LeishMANIAdb
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DUF4953 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF4953 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AFN0_LEIMA
TriTrypDb:
LmjF.35.4045 , LMJLV39_350048300 * , LMJSD75_350047700
Length:
115

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFN0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFN0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 77 79 PF00675 0.448
CLV_PCSK_KEX2_1 77 79 PF00082 0.518
CLV_PCSK_SKI1_1 64 68 PF00082 0.338
DEG_SCF_FBW7_1 1 7 PF00400 0.482
DOC_CKS1_1 1 6 PF01111 0.485
DOC_MAPK_gen_1 14 23 PF00069 0.406
DOC_MAPK_MEF2A_6 16 25 PF00069 0.386
DOC_USP7_MATH_1 106 110 PF00917 0.373
DOC_USP7_MATH_1 111 115 PF00917 0.428
DOC_USP7_MATH_1 4 8 PF00917 0.547
DOC_USP7_MATH_1 71 75 PF00917 0.443
LIG_BRCT_BRCA1_1 108 112 PF00533 0.574
LIG_FHA_1 39 45 PF00498 0.357
LIG_FHA_1 49 55 PF00498 0.490
LIG_FHA_2 15 21 PF00498 0.499
LIG_FHA_2 95 101 PF00498 0.397
LIG_LIR_Gen_1 100 108 PF02991 0.382
LIG_LIR_Nem_3 100 104 PF02991 0.385
LIG_SH2_STAT3 76 79 PF00017 0.399
LIG_SH2_STAT3 87 90 PF00017 0.312
LIG_SH2_STAT5 38 41 PF00017 0.464
LIG_SH2_STAT5 88 91 PF00017 0.361
LIG_SH3_3 105 111 PF00018 0.448
MOD_CK1_1 82 88 PF00069 0.402
MOD_GlcNHglycan 73 76 PF01048 0.390
MOD_GlcNHglycan 81 84 PF01048 0.436
MOD_GSK3_1 90 97 PF00069 0.407
MOD_N-GLC_2 27 29 PF02516 0.349
MOD_NEK2_1 39 44 PF00069 0.348
MOD_PIKK_1 56 62 PF00454 0.421
MOD_Plk_4 50 56 PF00069 0.399
MOD_Plk_4 82 88 PF00069 0.416
TRG_ER_diArg_1 76 78 PF00400 0.462

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5B2 Leptomonas seymouri 68% 100%
A0A1X0P535 Trypanosomatidae 52% 94%
A0A3Q8IVH8 Leishmania donovani 88% 100%
A0A3R7MNW4 Trypanosoma rangeli 55% 100%
A4HN75 Leishmania braziliensis 82% 100%
A4IBU3 Leishmania infantum 88% 100%
C9ZYR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9B6T3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS