LeishMANIAdb
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Serine peptidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine peptidase
Gene product:
Bem46-like serine peptidase
Species:
Leishmania major
UniProt:
E9AFM7_LEIMA
TriTrypDb:
LmjF.35.4020 , LMJLV39_350048000 * , LMJSD75_350047400
Length:
394

Annotations

LeishMANIAdb annotations

A signal-anchored protein probably with an extra re-entrant loop. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

E9AFM7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFM7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008474 palmitoyl-(protein) hydrolase activity 3 2
GO:0016787 hydrolase activity 2 3
GO:0016788 hydrolase activity, acting on ester bonds 3 2
GO:0016790 thiolester hydrolase activity 4 2
GO:0098599 palmitoyl hydrolase activity 3 2
GO:0140096 catalytic activity, acting on a protein 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 125 129 PF00656 0.709
CLV_C14_Caspase3-7 97 101 PF00656 0.710
CLV_NRD_NRD_1 248 250 PF00675 0.318
CLV_NRD_NRD_1 355 357 PF00675 0.332
CLV_PCSK_KEX2_1 248 250 PF00082 0.300
CLV_PCSK_KEX2_1 355 357 PF00082 0.345
CLV_PCSK_SKI1_1 141 145 PF00082 0.532
CLV_PCSK_SKI1_1 271 275 PF00082 0.313
CLV_PCSK_SKI1_1 336 340 PF00082 0.443
CLV_PCSK_SKI1_1 355 359 PF00082 0.214
DEG_APCC_DBOX_1 270 278 PF00400 0.562
DOC_CYCLIN_RxL_1 291 301 PF00134 0.631
DOC_CYCLIN_RxL_1 353 362 PF00134 0.643
DOC_MAPK_DCC_7 310 318 PF00069 0.579
DOC_MAPK_gen_1 219 227 PF00069 0.562
DOC_MAPK_gen_1 245 255 PF00069 0.501
DOC_MAPK_gen_1 307 317 PF00069 0.560
DOC_MAPK_JIP1_4 294 300 PF00069 0.524
DOC_MAPK_MEF2A_6 280 288 PF00069 0.463
DOC_MAPK_MEF2A_6 307 315 PF00069 0.526
DOC_PP1_RVXF_1 297 303 PF00149 0.551
DOC_PP1_RVXF_1 354 361 PF00149 0.567
DOC_PP2B_LxvP_1 350 353 PF13499 0.670
DOC_PP2B_LxvP_1 59 62 PF13499 0.649
DOC_USP7_MATH_1 126 130 PF00917 0.812
DOC_USP7_MATH_1 86 90 PF00917 0.703
DOC_USP7_UBL2_3 336 340 PF12436 0.614
LIG_14-3-3_CanoR_1 141 146 PF00244 0.745
LIG_14-3-3_CanoR_1 299 303 PF00244 0.638
LIG_14-3-3_CanoR_1 31 40 PF00244 0.639
LIG_14-3-3_CanoR_1 66 75 PF00244 0.581
LIG_Actin_WH2_2 286 301 PF00022 0.556
LIG_Actin_WH2_2 327 345 PF00022 0.638
LIG_BIR_II_1 1 5 PF00653 0.394
LIG_BIR_III_4 121 125 PF00653 0.753
LIG_FHA_1 200 206 PF00498 0.586
LIG_FHA_1 307 313 PF00498 0.598
LIG_FHA_1 337 343 PF00498 0.654
LIG_FHA_1 349 355 PF00498 0.610
LIG_FHA_2 68 74 PF00498 0.606
LIG_G3BP_FGDF_1 1 6 PF02136 0.298
LIG_IRF3_LxIS_1 295 301 PF10401 0.632
LIG_LIR_Apic_2 212 218 PF02991 0.516
LIG_LIR_Apic_2 290 295 PF02991 0.543
LIG_LIR_Gen_1 151 157 PF02991 0.539
LIG_LIR_Gen_1 22 32 PF02991 0.397
LIG_LIR_Gen_1 256 266 PF02991 0.482
LIG_LIR_Nem_3 151 155 PF02991 0.539
LIG_LIR_Nem_3 186 190 PF02991 0.474
LIG_LIR_Nem_3 2 6 PF02991 0.412
LIG_LIR_Nem_3 22 27 PF02991 0.150
LIG_LIR_Nem_3 256 262 PF02991 0.482
LIG_LYPXL_yS_3 42 45 PF13949 0.670
