Protein kinase A catalytic subunit isoform 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cAMP-dependent protein kinase catalytic subunit 2

Species:

Leishmania major

UniProt:

E9AFM1_LEIMA

TriTrypDb:

LmjF.35.3960 , LMJLV39_350047400 , LMJSD75_180016500

Length:

340

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 28

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005930	axoneme	2	3
GO:0005952	cAMP-dependent protein kinase complex	3	4
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0032991	protein-containing complex	1	4
GO:0043233	organelle lumen	3	3
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	4
GO:0070013	intracellular organelle lumen	4	3
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3
GO:0110165	cellular anatomical entity	1	5
GO:0140535	intracellular protein-containing complex	2	4
GO:1902494	catalytic complex	2	4
GO:1902554	serine/threonine protein kinase complex	6	4
GO:1902911	protein kinase complex	5	4
GO:1990234	transferase complex	3	4
GO:0016020	membrane	2	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1

Expansion

Sequence features

E9AFM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFM1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	27
GO:0006793	phosphorus metabolic process	3	27
GO:0006796	phosphate-containing compound metabolic process	4	27
GO:0006807	nitrogen compound metabolic process	2	27
GO:0007165	signal transduction	2	4
GO:0008152	metabolic process	1	27
GO:0009987	cellular process	1	27
GO:0016310	phosphorylation	5	27
GO:0018105	peptidyl-serine phosphorylation	6	4
GO:0018193	peptidyl-amino acid modification	5	4
GO:0018209	peptidyl-serine modification	6	4
GO:0019538	protein metabolic process	3	27
GO:0036211	protein modification process	4	27
GO:0043170	macromolecule metabolic process	3	27
GO:0043412	macromolecule modification	4	27
GO:0044237	cellular metabolic process	2	27
GO:0044238	primary metabolic process	2	27
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0065007	biological regulation	1	4
GO:0071704	organic substance metabolic process	2	27
GO:1901564	organonitrogen compound metabolic process	3	27

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	27
GO:0003824	catalytic activity	1	27
GO:0004672	protein kinase activity	3	27
GO:0004674	protein serine/threonine kinase activity	4	27
GO:0004690	cyclic nucleotide-dependent protein kinase activity	5	5
GO:0004691	cAMP-dependent protein kinase activity	6	5
GO:0005488	binding	1	27
GO:0005524	ATP binding	5	27
GO:0016301	kinase activity	4	27
GO:0016740	transferase activity	2	27
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	27
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	27
GO:0017076	purine nucleotide binding	4	27
GO:0030554	adenyl nucleotide binding	5	27
GO:0032553	ribonucleotide binding	3	27
GO:0032555	purine ribonucleotide binding	4	27
GO:0032559	adenyl ribonucleotide binding	5	27
GO:0035639	purine ribonucleoside triphosphate binding	4	27
GO:0036094	small molecule binding	2	27
GO:0043167	ion binding	2	27
GO:0043168	anion binding	3	27
