UNC93-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

UNC93-like protein

Gene product:

unc-50 related protein homolog

Species:

Leishmania major

UniProt:

E9AFL8_LEIMA

TriTrypDb:

LmjF.35.3930 , LMJLV39_350047100 , LMJSD75_350046400

Length:

256

Annotations

LeishMANIAdb annotations

Related to animal UNC50 proteins. Localization: Inner nuclear membrane (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AFL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	21	23	PF00675	0.265
CLV_NRD_NRD_1	54	56	PF00675	0.265
CLV_PCSK_KEX2_1	21	23	PF00082	0.279
CLV_PCSK_KEX2_1	91	93	PF00082	0.504
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.392
CLV_PCSK_SKI1_1	159	163	PF00082	0.340
CLV_PCSK_SKI1_1	55	59	PF00082	0.252
CLV_PCSK_SKI1_1	92	96	PF00082	0.504
DEG_APCC_DBOX_1	91	99	PF00400	0.337
DEG_Nend_Nbox_1	1	3	PF02207	0.701
DOC_CDC14_PxL_1	212	220	PF14671	0.295
DOC_CYCLIN_RxL_1	89	97	PF00134	0.304
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.355
DOC_MAPK_MEF2A_6	223	231	PF00069	0.392
DOC_MAPK_RevD_3	77	92	PF00069	0.370
DOC_PP2B_LxvP_1	213	216	PF13499	0.446
DOC_PP4_FxxP_1	182	185	PF00568	0.454
DOC_USP7_MATH_1	185	189	PF00917	0.454
DOC_WW_Pin1_4	122	127	PF00397	0.559
LIG_14-3-3_CanoR_1	11	19	PF00244	0.584
LIG_deltaCOP1_diTrp_1	155	162	PF00928	0.457
LIG_EH1_1	68	76	PF00400	0.427
LIG_eIF4E_1	181	187	PF01652	0.220
LIG_FHA_1	101	107	PF00498	0.385
LIG_FHA_1	11	17	PF00498	0.663
LIG_FHA_1	200	206	PF00498	0.410
LIG_FHA_1	246	252	PF00498	0.396
LIG_GBD_Chelix_1	82	90	PF00786	0.468
LIG_LIR_Apic_2	150	154	PF02991	0.556
LIG_LIR_Apic_2	179	185	PF02991	0.220
LIG_LIR_Gen_1	203	213	PF02991	0.423
LIG_LIR_Gen_1	66	77	PF02991	0.454
LIG_LIR_Gen_1	97	107	PF02991	0.299
LIG_LIR_Nem_3	103	107	PF02991	0.339
LIG_LIR_Nem_3	114	119	PF02991	0.254
LIG_LIR_Nem_3	203	209	PF02991	0.395
LIG_LIR_Nem_3	66	72	PF02991	0.454
LIG_LIR_Nem_3	97	102	PF02991	0.302
LIG_LYPXL_L_2	225	234	PF13949	0.454
LIG_LYPXL_S_1	225	229	PF13949	0.392
LIG_LYPXL_yS_3	226	229	PF13949	0.392
LIG_NRBOX	233	239	PF00104	0.429
LIG_Pex14_1	158	162	PF04695	0.454
LIG_SH2_SRC	151	154	PF00017	0.504
LIG_SH2_SRC	204	207	PF00017	0.350
LIG_SH2_SRC	212	215	PF00017	0.328
LIG_SH2_STAP1	160	164	PF00017	0.465
LIG_SH2_STAP1	206	210	PF00017	0.372
LIG_SH2_STAP1	39	43	PF00017	0.479
LIG_SH2_STAT5	105	108	PF00017	0.321
LIG_SH2_STAT5	123	126	PF00017	0.399
LIG_SH2_STAT5	151	154	PF00017	0.514
LIG_SH2_STAT5	169	172	PF00017	0.166
LIG_SH2_STAT5	181	184	PF00017	0.296
LIG_SH2_STAT5	204	207	PF00017	0.324
LIG_SH2_STAT5	212	215	PF00017	0.314
