SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted zinc finger protein

Species:

Leishmania major

UniProt:

E9AFM2_LEIMA

TriTrypDb:

LmjF.35.3970 , LMJLV39_350047500 , LMJSD75_350046800

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFM2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0008270	zinc ion binding	6	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.597
CLV_C14_Caspase3-7	569	573	PF00656	0.308
CLV_C14_Caspase3-7	612	616	PF00656	0.626
CLV_MEL_PAP_1	14	20	PF00089	0.384
CLV_NRD_NRD_1	156	158	PF00675	0.681
CLV_NRD_NRD_1	308	310	PF00675	0.486
CLV_NRD_NRD_1	680	682	PF00675	0.681
CLV_NRD_NRD_1	7	9	PF00675	0.523
CLV_NRD_NRD_1	95	97	PF00675	0.617
CLV_PCSK_KEX2_1	132	134	PF00082	0.556
CLV_PCSK_KEX2_1	156	158	PF00082	0.681
CLV_PCSK_KEX2_1	308	310	PF00082	0.397
CLV_PCSK_KEX2_1	372	374	PF00082	0.460
CLV_PCSK_KEX2_1	682	684	PF00082	0.694
CLV_PCSK_KEX2_1	7	9	PF00082	0.436
CLV_PCSK_KEX2_1	95	97	PF00082	0.617
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.534
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.460
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.746
CLV_PCSK_SKI1_1	448	452	PF00082	0.531
CLV_PCSK_SKI1_1	49	53	PF00082	0.360
DEG_SPOP_SBC_1	191	195	PF00917	0.698
DEG_SPOP_SBC_1	264	268	PF00917	0.615
DEG_SPOP_SBC_1	281	285	PF00917	0.420
DEG_SPOP_SBC_1	462	466	PF00917	0.520
DOC_CKS1_1	346	351	PF01111	0.493
DOC_CKS1_1	367	372	PF01111	0.459
DOC_CKS1_1	413	418	PF01111	0.402
DOC_MAPK_gen_1	156	164	PF00069	0.686
DOC_MAPK_gen_1	308	314	PF00069	0.379
DOC_MAPK_gen_1	334	343	PF00069	0.337
DOC_MAPK_gen_1	95	102	PF00069	0.523
DOC_PP2B_LxvP_1	141	144	PF13499	0.576
DOC_PP2B_LxvP_1	278	281	PF13499	0.599
DOC_PP2B_LxvP_1	304	307	PF13499	0.390
DOC_PP2B_LxvP_1	511	514	PF13499	0.507
DOC_PP2B_LxvP_1	660	663	PF13499	0.633
DOC_PP4_FxxP_1	321	324	PF00568	0.331
DOC_SPAK_OSR1_1	320	324	PF12202	0.372
DOC_USP7_MATH_1	146	150	PF00917	0.680
DOC_USP7_MATH_1	155	159	PF00917	0.694
DOC_USP7_MATH_1	224	228	PF00917	0.715
DOC_USP7_MATH_1	245	249	PF00917	0.713
DOC_USP7_MATH_1	255	259	PF00917	0.577
DOC_USP7_MATH_1	265	269	PF00917	0.497
DOC_USP7_MATH_1	460	464	PF00917	0.610
DOC_USP7_MATH_1	625	629	PF00917	0.644
DOC_USP7_MATH_1	631	635	PF00917	0.773
DOC_USP7_MATH_1	664	668	PF00917	0.735
DOC_USP7_UBL2_3	39	43	PF12436	0.410
DOC_WW_Pin1_4	113	118	PF00397	0.800
DOC_WW_Pin1_4	151	156	PF00397	0.677
DOC_WW_Pin1_4	199	204	PF00397	0.791
DOC_WW_Pin1_4	267	272	PF00397	0.566
DOC_WW_Pin1_4	345	350	PF00397	0.502
DOC_WW_Pin1_4	366	371	PF00397	0.436
DOC_WW_Pin1_4	412	417	PF00397	0.455
DOC_WW_Pin1_4	582	587	PF00397	0.368
DOC_WW_Pin1_4	621	626	PF00397	0.538
DOC_WW_Pin1_4	686	691	PF00397	0.660
