J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania major

UniProt:

E9AFM9_LEIMA

TriTrypDb:

LmjF.35.4040 , LMJLV39_350048200 , LMJSD75_350047600

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	46	50	PF00656	0.604
CLV_NRD_NRD_1	101	103	PF00675	0.398
CLV_NRD_NRD_1	21	23	PF00675	0.361
CLV_NRD_NRD_1	216	218	PF00675	0.642
CLV_NRD_NRD_1	293	295	PF00675	0.630
CLV_NRD_NRD_1	345	347	PF00675	0.549
CLV_PCSK_FUR_1	272	276	PF00082	0.644
CLV_PCSK_FUR_1	343	347	PF00082	0.546
CLV_PCSK_KEX2_1	101	103	PF00082	0.398
CLV_PCSK_KEX2_1	125	127	PF00082	0.519
CLV_PCSK_KEX2_1	21	23	PF00082	0.348
CLV_PCSK_KEX2_1	215	217	PF00082	0.700
CLV_PCSK_KEX2_1	25	27	PF00082	0.303
CLV_PCSK_KEX2_1	274	276	PF00082	0.644
CLV_PCSK_KEX2_1	293	295	PF00082	0.573
CLV_PCSK_KEX2_1	301	303	PF00082	0.722
CLV_PCSK_KEX2_1	345	347	PF00082	0.670
CLV_PCSK_KEX2_1	58	60	PF00082	0.655
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.525
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.404
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.629
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.674
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.655
CLV_PCSK_PC7_1	21	27	PF00082	0.304
CLV_PCSK_PC7_1	54	60	PF00082	0.606
CLV_PCSK_SKI1_1	21	25	PF00082	0.347
CLV_PCSK_SKI1_1	26	30	PF00082	0.311
CLV_PCSK_SKI1_1	379	383	PF00082	0.493
CLV_PCSK_SKI1_1	54	58	PF00082	0.561
CLV_PCSK_SKI1_1	84	88	PF00082	0.426
DEG_APCC_DBOX_1	100	108	PF00400	0.405
DEG_Nend_Nbox_1	1	3	PF02207	0.431
DEG_SPOP_SBC_1	316	320	PF00917	0.620
DOC_MAPK_gen_1	21	31	PF00069	0.369
DOC_MAPK_MEF2A_6	22	31	PF00069	0.376
DOC_PP1_RVXF_1	377	383	PF00149	0.480
DOC_PP2B_PxIxI_1	311	317	PF00149	0.502
DOC_PP4_FxxP_1	255	258	PF00568	0.653
DOC_PP4_FxxP_1	382	385	PF00568	0.537
DOC_USP7_MATH_1	13	17	PF00917	0.369
DOC_USP7_MATH_1	189	193	PF00917	0.542
DOC_USP7_MATH_1	339	343	PF00917	0.633
DOC_USP7_MATH_1	75	79	PF00917	0.599
DOC_USP7_MATH_2	261	267	PF00917	0.596
DOC_WW_Pin1_4	151	156	PF00397	0.535
DOC_WW_Pin1_4	180	185	PF00397	0.636
DOC_WW_Pin1_4	201	206	PF00397	0.615
LIG_14-3-3_CanoR_1	158	164	PF00244	0.600
LIG_14-3-3_CanoR_1	252	258	PF00244	0.748
LIG_14-3-3_CanoR_1	285	295	PF00244	0.620
LIG_14-3-3_CanoR_1	349	353	PF00244	0.817
LIG_14-3-3_CanoR_1	379	385	PF00244	0.501
LIG_BRCT_BRCA1_1	319	323	PF00533	0.619
LIG_BRCT_BRCA1_1	82	86	PF00533	0.630
LIG_FHA_1	375	381	PF00498	0.464
LIG_FHA_1	43	49	PF00498	0.649
LIG_FHA_2	55	61	PF00498	0.635
LIG_LIR_Gen_1	106	115	PF02991	0.611
