Proteasome subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome beta 2 subunit, putative

Species:

Leishmania major

UniProt:

E9AFK8_LEIMA

TriTrypDb:

LmjF.35.3840 , LMJLV39_350046100 , LMJSD75_350045400

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	12
GO:0005839	proteasome core complex	3	12
GO:0019774	proteasome core complex, beta-subunit complex	2	2
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12

Expansion

Sequence features

E9AFK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFK8

PDB structure(s): 6qm7_I , 6qm7_W , 6qm8_I , 6qm8_W , 6tcz_i , 6td5_i

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0010498	proteasomal protein catabolic process	5	7
GO:0019538	protein metabolic process	3	12
GO:0030163	protein catabolic process	4	7
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	7
GO:1901575	organic substance catabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004298	threonine-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0016787	hydrolase activity	2	12
GO:0070003	threonine-type peptidase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	60	62	PF00675	0.364
CLV_PCSK_KEX2_1	113	115	PF00082	0.288
CLV_PCSK_KEX2_1	223	225	PF00082	0.615
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.288
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.543
CLV_PCSK_SKI1_1	190	194	PF00082	0.303
CLV_PCSK_SKI1_1	24	28	PF00082	0.492
DEG_ODPH_VHL_1	142	153	PF01847	0.571
DOC_CKS1_1	218	223	PF01111	0.544
DOC_CYCLIN_RxL_1	8	18	PF00134	0.530
DOC_MAPK_gen_1	101	111	PF00069	0.529
DOC_MAPK_gen_1	209	216	PF00069	0.486
DOC_PP4_FxxP_1	193	196	PF00568	0.479
DOC_PP4_MxPP_1	232	235	PF00568	0.548
DOC_USP7_MATH_1	144	148	PF00917	0.488
DOC_USP7_MATH_1	75	79	PF00917	0.574
DOC_USP7_UBL2_3	58	62	PF12436	0.488
DOC_WW_Pin1_4	217	222	PF00397	0.534
DOC_WW_Pin1_4	235	240	PF00397	0.511
LIG_14-3-3_CanoR_1	48	55	PF00244	0.485
LIG_FHA_1	146	152	PF00498	0.488
LIG_FHA_1	183	189	PF00498	0.538
LIG_FHA_1	235	241	PF00498	0.490
LIG_FHA_1	28	34	PF00498	0.479
LIG_FHA_1	79	85	PF00498	0.488
LIG_FHA_2	174	180	PF00498	0.490
LIG_FHA_2	198	204	PF00498	0.480
LIG_FHA_2	75	81	PF00498	0.488
LIG_LIR_Apic_2	18	23	PF02991	0.600
LIG_LIR_Apic_2	215	221	PF02991	0.510
LIG_PDZ_Class_2	249	254	PF00595	0.635
LIG_PTB_Apo_2	14	21	PF02174	0.519
LIG_PTB_Apo_2	191	198	PF02174	0.493
LIG_PTB_Phospho_1	14	20	PF10480	0.514
LIG_PTB_Phospho_1	191	197	PF10480	0.488
LIG_SH2_CRK	20	24	PF00017	0.637
LIG_SH2_CRK	218	222	PF00017	0.484
LIG_SH2_CRK	65	69	PF00017	0.500
LIG_SH2_STAT3	117	120	PF00017	0.488
LIG_SH3_3	131	137	PF00018	0.491
LIG_SH3_3	228	234	PF00018	0.639
LIG_SUMO_SIM_anti_2	107	113	PF11976	0.530
LIG_SUMO_SIM_par_1	247	253	PF11976	0.502
LIG_TRAF2_1	176	179	PF00917	0.488
LIG_TRAF2_1	227	230	PF00917	0.567
MOD_CDK_SPxK_1	217	223	PF00069	0.501
MOD_CDK_SPxxK_3	217	224	PF00069	0.545
MOD_CDK_SPxxK_3	235	242	PF00069	0.512
MOD_CK1_1	78	84	PF00069	0.574
MOD_CK2_1	173	179	PF00069	0.501
MOD_GlcNHglycan	123	126	PF01048	0.288
MOD_GlcNHglycan	157	160	PF01048	0.287
MOD_GlcNHglycan	185	188	PF01048	0.289
MOD_GlcNHglycan	197	200	PF01048	0.274
MOD_GlcNHglycan	20	23	PF01048	0.660
MOD_GlcNHglycan	77	80	PF01048	0.364
MOD_GSK3_1	18	25	PF00069	0.643
MOD_GSK3_1	205	212	PF00069	0.547
MOD_GSK3_1	74	81	PF00069	0.488
MOD_GSK3_1	82	89	PF00069	0.488
MOD_GSK3_1	96	103	PF00069	0.488
MOD_N-GLC_1	173	178	PF02516	0.300
MOD_NEK2_1	138	143	PF00069	0.488
MOD_NEK2_1	183	188	PF00069	0.497
MOD_NEK2_1	87	92	PF00069	0.566
MOD_PIKK_1	197	203	PF00454	0.488
MOD_PKA_2	47	53	PF00069	0.488
MOD_Plk_1	212	218	PF00069	0.356
MOD_Plk_4	107	113	PF00069	0.488
MOD_Plk_4	28	34	PF00069	0.488
MOD_Plk_4	50	56	PF00069	0.488
MOD_ProDKin_1	217	223	PF00069	0.540
MOD_ProDKin_1	235	241	PF00069	0.512
MOD_SUMO_for_1	241	244	PF00179	0.579
MOD_SUMO_rev_2	173	183	PF00179	0.488
TRG_DiLeu_BaEn_1	107	112	PF01217	0.529
TRG_DiLeu_BaEn_1	179	184	PF01217	0.488
TRG_DiLeu_BaEn_1	244	249	PF01217	0.478