LIG_14-3-3_CanoR_1	111	117	PF00244	0.548
LIG_14-3-3_CanoR_1	156	164	PF00244	0.651
LIG_14-3-3_CanoR_1	17	21	PF00244	0.618
LIG_14-3-3_CanoR_1	196	204	PF00244	0.660
LIG_14-3-3_CanoR_1	238	247	PF00244	0.658
LIG_14-3-3_CanoR_1	302	307	PF00244	0.394
LIG_14-3-3_CanoR_1	313	319	PF00244	0.253
LIG_14-3-3_CanoR_1	397	404	PF00244	0.398
LIG_14-3-3_CanoR_1	519	526	PF00244	0.510
LIG_14-3-3_CanoR_1	579	586	PF00244	0.474
LIG_14-3-3_CanoR_1	75	84	PF00244	0.492
LIG_Actin_WH2_2	297	315	PF00022	0.338
LIG_Actin_WH2_2	44	61	PF00022	0.409
LIG_Actin_WH2_2	564	581	PF00022	0.352
LIG_BIR_III_2	572	576	PF00653	0.342
LIG_BRCT_BRCA1_1	233	237	PF00533	0.579
LIG_EVH1_1	660	664	PF00568	0.586
LIG_FHA_1	103	109	PF00498	0.602
LIG_FHA_1	148	154	PF00498	0.629
LIG_FHA_1	163	169	PF00498	0.536
LIG_FHA_1	277	283	PF00498	0.679
LIG_FHA_1	390	396	PF00498	0.341
LIG_FHA_1	413	419	PF00498	0.541
LIG_FHA_2	29	35	PF00498	0.537
LIG_FHA_2	352	358	PF00498	0.417
LIG_FHA_2	599	605	PF00498	0.566
LIG_FHA_2	687	693	PF00498	0.718
LIG_FHA_2	695	701	PF00498	0.687
LIG_GBD_Chelix_1	37	45	PF00786	0.423
LIG_LIR_Apic_2	412	416	PF02991	0.464
LIG_LIR_Gen_1	257	265	PF02991	0.769
LIG_LIR_Gen_1	479	485	PF02991	0.397
LIG_LIR_Gen_1	559	568	PF02991	0.391
LIG_LIR_Nem_3	22	26	PF02991	0.334
LIG_LIR_Nem_3	257	262	PF02991	0.740
LIG_LIR_Nem_3	3	9	PF02991	0.380
LIG_LIR_Nem_3	384	389	PF02991	0.379
LIG_LIR_Nem_3	479	483	PF02991	0.400
LIG_LIR_Nem_3	559	565	PF02991	0.334
LIG_LIR_Nem_3	567	571	PF02991	0.388
LIG_LIR_Nem_3	572	577	PF02991	0.411
LIG_NRBOX	47	53	PF00104	0.441
LIG_PDZ_Class_2	699	704	PF00595	0.607
LIG_Pex14_2	310	314	PF04695	0.374
LIG_PTB_Apo_2	407	414	PF02174	0.475
LIG_PTB_Phospho_1	407	413	PF10480	0.473
LIG_REV1ctd_RIR_1	298	306	PF16727	0.425
LIG_SH2_CRK	259	263	PF00017	0.775
LIG_SH2_CRK	339	343	PF00017	0.385
LIG_SH2_CRK	413	417	PF00017	0.408
LIG_SH2_CRK	480	484	PF00017	0.393
LIG_SH2_GRB2like	361	364	PF00017	0.377
LIG_SH2_GRB2like	540	543	PF00017	0.440
LIG_SH2_NCK_1	259	263	PF00017	0.602
LIG_SH2_SRC	327	330	PF00017	0.438
LIG_SH2_SRC	53	56	PF00017	0.461
LIG_SH2_STAP1	480	484	PF00017	0.393
LIG_SH2_STAT5	327	330	PF00017	0.442
LIG_SH2_STAT5	36	39	PF00017	0.499
LIG_SH2_STAT5	361	364	PF00017	0.377
LIG_SH2_STAT5	386	389	PF00017	0.407
LIG_SH2_STAT5	393	396	PF00017	0.424
LIG_SH2_STAT5	564	567	PF00017	0.390
LIG_SH2_STAT5	577	580	PF00017	0.310
LIG_SH3_2	346	351	PF14604	0.399
LIG_SH3_3	15	21	PF00018	0.377
LIG_SH3_3	186	192	PF00018	0.785
LIG_SH3_3	259	265	PF00018	0.716
LIG_SH3_3	268	274	PF00018	0.523
LIG_SH3_3	343	349	PF00018	0.409
LIG_SH3_3	364	370	PF00018	0.429
LIG_SH3_3	492	498	PF00018	0.473
LIG_SH3_3	624	630	PF00018	0.619
LIG_SH3_3	649	655	PF00018	0.616
LIG_SH3_3	658	664	PF00018	0.595
LIG_SUMO_SIM_par_1	149	154	PF11976	0.600
LIG_SUMO_SIM_par_1	387	392	PF11976	0.325
LIG_TRAF2_1	208	211	PF00917	0.568
LIG_TRAF2_1	426	429	PF00917	0.453
LIG_TRAF2_1	690	693	PF00917	0.735
LIG_TRAF2_2	324	329	PF00917	0.459
LIG_TYR_ITSM	255	262	PF00017	0.573
LIG_WRC_WIRS_1	565	570	PF05994	0.396
MOD_CDC14_SPxK_1	154	157	PF00782	0.677
MOD_CDK_SPK_2	151	156	PF00069	0.669
MOD_CDK_SPK_2	582	587	PF00069	0.368
MOD_CDK_SPxK_1	151	157	PF00069	0.681
MOD_CDK_SPxK_1	345	351	PF00069	0.504
MOD_CDK_SPxK_1	366	372	PF00069	0.449
MOD_CDK_SPxxK_3	366	373	PF00069	0.453
MOD_CK1_1	149	155	PF00069	0.791
MOD_CK1_1	174	180	PF00069	0.607
MOD_CK1_1	198	204	PF00069	0.661
MOD_CK1_1	225	231	PF00069	0.759
MOD_CK1_1	25	31	PF00069	0.401
MOD_CK1_1	276	282	PF00069	0.764
MOD_CK1_1	283	289	PF00069	0.529
MOD_CK1_1	396	402	PF00069	0.414
MOD_CK1_1	453	459	PF00069	0.573
MOD_CK1_1	463	469	PF00069	0.567
MOD_CK1_1	518	524	PF00069	0.332
MOD_CK1_1	598	604	PF00069	0.572
MOD_CK1_1	636	642	PF00069	0.619
MOD_CK1_1	647	653	PF00069	0.524
MOD_CK1_1	98	104	PF00069	0.627
MOD_CK2_1	16	22	PF00069	0.571
MOD_CK2_1	283	289	PF00069	0.486
MOD_CK2_1	351	357	PF00069	0.485
MOD_CK2_1	582	588	PF00069	0.378
MOD_CK2_1	611	617	PF00069	0.807
MOD_CK2_1	635	641	PF00069	0.641
MOD_CK2_1	686	692	PF00069	0.659
MOD_Cter_Amidation	130	133	PF01082	0.533
MOD_Cter_Amidation	67	70	PF01082	0.471
MOD_GlcNHglycan	120	123	PF01048	0.640
MOD_GlcNHglycan	133	136	PF01048	0.636
MOD_GlcNHglycan	176	179	PF01048	0.708
MOD_GlcNHglycan	198	201	PF01048	0.658
MOD_GlcNHglycan	224	227	PF01048	0.687
MOD_GlcNHglycan	230	233	PF01048	0.724
MOD_GlcNHglycan	267	270	PF01048	0.630
MOD_GlcNHglycan	295	298	PF01048	0.426
MOD_GlcNHglycan	456	459	PF01048	0.662
MOD_GlcNHglycan	580	583	PF01048	0.433
MOD_GlcNHglycan	627	630	PF01048	0.661
MOD_GlcNHglycan	635	638	PF01048	0.615
MOD_GlcNHglycan	652	655	PF01048	0.689
MOD_GlcNHglycan	85	89	PF01048	0.633
MOD_GSK3_1	111	118	PF00069	0.588
MOD_GSK3_1	147	154	PF00069	0.689
MOD_GSK3_1	191	198	PF00069	0.702
MOD_GSK3_1	199	206	PF00069	0.730
MOD_GSK3_1	215	222	PF00069	0.521
MOD_GSK3_1	224	231	PF00069	0.634
MOD_GSK3_1	232	239	PF00069	0.572
MOD_GSK3_1	263	270	PF00069	0.785
MOD_GSK3_1	276	283	PF00069	0.531
MOD_GSK3_1	389	396	PF00069	0.398
MOD_GSK3_1	450	457	PF00069	0.548
MOD_GSK3_1	460	467	PF00069	0.619
MOD_GSK3_1	532	539	PF00069	0.328
MOD_GSK3_1	556	563	PF00069	0.379
MOD_GSK3_1	578	585	PF00069	0.415
MOD_GSK3_1	621	628	PF00069	0.655
MOD_GSK3_1	631	638	PF00069	0.702
MOD_GSK3_1	640	647	PF00069	0.617
MOD_GSK3_1	98	105	PF00069	0.649
MOD_N-GLC_1	293	298	PF02516	0.533
MOD_N-GLC_1	686	691	PF02516	0.551
