Mitochondrial carrier protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania major

UniProt:

E9AFM4_LEIMA

TriTrypDb:

LmjF.35.3990 , LMJLV39_350047700 , LMJSD75_350047000

Length:

236

Annotations

LeishMANIAdb annotations

The kinetoplastid protzeins appear to be a split-protein version of mammalian transporters (3TM intead of 6). Likely functional as dimers, unlike the animal homologs.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AFM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFM4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0009987	cellular process	1	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0055085	transmembrane transport	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.565
CLV_NRD_NRD_1	172	174	PF00675	0.329
CLV_PCSK_KEX2_1	172	174	PF00082	0.329
CLV_PCSK_SKI1_1	167	171	PF00082	0.285
DEG_APCC_DBOX_1	190	198	PF00400	0.557
DEG_Nend_UBRbox_3	1	3	PF02207	0.492
DOC_AGCK_PIF_2	95	100	PF00069	0.377
DOC_CYCLIN_yCln2_LP_2	152	158	PF00134	0.458
DOC_SPAK_OSR1_1	20	24	PF12202	0.458
DOC_USP7_MATH_1	14	18	PF00917	0.345
DOC_WW_Pin1_4	12	17	PF00397	0.428
DOC_WW_Pin1_4	176	181	PF00397	0.522
LIG_14-3-3_CanoR_1	129	133	PF00244	0.265
LIG_14-3-3_CanoR_1	213	219	PF00244	0.539
LIG_14-3-3_CanoR_1	45	50	PF00244	0.476
LIG_14-3-3_CanoR_1	56	62	PF00244	0.451
LIG_BRCT_BRCA1_1	17	21	PF00533	0.306
LIG_CSL_BTD_1	35	38	PF09270	0.321
LIG_CtBP_PxDLS_1	155	159	PF00389	0.421
LIG_FHA_1	100	106	PF00498	0.351
LIG_FHA_1	132	138	PF00498	0.342
LIG_FHA_1	151	157	PF00498	0.309
LIG_FHA_1	177	183	PF00498	0.578
LIG_FHA_1	56	62	PF00498	0.563
LIG_FHA_2	115	121	PF00498	0.463
LIG_LIR_Gen_1	99	109	PF02991	0.293
LIG_LIR_Nem_3	184	190	PF02991	0.493
LIG_LIR_Nem_3	224	230	PF02991	0.508
LIG_LIR_Nem_3	85	90	PF02991	0.338
LIG_LIR_Nem_3	91	97	PF02991	0.299
LIG_Pex14_2	97	101	PF04695	0.293
LIG_SH2_CRK	187	191	PF00017	0.472
LIG_SH2_CRK	216	220	PF00017	0.489
LIG_SH2_NCK_1	109	113	PF00017	0.268
LIG_SH2_NCK_1	216	220	PF00017	0.508
LIG_SH2_STAP1	57	61	PF00017	0.565
LIG_SH2_STAP1	80	84	PF00017	0.434
LIG_SH2_STAT5	100	103	PF00017	0.253
LIG_SH2_STAT5	109	112	PF00017	0.320
LIG_SH2_STAT5	216	219	PF00017	0.540
LIG_SH2_STAT5	57	60	PF00017	0.565
LIG_SH2_STAT5	94	97	PF00017	0.301
LIG_SH3_3	32	38	PF00018	0.391
LIG_WRC_WIRS_1	132	137	PF05994	0.293
LIG_WRC_WIRS_1	84	89	PF05994	0.321
MOD_CK1_1	131	137	PF00069	0.306
MOD_CK1_1	150	156	PF00069	0.194
MOD_CK1_1	82	88	PF00069	0.383
MOD_CK2_1	122	128	PF00069	0.401
MOD_CMANNOS	204	207	PF00535	0.169
MOD_GlcNHglycan	112	115	PF01048	0.642
MOD_GlcNHglycan	124	127	PF01048	0.632
MOD_GlcNHglycan	90	93	PF01048	0.321
MOD_GSK3_1	110	117	PF00069	0.473
MOD_GSK3_1	45	52	PF00069	0.500
MOD_GSK3_1	79	86	PF00069	0.317
MOD_N-GLC_1	1	6	PF02516	0.670
MOD_NEK2_1	1	6	PF00069	0.425
MOD_NEK2_1	158	163	PF00069	0.453
MOD_NEK2_1	230	235	PF00069	0.546
MOD_PIKK_1	114	120	PF00454	0.474
MOD_PIKK_1	45	51	PF00454	0.485
MOD_PKA_2	128	134	PF00069	0.379
MOD_PKA_2	55	61	PF00069	0.484
MOD_Plk_1	1	7	PF00069	0.469
MOD_Plk_4	147	153	PF00069	0.372
MOD_ProDKin_1	12	18	PF00069	0.428
MOD_ProDKin_1	176	182	PF00069	0.522
