Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Chromosome passenger complex (CPC) protein INCENP N terminal, putative

Species:

Leishmania major

UniProt:

E9AFL9_LEIMA

TriTrypDb:

LmjF.35.3940 , LMJLV39_350047200 , LMJSD75_350046500

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFL9

PDB structure(s): 7ane_o

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	528	532	PF00656	0.410
CLV_NRD_NRD_1	129	131	PF00675	0.515
CLV_NRD_NRD_1	20	22	PF00675	0.435
CLV_NRD_NRD_1	201	203	PF00675	0.385
CLV_NRD_NRD_1	235	237	PF00675	0.410
CLV_NRD_NRD_1	3	5	PF00675	0.501
CLV_NRD_NRD_1	300	302	PF00675	0.317
CLV_NRD_NRD_1	338	340	PF00675	0.312
CLV_NRD_NRD_1	370	372	PF00675	0.396
CLV_NRD_NRD_1	406	408	PF00675	0.383
CLV_NRD_NRD_1	471	473	PF00675	0.363
CLV_NRD_NRD_1	534	536	PF00675	0.408
CLV_NRD_NRD_1	538	540	PF00675	0.358
CLV_NRD_NRD_1	570	572	PF00675	0.413
CLV_NRD_NRD_1	88	90	PF00675	0.378
CLV_NRD_NRD_1	9	11	PF00675	0.462
CLV_PCSK_KEX2_1	131	133	PF00082	0.441
CLV_PCSK_KEX2_1	15	17	PF00082	0.423
CLV_PCSK_KEX2_1	235	237	PF00082	0.427
CLV_PCSK_KEX2_1	253	255	PF00082	0.385
CLV_PCSK_KEX2_1	3	5	PF00082	0.501
CLV_PCSK_KEX2_1	325	327	PF00082	0.317
CLV_PCSK_KEX2_1	370	372	PF00082	0.396
CLV_PCSK_KEX2_1	406	408	PF00082	0.383
CLV_PCSK_KEX2_1	469	471	PF00082	0.366
CLV_PCSK_KEX2_1	538	540	PF00082	0.374
CLV_PCSK_KEX2_1	570	572	PF00082	0.413
CLV_PCSK_KEX2_1	88	90	PF00082	0.378
CLV_PCSK_KEX2_1	9	11	PF00082	0.462
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.441
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.428
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.385
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.317
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.366
CLV_PCSK_PC7_1	566	572	PF00082	0.397
CLV_PCSK_SKI1_1	132	136	PF00082	0.557
CLV_PCSK_SKI1_1	205	209	PF00082	0.362
CLV_PCSK_SKI1_1	288	292	PF00082	0.411
CLV_PCSK_SKI1_1	301	305	PF00082	0.258
CLV_PCSK_SKI1_1	325	329	PF00082	0.313
CLV_PCSK_SKI1_1	361	365	PF00082	0.378
CLV_PCSK_SKI1_1	4	8	PF00082	0.554
CLV_PCSK_SKI1_1	406	410	PF00082	0.385
CLV_PCSK_SKI1_1	483	487	PF00082	0.341
CLV_PCSK_SKI1_1	543	547	PF00082	0.376
DEG_APCC_DBOX_1	204	212	PF00400	0.357
DEG_MDM2_SWIB_1	180	188	PF02201	0.322
DEG_MDM2_SWIB_1	328	336	PF02201	0.316
DEG_Nend_Nbox_1	1	3	PF02207	0.523
DEG_SCF_FBW7_2	513	520	PF00400	0.387
DOC_CKS1_1	243	248	PF01111	0.389
DOC_CKS1_1	527	532	PF01111	0.441
DOC_CYCLIN_RxL_1	155	167	PF00134	0.390
DOC_CYCLIN_RxL_1	199	212	PF00134	0.365
DOC_CYCLIN_RxL_1	322	331	PF00134	0.322
DOC_CYCLIN_RxL_1	455	466	PF00134	0.388
DOC_MAPK_gen_1	155	163	PF00069	0.356
DOC_MAPK_gen_1	202	210	PF00069	0.365
DOC_MAPK_gen_1	288	297	PF00069	0.358
DOC_MAPK_MEF2A_6	202	210	PF00069	0.365
DOC_PP1_RVXF_1	157	164	PF00149	0.351
DOC_PP1_RVXF_1	233	240	PF00149	0.400
DOC_PP1_RVXF_1	300	307	PF00149	0.312
DOC_PP1_RVXF_1	32	39	PF00149	0.445
DOC_PP1_RVXF_1	345	351	PF00149	0.393
DOC_PP1_RVXF_1	352	358	PF00149	0.344
DOC_PP1_RVXF_1	541	548	PF00149	0.378
DOC_PP1_RVXF_1	572	579	PF00149	0.391
DOC_PP4_FxxP_1	504	507	PF00568	0.336
DOC_PP4_FxxP_1	54	57	PF00568	0.393
DOC_SPAK_OSR1_1	472	476	PF12202	0.364
DOC_USP7_MATH_1	437	441	PF00917	0.402
DOC_USP7_MATH_1	478	482	PF00917	0.375
DOC_USP7_MATH_1	485	489	PF00917	0.335
DOC_USP7_MATH_2	18	24	PF00917	0.445
DOC_USP7_UBL2_3	151	155	PF12436	0.398
DOC_USP7_UBL2_3	42	46	PF12436	0.424
DOC_WW_Pin1_4	242	247	PF00397	0.473
DOC_WW_Pin1_4	513	518	PF00397	0.381
DOC_WW_Pin1_4	526	531	PF00397	0.411
LIG_14-3-3_CanoR_1	132	137	PF00244	0.452
LIG_14-3-3_CanoR_1	157	162	PF00244	0.374
LIG_14-3-3_CanoR_1	21	25	PF00244	0.382
LIG_14-3-3_CanoR_1	3	11	PF00244	0.539
LIG_14-3-3_CanoR_1	386	394	PF00244	0.356
LIG_14-3-3_CanoR_1	570	578	PF00244	0.409
LIG_APCC_ABBA_1	75	80	PF00400	0.357
LIG_BRCT_BRCA1_1	358	362	PF00533	0.379
LIG_BRCT_BRCA1_1	555	559	PF00533	0.402
LIG_BRCT_BRCA1_1	594	598	PF00533	0.449
LIG_Clathr_ClatBox_1	216	220	PF01394	0.426
LIG_Clathr_ClatBox_1	327	331	PF01394	0.325
LIG_deltaCOP1_diTrp_1	156	163	PF00928	0.354
LIG_deltaCOP1_diTrp_1	318	328	PF00928	0.328
LIG_deltaCOP1_diTrp_1	37	44	PF00928	0.551
LIG_deltaCOP1_diTrp_1	441	446	PF00928	0.420
LIG_deltaCOP1_diTrp_1	497	505	PF00928	0.333
LIG_deltaCOP1_diTrp_1	91	99	PF00928	0.337
LIG_EH_1	96	100	PF12763	0.298
LIG_eIF4E_1	358	364	PF01652	0.378
LIG_FHA_1	43	49	PF00498	0.383
LIG_FHA_2	117	123	PF00498	0.416
LIG_FHA_2	171	177	PF00498	0.324
LIG_FHA_2	210	216	PF00498	0.488
LIG_FHA_2	388	394	PF00498	0.355
LIG_FHA_2	570	576	PF00498	0.391
LIG_LIR_Apic_2	318	324	PF02991	0.346
LIG_LIR_Apic_2	37	41	PF02991	0.513
LIG_LIR_Apic_2	501	507	PF02991	0.322
LIG_LIR_Apic_2	53	57	PF02991	0.311
LIG_LIR_Apic_2	87	93	PF02991	0.372
LIG_LIR_Gen_1	175	185	PF02991	0.343
LIG_LIR_Gen_1	296	305	PF02991	0.323