TRG_Pf-PMV_PEXEL_1	11	16	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I1	Leptomonas seymouri	28%	100%
A0A0N0P7F8	Leptomonas seymouri	27%	84%
A0A0N1HVL0	Leptomonas seymouri	92%	100%
A0A0N1PB37	Leptomonas seymouri	34%	90%
A0A0S4IQU5	Bodo saltans	25%	95%
A0A0S4IX63	Bodo saltans	29%	86%
A0A0S4IXL2	Bodo saltans	76%	99%
A0A0S4KNR5	Bodo saltans	34%	82%
A0A1X0NHF3	Trypanosomatidae	24%	100%
A0A1X0NJ65	Trypanosomatidae	24%	100%
A0A1X0NNS8	Trypanosomatidae	31%	89%
A0A1X0P5G1	Trypanosomatidae	81%	99%
A0A1X0P7U3	Trypanosomatidae	27%	82%
A0A3Q8IB07	Leishmania donovani	26%	100%
A0A3Q8IC41	Leishmania donovani	28%	100%
A0A3Q8IIY4	Leishmania donovani	28%	84%
A0A3Q8IVH0	Leishmania donovani	98%	100%
A0A3R7M7V4	Trypanosoma rangeli	29%	89%
A0A3R7MZI3	Trypanosoma rangeli	26%	82%
A0A3S5H6K1	Leishmania donovani	33%	90%
A0A422N1Q5	Trypanosoma rangeli	82%	100%
A0A422N8R3	Trypanosoma rangeli	24%	100%
A0A422N8U2	Trypanosoma rangeli	24%	100%
A0B5B1	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	32%	100%
A0RU86	Cenarchaeum symbiosum (strain A)	23%	100%
A0RXV1	Cenarchaeum symbiosum (strain A)	35%	100%
A1RSJ8	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	30%	100%
A1RTI7	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	33%	100%
A1RWY6	Thermofilum pendens (strain DSM 2475 / Hrk 5)	36%	100%
A1RX71	Thermofilum pendens (strain DSM 2475 / Hrk 5)	32%	100%
A1SK13	Nocardioides sp. (strain ATCC BAA-499 / JS614)	25%	90%
A1XQU1	Sus scrofa	56%	92%
A2BN24	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	30%	100%
A2BN27	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	35%	100%
A2SS78	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	35%	100%
A3CUS9	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	36%	100%
A3DN21	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	30%	100%
A3DN27	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	35%	100%
A3MS44	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	35%	100%
A3MXQ6	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	30%	100%
A4FYA5	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	32%	100%
A4FZT6	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	29%	98%
A4H6R7	Leishmania braziliensis	31%	90%
A4HLC5	Leishmania braziliensis	27%	100%
A4HN55	Leishmania braziliensis	93%	100%
A4HP29	Leishmania braziliensis	26%	84%
A4HV47	Leishmania infantum	33%	90%
A4HZI9	Leishmania infantum	28%	100%
A4IBS2	Leishmania infantum	98%	100%
A4IDD6	Leishmania infantum	28%	84%
A4WH05	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	30%	100%
A4WMZ0	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	31%	100%
A4YIE0	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	33%	100%
A4YJ04	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	29%	100%
A5LHX3	Homo sapiens	31%	85%
A5UJS2	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	28%	100%
A5UM14	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	30%	100%
A6URN9	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	29%	98%
A6USJ3	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	32%	100%
A6UT20	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	32%	100%
A6VIP0	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	29%	98%
A6VK02	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	32%	100%
A7I841	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	34%	100%
A7KE01	Salmo salar	32%	100%
A7KII6	Salmo salar	32%	100%
A8AA46	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	31%	100%
A8AB58	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	32%	100%
A8LH54	Frankia sp. (strain EAN1pec)	27%	93%
A8M8R5	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	35%	100%
A8MBW0	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	34%	100%
A9A2U7	Nitrosopumilus maritimus (strain SCM1)	33%	100%
A9A4A1	Nitrosopumilus maritimus (strain SCM1)	29%	100%
A9A788	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	32%	100%