TRG_ENDOCYTIC_2	187	190	PF00928	0.467
TRG_ENDOCYTIC_2	94	97	PF00928	0.357
TRG_ENDOCYTIC_2	98	101	PF00928	0.296
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2K5L2	Rattus norvegicus	27%	73%
A0A0N0P7Y4	Leptomonas seymouri	25%	81%
A0A0N0P8W6	Leptomonas seymouri	25%	69%
A0A0N1I6I9	Leptomonas seymouri	29%	81%
A0A0N1IMP5	Leptomonas seymouri	26%	70%
A0A0S4IV98	Bodo saltans	25%	86%
A0A0S4J045	Bodo saltans	46%	66%
A0A0S4JHC1	Bodo saltans	26%	68%
A0A0S4JHF7	Bodo saltans	26%	74%
A0A0S4KJX8	Bodo saltans	27%	67%
A0A1D6N272	Zea mays	26%	70%
A0A1X0NFT4	Trypanosomatidae	27%	78%
A0A1X0NJD2	Trypanosomatidae	25%	83%
A0A1X0NUU7	Trypanosomatidae	26%	70%
A0A1X0P4Q9	Trypanosomatidae	27%	76%
A0A1X0P555	Trypanosomatidae	54%	77%
A0A1X0P952	Trypanosomatidae	29%	76%
A0A3Q8IFU6	Leishmania donovani	25%	70%
A0A3Q8IIC0	Leishmania donovani	92%	100%
A0A3Q8IKX9	Leishmania donovani	26%	74%
A0A3R7KLL6	Trypanosoma rangeli	27%	82%
A0A3R7LCB2	Trypanosoma rangeli	27%	75%
A0A3S5H7M7	Leishmania donovani	30%	70%
A0A3S7WTS6	Leishmania donovani	25%	79%
A0A3S7X2U2	Leishmania donovani	26%	81%
A0JN87	Bos taurus	25%	79%
A1CIF6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	28%	71%
A1CWA4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	28%	71%
A1DI57	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	26%	74%
A2A3V2	Mus musculus	27%	69%
A2Q9F0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	27%	75%
A2R5A0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	24%	74%
A4H8E6	Leishmania braziliensis	22%	79%
A4HHT5	Leishmania braziliensis	27%	81%
A4HI60	Leishmania braziliensis	29%	70%
A4HK94	Leishmania braziliensis	24%	70%
A4HN69	Leishmania braziliensis	80%	100%
A4HWR9	Leishmania infantum	25%	79%
A4I4Z5	Leishmania infantum	26%	81%
A4I5D6	Leishmania infantum	30%	70%
A4I7S8	Leishmania infantum	26%	74%
A4I7S9	Leishmania infantum	25%	70%
A4IBT7	Leishmania infantum	94%	100%
A4QNX2	Danio rerio	25%	82%
A4RF23	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	27%	72%
A4RPU0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	27%	71%
A6QR09	Bos taurus	30%	86%
A6RAY2	Ajellomyces capsulatus (strain NAm1 / WU24)	27%	67%
A6RF73	Ajellomyces capsulatus (strain NAm1 / WU24)	24%	73%
A6SL61	Botryotinia fuckeliana (strain B05.10)	22%	73%
A7ER02	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	23%	73%
A7F9Y3	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	24%	72%
B0Y4J4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	28%	74%
B2MVX9	Ovis aries	28%	77%
B2VSU4	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	24%	74%
B4FIJ0	Zea mays	26%	70%
B8ZHC9	Rattus norvegicus	25%	76%
C9ZW54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	78%
C9ZYS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	77%
D0A728	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	94%
D0A9Z0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	70%
E9ALE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	81%
E9AQH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	79%
E9B0N4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	70%