LIG_LIR_Gen_1	372	381	PF02991	0.405
LIG_LIR_Gen_1	497	507	PF02991	0.333
LIG_LIR_Nem_3	156	161	PF02991	0.365
LIG_LIR_Nem_3	173	177	PF02991	0.446
LIG_LIR_Nem_3	183	188	PF02991	0.371
LIG_LIR_Nem_3	296	300	PF02991	0.335
LIG_LIR_Nem_3	372	378	PF02991	0.401
LIG_LIR_Nem_3	382	388	PF02991	0.370
LIG_LIR_Nem_3	391	397	PF02991	0.330
LIG_LIR_Nem_3	400	405	PF02991	0.339
LIG_LIR_Nem_3	497	502	PF02991	0.336
LIG_LIR_Nem_3	556	562	PF02991	0.347
LIG_LIR_Nem_3	575	581	PF02991	0.410
LIG_LIR_Nem_3	595	601	PF02991	0.312
LIG_PALB2_WD40_1	180	188	PF16756	0.322
LIG_Pex14_1	398	402	PF04695	0.329
LIG_Pex14_1	95	99	PF04695	0.313
LIG_Pex14_2	180	184	PF04695	0.309
LIG_Pex14_2	328	332	PF04695	0.328
LIG_PTB_Apo_2	179	186	PF02174	0.317
LIG_SH2_CRK	345	349	PF00017	0.498
LIG_SH2_CRK	385	389	PF00017	0.358
LIG_SH2_GRB2like	375	378	PF00017	0.411
LIG_SH2_SRC	375	378	PF00017	0.411
LIG_SH2_SRC	522	525	PF00017	0.402
LIG_SH2_SRC	90	93	PF00017	0.392
LIG_SH2_STAP1	313	317	PF00017	0.396
LIG_SH2_STAP1	358	362	PF00017	0.379
LIG_SH2_STAP1	375	379	PF00017	0.414
LIG_SH2_STAP1	394	398	PF00017	0.442
LIG_SH2_STAP1	549	553	PF00017	0.369
LIG_SH2_STAT3	534	537	PF00017	0.509
LIG_SH2_STAT5	103	106	PF00017	0.333
LIG_SH2_STAT5	177	180	PF00017	0.336
LIG_SH2_STAT5	596	599	PF00017	0.422
LIG_SH3_3	29	35	PF00018	0.452
LIG_SH3_3	524	530	PF00018	0.442
LIG_SH3_3	573	579	PF00018	0.407
LIG_SH3_5	530	534	PF00018	0.498
LIG_SUMO_SIM_anti_2	109	114	PF11976	0.383
LIG_SUMO_SIM_anti_2	212	218	PF11976	0.347
LIG_SUMO_SIM_par_1	106	111	PF11976	0.356
LIG_SUMO_SIM_par_1	206	212	PF11976	0.353
LIG_TYR_ITIM	343	348	PF00017	0.488
LIG_UBA3_1	149	155	PF00899	0.401
LIG_UBA3_1	273	279	PF00899	0.357
LIG_UBA3_1	408	415	PF00899	0.473
LIG_WRC_WIRS_1	51	56	PF05994	0.390
MOD_CK1_1	242	248	PF00069	0.396
MOD_CK1_1	481	487	PF00069	0.434
MOD_CK1_1	551	557	PF00069	0.349
MOD_CK1_1	591	597	PF00069	0.449
MOD_CK2_1	116	122	PF00069	0.401
MOD_CK2_1	184	190	PF00069	0.367
MOD_CK2_1	569	575	PF00069	0.387
MOD_CMANNOS	59	62	PF00535	0.370
MOD_Cter_Amidation	128	131	PF01082	0.489
MOD_GlcNHglycan	4	7	PF01048	0.426
MOD_GlcNHglycan	415	418	PF01048	0.402
MOD_GlcNHglycan	483	486	PF01048	0.333
MOD_GlcNHglycan	555	558	PF01048	0.405
MOD_GSK3_1	132	139	PF00069	0.565
MOD_GSK3_1	238	245	PF00069	0.392
MOD_GSK3_1	42	49	PF00069	0.411
MOD_GSK3_1	481	488	PF00069	0.346
MOD_GSK3_1	551	558	PF00069	0.340