A9A846	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	28%	98%
B0R4C8	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	27%	100%
B1L6S7	Korarchaeum cryptofilum (strain OPF8)	34%	100%
B1L6X8	Korarchaeum cryptofilum (strain OPF8)	31%	100%
B1W306	Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)	28%	90%
B1YA36	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	33%	100%
B1YDJ0	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	31%	100%
B5IEE5	Aciduliprofundum boonei (strain DSM 19572 / T469)	28%	100%
B6YSH9	Thermococcus onnurineus (strain NA1)	29%	98%
B6YSW2	Thermococcus onnurineus (strain NA1)	31%	100%
B6YXV3	Thermococcus onnurineus (strain NA1)	34%	100%
B8D673	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	31%	100%
B8D683	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	33%	100%
B8GG66	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	36%	100%
B9LTS6	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	33%	100%
C3MQ16	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	34%	100%
C3MQ43	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	26%	100%
C3MRE5	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	32%	100%
C3MVD5	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	34%	100%
C3MVG1	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	26%	100%
C3MY41	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	32%	100%
C3MZI0	Sulfolobus islandicus (strain M.16.27)	32%	100%
C3N5N4	Sulfolobus islandicus (strain M.16.27)	34%	100%
C3N5R0	Sulfolobus islandicus (strain M.16.27)	26%	100%
C3N7K2	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	32%	100%
C3NE98	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	34%	100%
C3NEC6	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	26%	100%
C3NFX2	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	32%	100%
C3NHC6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	26%	100%
C3NHF1	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	34%	100%
C4KHB0	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	34%	100%
C4KHD9	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	26%	100%
C4KIR0	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	32%	100%
C5A2C2	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	30%	98%
C5A2D5	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	34%	100%
C5A7L1	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	35%	100%
C6A2V9	Thermococcus sibiricus (strain DSM 12597 / MM 739)	33%	100%
C6A3R1	Thermococcus sibiricus (strain DSM 12597 / MM 739)	34%	100%
C6A459	Thermococcus sibiricus (strain DSM 12597 / MM 739)	32%	98%
C7NQ99	Halorhabdus utahensis (strain DSM 12940 / JCM 11049 / AX-2)	28%	100%
C7NVQ4	Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541)	28%	100%
C7P6N4	Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86)	35%	100%
C9REN7	Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7)	34%	100%
C9Z4D0	Streptomyces scabiei (strain 87.22)	27%	90%
C9ZQD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	90%
C9ZYV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
D0A0Z1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A312	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	82%
D0KRX1	Saccharolobus solfataricus (strain 98/2)	33%	100%
D0KTH0	Saccharolobus solfataricus (strain 98/2)	33%	100%
D1Z199	Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / SANAE)	34%	100%
D2PDG6	Sulfolobus islandicus (strain L.D.8.5 / Lassen #2)	32%	100%
D2PK63	Sulfolobus islandicus (strain L.D.8.5 / Lassen #2)	34%	100%
D2RGT4	Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)	34%	100%
D2RQX3	Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / JCM 9101 / NCIMB 13204 / VKM B-1734 / 4k)	29%	100%
D2RUI0	Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / JCM 9101 / NCIMB 13204 / VKM B-1734 / 4k)	27%	100%
D3E0A3	Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1)	33%	100%