E9B2N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	75%
E9B2N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	70%
E9B6S7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
F4HT41	Arabidopsis thaliana	30%	68%
F4HW79	Arabidopsis thaliana	25%	71%
K7VYZ9	Zea mays	26%	69%
O04200	Arabidopsis thaliana	25%	71%
O04619	Arabidopsis thaliana	29%	67%
O14281	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	78%
O22261	Arabidopsis thaliana	28%	76%
O43772	Homo sapiens	25%	78%
O43808	Homo sapiens	26%	77%
O60029	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	87%
O70579	Mus musculus	27%	77%
O77792	Bos taurus	25%	76%
O81845	Arabidopsis thaliana	26%	77%
O95258	Homo sapiens	26%	73%
O97562	Sus scrofa	26%	76%
P0C582	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	71%
P16036	Rattus norvegicus	28%	66%
P22292	Bos taurus	26%	75%
P32332	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	73%
P33303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	73%
P38921	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	83%
P39953	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	70%
P55851	Homo sapiens	25%	76%
P56499	Rattus norvegicus	25%	77%
P56500	Rattus norvegicus	26%	76%
P56501	Mus musculus	25%	77%
P70406	Mus musculus	26%	76%
P90992	Caenorhabditis elegans	27%	77%
P97521	Rattus norvegicus	27%	78%
Q02978	Homo sapiens	27%	75%
Q08CI8	Danio rerio	29%	82%
Q08DK4	Bos taurus	28%	73%
Q08DK7	Bos taurus	31%	79%
Q09834	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	87%
Q0CEN9	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	27%	74%
Q0CT66	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	25%	72%
Q0II44	Bos taurus	24%	68%
Q0UUH1	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	27%	74%
Q0VCH6	Bos taurus	25%	70%
Q10442	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	68%
Q12251	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	72%
Q1DRJ3	Coccidioides immitis (strain RS)	27%	68%
Q1E7P0	Coccidioides immitis (strain RS)	25%	74%
Q1LZB3	Bos taurus	24%	74%
Q23125	Caenorhabditis elegans	22%	76%
Q27257	Caenorhabditis elegans	27%	76%
Q287T7	Danio rerio	25%	71%
Q29RM1	Bos taurus	25%	74%
Q2H608	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	29%	71%
Q2UCW8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	25%	74%
Q2UU67	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	26%	72%
Q3SZI5	Bos taurus	26%	76%
Q3TZX3	Mus musculus	23%	74%
Q499U1	Rattus norvegicus	28%	72%
Q4Q5H0	Leishmania major	24%	100%
Q4Q5H1	Leishmania major	25%	74%
Q4Q7J8	Leishmania major	29%	70%
Q4QF00	Leishmania major	24%	79%
Q4V9P0	Danio rerio	30%	88%
Q4WQC5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	28%	74%
Q4X022	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	74%
Q505J6	Rattus norvegicus	25%	74%
Q54BM3	Dictyostelium discoideum	25%	79%
Q54DU1	Dictyostelium discoideum	25%	79%
Q54QN2	Dictyostelium discoideum	23%	77%
Q54VX4	Dictyostelium discoideum	25%	68%
Q55DY8	Dictyostelium discoideum	29%	77%
Q55E45	Dictyostelium discoideum	32%	78%
Q55E85	Dictyostelium discoideum	25%	69%
Q55GE2	Dictyostelium discoideum	24%	79%