GO:0097159	organic cyclic compound binding	2	27
GO:0097367	carbohydrate derivative binding	2	27
GO:0140096	catalytic activity, acting on a protein	2	27
GO:1901265	nucleoside phosphate binding	3	27
GO:1901363	heterocyclic compound binding	2	27
GO:0004679	AMP-activated protein kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	49	51	PF00675	0.278
CLV_NRD_NRD_1	62	64	PF00675	0.153
CLV_PCSK_KEX2_1	267	269	PF00082	0.270
CLV_PCSK_KEX2_1	64	66	PF00082	0.283
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.270
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.283
CLV_PCSK_SKI1_1	153	157	PF00082	0.270
CLV_PCSK_SKI1_1	182	186	PF00082	0.282
CLV_PCSK_SKI1_1	258	262	PF00082	0.249
CLV_PCSK_SKI1_1	80	84	PF00082	0.246
DEG_SCF_FBW7_1	323	330	PF00400	0.435
DEG_SPOP_SBC_1	21	25	PF00917	0.543
DOC_CYCLIN_RxL_1	252	264	PF00134	0.277
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.227
DOC_MAPK_DCC_7	296	306	PF00069	0.380
DOC_MAPK_gen_1	102	110	PF00069	0.362
DOC_MAPK_gen_1	153	162	PF00069	0.270
DOC_MAPK_JIP1_4	156	162	PF00069	0.241
DOC_PP1_RVXF_1	100	107	PF00149	0.377
DOC_PP1_RVXF_1	203	210	PF00149	0.278
DOC_PP1_RVXF_1	240	246	PF00149	0.305
DOC_PP4_FxxP_1	18	21	PF00568	0.389
DOC_USP7_MATH_1	21	25	PF00917	0.408
DOC_USP7_MATH_1	328	332	PF00917	0.448
DOC_USP7_UBL2_3	165	169	PF12436	0.283
DOC_USP7_UBL2_3	201	205	PF12436	0.320
DOC_USP7_UBL2_3	60	64	PF12436	0.276
DOC_WW_Pin1_4	186	191	PF00397	0.287
DOC_WW_Pin1_4	227	232	PF00397	0.270
DOC_WW_Pin1_4	305	310	PF00397	0.475
DOC_WW_Pin1_4	318	323	PF00397	0.451
LIG_14-3-3_CanoR_1	182	187	PF00244	0.269
LIG_Actin_WH2_2	105	123	PF00022	0.277
LIG_ActinCP_TwfCPI_2	18	27	PF01115	0.360
LIG_FHA_1	181	187	PF00498	0.276
LIG_FHA_1	209	215	PF00498	0.270
LIG_FHA_1	264	270	PF00498	0.277
LIG_FHA_1	324	330	PF00498	0.430
LIG_LIR_Apic_2	189	195	PF02991	0.270
LIG_LIR_Gen_1	115	123	PF02991	0.297
LIG_LIR_Gen_1	4	15	PF02991	0.666
LIG_LIR_Nem_3	115	120	PF02991	0.297
LIG_LIR_Nem_3	149	155	PF02991	0.305
LIG_LIR_Nem_3	229	235	PF02991	0.256
LIG_LIR_Nem_3	291	297	PF02991	0.434
LIG_LIR_Nem_3	312	318	PF02991	0.414
LIG_LIR_Nem_3	39	45	PF02991	0.292
LIG_LIR_Nem_3	4	10	PF02991	0.672
LIG_LIR_Nem_3	53	59	PF02991	0.292
LIG_Pex14_1	290	294	PF04695	0.337
LIG_Pex14_2	106	110	PF04695	0.374
LIG_Pex14_2	2	6	PF04695	0.627
LIG_Pex14_2	245	249	PF04695	0.283
LIG_PTB_Apo_2	278	285	PF02174	0.307
LIG_PTB_Phospho_1	278	284	PF10480	0.339
LIG_SH2_CRK	7	11	PF00017	0.539
LIG_SH2_SRC	144	147	PF00017	0.272
LIG_SH2_STAP1	217	221	PF00017	0.277
LIG_SH2_STAP1	235	239	PF00017	0.270
LIG_SH2_STAP1	294	298	PF00017	0.412
LIG_SH2_STAT5	105	108	PF00017	0.270
LIG_SH2_STAT5	144	147	PF00017	0.240
LIG_SH2_STAT5	192	195	PF00017	0.300
LIG_SH2_STAT5	284	287	PF00017	0.420
LIG_SH3_3	303	309	PF00018	0.417
LIG_SH3_3	316	322	PF00018	0.429
LIG_SUMO_SIM_anti_2	147	152	PF11976	0.271
LIG_TYR_ITIM	150	155	PF00017	0.270
LIG_TYR_ITIM	215	220	PF00017	0.277
LIG_UBA3_1	67	71	PF00899	0.276
LIG_WRC_WIRS_1	95	100	PF05994	0.299
LIG_WW_1	224	227	PF00397	0.319
MOD_CDK_SPxK_1	227	233	PF00069	0.270
MOD_CDK_SPxxK_3	318	325	PF00069	0.450
MOD_CK2_1	26	32	PF00069	0.395
MOD_CK2_1	310	316	PF00069	0.409
MOD_DYRK1A_RPxSP_1	305	309	PF00069	0.415
MOD_GlcNHglycan	330	333	PF01048	0.522
MOD_GlcNHglycan	7	10	PF01048	0.558
MOD_GSK3_1	1	8	PF00069	0.678
MOD_GSK3_1	115	122	PF00069	0.315
MOD_GSK3_1	182	189	PF00069	0.279
MOD_GSK3_1	22	29	PF00069	0.472
MOD_GSK3_1	305	312	PF00069	0.447
MOD_GSK3_1	323	330	PF00069	0.570
MOD_NEK2_1	33	38	PF00069	0.277
MOD_NEK2_1	94	99	PF00069	0.364
MOD_PKA_1	50	56	PF00069	0.271
MOD_Plk_1	180	186	PF00069	0.270
MOD_Plk_1	21	27	PF00069	0.462
MOD_Plk_4	2	8	PF00069	0.614
MOD_ProDKin_1	186	192	PF00069	0.287
MOD_ProDKin_1	227	233	PF00069	0.270
MOD_ProDKin_1	305	311	PF00069	0.468
MOD_ProDKin_1	318	324	PF00069	0.446
MOD_SUMO_for_1	155	158	PF00179	0.270
MOD_SUMO_rev_2	149	157	PF00179	0.265
MOD_SUMO_rev_2	29	36	PF00179	0.374
MOD_SUMO_rev_2	331	340	PF00179	0.413
MOD_SUMO_rev_2	97	104	PF00179	0.423
TRG_DiLeu_BaEn_1	79	84	PF01217	0.299
TRG_ENDOCYTIC_2	105	108	PF00928	0.273
TRG_ENDOCYTIC_2	152	155	PF00928	0.270
TRG_ENDOCYTIC_2	217	220	PF00928	0.272
TRG_ENDOCYTIC_2	223	226	PF00928	0.266
TRG_ENDOCYTIC_2	235	238	PF00928	0.237
TRG_ENDOCYTIC_2	56	59	PF00928	0.270
TRG_ENDOCYTIC_2	7	10	PF00928	0.619
TRG_ER_diArg_1	44	47	PF00400	0.270
TRG_ER_diArg_1	62	65	PF00400	0.246
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N5	Leptomonas seymouri	29%	79%
A0A0N0P3Q8	Leptomonas seymouri	30%	95%
A0A0N0P787	Leptomonas seymouri	31%	88%
A0A0N0P8H5	Leptomonas seymouri	57%	100%
A0A0N1HWQ2	Leptomonas seymouri	33%	100%
A0A0N1I6T8	Leptomonas seymouri	35%	100%
A0A0N1IIF9	Leptomonas seymouri	35%	100%
A0A0N1PBE9	Leptomonas seymouri	28%	68%
A0A0N1PC31	Leptomonas seymouri	36%	87%
A0A0N1PD05	Leptomonas seymouri	25%	76%
A0A0N1PDW7	Leptomonas seymouri	31%	86%
A0A0S4IKH2	Bodo saltans	29%	69%
A0A0S4IMB7	Bodo saltans	26%	77%
A0A0S4IRU8	Bodo saltans	32%	79%
A0A0S4IRZ7	Bodo saltans	31%	69%
A0A0S4IX86	Bodo saltans	28%	79%
A0A0S4IZY3	Bodo saltans	79%	100%
A0A0S4J3Y5	Bodo saltans	26%	79%
A0A0S4J4B3	Bodo saltans	35%	76%
A0A0S4J6L4	Bodo saltans	35%	89%
A0A0S4J7K4	Bodo saltans	28%	70%
A0A0S4JBR3	Bodo saltans	31%	100%
A0A0S4JCG2	Bodo saltans	37%	76%
A0A0S4JER5	Bodo saltans	44%	75%
A0A0S4JI67	Bodo saltans	33%	74%
A0A0S4JPZ1	Bodo saltans	30%	76%
A0A0S4JTJ8	Bodo saltans	32%	74%
A0A0S4JUJ2	Bodo saltans	29%	100%
A0A0S4JWD5	Bodo saltans	33%	87%
A0A0S4KFT7	Bodo saltans	63%	100%
A0A0S4KMV7	Bodo saltans	29%	100%
A0A1X0NF53	Trypanosomatidae	27%	73%
A0A1X0NIA0	Trypanosomatidae	29%	79%
A0A1X0NIX2	Trypanosomatidae	29%	77%
A0A1X0NJV4	Trypanosomatidae	26%	66%
A0A1X0NQ63	Trypanosomatidae	34%	100%
A0A1X0NRZ9	Trypanosomatidae	27%	92%
A0A1X0NTR6	Trypanosomatidae	29%	97%
A0A1X0NUQ4	Trypanosomatidae	29%	90%
A0A1X0NY93	Trypanosomatidae	34%	87%
A0A1X0NYK8	Trypanosomatidae	35%	100%
A0A1X0P1A2	Trypanosomatidae	27%	74%
A0A1X0P3J5	Trypanosomatidae	45%	74%
A0A1X0P527	Trypanosomatidae	28%	77%
A0A1X0P549	Trypanosomatidae	29%	72%
A0A1X0P5B1	Trypanosomatidae	83%	100%
A0A1X0P5F2	Trypanosomatidae	82%	100%
A0A1X0P6V1	Trypanosomatidae	34%	100%
A0A1X0P735	Trypanosomatidae	34%	100%
