Putative PFPI/DJ-1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PFPI/DJ-1-like protein, putative

Species:

Leishmania major

UniProt:

E9AFL5_LEIMA

TriTrypDb:

LmjF.35.3910 , LMJLV39_350046800 , LMJSD75_350046100

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFL5

Function

Biological processes
Term	Name	Level	Count
GO:0006081	cellular aldehyde metabolic process	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1903189	glyoxal metabolic process	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.357
CLV_NRD_NRD_1	97	99	PF00675	0.474
CLV_PCSK_KEX2_1	134	136	PF00082	0.357
CLV_PCSK_KEX2_1	28	30	PF00082	0.673
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.673
CLV_PCSK_SKI1_1	134	138	PF00082	0.299
CLV_PCSK_SKI1_1	162	166	PF00082	0.357
CLV_PCSK_SKI1_1	182	186	PF00082	0.242
CLV_PCSK_SKI1_1	32	36	PF00082	0.346
DEG_Nend_Nbox_1	1	3	PF02207	0.718
DOC_CDC14_PxL_1	164	172	PF14671	0.474
DOC_CYCLIN_RxL_1	124	133	PF00134	0.340
DOC_MAPK_gen_1	124	132	PF00069	0.474
DOC_MAPK_gen_1	27	38	PF00069	0.474
DOC_MAPK_gen_1	98	106	PF00069	0.474
DOC_PP1_RVXF_1	126	133	PF00149	0.340
DOC_USP7_MATH_1	53	57	PF00917	0.357
DOC_USP7_UBL2_3	28	32	PF12436	0.632
DOC_WW_Pin1_4	168	173	PF00397	0.357
LIG_14-3-3_CanoR_1	162	170	PF00244	0.357
LIG_14-3-3_CanoR_1	91	96	PF00244	0.416
LIG_14-3-3_CanoR_1	98	102	PF00244	0.346
LIG_EH1_1	147	155	PF00400	0.357
LIG_FHA_1	185	191	PF00498	0.487
LIG_FHA_1	73	79	PF00498	0.435
LIG_FHA_2	98	104	PF00498	0.357
LIG_LIR_Gen_1	100	107	PF02991	0.435
LIG_LIR_Gen_1	43	53	PF02991	0.357
LIG_LIR_Nem_3	100	104	PF02991	0.428
LIG_LIR_Nem_3	165	170	PF02991	0.357
LIG_LIR_Nem_3	43	48	PF02991	0.474
LIG_LYPXL_S_1	12	16	PF13949	0.598
LIG_LYPXL_yS_3	13	16	PF13949	0.588
LIG_LYPXL_yS_3	167	170	PF13949	0.357
LIG_MYND_1	168	172	PF01753	0.474
LIG_Pex14_2	132	136	PF04695	0.474
LIG_SH2_PTP2	122	125	PF00017	0.357
LIG_SH2_STAP1	45	49	PF00017	0.357
LIG_SH2_STAT5	113	116	PF00017	0.321
LIG_SH2_STAT5	122	125	PF00017	0.270
LIG_SH2_STAT5	87	90	PF00017	0.357
LIG_SH3_3	31	37	PF00018	0.474
LIG_SH3_3	44	50	PF00018	0.357
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.474
LIG_TYR_ITIM	11	16	PF00017	0.613
MOD_CDK_SPxxK_3	168	175	PF00069	0.474
MOD_CK2_1	97	103	PF00069	0.357
MOD_GlcNHglycan	65	68	PF01048	0.474
MOD_GlcNHglycan	7	10	PF01048	0.624
MOD_GSK3_1	156	163	PF00069	0.336
MOD_NEK2_1	112	117	PF00069	0.357
MOD_NEK2_1	130	135	PF00069	0.357
MOD_NEK2_1	23	28	PF00069	0.661
MOD_PKA_2	97	103	PF00069	0.474
MOD_Plk_4	91	97	PF00069	0.399
MOD_ProDKin_1	168	174	PF00069	0.357
MOD_SUMO_rev_2	26	35	PF00179	0.606
TRG_ENDOCYTIC_2	122	125	PF00928	0.333
TRG_ENDOCYTIC_2	13	16	PF00928	0.588
TRG_ENDOCYTIC_2	167	170	PF00928	0.357
TRG_ENDOCYTIC_2	181	184	PF00928	0.357
TRG_ENDOCYTIC_2	45	48	PF00928	0.357
TRG_ENDOCYTIC_2	87	90	PF00928	0.357
TRG_ER_diArg_1	134	136	PF00400	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X5	Leptomonas seymouri	66%	100%
O06006	Bacillus subtilis (strain 168)	27%	100%
O28987	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	25%	100%
O59413	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	31%	100%
Q51732	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	30%	100%
Q58377	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	28%	94%
Q5JGM7	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	30%	100%
Q9V1F8	Pyrococcus abyssi (strain GE5 / Orsay)	29%	100%