D3RX66	Ferroglobus placidus (strain DSM 10642 / AEDII12DO)	34%	100%
D3S8M7	Methanocaldococcus sp. (strain FS406-22)	33%	100%
D3SSQ6	Natrialba magadii (strain ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM 8861 / NBRC 102185 / NCIMB 2190 / MS3)	26%	100%
D4GYZ1	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	32%	100%
D5EAS6	Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)	32%	100%
E9ANS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	90%
E9AST7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	84%
E9AVH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B6R2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O09061	Mus musculus	22%	100%
O23710	Arabidopsis thaliana	61%	93%
O23715	Arabidopsis thaliana	26%	100%
O23717	Arabidopsis thaliana	32%	93%
O24361	Spinacia oleracea	31%	93%
O24362	Spinacia oleracea	26%	100%
O24733	Thermococcus sp. (strain JCM 11816 / KS-1)	29%	98%
O26782	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	30%	100%
O27270	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	33%	100%
O35521	Mus terricolor	34%	100%
O35522	Mus musculus bactrianus	34%	100%
O35523	Mus platythrix	34%	100%
O35524	Mus spicilegus	34%	100%
O35955	Mus musculus	52%	93%
O43063	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
O50110	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	36%	100%
O55234	Mus musculus	28%	96%
O57983	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	33%	100%
O59219	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	31%	98%
O81149	Arabidopsis thaliana	25%	100%
P20618	Homo sapiens	22%	100%
P23638	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	98%
P25043	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	50%	97%
P25156	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	21%	100%
P28061	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	30%	100%
P28062	Homo sapiens	27%	92%
P28063	Mus musculus	26%	92%
P28064	Rattus norvegicus	27%	92%
P28065	Homo sapiens	34%	100%
P28066	Homo sapiens	24%	100%
P28072	Homo sapiens	34%	100%
P28073	Rattus norvegicus	33%	100%
P28074	Homo sapiens	26%	97%
P28075	Rattus norvegicus	28%	97%
P28076	Mus musculus	34%	100%
P28077	Rattus norvegicus	34%	100%
P30655	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	93%
P30656	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	89%
P32379	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	98%
P34064	Rattus norvegicus	24%	100%
P34065	Gallus gallus	31%	99%
P38624	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P40306	Homo sapiens	50%	93%
P42742	Arabidopsis thaliana	27%	100%
P70195	Mus musculus	56%	92%
P93395	Nicotiana tabacum	35%	100%
Q09682	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q09841	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	95%
Q0RLT7	Frankia alni (strain ACN14a)	27%	93%
Q0W2D6	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	32%	100%
Q12YV7	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	34%	100%
Q18GX3	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	33%	100%
Q18K08	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	24%	100%
Q27563	Dictyostelium discoideum	25%	100%
Q2FQL8	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	34%	100%
Q2J9Q3	Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3)	24%	93%
Q2NI68	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	35%	100%
Q2TBP0	Bos taurus	56%	92%
Q32KL2	Bos taurus	28%	97%
Q3IPX1	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	28%	100%
Q3MHN0	Bos taurus	34%	100%
Q3SZC2	Bos taurus	33%	100%
Q3T0T1	Bos taurus	49%	93%
Q3T112	Bos taurus	27%	92%
Q42134	Arabidopsis thaliana	25%	100%
Q469M6	Methanosarcina barkeri (strain Fusaro / DSM 804)	26%	100%
Q46G14	Methanosarcina barkeri (strain Fusaro / DSM 804)	33%	100%
Q4JAA8	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	35%	100%
Q4JAY3	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	31%	100%
Q4KM35	Rattus norvegicus	51%	93%
Q4Q1Q9	Leishmania major	28%	84%