LIG_LIR_Gen_1	4	13	PF02991	0.304
LIG_LIR_Gen_1	83	93	PF02991	0.417
LIG_LIR_Nem_3	106	112	PF02991	0.605
LIG_LIR_Nem_3	162	166	PF02991	0.515
LIG_LIR_Nem_3	4	9	PF02991	0.304
LIG_LIR_Nem_3	83	89	PF02991	0.482
LIG_LIR_Nem_3	91	96	PF02991	0.408
LIG_MYND_1	205	209	PF01753	0.639
LIG_RPA_C_Fungi	127	139	PF08784	0.387
LIG_SH2_STAP1	105	109	PF00017	0.412
LIG_SH2_STAT3	368	371	PF00017	0.471
LIG_SH2_STAT5	103	106	PF00017	0.424
LIG_SH3_3	179	185	PF00018	0.685
LIG_SH3_3	255	261	PF00018	0.584
LIG_SH3_3	333	339	PF00018	0.637
LIG_SH3_3	359	365	PF00018	0.607
LIG_TRAF2_1	16	19	PF00917	0.369
MOD_CDK_SPxxK_3	151	158	PF00069	0.545
MOD_CK1_1	288	294	PF00069	0.640
MOD_CK2_1	13	19	PF00069	0.304
MOD_CK2_1	332	338	PF00069	0.579
MOD_Cter_Amidation	343	346	PF01082	0.542
MOD_GlcNHglycan	15	18	PF01048	0.468
MOD_GlcNHglycan	241	245	PF01048	0.763
MOD_GlcNHglycan	63	66	PF01048	0.710
MOD_GSK3_1	162	169	PF00069	0.654
MOD_GSK3_1	197	204	PF00069	0.591
MOD_GSK3_1	284	291	PF00069	0.660
MOD_GSK3_1	293	300	PF00069	0.665
MOD_GSK3_1	317	324	PF00069	0.658
MOD_GSK3_1	325	332	PF00069	0.635
MOD_GSK3_1	370	377	PF00069	0.451
MOD_GSK3_1	39	46	PF00069	0.632
MOD_GSK3_1	80	87	PF00069	0.443
MOD_NEK2_1	166	171	PF00069	0.531
MOD_NEK2_1	286	291	PF00069	0.614
MOD_NEK2_1	315	320	PF00069	0.656
MOD_NEK2_2	231	236	PF00069	0.597
MOD_NEK2_2	75	80	PF00069	0.511
MOD_PIKK_1	246	252	PF00454	0.645
MOD_PIKK_1	286	292	PF00454	0.647
MOD_PKA_1	293	299	PF00069	0.667
MOD_PKA_2	13	19	PF00069	0.320
MOD_PKA_2	279	285	PF00069	0.635
MOD_PKA_2	293	299	PF00069	0.553
MOD_PKA_2	348	354	PF00069	0.654
MOD_Plk_1	166	172	PF00069	0.554
MOD_Plk_1	231	237	PF00069	0.641
MOD_Plk_1	374	380	PF00069	0.456
MOD_Plk_4	332	338	PF00069	0.563
MOD_ProDKin_1	151	157	PF00069	0.540
MOD_ProDKin_1	180	186	PF00069	0.641
MOD_ProDKin_1	201	207	PF00069	0.616
MOD_SUMO_rev_2	296	303	PF00179	0.641
TRG_ENDOCYTIC_2	109	112	PF00928	0.613
TRG_ENDOCYTIC_2	5	8	PF00928	0.304
TRG_ENDOCYTIC_2	93	96	PF00928	0.376
TRG_ER_diArg_1	101	103	PF00400	0.398
TRG_ER_diArg_1	20	22	PF00400	0.334
TRG_ER_diArg_1	215	217	PF00400	0.593
TRG_ER_diArg_1	293	295	PF00400	0.743
TRG_ER_diArg_1	343	346	PF00400	0.542
TRG_NES_CRM1_1	18	30	PF08389	0.369
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL0	Leptomonas seymouri	31%	100%
A0A3Q8IIN7	Leishmania donovani	85%	100%
A4HN74	Leishmania braziliensis	64%	98%
A4IBU2	Leishmania infantum	86%	100%
E9B6T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%