MOD_GSK3_1	588	595	PF00069	0.445
MOD_N-GLC_1	437	442	PF02516	0.403
MOD_N-GLC_1	63	68	PF02516	0.441
MOD_NEK2_1	2	7	PF00069	0.557
MOD_NEK2_1	239	244	PF00069	0.393
MOD_NEK2_1	249	254	PF00069	0.377
MOD_NEK2_1	295	300	PF00069	0.334
MOD_NEK2_1	548	553	PF00069	0.372
MOD_NEK2_1	63	68	PF00069	0.479
MOD_NEK2_2	478	483	PF00069	0.366
MOD_PIKK_1	220	226	PF00454	0.433
MOD_PIKK_1	421	427	PF00454	0.531
MOD_PIKK_1	46	52	PF00454	0.618
MOD_PIKK_1	569	575	PF00454	0.532
MOD_PIKK_1	65	71	PF00454	0.368
MOD_PKA_2	2	8	PF00069	0.552
MOD_PKA_2	20	26	PF00069	0.382
MOD_PKA_2	569	575	PF00069	0.387
MOD_PKB_1	130	138	PF00069	0.577
MOD_Plk_1	295	301	PF00069	0.331
MOD_Plk_1	319	325	PF00069	0.322
MOD_Plk_1	371	377	PF00069	0.397
MOD_Plk_1	46	52	PF00069	0.418
MOD_Plk_4	592	598	PF00069	0.517
MOD_ProDKin_1	242	248	PF00069	0.475
MOD_ProDKin_1	513	519	PF00069	0.386
MOD_ProDKin_1	526	532	PF00069	0.410
MOD_SUMO_rev_2	198	204	PF00179	0.473
MOD_SUMO_rev_2	258	265	PF00179	0.425
MOD_SUMO_rev_2	37	43	PF00179	0.526
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.360
TRG_ENDOCYTIC_2	177	180	PF00928	0.305
TRG_ENDOCYTIC_2	345	348	PF00928	0.346
TRG_ENDOCYTIC_2	375	378	PF00928	0.411
TRG_ENDOCYTIC_2	385	388	PF00928	0.349
TRG_ENDOCYTIC_2	405	408	PF00928	0.360
TRG_ENDOCYTIC_2	423	426	PF00928	0.510
TRG_ER_diArg_1	127	130	PF00400	0.472
TRG_ER_diArg_1	2	4	PF00400	0.509
TRG_ER_diArg_1	235	237	PF00400	0.452
TRG_ER_diArg_1	254	257	PF00400	0.414
TRG_ER_diArg_1	336	339	PF00400	0.302
TRG_ER_diArg_1	405	407	PF00400	0.363
TRG_ER_diArg_1	470	472	PF00400	0.370
TRG_ER_diArg_1	538	540	PF00400	0.374
TRG_ER_diArg_1	88	90	PF00400	0.373
TRG_ER_diArg_1	9	11	PF00400	0.462
TRG_NLS_Bipartite_1	235	257	PF00514	0.398
TRG_NLS_MonoExtC_3	252	258	PF00514	0.419
TRG_NLS_MonoExtC_3	534	539	PF00514	0.408
TRG_NLS_MonoExtN_4	128	134	PF00514	0.432
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	386	391	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3J0	Leptomonas seymouri	96%	100%
A0A0S4IZR5	Bodo saltans	83%	97%
A0A1X0P5F3	Trypanosomatidae	88%	100%
A0A3S5H804	Leishmania donovani	100%	100%
A0A422N423	Trypanosoma rangeli	89%	100%
A4HN65	Leishmania braziliensis	99%	100%
A4IBT2	Leishmania infantum	99%	100%
C9ZYT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	86%	100%
E9B6S2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5DUK9	Trypanosoma cruzi	88%	100%