LIG_Pex14_2 20 24 PF04695 0.413
LIG_Pex14_2 211 215 PF04695 0.562
LIG_SH2_PTP2 292 295 PF00017 0.555
LIG_SH2_STAP1 63 67 PF00017 0.616
LIG_SH2_STAT3 213 216 PF00017 0.530
LIG_SH2_STAT3 32 35 PF00017 0.658
LIG_SH2_STAT5 13 16 PF00017 0.413
LIG_SH2_STAT5 156 159 PF00017 0.486
LIG_SH2_STAT5 213 216 PF00017 0.496
LIG_SH2_STAT5 292 295 PF00017 0.523
LIG_SH3_3 117 123 PF00018 0.793
LIG_SH3_3 215 221 PF00018 0.506
LIG_SH3_3 308 314 PF00018 0.547
LIG_SH3_3 366 372 PF00018 0.597
LIG_SH3_3 40 46 PF00018 0.577
LIG_SUMO_SIM_anti_2 223 231 PF11976 0.562
LIG_SUMO_SIM_par_1 201 206 PF11976 0.589
LIG_TRFH_1 80 84 PF08558 0.588
LIG_TYR_ITIM 40 45 PF00017 0.680
LIG_WRC_WIRS_1 149 154 PF05994 0.629
LIG_WRC_WIRS_1 3 8 PF05994 0.407
MOD_CK1_1 137 143 PF00069 0.675
MOD_CK1_1 193 199 PF00069 0.530
MOD_CK1_1 2 8 PF00069 0.407
MOD_CK1_1 258 264 PF00069 0.570
MOD_CK1_1 267 273 PF00069 0.548
MOD_CK1_1 301 307 PF00069 0.594
MOD_Cter_Amidation 246 249 PF01082 0.219
MOD_GlcNHglycan 124 127 PF01048 0.563
MOD_GlcNHglycan 130 133 PF01048 0.546
MOD_GlcNHglycan 136 139 PF01048 0.460
MOD_GlcNHglycan 146 149 PF01048 0.460
MOD_GlcNHglycan 266 269 PF01048 0.339
MOD_GlcNHglycan 303 306 PF01048 0.400
MOD_GlcNHglycan 318 321 PF01048 0.302
MOD_GlcNHglycan 375 378 PF01048 0.420
MOD_GlcNHglycan 8 11 PF01048 0.432
MOD_GlcNHglycan 88 91 PF01048 0.485
MOD_GlcNHglycan 92 95 PF01048 0.498
MOD_GSK3_1 104 111 PF00069 0.665
MOD_GSK3_1 122 129 PF00069 0.739
MOD_GSK3_1 130 137 PF00069 0.672
MOD_GSK3_1 139 146 PF00069 0.648
MOD_GSK3_1 2 9 PF00069 0.288
MOD_GSK3_1 260 267 PF00069 0.493
MOD_GSK3_1 272 279 PF00069 0.501
MOD_GSK3_1 86 93 PF00069 0.729
MOD_GSK3_1 94 101 PF00069 0.790
MOD_N-GLC_1 94 99 PF02516 0.598
MOD_NEK2_1 228 233 PF00069 0.482
MOD_NEK2_1 298 303 PF00069 0.615
MOD_NEK2_1 316 321 PF00069 0.487
MOD_NEK2_1 6 11 PF00069 0.420
MOD_NEK2_2 234 239 PF00069 0.586
MOD_PIKK_1 196 202 PF00454 0.534
MOD_PIKK_1 31 37 PF00454 0.604
MOD_PKA_2 103 109 PF00069 0.695
MOD_PKA_2 298 304 PF00069 0.633
MOD_Plk_1 255 261 PF00069 0.482
MOD_Plk_1 348 354 PF00069 0.660
MOD_Plk_1 94 100 PF00069 0.736
MOD_Plk_4 148 154 PF00069 0.577
MOD_Plk_4 19 25 PF00069 0.402
MOD_Plk_4 2 8 PF00069 0.339
TRG_ENDOCYTIC_2 13 16 PF00928 0.447
TRG_ENDOCYTIC_2 187 190 PF00928 0.496
TRG_ENDOCYTIC_2 42 45 PF00928 0.670
TRG_ER_diArg_1 248 250 PF00400 0.518
TRG_ER_diArg_1 354 356 PF00400 0.553
TRG_Pf-PMV_PEXEL_1 356 361 PF00026 0.439

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK32 Leptomonas seymouri 61% 96%
A0A1X0P675 Trypanosomatidae 43% 100%
A0A3Q8IMT8 Leishmania donovani 94% 100%
A0A3R7NFR6 Trypanosoma rangeli 44% 100%
A4HN72 Leishmania braziliensis 83% 100%
A4IBU0 Leishmania infantum 94% 100%
C9ZYS4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9B6T0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
V5BXX8 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS