4E-interacting_protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

4E-interacting protein, putative

Species:

Leishmania major

UniProt:

E9AFM3_LEIMA

TriTrypDb:

LmjF.35.3980 , LMJLV39_350047600 , LMJSD75_350046900

Length:

796

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFM3

PDB structure(s): 5wb5_B

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0045182	translation regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.551
CLV_NRD_NRD_1	119	121	PF00675	0.621
CLV_NRD_NRD_1	191	193	PF00675	0.483
CLV_NRD_NRD_1	30	32	PF00675	0.552
CLV_NRD_NRD_1	47	49	PF00675	0.608
CLV_NRD_NRD_1	747	749	PF00675	0.559
CLV_PCSK_KEX2_1	119	121	PF00082	0.610
CLV_PCSK_KEX2_1	181	183	PF00082	0.469
CLV_PCSK_KEX2_1	46	48	PF00082	0.621
CLV_PCSK_KEX2_1	747	749	PF00082	0.559
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.469
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.620
CLV_PCSK_SKI1_1	15	19	PF00082	0.487
CLV_PCSK_SKI1_1	198	202	PF00082	0.478
CLV_PCSK_SKI1_1	503	507	PF00082	0.599
CLV_PCSK_SKI1_1	548	552	PF00082	0.614
CLV_Separin_Metazoa	12	16	PF03568	0.509
CLV_Separin_Metazoa	28	32	PF03568	0.406
DEG_APCC_DBOX_1	9	17	PF00400	0.458
DEG_COP1_1	481	491	PF00400	0.660
DEG_SCF_FBW7_1	296	303	PF00400	0.609
DEG_SCF_FBW7_1	451	458	PF00400	0.634
DEG_SIAH_1	291	299	PF03145	0.626
DEG_SPOP_SBC_1	100	104	PF00917	0.679
DEG_SPOP_SBC_1	368	372	PF00917	0.615
DOC_CKS1_1	297	302	PF01111	0.606
DOC_CKS1_1	42	47	PF01111	0.541
DOC_CKS1_1	452	457	PF01111	0.667
DOC_CYCLIN_yClb3_PxF_3	559	565	PF00134	0.657
DOC_CYCLIN_yClb5_NLxxxL_5	193	201	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	715	721	PF00134	0.570
DOC_MAPK_gen_1	31	38	PF00069	0.597
DOC_PP2B_LxvP_1	629	632	PF13499	0.622
DOC_PP2B_LxvP_1	715	718	PF13499	0.582
DOC_PP4_FxxP_1	148	151	PF00568	0.538
DOC_PP4_FxxP_1	277	280	PF00568	0.612
DOC_PP4_FxxP_1	401	404	PF00568	0.604
DOC_PP4_FxxP_1	565	568	PF00568	0.657
DOC_PP4_FxxP_1	578	581	PF00568	0.566
DOC_PP4_FxxP_1	728	731	PF00568	0.491
DOC_PP4_FxxP_1	746	749	PF00568	0.426
DOC_USP7_MATH_1	100	104	PF00917	0.827
DOC_USP7_MATH_1	269	273	PF00917	0.633
DOC_USP7_MATH_1	280	284	PF00917	0.575
DOC_USP7_MATH_1	292	296	PF00917	0.733
DOC_USP7_MATH_1	300	304	PF00917	0.532
DOC_USP7_MATH_1	312	316	PF00917	0.583
DOC_USP7_MATH_1	346	350	PF00917	0.762
DOC_USP7_MATH_1	369	373	PF00917	0.656
DOC_USP7_MATH_1	383	387	PF00917	0.551
DOC_USP7_MATH_1	393	397	PF00917	0.714
DOC_USP7_MATH_1	415	419	PF00917	0.664
DOC_USP7_MATH_1	459	463	PF00917	0.763
DOC_USP7_MATH_1	479	483	PF00917	0.556
DOC_USP7_MATH_1	579	583	PF00917	0.744
DOC_USP7_MATH_1	588	592	PF00917	0.623
DOC_USP7_MATH_1	635	639	PF00917	0.640
DOC_USP7_MATH_1	641	645	PF00917	0.637
DOC_WW_Pin1_4	102	107	PF00397	0.623
DOC_WW_Pin1_4	262	267	PF00397	0.653
DOC_WW_Pin1_4	288	293	PF00397	0.640
DOC_WW_Pin1_4	296	301	PF00397	0.586
DOC_WW_Pin1_4	344	349	PF00397	0.661
DOC_WW_Pin1_4	407	412	PF00397	0.602
DOC_WW_Pin1_4	41	46	PF00397	0.550
DOC_WW_Pin1_4	451	456	PF00397	0.663
DOC_WW_Pin1_4	558	563	PF00397	0.652
DOC_WW_Pin1_4	581	586	PF00397	0.659
DOC_WW_Pin1_4	597	602	PF00397	0.531
DOC_WW_Pin1_4	664	669	PF00397	0.593
DOC_WW_Pin1_4	686	691	PF00397	0.667
LIG_14-3-3_CanoR_1	15	20	PF00244	0.527
LIG_14-3-3_CanoR_1	244	251	PF00244	0.630
LIG_AP2alpha_1	59	63	PF02296	0.538
LIG_APCC_ABBAyCdc20_2	55	61	PF00400	0.544
LIG_BIR_III_2	345	349	PF00653	0.633
LIG_BRCT_BRCA1_1	242	246	PF00533	0.556
LIG_EH_1	776	780	PF12763	0.614
LIG_eIF4E_1	8	14	PF01652	0.453
LIG_EVH1_1	629	633	PF00568	0.622
LIG_FHA_1	218	224	PF00498	0.509
LIG_FHA_1	526	532	PF00498	0.630
LIG_FHA_1	692	698	PF00498	0.665
LIG_FHA_2	162	168	PF00498	0.531
LIG_FHA_2	229	235	PF00498	0.585
LIG_FHA_2	252	258	PF00498	0.631
LIG_FHA_2	530	536	PF00498	0.585
LIG_FHA_2	7	13	PF00498	0.460
LIG_LIR_Apic_2	146	151	PF02991	0.548
LIG_LIR_Apic_2	274	280	PF02991	0.614
LIG_LIR_Apic_2	400	404	PF02991	0.603
LIG_LIR_Gen_1	143	151	PF02991	0.608
LIG_LIR_Gen_1	667	676	PF02991	0.580
LIG_LIR_Nem_3	143	148	PF02991	0.727
LIG_MLH1_MIPbox_1	242	246	PF16413	0.556
LIG_MYND_1	695	699	PF01753	0.661
LIG_NRBOX	496	502	PF00104	0.513
LIG_NRP_CendR_1	795	796	PF00754	0.584
LIG_Pex14_2	59	63	PF04695	0.559
LIG_SH2_STAP1	145	149	PF00017	0.555
LIG_SH2_STAT5	727	730	PF00017	0.520
LIG_SH2_STAT5	8	11	PF00017	0.455
LIG_SH3_2	348	353	PF14604	0.552
LIG_SH3_3	261	267	PF00018	0.644
LIG_SH3_3	345	351	PF00018	0.637
LIG_SH3_3	35	41	PF00018	0.583
LIG_SH3_3	400	406	PF00018	0.659
LIG_SH3_3	408	414	PF00018	0.581
LIG_SH3_3	416	422	PF00018	0.547
LIG_SH3_3	445	451	PF00018	0.669
LIG_SH3_3	453	459	PF00018	0.622
LIG_SH3_3	463	469	PF00018	0.648
LIG_SH3_3	509	515	PF00018	0.618
LIG_SH3_3	556	562	PF00018	0.658
LIG_SH3_3	565	571	PF00018	0.573
LIG_SH3_3	582	588	PF00018	0.523
LIG_SH3_3	616	622	PF00018	0.662
LIG_SH3_3	625	631	PF00018	0.585
LIG_SH3_3	670	676	PF00018	0.651
LIG_SH3_3	693	699	PF00018	0.665
LIG_SH3_3	772	778	PF00018	0.628
LIG_SUMO_SIM_anti_2	496	501	PF11976	0.524
LIG_SUMO_SIM_par_1	34	40	PF11976	0.573
LIG_TRAF2_1	164	167	PF00917	0.530
LIG_TRAF2_1	9	12	PF00917	0.508
LIG_WW_3	569	573	PF00397	0.534
MOD_CDK_SPK_2	41	46	PF00069	0.532
MOD_CDK_SPxK_1	41	47	PF00069	0.539
MOD_CDK_SPxxK_3	41	48	PF00069	0.531
MOD_CK1_1	102	108	PF00069	0.610
MOD_CK1_1	134	140	PF00069	0.528
MOD_CK1_1	3	9	PF00069	0.444
MOD_CK1_1	315	321	PF00069	0.762
MOD_CK1_1	328	334	PF00069	0.484
MOD_CK1_1	359	365	PF00069	0.719
MOD_CK1_1	386	392	PF00069	0.665
MOD_CK1_1	464	470	PF00069	0.611
MOD_CK1_1	481	487	PF00069	0.647
MOD_CK1_1	57	63	PF00069	0.663
MOD_CK1_1	591	597	PF00069	0.630
MOD_CK1_1	64	70	PF00069	0.595
MOD_CK1_1	686	692	PF00069	0.581
MOD_CK2_1	161	167	PF00069	0.539
MOD_CK2_1	251	257	PF00069	0.625
MOD_CK2_1	529	535	PF00069	0.595
MOD_CK2_1	6	12	PF00069	0.542
MOD_GlcNHglycan	109	112	PF01048	0.585
MOD_GlcNHglycan	142	145	PF01048	0.593
MOD_GlcNHglycan	175	178	PF01048	0.434
MOD_GlcNHglycan	20	23	PF01048	0.497
MOD_GlcNHglycan	246	249	PF01048	0.579
MOD_GlcNHglycan	254	257	PF01048	0.620
MOD_GlcNHglycan	302	305	PF01048	0.609
MOD_GlcNHglycan	330	333	PF01048	0.577
MOD_GlcNHglycan	385	388	PF01048	0.686
MOD_GlcNHglycan	393	396	PF01048	0.604
MOD_GlcNHglycan	443	446	PF01048	0.669
MOD_GlcNHglycan	481	484	PF01048	0.643
MOD_GlcNHglycan	492	495	PF01048	0.620
MOD_GlcNHglycan	509	512	PF01048	0.537
MOD_GlcNHglycan	520	523	PF01048	0.756
MOD_GlcNHglycan	594	597	PF01048	0.629
MOD_GlcNHglycan	79	82	PF01048	0.790
MOD_GlcNHglycan	87	90	PF01048	0.662
MOD_GSK3_1	132	139	PF00069	0.633
MOD_GSK3_1	240	247	PF00069	0.600
MOD_GSK3_1	258	265	PF00069	0.770
MOD_GSK3_1	269	276	PF00069	0.648
MOD_GSK3_1	288	295	PF00069	0.668
MOD_GSK3_1	296	303	PF00069	0.574
MOD_GSK3_1	311	318	PF00069	0.603
MOD_GSK3_1	321	328	PF00069	0.647
MOD_GSK3_1	333	340	PF00069	0.607
MOD_GSK3_1	359	366	PF00069	0.676
MOD_GSK3_1	369	376	PF00069	0.580
MOD_GSK3_1	383	390	PF00069	0.607
MOD_GSK3_1	393	400	PF00069	0.562
MOD_GSK3_1	426	433	PF00069	0.736
MOD_GSK3_1	436	443	PF00069	0.596
MOD_GSK3_1	451	458	PF00069	0.603
MOD_GSK3_1	478	485	PF00069	0.676
MOD_GSK3_1	486	493	PF00069	0.731
MOD_GSK3_1	503	510	PF00069	0.595
MOD_GSK3_1	514	521	PF00069	0.574
MOD_GSK3_1	525	532	PF00069	0.755
MOD_GSK3_1	554	561	PF00069	0.660
MOD_GSK3_1	57	64	PF00069	0.714
MOD_GSK3_1	588	595	PF00069	0.634
MOD_GSK3_1	641	648	PF00069	0.657
MOD_N-GLC_1	383	388	PF02516	0.580
MOD_N-GLC_1	61	66	PF02516	0.594
MOD_N-GLC_1	686	691	PF02516	0.667
MOD_NEK2_1	173	178	PF00069	0.480
MOD_NEK2_1	322	327	PF00069	0.585
MOD_NEK2_1	333	338	PF00069	0.597
MOD_NEK2_1	507	512	PF00069	0.628
MOD_NEK2_1	54	59	PF00069	0.728
MOD_NEK2_1	63	68	PF00069	0.585
MOD_NEK2_2	312	317	PF00069	0.637
MOD_NEK2_2	749	754	PF00069	0.555
MOD_PIKK_1	259	265	PF00454	0.543
MOD_PIKK_1	302	308	PF00454	0.624
MOD_PIKK_1	356	362	PF00454	0.734
MOD_PIKK_1	459	465	PF00454	0.711
MOD_PIKK_1	525	531	PF00454	0.692
MOD_PIKK_1	635	641	PF00454	0.641
MOD_PIKK_1	645	651	PF00454	0.601
MOD_PKA_2	140	146	PF00069	0.537
MOD_PKA_2	173	179	PF00069	0.458
MOD_PKA_2	479	485	PF00069	0.656
MOD_PKB_1	242	250	PF00069	0.568
MOD_Plk_2-3	217	223	PF00069	0.572
MOD_Plk_4	292	298	PF00069	0.667
MOD_Plk_4	415	421	PF00069	0.677
MOD_Plk_4	503	509	PF00069	0.606
MOD_Plk_4	535	541	PF00069	0.511
MOD_Plk_4	54	60	PF00069	0.671
MOD_Plk_4	749	755	PF00069	0.558
MOD_ProDKin_1	102	108	PF00069	0.625
MOD_ProDKin_1	262	268	PF00069	0.650
MOD_ProDKin_1	288	294	PF00069	0.641
MOD_ProDKin_1	296	302	PF00069	0.587
MOD_ProDKin_1	344	350	PF00069	0.661
MOD_ProDKin_1	407	413	PF00069	0.604
MOD_ProDKin_1	41	47	PF00069	0.553
MOD_ProDKin_1	451	457	PF00069	0.668
MOD_ProDKin_1	558	564	PF00069	0.656
MOD_ProDKin_1	581	587	PF00069	0.661
MOD_ProDKin_1	597	603	PF00069	0.533
MOD_ProDKin_1	664	670	PF00069	0.592
MOD_ProDKin_1	686	692	PF00069	0.667
MOD_SUMO_for_1	204	207	PF00179	0.550
TRG_DiLeu_BaEn_1	222	227	PF01217	0.537
TRG_DiLeu_BaLyEn_6	572	577	PF01217	0.612
TRG_DiLeu_LyEn_5	222	227	PF01217	0.537
TRG_ENDOCYTIC_2	145	148	PF00928	0.620
TRG_ER_diArg_1	241	244	PF00400	0.552
TRG_ER_diArg_1	746	748	PF00400	0.524
TRG_NES_CRM1_1	24	37	PF08389	0.561
TRG_NLS_MonoExtC_3	179	185	PF00514	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU08	Leptomonas seymouri	41%	100%
A0A3S7X9R7	Leishmania donovani	90%	100%
A4HN68	Leishmania braziliensis	72%	100%
A4IBT6	Leishmania infantum	90%	100%
E9B6S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%