Ufd2P_core domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFL6_LEIMA

TriTrypDb:

LmjF.35.3920 , LMJLV39_350046900 , LMJSD75_350046200

Length:

804

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AFL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.440
CLV_NRD_NRD_1	180	182	PF00675	0.679
CLV_NRD_NRD_1	222	224	PF00675	0.639
CLV_NRD_NRD_1	377	379	PF00675	0.631
CLV_PCSK_KEX2_1	180	182	PF00082	0.687
CLV_PCSK_KEX2_1	210	212	PF00082	0.543
CLV_PCSK_KEX2_1	245	247	PF00082	0.497
CLV_PCSK_KEX2_1	277	279	PF00082	0.609
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.589
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.497
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.609
CLV_PCSK_SKI1_1	203	207	PF00082	0.527
CLV_PCSK_SKI1_1	305	309	PF00082	0.686
CLV_PCSK_SKI1_1	35	39	PF00082	0.552
CLV_PCSK_SKI1_1	466	470	PF00082	0.380
CLV_PCSK_SKI1_1	597	601	PF00082	0.483
CLV_PCSK_SKI1_1	726	730	PF00082	0.418
CLV_Separin_Metazoa	547	551	PF03568	0.590
DEG_APCC_DBOX_1	202	210	PF00400	0.407
DEG_APCC_DBOX_1	304	312	PF00400	0.473
DEG_APCC_DBOX_1	382	390	PF00400	0.292
DEG_COP1_1	585	593	PF00400	0.626
DEG_SCF_FBW7_1	104	110	PF00400	0.443
DEG_SPOP_SBC_1	125	129	PF00917	0.531
DEG_SPOP_SBC_1	356	360	PF00917	0.536
DOC_CDC14_PxL_1	189	197	PF14671	0.438
DOC_CDC14_PxL_1	295	303	PF14671	0.370
DOC_CKS1_1	104	109	PF01111	0.438
DOC_CYCLIN_RxL_1	302	312	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.445
DOC_MAPK_gen_1	161	170	PF00069	0.349
DOC_MAPK_gen_1	245	253	PF00069	0.376
DOC_MAPK_gen_1	466	475	PF00069	0.563
DOC_MAPK_MEF2A_6	161	170	PF00069	0.373
DOC_MAPK_MEF2A_6	390	398	PF00069	0.401
DOC_MAPK_MEF2A_6	785	793	PF00069	0.418
DOC_MAPK_RevD_3	166	181	PF00069	0.459
DOC_PP1_RVXF_1	201	208	PF00149	0.382
DOC_PP1_RVXF_1	602	608	PF00149	0.661
DOC_PP2B_LxvP_1	133	136	PF13499	0.439
DOC_PP2B_LxvP_1	168	171	PF13499	0.433
DOC_PP2B_LxvP_1	622	625	PF13499	0.755
DOC_PP4_FxxP_1	172	175	PF00568	0.380
DOC_PP4_FxxP_1	330	333	PF00568	0.404
DOC_PP4_MxPP_1	427	430	PF00568	0.387
DOC_USP7_MATH_1	124	128	PF00917	0.505
DOC_USP7_MATH_1	290	294	PF00917	0.414
DOC_USP7_MATH_1	356	360	PF00917	0.431
DOC_USP7_MATH_1	533	537	PF00917	0.558
DOC_USP7_MATH_1	582	586	PF00917	0.743
DOC_USP7_MATH_1	79	83	PF00917	0.446
DOC_USP7_UBL2_3	116	120	PF12436	0.418
DOC_USP7_UBL2_3	466	470	PF12436	0.588
DOC_USP7_UBL2_3	579	583	PF12436	0.735
DOC_USP7_UBL2_3	612	616	PF12436	0.768
DOC_WW_Pin1_4	103	108	PF00397	0.425
DOC_WW_Pin1_4	346	351	PF00397	0.507
DOC_WW_Pin1_4	578	583	PF00397	0.678
LIG_14-3-3_CanoR_1	126	131	PF00244	0.509
LIG_14-3-3_CanoR_1	214	222	PF00244	0.455
LIG_14-3-3_CanoR_1	316	322	PF00244	0.393
LIG_14-3-3_CanoR_1	378	382	PF00244	0.329
LIG_14-3-3_CanoR_1	383	389	PF00244	0.278
LIG_14-3-3_CanoR_1	532	538	PF00244	0.617
LIG_14-3-3_CanoR_1	566	574	PF00244	0.624
LIG_14-3-3_CanoR_1	575	582	PF00244	0.652
LIG_14-3-3_CanoR_1	597	605	PF00244	0.694
LIG_14-3-3_CanoR_1	771	780	PF00244	0.581
LIG_APCC_ABBA_1	169	174	PF00400	0.440
LIG_BRCT_BRCA1_1	107	111	PF00533	0.379
LIG_BRCT_BRCA1_1	126	130	PF00533	0.398
LIG_BRCT_BRCA1_1	215	219	PF00533	0.436
LIG_BRCT_BRCA1_1	347	351	PF00533	0.483
LIG_BRCT_BRCA1_1	362	366	PF00533	0.367
LIG_BRCT_BRCA1_1	438	442	PF00533	0.396
LIG_BRCT_BRCA1_1	750	754	PF00533	0.651
LIG_BRCT_BRCA1_1	769	773	PF00533	0.562
LIG_BRCT_BRCA1_1	93	97	PF00533	0.376
LIG_deltaCOP1_diTrp_1	412	421	PF00928	0.402
LIG_DLG_GKlike_1	126	133	PF00625	0.450
LIG_EH_1	418	422	PF12763	0.420
LIG_EH1_1	494	502	PF00400	0.619
LIG_eIF4E_1	199	205	PF01652	0.357
LIG_FHA_1	289	295	PF00498	0.343
LIG_FHA_1	334	340	PF00498	0.322
LIG_FHA_1	406	412	PF00498	0.356
LIG_FHA_1	480	486	PF00498	0.472
LIG_FHA_1	524	530	PF00498	0.589
LIG_FHA_1	543	549	PF00498	0.634
LIG_FHA_1	554	560	PF00498	0.578
LIG_FHA_1	566	572	PF00498	0.643
LIG_FHA_1	590	596	PF00498	0.740
LIG_FHA_1	784	790	PF00498	0.333
LIG_FHA_2	177	183	PF00498	0.407
LIG_FHA_2	284	290	PF00498	0.429
LIG_FHA_2	356	362	PF00498	0.530
LIG_FHA_2	47	53	PF00498	0.376
LIG_FHA_2	494	500	PF00498	0.679
LIG_FHA_2	598	604	PF00498	0.686
LIG_HP1_1	136	140	PF01393	0.373
LIG_Integrin_isoDGR_2	628	630	PF01839	0.532
LIG_LIR_Apic_2	760	766	PF02991	0.645
LIG_LIR_Gen_1	18	27	PF02991	0.397
LIG_LIR_Gen_1	237	248	PF02991	0.459
LIG_LIR_Gen_1	260	268	PF02991	0.387
LIG_LIR_Gen_1	391	401	PF02991	0.382
LIG_LIR_Gen_1	412	421	PF02991	0.319
LIG_LIR_Gen_1	439	450	PF02991	0.290
LIG_LIR_Gen_1	49	58	PF02991	0.411
LIG_LIR_Gen_1	666	674	PF02991	0.646
LIG_LIR_Gen_1	73	79	PF02991	0.333
LIG_LIR_Gen_1	770	781	PF02991	0.595
LIG_LIR_Gen_1	786	795	PF02991	0.335
LIG_LIR_Gen_1	797	804	PF02991	0.348
LIG_LIR_Nem_3	127	133	PF02991	0.424
LIG_LIR_Nem_3	15	19	PF02991	0.306
LIG_LIR_Nem_3	237	243	PF02991	0.436
LIG_LIR_Nem_3	260	264	PF02991	0.347
LIG_LIR_Nem_3	3	7	PF02991	0.454
LIG_LIR_Nem_3	391	396	PF02991	0.325
LIG_LIR_Nem_3	412	417	PF02991	0.327
LIG_LIR_Nem_3	438	443	PF02991	0.293
LIG_LIR_Nem_3	49	53	PF02991	0.346
LIG_LIR_Nem_3	561	567	PF02991	0.563
LIG_LIR_Nem_3	666	672	PF02991	0.683
LIG_LIR_Nem_3	68	74	PF02991	0.325
LIG_LIR_Nem_3	770	776	PF02991	0.594
LIG_LIR_Nem_3	786	790	PF02991	0.236
LIG_LIR_Nem_3	797	802	PF02991	0.391
LIG_NRBOX	200	206	PF00104	0.359
LIG_PCNA_yPIPBox_3	470	484	PF02747	0.596
LIG_PDZ_Class_2	799	804	PF00595	0.357
LIG_Pex14_1	780	784	PF04695	0.545
LIG_Pex14_2	16	20	PF04695	0.377
LIG_Pex14_2	37	41	PF04695	0.417
LIG_Pex14_2	505	509	PF04695	0.533
LIG_Pex14_2	570	574	PF04695	0.646
LIG_Pex14_2	795	799	PF04695	0.412
LIG_REV1ctd_RIR_1	142	150	PF16727	0.443
LIG_REV1ctd_RIR_1	35	44	PF16727	0.410
LIG_REV1ctd_RIR_1	605	613	PF16727	0.724
LIG_SH2_CRK	157	161	PF00017	0.442
LIG_SH2_CRK	244	248	PF00017	0.399
LIG_SH2_CRK	254	258	PF00017	0.286
LIG_SH2_CRK	669	673	PF00017	0.642
LIG_SH2_GRB2like	74	77	PF00017	0.401
LIG_SH2_PTP2	261	264	PF00017	0.407
LIG_SH2_PTP2	534	537	PF00017	0.592
LIG_SH2_STAP1	131	135	PF00017	0.340
LIG_SH2_STAP1	240	244	PF00017	0.452
LIG_SH2_STAP1	254	258	PF00017	0.365
LIG_SH2_STAP1	335	339	PF00017	0.416
LIG_SH2_STAP1	669	673	PF00017	0.606
LIG_SH2_STAP1	686	690	PF00017	0.643
LIG_SH2_STAT3	25	28	PF00017	0.418
LIG_SH2_STAT3	432	435	PF00017	0.416
LIG_SH2_STAT5	19	22	PF00017	0.421
LIG_SH2_STAT5	199	202	PF00017	0.297
LIG_SH2_STAT5	261	264	PF00017	0.352
LIG_SH2_STAT5	265	268	PF00017	0.321
LIG_SH2_STAT5	335	338	PF00017	0.387
LIG_SH2_STAT5	401	404	PF00017	0.402
LIG_SH2_STAT5	409	412	PF00017	0.314
LIG_SH2_STAT5	432	435	PF00017	0.322
LIG_SH2_STAT5	534	537	PF00017	0.547
LIG_SH2_STAT5	58	61	PF00017	0.430
LIG_SH2_STAT5	62	65	PF00017	0.449
LIG_SH2_STAT5	683	686	PF00017	0.683
LIG_SH2_STAT5	763	766	PF00017	0.582
LIG_SH3_3	190	196	PF00018	0.390
LIG_SH3_3	20	26	PF00018	0.352
LIG_SH3_3	246	252	PF00018	0.367
LIG_SH3_3	592	598	PF00018	0.763
LIG_Sin3_3	202	209	PF02671	0.401
LIG_SUMO_SIM_anti_2	293	298	PF11976	0.411
LIG_SUMO_SIM_anti_2	555	561	PF11976	0.624
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.367
LIG_SUMO_SIM_par_1	481	486	PF11976	0.478
LIG_SUMO_SIM_par_1	555	561	PF11976	0.580
LIG_TRAF2_1	8	11	PF00917	0.439
LIG_TRFH_1	25	29	PF08558	0.404
LIG_UBA3_1	201	210	PF00899	0.348
LIG_WRC_WIRS_1	13	18	PF05994	0.301
LIG_WRC_WIRS_1	437	442	PF05994	0.339
LIG_WRC_WIRS_1	47	52	PF05994	0.369
LIG_WRC_WIRS_1	799	804	PF05994	0.447
LIG_WW_1	429	432	PF00397	0.380
MOD_CDK_SPK_2	578	583	PF00069	0.678
MOD_CK1_1	105	111	PF00069	0.424
MOD_CK1_1	129	135	PF00069	0.373
MOD_CK1_1	276	282	PF00069	0.461
MOD_CK1_1	31	37	PF00069	0.427
MOD_CK1_1	343	349	PF00069	0.459
MOD_CK1_1	360	366	PF00069	0.443
MOD_CK1_1	405	411	PF00069	0.379
MOD_CK1_1	490	496	PF00069	0.620
MOD_CK1_1	589	595	PF00069	0.711
MOD_CK1_1	774	780	PF00069	0.646
MOD_CK1_1	783	789	PF00069	0.391
MOD_CK2_1	12	18	PF00069	0.363
MOD_CK2_1	176	182	PF00069	0.414
MOD_CK2_1	456	462	PF00069	0.475
MOD_CK2_1	493	499	PF00069	0.661
MOD_CK2_1	54	60	PF00069	0.424
MOD_CK2_1	555	561	PF00069	0.603
MOD_CK2_1	597	603	PF00069	0.695
MOD_CK2_1	702	708	PF00069	0.655
MOD_CK2_1	96	102	PF00069	0.373
MOD_GlcNHglycan	107	110	PF01048	0.667
MOD_GlcNHglycan	215	218	PF01048	0.608
MOD_GlcNHglycan	240	243	PF01048	0.694
MOD_GlcNHglycan	266	269	PF01048	0.640
MOD_GlcNHglycan	586	589	PF01048	0.557
MOD_GlcNHglycan	734	737	PF01048	0.430
MOD_GSK3_1	103	110	PF00069	0.356
MOD_GSK3_1	120	127	PF00069	0.411
MOD_GSK3_1	176	183	PF00069	0.440
MOD_GSK3_1	264	271	PF00069	0.428
MOD_GSK3_1	284	291	PF00069	0.373
MOD_GSK3_1	340	347	PF00069	0.410
MOD_GSK3_1	356	363	PF00069	0.474
MOD_GSK3_1	452	459	PF00069	0.386
MOD_GSK3_1	487	494	PF00069	0.625
MOD_GSK3_1	521	528	PF00069	0.518
MOD_GSK3_1	570	577	PF00069	0.611
MOD_GSK3_1	578	585	PF00069	0.669
MOD_GSK3_1	767	774	PF00069	0.626
MOD_GSK3_1	79	86	PF00069	0.438
MOD_GSK3_1	794	801	PF00069	0.442
MOD_GSK3_1	92	99	PF00069	0.315
MOD_N-GLC_1	120	125	PF02516	0.681
MOD_N-GLC_1	487	492	PF02516	0.444
MOD_NEK2_1	257	262	PF00069	0.365
MOD_NEK2_1	456	461	PF00069	0.455
MOD_NEK2_1	521	526	PF00069	0.643
MOD_NEK2_1	54	59	PF00069	0.412
MOD_NEK2_1	553	558	PF00069	0.632
MOD_NEK2_1	570	575	PF00069	0.528
MOD_NEK2_1	639	644	PF00069	0.686
MOD_NEK2_1	651	656	PF00069	0.558
MOD_NEK2_1	682	687	PF00069	0.627
MOD_NEK2_1	794	799	PF00069	0.476
MOD_NEK2_1	83	88	PF00069	0.416
MOD_OFUCOSY	707	714	PF10250	0.457
MOD_PIKK_1	181	187	PF00454	0.502
MOD_PIKK_1	473	479	PF00454	0.597
MOD_PIKK_1	487	493	PF00454	0.672
MOD_PIKK_1	565	571	PF00454	0.591
MOD_PK_1	586	592	PF00069	0.744
MOD_PKA_1	180	186	PF00069	0.489
MOD_PKA_2	125	131	PF00069	0.508
MOD_PKA_2	180	186	PF00069	0.401
MOD_PKA_2	213	219	PF00069	0.410
MOD_PKA_2	315	321	PF00069	0.420
MOD_PKA_2	377	383	PF00069	0.328
MOD_PKA_2	565	571	PF00069	0.619
MOD_PKA_2	574	580	PF00069	0.639
MOD_Plk_1	360	366	PF00069	0.523
MOD_Plk_1	702	708	PF00069	0.634
MOD_Plk_1	748	754	PF00069	0.653
MOD_Plk_2-3	555	561	PF00069	0.621
MOD_Plk_4	126	132	PF00069	0.453
MOD_Plk_4	257	263	PF00069	0.400
MOD_Plk_4	290	296	PF00069	0.356
MOD_Plk_4	377	383	PF00069	0.329
MOD_Plk_4	384	390	PF00069	0.279
MOD_Plk_4	452	458	PF00069	0.441
MOD_Plk_4	479	485	PF00069	0.585
MOD_Plk_4	555	561	PF00069	0.561
MOD_Plk_4	656	662	PF00069	0.569
MOD_Plk_4	668	674	PF00069	0.609
MOD_Plk_4	748	754	PF00069	0.586
MOD_Plk_4	794	800	PF00069	0.417
MOD_Plk_4	83	89	PF00069	0.370
MOD_Plk_4	93	99	PF00069	0.340
MOD_ProDKin_1	103	109	PF00069	0.435
MOD_ProDKin_1	346	352	PF00069	0.506
MOD_ProDKin_1	578	584	PF00069	0.684
MOD_SUMO_for_1	235	238	PF00179	0.318
MOD_SUMO_rev_2	31	37	PF00179	0.387
MOD_SUMO_rev_2	547	556	PF00179	0.656
TRG_DiLeu_BaEn_1	555	560	PF01217	0.621
TRG_DiLeu_BaEn_1	646	651	PF01217	0.579
TRG_DiLeu_BaEn_2	437	443	PF01217	0.333
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.381
TRG_DiLeu_BaLyEn_6	536	541	PF01217	0.585
TRG_ENDOCYTIC_2	199	202	PF00928	0.297
TRG_ENDOCYTIC_2	240	243	PF00928	0.445
TRG_ENDOCYTIC_2	244	247	PF00928	0.397
TRG_ENDOCYTIC_2	254	257	PF00928	0.267
TRG_ENDOCYTIC_2	261	264	PF00928	0.256
TRG_ENDOCYTIC_2	335	338	PF00928	0.410
TRG_ENDOCYTIC_2	534	537	PF00928	0.567
TRG_ENDOCYTIC_2	669	672	PF00928	0.668
TRG_ENDOCYTIC_2	74	77	PF00928	0.401
TRG_ER_diArg_1	160	163	PF00400	0.412
TRG_NES_CRM1_1	547	561	PF08389	0.624
TRG_NLS_Bipartite_1	210	227	PF00514	0.380
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.662
TRG_Pf-PMV_PEXEL_1	539	543	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	597	601	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.685
TRG_Pf-PMV_PEXEL_1	663	667	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IID0	Leptomonas seymouri	58%	100%
A0A0S4IXF5	Bodo saltans	25%	83%
A0A1X0P5G3	Trypanosomatidae	32%	99%
A0A3R7K1M8	Trypanosoma rangeli	33%	89%
A0A3S7X9Q6	Leishmania donovani	95%	100%
A4HN62	Leishmania braziliensis	81%	100%
A4IBS9	Leishmania infantum	95%	100%
C9ZYT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	91%
E9B6R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BTB4	Trypanosoma cruzi	33%	100%