Sperm-tail_PG-rich_repeat

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFL7_LEIMA

TriTrypDb:

LmjF.35.3925 , LMJLV39_350047000 , LMJSD75_350046300

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFL7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.603
CLV_NRD_NRD_1	111	113	PF00675	0.335
CLV_NRD_NRD_1	150	152	PF00675	0.337
CLV_NRD_NRD_1	163	165	PF00675	0.619
CLV_NRD_NRD_1	267	269	PF00675	0.577
CLV_NRD_NRD_1	304	306	PF00675	0.320
CLV_NRD_NRD_1	307	309	PF00675	0.308
CLV_NRD_NRD_1	353	355	PF00675	0.608
CLV_NRD_NRD_1	425	427	PF00675	0.708
CLV_PCSK_FUR_1	305	309	PF00082	0.356
CLV_PCSK_KEX2_1	150	152	PF00082	0.337
CLV_PCSK_KEX2_1	267	269	PF00082	0.575
CLV_PCSK_KEX2_1	304	306	PF00082	0.356
CLV_PCSK_KEX2_1	307	309	PF00082	0.320
CLV_PCSK_KEX2_1	31	33	PF00082	0.364
CLV_PCSK_KEX2_1	352	354	PF00082	0.604
CLV_PCSK_KEX2_1	425	427	PF00082	0.737
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.364
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.702
CLV_PCSK_PC7_1	348	354	PF00082	0.651
DEG_Nend_UBRbox_2	1	3	PF02207	0.712
DEG_SCF_TRCP1_1	129	135	PF00400	0.611
DEG_SPOP_SBC_1	273	277	PF00917	0.569
DOC_CDC14_PxL_1	1	9	PF14671	0.680
DOC_PP1_RVXF_1	432	439	PF00149	0.669
DOC_PP2B_LxvP_1	67	70	PF13499	0.500
DOC_PP4_FxxP_1	120	123	PF00568	0.537
DOC_PP4_FxxP_1	312	315	PF00568	0.737
DOC_PP4_FxxP_1	58	61	PF00568	0.373
DOC_USP7_MATH_1	123	127	PF00917	0.609
DOC_USP7_MATH_1	238	242	PF00917	0.556
DOC_USP7_MATH_1	273	277	PF00917	0.668
DOC_USP7_MATH_1	279	283	PF00917	0.617
DOC_USP7_MATH_1	317	321	PF00917	0.543
DOC_USP7_MATH_1	41	45	PF00917	0.476
DOC_USP7_MATH_1	68	72	PF00917	0.473
DOC_USP7_MATH_1	81	85	PF00917	0.570
DOC_USP7_MATH_2	232	238	PF00917	0.688
DOC_WW_Pin1_4	210	215	PF00397	0.601
DOC_WW_Pin1_4	292	297	PF00397	0.659
DOC_WW_Pin1_4	323	328	PF00397	0.561
DOC_WW_Pin1_4	94	99	PF00397	0.574
LIG_14-3-3_CanoR_1	116	121	PF00244	0.482
LIG_14-3-3_CanoR_1	274	281	PF00244	0.613
LIG_14-3-3_CanoR_1	332	337	PF00244	0.568
LIG_14-3-3_CanoR_1	437	444	PF00244	0.623
LIG_BIR_III_4	253	257	PF00653	0.601
LIG_BRCT_BRCA1_1	116	120	PF00533	0.556
LIG_BRCT_BRCA1_1	192	196	PF00533	0.583
LIG_BRCT_BRCA1_1	242	246	PF00533	0.638
LIG_BRCT_BRCA1_1	276	280	PF00533	0.616
LIG_BRCT_BRCA1_1	71	75	PF00533	0.500
LIG_BRCT_BRCA1_1	78	82	PF00533	0.429
LIG_BRCT_BRCA1_1	85	89	PF00533	0.653
LIG_FHA_1	216	222	PF00498	0.523
LIG_FHA_1	259	265	PF00498	0.560
LIG_FHA_1	403	409	PF00498	0.737
LIG_FHA_1	470	476	PF00498	0.624
LIG_Integrin_isoDGR_2	346	348	PF01839	0.564
LIG_LIR_Apic_2	117	123	PF02991	0.537
LIG_LIR_Apic_2	311	315	PF02991	0.737
LIG_LIR_Apic_2	378	384	PF02991	0.550
LIG_LIR_Apic_2	55	61	PF02991	0.629
LIG_LIR_Gen_1	282	292	PF02991	0.645
LIG_LIR_Gen_1	435	444	PF02991	0.658
LIG_LIR_Nem_3	157	161	PF02991	0.600
LIG_LIR_Nem_3	177	181	PF02991	0.566
LIG_LIR_Nem_3	234	239	PF02991	0.618
LIG_LIR_Nem_3	282	287	PF02991	0.639
LIG_LIR_Nem_3	413	417	PF02991	0.746
LIG_LIR_Nem_3	435	441	PF02991	0.663
LIG_MLH1_MIPbox_1	243	247	PF16413	0.574
LIG_MYND_1	180	184	PF01753	0.609
LIG_Pex14_2	325	329	PF04695	0.673
LIG_PTB_Apo_2	139	146	PF02174	0.512
LIG_PTB_Phospho_1	139	145	PF10480	0.512
LIG_REV1ctd_RIR_1	244	254	PF16727	0.578
LIG_SH2_CRK	178	182	PF00017	0.591
LIG_SH2_CRK	64	68	PF00017	0.512
LIG_SH2_NCK_1	145	149	PF00017	0.537
LIG_SH2_SRC	219	222	PF00017	0.648
LIG_SH2_STAP1	124	128	PF00017	0.696
LIG_SH2_STAP1	377	381	PF00017	0.574
LIG_SH2_STAT5	118	121	PF00017	0.500
LIG_SH2_STAT5	235	238	PF00017	0.665
LIG_SH2_STAT5	260	263	PF00017	0.564
LIG_SH3_1	354	360	PF00018	0.619
LIG_SH3_2	357	362	PF14604	0.484
LIG_SH3_3	167	173	PF00018	0.613
LIG_SH3_3	354	360	PF00018	0.579
LIG_SH3_3	405	411	PF00018	0.660
MOD_CK1_1	241	247	PF00069	0.671
MOD_CK1_1	84	90	PF00069	0.574
MOD_CK2_1	410	416	PF00069	0.688
MOD_Cter_Amidation	162	165	PF01082	0.632
MOD_GlcNHglycan	120	123	PF01048	0.337
MOD_GlcNHglycan	125	128	PF01048	0.653
MOD_GlcNHglycan	129	132	PF01048	0.363
MOD_GlcNHglycan	161	164	PF01048	0.495
MOD_GlcNHglycan	236	239	PF01048	0.560
MOD_GlcNHglycan	276	279	PF01048	0.563
MOD_GlcNHglycan	281	284	PF01048	0.525
MOD_GlcNHglycan	340	343	PF01048	0.674
MOD_GlcNHglycan	366	369	PF01048	0.667
MOD_GlcNHglycan	444	447	PF01048	0.609
MOD_GlcNHglycan	52	55	PF01048	0.712
MOD_GSK3_1	114	121	PF00069	0.537
MOD_GSK3_1	123	130	PF00069	0.359
MOD_GSK3_1	14	21	PF00069	0.590
MOD_GSK3_1	191	198	PF00069	0.550
MOD_GSK3_1	234	241	PF00069	0.623
MOD_GSK3_1	323	330	PF00069	0.570
MOD_GSK3_1	385	392	PF00069	0.604
MOD_GSK3_1	417	424	PF00069	0.596
MOD_GSK3_1	460	467	PF00069	0.535
MOD_GSK3_1	99	106	PF00069	0.541
MOD_N-GLC_1	200	205	PF02516	0.614
MOD_N-GLC_1	35	40	PF02516	0.305
MOD_N-GLC_1	390	395	PF02516	0.723
MOD_N-GLC_1	42	47	PF02516	0.463
MOD_N-GLC_1	464	469	PF02516	0.535
MOD_N-GLC_1	94	99	PF02516	0.574
MOD_NEK2_1	132	137	PF00069	0.592
MOD_NEK2_1	239	244	PF00069	0.532
MOD_NEK2_1	318	323	PF00069	0.629
MOD_NEK2_1	402	407	PF00069	0.646
MOD_NEK2_1	417	422	PF00069	0.616
MOD_NEK2_1	42	47	PF00069	0.634
MOD_NEK2_1	460	465	PF00069	0.543
MOD_PIKK_1	327	333	PF00454	0.696
MOD_PIKK_1	69	75	PF00454	0.424
MOD_PIKK_1	76	82	PF00454	0.524
MOD_PK_1	191	197	PF00069	0.592
MOD_PKA_2	14	20	PF00069	0.713
MOD_PKA_2	273	279	PF00069	0.627
MOD_PKA_2	436	442	PF00069	0.651
MOD_Plk_1	200	206	PF00069	0.616
MOD_Plk_1	373	379	PF00069	0.696
MOD_Plk_1	390	396	PF00069	0.616
MOD_Plk_1	42	48	PF00069	0.710
MOD_Plk_1	464	470	PF00069	0.534
MOD_Plk_1	84	90	PF00069	0.574
MOD_Plk_4	191	197	PF00069	0.623
MOD_Plk_4	455	461	PF00069	0.520
MOD_Plk_4	469	475	PF00069	0.596
MOD_ProDKin_1	210	216	PF00069	0.606
MOD_ProDKin_1	292	298	PF00069	0.436
MOD_ProDKin_1	323	329	PF00069	0.566
MOD_ProDKin_1	94	100	PF00069	0.373
TRG_DiLeu_BaEn_2	84	90	PF01217	0.651
TRG_DiLeu_BaEn_4	2	8	PF01217	0.703
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.565
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.664
TRG_DiLeu_LyEn_5	2	7	PF01217	0.674
TRG_ENDOCYTIC_2	178	181	PF00928	0.634
TRG_ENDOCYTIC_2	284	287	PF00928	0.640
TRG_ENDOCYTIC_2	414	417	PF00928	0.715
TRG_ENDOCYTIC_2	64	67	PF00928	0.499
TRG_ER_diArg_1	150	152	PF00400	0.537
TRG_ER_diArg_1	266	268	PF00400	0.575
TRG_ER_diArg_1	304	307	PF00400	0.562
TRG_ER_diArg_1	353	356	PF00400	0.573
TRG_ER_diArg_1	425	427	PF00400	0.733
TRG_NLS_MonoExtC_3	351	356	PF00514	0.647
TRG_NLS_MonoExtN_4	350	356	PF00514	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ4	Leptomonas seymouri	60%	99%
A0A0S4IX55	Bodo saltans	31%	89%
A0A1X0P6L3	Trypanosomatidae	38%	100%
A0A3Q8IGK1	Leishmania donovani	93%	100%
A0A3R7LN85	Trypanosoma rangeli	36%	100%
A4HN63	Leishmania braziliensis	78%	100%
A4IBT0	Leishmania infantum	93%	100%
C9ZYT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B6S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q08BC4	Danio rerio	29%	85%
Q8C8J0	Mus musculus	25%	85%
V5C2R9	Trypanosoma cruzi	35%	100%