Q5AVW1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	72%
Q5B717	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	72%
Q5EAC0	Bos taurus	25%	77%
Q5HZE0	Rattus norvegicus	31%	77%
Q5IS35	Macaca fascicularis	29%	74%
Q5NVC1	Pongo abelii	27%	74%
Q5PQM9	Rattus norvegicus	27%	81%
Q5R5A8	Pongo abelii	25%	76%
Q5RD67	Pongo abelii	27%	75%
Q5RD81	Pongo abelii	27%	73%
Q5RFB7	Pongo abelii	26%	79%
Q5SVS4	Homo sapiens	29%	81%
Q5U680	Mus musculus	28%	86%
Q5ZKP7	Gallus gallus	24%	75%
Q620A6	Caenorhabditis briggsae	23%	76%
Q641C8	Xenopus laevis	27%	89%
Q66H23	Rattus norvegicus	23%	70%
Q6C6I3	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	78%
Q6CNY8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	80%
Q6DE75	Xenopus laevis	24%	78%
Q6DFK2	Xenopus laevis	26%	69%
Q6DG32	Danio rerio	24%	76%
Q6DHC3	Danio rerio	27%	67%
Q6GLA2	Xenopus tropicalis	27%	88%
Q6IZB5	Cricetulus griseus	27%	75%
Q6P036	Danio rerio	23%	75%
Q6P316	Xenopus tropicalis	25%	69%
Q70HW3	Homo sapiens	26%	86%
Q74Z23	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	81%
Q75EP3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	74%
Q76PC3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	70%
Q7S2H8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	71%
Q86AV5	Dictyostelium discoideum	27%	78%
Q86I81	Dictyostelium discoideum	26%	70%
Q8BGF9	Mus musculus	27%	75%
Q8BGP6	Mus musculus	27%	70%
Q8BL03	Mus musculus	31%	77%
Q8BMG8	Mus musculus	27%	75%
Q8BVN7	Mus musculus	25%	76%
Q8BZ09	Mus musculus	25%	79%
Q8CFJ7	Mus musculus	28%	82%
Q8HXE3	Macaca fascicularis	27%	81%
Q8HXY2	Macaca fascicularis	25%	78%
Q8N413	Homo sapiens	26%	82%
Q8N8R3	Homo sapiens	31%	78%
Q8RXZ9	Arabidopsis thaliana	26%	70%
Q8VEM8	Mus musculus	28%	66%
Q8WUT9	Homo sapiens	26%	69%
Q91XD8	Mus musculus	27%	72%
Q920G8	Mus musculus	23%	70%
Q922G0	Mus musculus	23%	76%
Q93XM7	Arabidopsis thaliana	31%	79%
Q94AG6	Arabidopsis thaliana	30%	73%
Q95J75	Macaca fascicularis	27%	75%
Q96CQ1	Homo sapiens	24%	76%
Q96DW6	Homo sapiens	29%	78%
Q96H78	Homo sapiens	27%	75%
Q96U08	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	68%
Q99297	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	77%
Q99JD3	Rattus norvegicus	25%	79%
Q9BQT8	Homo sapiens	26%	79%
Q9CA93	Arabidopsis thaliana	28%	80%
Q9CR58	Mus musculus	28%	81%
Q9CR62	Mus musculus	27%	75%
Q9D6M3	Mus musculus	27%	73%
Q9DAM5	Mus musculus	27%	74%
Q9FI73	Arabidopsis thaliana	30%	70%
Q9H1K4	Homo sapiens	27%	75%
Q9H2D1	Homo sapiens	27%	75%
Q9H936	Homo sapiens	27%	73%
Q9HC21	Homo sapiens	27%	74%
Q9LJX5	Arabidopsis thaliana	26%	68%
Q9N2J1	Canis lupus familiaris	25%	76%
Q9NYZ2	Homo sapiens	23%	70%
Q9P7X9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	70%
Q9VBN7	Drosophila melanogaster	32%	83%
Q9VM51	Drosophila melanogaster	26%	79%
Q9VQG4	Drosophila melanogaster	24%	77%
Q9W720	Danio rerio	24%	76%
Q9W725	Cyprinus carpio	26%	76%
Q9Z2B2	Mus musculus	26%	73%
Q9Z2Z6	Mus musculus	26%	78%
Q9ZWG1	Arabidopsis thaliana	28%	77%
V5B150	Trypanosoma cruzi	27%	74%
V5BDR1	Trypanosoma cruzi	25%	80%
V5BTA6	Trypanosoma cruzi	51%	78%
V5C243	Trypanosoma cruzi	26%	73%