A0A1X0P7V0	Trypanosomatidae	60%	100%
A0A1X0P8F7	Trypanosomatidae	30%	78%
A0A1X0P963	Trypanosomatidae	27%	70%
A0A1X0P9C4	Trypanosomatidae	28%	68%
A0A3Q8IB30	Leishmania donovani	58%	100%
A0A3Q8IBT5	Leishmania donovani	26%	100%
A0A3Q8IC87	Leishmania donovani	31%	92%
A0A3Q8IEH3	Leishmania donovani	32%	100%
A0A3Q8IFK8	Leishmania donovani	30%	77%
A0A3Q8IFW0	Leishmania donovani	29%	79%
A0A3Q8IHH8	Leishmania donovani	31%	68%
A0A3Q8INQ4	Leishmania donovani	35%	87%
A0A3Q8IRT6	Leishmania donovani	39%	67%
A0A3R7KCZ4	Trypanosoma rangeli	30%	84%
A0A3R7M5C7	Trypanosoma rangeli	33%	100%
A0A3R7M819	Trypanosoma rangeli	30%	97%
A0A3R7MHW5	Trypanosoma rangeli	29%	85%
A0A3R7MJP3	Trypanosoma rangeli	29%	100%
A0A3R7MKG5	Trypanosoma rangeli	30%	77%
A0A3R7N4D8	Trypanosoma rangeli	34%	84%
A0A3R7N5S4	Trypanosoma rangeli	30%	90%
A0A3R7NKI8	Trypanosoma rangeli	29%	100%
A0A3R7RIN5	Trypanosoma rangeli	27%	68%
A0A3R7RLL1	Trypanosoma rangeli	32%	79%
A0A3S5H5G0	Leishmania donovani	25%	100%
A0A3S5H5U5	Leishmania donovani	31%	75%
A0A3S5H606	Leishmania donovani	35%	100%
A0A3S7WTN9	Leishmania donovani	31%	88%
A0A3S7WUX5	Leishmania donovani	35%	100%
A0A3S7WVE9	Leishmania donovani	30%	100%
A0A3S7WWE7	Leishmania donovani	23%	100%
A0A3S7WYP4	Leishmania donovani	32%	97%
A0A3S7X123	Leishmania donovani	24%	100%
A0A3S7X6T8	Leishmania donovani	26%	76%
A0A3S7X8Z8	Leishmania donovani	28%	70%
A0A3S7X9R4	Leishmania donovani	95%	92%
A0A3S7X9S2	Leishmania donovani	96%	100%
A0A3S7XAL3	Leishmania donovani	30%	69%
A0A3S7XAT9	Leishmania donovani	27%	68%
A0A3S7XAX0	Leishmania donovani	27%	100%
A0A422MYB4	Trypanosoma rangeli	83%	100%
A0A422NCP0	Trypanosoma rangeli	28%	68%
A0A422NCU3	Trypanosoma rangeli	31%	100%
A0A422NUF0	Trypanosoma rangeli	26%	85%
A0A422P0J2	Trypanosoma rangeli	59%	100%
A0A422P0N6	Trypanosoma rangeli	30%	100%
A0A422P1R5	Trypanosoma rangeli	34%	100%
A0A422P270	Trypanosoma rangeli	31%	77%
A0A422P4V9	Trypanosoma rangeli	45%	74%
A0A8I3S724	Canis lupus familiaris	39%	84%
A2VDV2	Bos taurus	36%	73%
A2XFF4	Oryza sativa subsp. indica	37%	67%
A3B529	Oryza sativa subsp. japonica	35%	78%
A4H459	Leishmania braziliensis	24%	100%
A4H4S9	Leishmania braziliensis	31%	75%
A4H539	Leishmania braziliensis	35%	100%
A4H8C4	Leishmania braziliensis	32%	88%
A4H9H4	Leishmania braziliensis	35%	100%
A4H9L8	Leishmania braziliensis	58%	100%
A4H9X2	Leishmania braziliensis	30%	100%
A4HBL4	Leishmania braziliensis	24%	100%
A4HDU3	Leishmania braziliensis	31%	97%
A4HED7	Leishmania braziliensis	34%	87%
A4HFF3	Leishmania braziliensis	27%	68%
A4HG26	Leishmania braziliensis	24%	100%
A4HG92	Leishmania braziliensis	33%	100%
A4HH03	Leishmania braziliensis	26%	100%
A4HHQ5	Leishmania braziliensis	30%	67%
A4HI35	Leishmania braziliensis	40%	67%
A4HJT5	Leishmania braziliensis	30%	77%
A4HJW2	Leishmania braziliensis	28%	79%
A4HLR0	Leishmania braziliensis	25%	76%
A4HN71	Leishmania braziliensis	93%	91%
A4HP12	Leishmania braziliensis	29%	67%
A4HSE2	Leishmania infantum	25%	100%
A4HTB4	Leishmania infantum	35%	100%
A4HWP5	Leishmania infantum	31%	88%
A4HXU0	Leishmania infantum	35%	100%
