	0.414
CLV_PCSK_SKI1_1	109	113	PF00082	0.360
CLV_PCSK_SKI1_1	208	212	PF00082	0.466
CLV_PCSK_SKI1_1	263	267	PF00082	0.331
CLV_PCSK_SKI1_1	34	38	PF00082	0.278
CLV_PCSK_SKI1_1	54	58	PF00082	0.285
CLV_PCSK_SKI1_1	81	85	PF00082	0.397
CLV_PCSK_SKI1_1	87	91	PF00082	0.372
CLV_Separin_Metazoa	35	39	PF03568	0.266
DEG_APCC_DBOX_1	262	270	PF00400	0.265
DOC_CYCLIN_RxL_1	205	213	PF00134	0.477
DOC_CYCLIN_RxL_1	259	268	PF00134	0.376
DOC_CYCLIN_RxL_1	50	60	PF00134	0.281
DOC_MAPK_gen_1	87	97	PF00069	0.509
DOC_PP2B_LxvP_1	127	130	PF13499	0.426
DOC_WW_Pin1_4	147	152	PF00397	0.371
DOC_WW_Pin1_4	70	75	PF00397	0.650
LIG_14-3-3_CanoR_1	102	112	PF00244	0.489
LIG_14-3-3_CanoR_1	9	17	PF00244	0.670
LIG_APCC_ABBA_1	270	275	PF00400	0.381
LIG_BIR_II_1	1	5	PF00653	0.617
LIG_BRCT_BRCA1_1	2	6	PF00533	0.448
LIG_deltaCOP1_diTrp_1	46	52	PF00928	0.411
LIG_FHA_1	130	136	PF00498	0.496
LIG_FHA_1	204	210	PF00498	0.394
LIG_FHA_1	57	63	PF00498	0.486
LIG_FHA_1	71	77	PF00498	0.636
LIG_FHA_1	92	98	PF00498	0.484
LIG_FHA_2	131	137	PF00498	0.529
LIG_FHA_2	224	230	PF00498	0.344
LIG_FHA_2	3	9	PF00498	0.530
LIG_LIR_Gen_1	128	135	PF02991	0.440
LIG_LIR_Gen_1	191	201	PF02991	0.387
LIG_LIR_Gen_1	268	276	PF02991	0.393
LIG_LIR_Nem_3	128	134	PF02991	0.433
LIG_LIR_Nem_3	148	152	PF02991	0.234
LIG_LIR_Nem_3	191	197	PF02991	0.378
LIG_LIR_Nem_3	268	273	PF02991	0.337
LIG_LIR_Nem_3	70	75	PF02991	0.608
LIG_Pex14_1	47	51	PF04695	0.266
LIG_Pex14_2	194	198	PF04695	0.370
LIG_PTB_Apo_2	217	224	PF02174	0.399
LIG_PTB_Phospho_1	217	223	PF10480	0.391
LIG_SH2_CRK	72	76	PF00017	0.695
LIG_SH2_STAP1	253	257	PF00017	0.361
LIG_SH2_STAP1	32	36	PF00017	0.266
LIG_SH2_STAT3	162	165	PF00017	0.513
LIG_SH2_STAT5	125	128	PF00017	0.344
LIG_SH2_STAT5	162	165	PF00017	0.484
LIG_SH2_STAT5	51	54	PF00017	0.280
LIG_SH2_STAT5	72	75	PF00017	0.649
LIG_SH3_3	73	79	PF00018	0.579
MOD_CK1_1	140	146	PF00069	0.645
MOD_CK1_1	150	156	PF00069	0.473
MOD_CK1_1	2	8	PF00069	0.661
MOD_CK2_1	130	136	PF00069	0.530
MOD_CK2_1	2	8	PF00069	0.550
MOD_GlcNHglycan	139	142	PF01048	0.603
MOD_GlcNHglycan	46	50	PF01048	0.270
MOD_GlcNHglycan	99	102	PF01048	0.513
MOD_GSK3_1	125	132	PF00069	0.389
MOD_GSK3_1	136	143	PF00069	0.619
MOD_GSK3_1	91	98	PF00069	0.445
MOD_N-GLC_1	137	142	PF02516	0.558
MOD_N-GLC_1	23	28	PF02516	0.411
MOD_NEK2_1	118	123	PF00069	0.407
MOD_NEK2_1	45	50	PF00069	0.300
MOD_NEK2_2	178	183	PF00069	0.376
MOD_PIKK_1	10	16	PF00454	0.670
MOD_PIKK_1	118	124	PF00454	0.368
MOD_Plk_1	167	173	PF00069	0.407
MOD_Plk_1	7	13	PF00069	0.555
MOD_Plk_4	130	136	PF00069	0.566
MOD_ProDKin_1	147	153	PF00069	0.364
MOD_ProDKin_1	70	76	PF00069	0.646
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.486
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.489
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.334
TRG_ENDOCYTIC_2	149	152	PF00928	0.361
TRG_ENDOCYTIC_2	72	75	PF00928	0.649
TRG_ER_diArg_1	108	110	PF00400	0.413
TRG_NES_CRM1_1	189	203	PF08389	0.390
TRG_NES_CRM1_1	256	268	PF08389	0.333
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	231	236	PF00026	0.275
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJL0	Leptomonas seymouri	70%	98%
A0A0S4IX78	Bodo saltans	46%	100%
A0A1X0P532	Trypanosomatidae	54%	100%
A0A3Q8IJR7	Leishmania donovani	96%	100%
A0A422NK65	Trypanosoma rangeli	49%	100%
A4HN77	Leishmania braziliensis	88%	100%
A4IBU5	Leishmania infantum	95%	100%
C9ZYR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B6T5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5C2Q7	Trypanosoma cruzi	52%	100%