LIG_SUMO_SIM_par_1	236	242	PF11976	0.354
LIG_SUMO_SIM_par_1	76	81	PF11976	0.465
LIG_TRFH_1	181	185	PF08558	0.341
LIG_TYR_ITIM	210	215	PF00017	0.345
LIG_TYR_ITIM	224	229	PF00017	0.322
LIG_UBA3_1	86	91	PF00899	0.220
LIG_WRC_WIRS_1	169	174	PF05994	0.454
MOD_CDK_SPxxK_3	122	129	PF00069	0.504
MOD_CK1_1	10	16	PF00069	0.577
MOD_CK1_1	125	131	PF00069	0.559
MOD_CK1_1	190	196	PF00069	0.276
MOD_CK1_1	3	9	PF00069	0.649
MOD_CK1_1	33	39	PF00069	0.465
MOD_CK1_1	46	52	PF00069	0.457
MOD_GlcNHglycan	107	110	PF01048	0.410
MOD_GlcNHglycan	132	135	PF01048	0.297
MOD_GlcNHglycan	140	143	PF01048	0.290
MOD_GlcNHglycan	146	149	PF01048	0.276
MOD_GlcNHglycan	32	35	PF01048	0.265
MOD_GSK3_1	124	131	PF00069	0.538
MOD_GSK3_1	134	141	PF00069	0.528
MOD_GSK3_1	200	207	PF00069	0.434
MOD_GSK3_1	3	10	PF00069	0.603
MOD_GSK3_1	33	40	PF00069	0.465
MOD_GSK3_1	90	97	PF00069	0.351
MOD_NEK2_1	187	192	PF00069	0.308
MOD_NEK2_1	236	241	PF00069	0.324
MOD_NEK2_1	7	12	PF00069	0.606
MOD_NEK2_1	90	95	PF00069	0.325
MOD_NEK2_2	168	173	PF00069	0.454
MOD_NEK2_2	204	209	PF00069	0.429
MOD_PIKK_1	128	134	PF00454	0.537
MOD_PIKK_1	33	39	PF00454	0.465
MOD_PKA_1	55	61	PF00069	0.465
MOD_PKA_2	10	16	PF00069	0.640
MOD_PKB_1	53	61	PF00069	0.515
MOD_Plk_1	176	182	PF00069	0.413
MOD_Plk_4	111	117	PF00069	0.212
MOD_Plk_4	187	193	PF00069	0.264
MOD_Plk_4	200	206	PF00069	0.364
MOD_Plk_4	245	251	PF00069	0.351
MOD_Plk_4	3	9	PF00069	0.705
MOD_Plk_4	43	49	PF00069	0.462
MOD_Plk_4	94	100	PF00069	0.266
MOD_ProDKin_1	122	128	PF00069	0.559
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.540
TRG_ENDOCYTIC_2	169	172	PF00928	0.453
TRG_ENDOCYTIC_2	206	209	PF00928	0.313
TRG_ENDOCYTIC_2	212	215	PF00928	0.315
TRG_ENDOCYTIC_2	226	229	PF00928	0.123

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ03	Leptomonas seymouri	55%	98%
A0A0S4J1Y7	Bodo saltans	38%	100%
A0A1X0P684	Trypanosomatidae	46%	100%
A0A3S7X9U7	Leishmania donovani	95%	100%
A0A422N434	Trypanosoma rangeli	47%	100%
A4HN64	Leishmania braziliensis	87%	100%
A4IBT1	Leishmania infantum	95%	100%
C9ZYT7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B6S1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P36125	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	94%
P87155	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q10045	Caenorhabditis elegans	29%	85%
Q53HI1	Homo sapiens	28%	99%
Q54DD7	Dictyostelium discoideum	32%	98%
Q5U520	Xenopus laevis	29%	99%
Q6DKM1	Xenopus laevis	28%	99%
Q7ZUU1	Danio rerio	29%	99%
Q9VHN5	Drosophila melanogaster	30%	93%
V5BXY5	Trypanosoma cruzi	46%	100%