A4HXY2	Leishmania infantum	58%	100%
A4HZA2	Leishmania infantum	23%	100%
A4HZV1	Leishmania infantum	31%	92%
A4I140	Leishmania infantum	32%	97%
A4I1T4	Leishmania infantum	35%	87%
A4I3C6	Leishmania infantum	32%	100%
A4I4X0	Leishmania infantum	31%	68%
A4I5B1	Leishmania infantum	39%	67%
A4I7A1	Leishmania infantum	30%	77%
A4I7C4	Leishmania infantum	29%	79%
A4I960	Leishmania infantum	26%	76%
A4IB02	Leishmania infantum	28%	70%
A4IBT4	Leishmania infantum	96%	89%
A4IBT9	Leishmania infantum	95%	92%
A4IDC1	Leishmania infantum	29%	67%
A4IDC2	Leishmania infantum	27%	68%
A4IDK3	Leishmania infantum	27%	100%
A4IGM9	Xenopus tropicalis	37%	94%
A5GFW1	Sus scrofa	38%	85%
A7MB74	Bos taurus	41%	79%
A8X6H4	Caenorhabditis briggsae	32%	96%
A8XJL7	Caenorhabditis briggsae	36%	72%
A8XJQ6	Caenorhabditis briggsae	47%	88%
A8XNJ6	Caenorhabditis briggsae	43%	73%
A8XW88	Caenorhabditis briggsae	52%	91%
B8BBT7	Oryza sativa subsp. indica	36%	67%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	84%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	81%
C9ZMH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	77%
C9ZN29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	70%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	74%
C9ZSI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZUK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZW46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	72%
C9ZW68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	97%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	79%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	77%
C9ZXP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	87%
C9ZYS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	87%
C9ZYT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	85%
C9ZZX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZZX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A2M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	72%
D0A2Z1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	69%
D0A2Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	69%
D0A5C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
D0A820	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D7UQM5	Patiria pectinifera	39%	84%
E9ACW6	Leishmania major	24%	100%
E9AEB9	Leishmania major	31%	68%
E9AET0	Leishmania major	29%	100%
E9AG71	Leishmania infantum	31%	75%
E9AGR7	Leishmania infantum	30%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	75%
E9ALA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ALG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	68%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	88%
E9ARK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9ARW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ASL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	70%
E9ASS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	67%
E9ASS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	68%
E9AUY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	92%
E9AX78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	97%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	87%
E9AZL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B0K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	67%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	77%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	79%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	76%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	69%
E9B6S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	89%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	92%
O00141	Homo sapiens	42%	79%
O01427	Caenorhabditis elegans	38%	100%
O08875	Rattus norvegicus	32%	79%
O13310	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	72%
O14965	Homo sapiens	39%	84%
O22932	Arabidopsis thaliana	35%	78%
O22971	Arabidopsis thaliana	38%	68%
O43930	Homo sapiens	51%	100%
O55099	Rattus norvegicus	37%	99%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	96%
O64629	Arabidopsis thaliana	37%	100%
O65554	Arabidopsis thaliana	36%	77%
O70126	Mus musculus	34%	99%
O70150	Rattus norvegicus	36%	99%
O74426	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O80902	Arabidopsis thaliana	36%	79%
O88445	Mus musculus	37%	100%
P00517	Bos taurus	53%	97%
P05131	Bos taurus	53%	97%
P05132	Mus musculus	53%	97%
P05383	Sus scrofa	54%	97%
P05986	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	85%
P06244	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	86%
P06245	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	89%
P12370	Drosophila melanogaster	54%	96%
P16911	Drosophila melanogaster	41%	96%
P17612	Homo sapiens	53%	97%
P21137	Caenorhabditis elegans	52%	84%
P21901	Aplysia californica	41%	97%
P22612	Homo sapiens	49%	97%
P22694	Homo sapiens	53%	97%
P25321	Cricetulus griseus	53%	97%
P25323	Dictyostelium discoideum	37%	100%
P27791	Rattus norvegicus	53%	97%
P28178	Dictyostelium discoideum	49%	71%
P31748	AKT8 murine leukemia virus	40%	68%
P31749	Homo sapiens	39%	71%
P31750	Mus musculus	39%	71%
P31751	Homo sapiens	40%	71%
P36887	Sus scrofa	53%	97%
P38991	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	93%
P40376	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	66%
P42818	Arabidopsis thaliana	41%	73%
P47196	Rattus norvegicus	39%	71%
P47197	Rattus norvegicus	39%	71%
P49673	Ascaris suum	49%	100%
P51817	Homo sapiens	49%	95%
P54644	Dictyostelium discoideum	46%	77%
P59241	Rattus norvegicus	38%	86%
P68180	Cricetulus griseus	54%	97%
P68181	Mus musculus	54%	97%
P68182	Rattus norvegicus	54%	97%
P92937	Arabidopsis thaliana	39%	81%
P92958	Arabidopsis thaliana	36%	66%
P97477	Mus musculus	38%	86%
Q01314	Bos taurus	39%	71%
Q02723	Secale cereale	33%	68%
Q06226	Rattus norvegicus	42%	79%
Q0JI49	Oryza sativa subsp. japonica	34%	68%
Q10LQ2	Oryza sativa subsp. japonica	36%	75%
Q10SC8	Oryza sativa subsp. japonica	35%	75%
Q12706	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	78%
Q14012	Homo sapiens	34%	92%
Q15208	Homo sapiens	36%	73%
Q27687	Leishmania major	58%	100%
Q2L6W9	Caenorhabditis elegans	36%	71%
Q2LZZ7	Drosophila pseudoobscura pseudoobscura	36%	74%
Q2PJ68	Caenorhabditis elegans	44%	73%
Q2QY53	Oryza sativa subsp. japonica	36%	78%
Q2QYM3	Oryza sativa subsp. japonica	34%	77%
Q2RAX3	Oryza sativa subsp. japonica	36%	75%
Q2RBF0	Oryza sativa subsp. japonica	35%	78%
Q2TA06	Bos taurus	39%	85%
Q2V452	Arabidopsis thaliana	36%	77%
Q38997	Arabidopsis thaliana	37%	66%
Q39030	Arabidopsis thaliana	40%	72%
Q4Q1S3	Leishmania major	27%	68%
Q4Q1S4	Leishmania major	29%	67%
Q4Q3Y9	Leishmania major	25%	76%
Q4Q5T9	Leishmania major	29%	79%
Q4Q5W2	Leishmania major	30%	77%
Q4Q7M5	Leishmania major	39%	67%
Q4Q9K2	Leishmania major	34%	88%
Q4QA98	Leishmania major	30%	97%
Q4QBR6	Leishmania major	31%	91%
Q4QCK0	Leishmania major	23%	100%
Q4QCR2	Leishmania major	26%	100%
Q4QDK6	Leishmania major	30%	100%
Q4QDX7	Leishmania major	35%	100%
Q4QF23	Leishmania major	31%	88%
Q4QIJ7	Leishmania major	35%	100%
Q4QIV8	Leishmania major	30%	75%
Q4QJJ0	Leishmania major	25%	100%
Q4R633	Macaca fascicularis	41%	79%
Q4V3C8	Arabidopsis thaliana	39%	70%
Q501V0	Danio rerio	36%	81%
Q54CY9	Dictyostelium discoideum	35%	100%
Q54L81	Dictyostelium discoideum	36%	74%
Q54UZ1	Dictyostelium discoideum	36%	83%
Q54WX4	Dictyostelium discoideum	37%	89%
Q5BKK4	Xenopus tropicalis	41%	81%
Q5JLD8	Oryza sativa subsp. japonica	35%	76%
Q5JLQ9	Oryza sativa subsp. japonica	34%	71%
Q5Q0U5	Fundulus heteroclitus	42%	79%
Q5QNM6	Oryza sativa subsp. japonica	38%	67%
Q5R7A7	Pongo abelii	43%	69%
Q5R8M1	Pongo abelii	36%	73%
Q5W736	Oryza sativa subsp. japonica	38%	74%
Q60823	Mus musculus	41%	71%
Q60EY8	Oryza sativa subsp. japonica	35%	73%
Q61XD3	Caenorhabditis briggsae	39%	100%
Q63450	Rattus norvegicus	34%	91%
Q63484	Rattus norvegicus	41%	71%
Q683C9	Arabidopsis thaliana	37%	100%
Q68Y49	Oryza sativa subsp. japonica	37%	67%
Q69Q47	Oryza sativa subsp. japonica	37%	75%
Q6A1A2	Homo sapiens	40%	86%
Q6BVA0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	36%	83%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	36%	92%
Q6CWQ4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	37%	94%
Q6DE08	Xenopus laevis	36%	94%
Q6ERS0	Oryza sativa subsp. japonica	37%	84%
Q6ERS4	Oryza sativa subsp. japonica	35%	75%
Q6FV07	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	37%	95%
Q6GLY8	Xenopus laevis	41%	78%
Q6GPL3	Xenopus laevis	36%	92%
Q6GPN6	Xenopus laevis	41%	78%
Q6H7U5	Oryza sativa subsp. japonica	34%	69%
Q6IP76	Xenopus laevis	42%	70%
Q6NW76	Danio rerio	36%	100%
Q6P2M8	Homo sapiens	36%	99%
Q6TGC6	Pneumocystis carinii	33%	67%
Q6U1I9	Gallus gallus	42%	79%
Q6X4A2	Oryza sativa subsp. japonica	36%	76%
Q6Z9F4	Oryza sativa subsp. japonica	36%	75%
Q6ZLP5	Oryza sativa subsp. japonica	36%	76%
Q755C4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	36%	93%
Q75L42	Oryza sativa subsp. japonica	34%	75%
Q7JP68	Caenorhabditis elegans	50%	85%
Q7TNJ7	Rattus norvegicus	32%	71%
Q7TSE6	Mus musculus	36%	73%
Q7X996	Oryza sativa subsp. japonica	34%	77%
Q7XIW5	Oryza sativa subsp. japonica	37%	77%
Q7YRC6	Bos taurus	36%	99%
Q7ZTW4	Danio rerio	42%	79%
Q7ZX15	Xenopus laevis	42%	70%
Q84VQ3	Arabidopsis thaliana	37%	77%
Q852Q0	Oryza sativa subsp. japonica	37%	67%