MOD_NEK2_1	102	107	PF00069	0.680
MOD_NEK2_1	237	242	PF00069	0.533
MOD_NEK2_1	282	287	PF00069	0.636
MOD_NEK2_1	293	298	PF00069	0.431
MOD_NEK2_1	314	319	PF00069	0.550
MOD_NEK2_1	389	394	PF00069	0.327
MOD_NEK2_1	434	439	PF00069	0.424
MOD_NEK2_1	450	455	PF00069	0.576
MOD_NEK2_1	461	466	PF00069	0.610
MOD_NEK2_1	468	473	PF00069	0.355
MOD_NEK2_1	531	536	PF00069	0.343
MOD_NEK2_1	578	583	PF00069	0.426
MOD_NEK2_1	640	645	PF00069	0.757
MOD_NEK2_1	677	682	PF00069	0.548
MOD_PIKK_1	504	510	PF00454	0.306
MOD_PK_1	302	308	PF00069	0.551
MOD_PK_1	59	65	PF00069	0.470
MOD_PKA_1	156	162	PF00069	0.650
MOD_PKA_1	95	101	PF00069	0.602
MOD_PKA_2	125	131	PF00069	0.642
MOD_PKA_2	155	161	PF00069	0.695
MOD_PKA_2	16	22	PF00069	0.514
MOD_PKA_2	195	201	PF00069	0.544
MOD_PKA_2	237	243	PF00069	0.771
MOD_PKA_2	245	251	PF00069	0.684
MOD_PKA_2	396	402	PF00069	0.414
MOD_PKA_2	515	521	PF00069	0.395
MOD_PKA_2	578	584	PF00069	0.452
MOD_PKA_2	694	700	PF00069	0.702
MOD_PKA_2	95	101	PF00069	0.652
MOD_Plk_1	389	395	PF00069	0.326
MOD_Plk_1	59	65	PF00069	0.470
MOD_Plk_1	647	653	PF00069	0.646
MOD_Plk_1	98	104	PF00069	0.526
MOD_Plk_2-3	611	617	PF00069	0.707
MOD_Plk_2-3	688	694	PF00069	0.647
MOD_Plk_4	185	191	PF00069	0.679
MOD_Plk_4	22	28	PF00069	0.423
MOD_Plk_4	273	279	PF00069	0.776
MOD_Plk_4	314	320	PF00069	0.386
MOD_Plk_4	382	388	PF00069	0.367
MOD_Plk_4	464	470	PF00069	0.469
MOD_Plk_4	536	542	PF00069	0.361
MOD_Plk_4	556	562	PF00069	0.333
MOD_Plk_4	59	65	PF00069	0.470
MOD_ProDKin_1	113	119	PF00069	0.685
MOD_ProDKin_1	151	157	PF00069	0.677
MOD_ProDKin_1	199	205	PF00069	0.792
MOD_ProDKin_1	267	273	PF00069	0.564
MOD_ProDKin_1	345	351	PF00069	0.504
MOD_ProDKin_1	366	372	PF00069	0.449
MOD_ProDKin_1	412	418	PF00069	0.448
MOD_ProDKin_1	582	588	PF00069	0.378
MOD_ProDKin_1	621	627	PF00069	0.537
MOD_ProDKin_1	686	692	PF00069	0.661
MOD_SUMO_rev_2	19	26	PF00179	0.489
TRG_DiLeu_BaEn_1	47	52	PF01217	0.403
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.429
TRG_ENDOCYTIC_2	259	262	PF00928	0.774
TRG_ENDOCYTIC_2	386	389	PF00928	0.447
TRG_ENDOCYTIC_2	480	483	PF00928	0.359
TRG_ENDOCYTIC_2	577	580	PF00928	0.428
TRG_ER_diArg_1	155	157	PF00400	0.678
TRG_ER_diArg_1	307	309	PF00400	0.498
TRG_ER_diArg_1	6	8	PF00400	0.437
TRG_ER_diArg_1	94	96	PF00400	0.661
TRG_NLS_MonoExtC_3	680	685	PF00514	0.652
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	49	54	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M6	Leptomonas seymouri	53%	97%
A0A0S4J3Y9	Bodo saltans	30%	100%
A0A3Q8IPZ9	Leishmania donovani	91%	100%
A0A422MY81	Trypanosoma rangeli	40%	100%
A4IBT5	Leishmania infantum	91%	100%
E9B6S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%