Q852Q1	Oryza sativa subsp. japonica	36%	67%
Q852Q2	Oryza sativa subsp. japonica	37%	67%
Q86UX6	Homo sapiens	34%	70%
Q8BGW6	Mus musculus	35%	85%
Q8BW96	Mus musculus	34%	88%
Q8IU85	Homo sapiens	34%	88%
Q8LIG4	Oryza sativa subsp. japonica	36%	76%
Q8MJ44	Canis lupus familiaris	53%	97%
Q8MYF1	Dictyostelium discoideum	41%	75%
Q8QZV4	Mus musculus	34%	70%
Q8R4U9	Rattus norvegicus	43%	93%
Q8R4V0	Rattus norvegicus	43%	69%
Q8RWC9	Arabidopsis thaliana	34%	77%
Q8SRK8	Encephalitozoon cuniculi (strain GB-M1)	37%	100%
Q8SRL5	Encephalitozoon cuniculi (strain GB-M1)	33%	100%
Q8W1D5	Arabidopsis thaliana	35%	70%
Q8WU08	Homo sapiens	35%	86%
Q91819	Xenopus laevis	39%	83%
Q91820	Xenopus laevis	39%	84%
Q91VB2	Mus musculus	32%	71%
Q91VJ4	Mus musculus	36%	73%
Q91YS8	Mus musculus	34%	91%
Q922R0	Mus musculus	49%	96%
Q93VD3	Arabidopsis thaliana	38%	71%
Q94C40	Arabidopsis thaliana	32%	79%
Q94CG0	Arabidopsis thaliana	36%	82%
Q96BR1	Homo sapiens	43%	69%
Q96GD4	Homo sapiens	36%	99%
Q96NX5	Homo sapiens	32%	71%
Q96QS6	Homo sapiens	35%	88%
Q98TY9	Xenopus laevis	41%	71%
Q9C562	Arabidopsis thaliana	34%	71%
Q9ERE3	Mus musculus	42%	69%
Q9FJ54	Arabidopsis thaliana	36%	77%
Q9FJ55	Arabidopsis thaliana	37%	70%
Q9FLZ3	Arabidopsis thaliana	35%	69%
Q9GNR4	Leishmania major	96%	92%
Q9HBY8	Homo sapiens	45%	93%
Q9JJX8	Mus musculus	34%	82%
Q9LDI3	Arabidopsis thaliana	34%	76%
Q9LEU7	Arabidopsis thaliana	37%	76%
Q9LGV5	Oryza sativa subsp. japonica	35%	74%
Q9LWM4	Oryza sativa subsp. japonica	34%	74%
Q9LYQ8	Arabidopsis thaliana	35%	75%
Q9M077	Arabidopsis thaliana	37%	100%
Q9MAM1	Arabidopsis thaliana	35%	76%
Q9MZD9	Ovis aries	53%	97%
Q9N0X0	Sus scrofa	36%	99%
Q9N2N1	Leishmania major	32%	100%
Q9NBK5	Drosophila melanogaster	35%	73%
Q9NY57	Homo sapiens	34%	82%
Q9QYK9	Mus musculus	36%	99%
Q9QZS5	Mus musculus	43%	93%
Q9SEZ7	Arabidopsis thaliana	33%	72%
Q9SN43	Arabidopsis thaliana	39%	70%
Q9STV4	Arabidopsis thaliana	36%	76%
Q9SUL7	Arabidopsis thaliana	35%	80%
Q9TXJ0	Caenorhabditis elegans	33%	98%
Q9UBS0	Homo sapiens	42%	71%
Q9UQB9	Homo sapiens	35%	100%
Q9VKN7	Drosophila melanogaster	36%	100%
Q9WUA6	Mus musculus	42%	71%
Q9WVC6	Mus musculus	42%	79%
Q9XF67	Arabidopsis thaliana	38%	69%
Q9XIW0	Arabidopsis thaliana	33%	79%
Q9XT18	Oryctolagus cuniculus	42%	79%
Q9Y243	Homo sapiens	42%	71%
Q9Y2H1	Homo sapiens	36%	73%
Q9Z1M4	Mus musculus	42%	70%
V5B871	Trypanosoma cruzi	32%	79%
V5B9R6	Trypanosoma cruzi	31%	97%
V5BAZ8	Trypanosoma cruzi	29%	89%
V5BC28	Trypanosoma cruzi	29%	68%
V5BC61	Trypanosoma cruzi	35%	100%
V5BCH2	Trypanosoma cruzi	34%	87%
V5BEK5	Trypanosoma cruzi	58%	100%
V5BG98	Trypanosoma cruzi	33%	100%
V5BI43	Trypanosoma cruzi	31%	68%
V5BNV8	Trypanosoma cruzi	33%	100%
V5BPJ0	Trypanosoma cruzi	28%	69%
V5BQH6	Trypanosoma cruzi	31%	78%
V5BR65	Trypanosoma cruzi	25%	85%
V5BWC2	Trypanosoma cruzi	34%	100%
V5C224	Trypanosoma cruzi	27%	68%
V5D579	Trypanosoma cruzi	30%	79%
V5DI55	Trypanosoma cruzi	29%	82%
V5DMJ4	Trypanosoma cruzi	28%	100%
V5DPP5	Trypanosoma cruzi	32%	79%
V5DQT5	Trypanosoma cruzi	44%	74%
W0LYS5	Macrobrachium nipponense	35%	99%