Q4QC00	Leishmania major	28%	100%
Q4QC13	Leishmania major	26%	100%
Q4QGU1	Leishmania major	31%	100%
Q54BC8	Dictyostelium discoideum	29%	93%
Q54QR2	Dictyostelium discoideum	61%	95%
Q556Q0	Dictyostelium discoideum	24%	98%
Q55G04	Dictyostelium discoideum	24%	100%
Q55GJ6	Dictyostelium discoideum	31%	100%
Q58634	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	33%	100%
Q59565	Methanosarcina thermophila	28%	100%
Q5E987	Bos taurus	24%	100%
Q5JDJ9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	32%	100%
Q5JHL8	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	34%	100%
Q5JIU9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	29%	98%
Q5R8S2	Pongo abelii	26%	97%
Q5V1D4	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	25%	100%
Q5V1D5	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	26%	100%
Q5V4S6	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	27%	100%
Q5W416	Canis lupus familiaris	28%	92%
Q60177	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	28%	97%
Q60692	Mus musculus	33%	100%
Q6L0W3	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	21%	100%
Q6L181	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	28%	100%
Q6LZD4	Methanococcus maripaludis (strain S2 / LL)	31%	100%
Q6M0L9	Methanococcus maripaludis (strain S2 / LL)	29%	98%
Q74MP5	Nanoarchaeum equitans (strain Kin4-M)	30%	100%
Q7AKQ5	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	29%	90%
Q7DLS1	Arabidopsis thaliana	62%	93%
Q828I8	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	28%	90%
Q86A21	Dictyostelium discoideum	26%	100%
Q8BG41	Mus musculus	32%	84%
Q8LD27	Arabidopsis thaliana	35%	100%
Q8PTU1	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	27%	100%
Q8PZ04	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	33%	100%
Q8SQN7	Encephalitozoon cuniculi (strain GB-M1)	42%	100%
Q8SR11	Encephalitozoon cuniculi (strain GB-M1)	27%	100%
Q8TJB5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	34%	100%
Q8TPX5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	27%	100%
Q8TW10	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	30%	100%
Q8TYB7	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	27%	100%
Q8U0L6	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	31%	98%
Q8U125	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	33%	100%
Q8U4C9	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	32%	100%
Q8UW64	Oryzias latipes	32%	100%
Q8ZST5	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	28%	100%
Q8ZYF2	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	33%	100%
Q94561	Entamoeba histolytica	26%	100%
Q95005	Caenorhabditis elegans	24%	100%
Q975D1	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	35%	100%
Q975U8	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	30%	100%
Q97AZ7	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	28%	100%
Q980L4	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	33%	100%
Q99436	Homo sapiens	57%	92%
Q9DD33	Salmo salar	32%	100%
Q9GNZ8	Leishmania infantum	26%	100%
Q9HR36	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	27%	100%
Q9JHW0	Rattus norvegicus	56%	92%
Q9LIP2	Arabidopsis thaliana	32%	93%
Q9LSU1	Oryza sativa subsp. japonica	25%	100%
Q9M4T8	Glycine max	25%	100%
Q9P992	Methanosarcina thermophila	34%	100%
Q9P996	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	33%	100%
Q9PT26	Oncorhynchus mykiss	32%	100%
Q9UT97	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q9UXC6	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	25%	100%
Q9UXF3	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	33%	100%
Q9V0N9	Pyrococcus abyssi (strain GE5 / Orsay)	34%	100%
Q9V122	Pyrococcus abyssi (strain GE5 / Orsay)	32%	98%
Q9V247	Pyrococcus abyssi (strain GE5 / Orsay)	30%	100%
Q9V2V6	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	27%	100%
Q9VNA5	Drosophila melanogaster	26%	95%
Q9XUV0	Caenorhabditis elegans	28%	89%
Q9XZG5	Trypanosoma brucei brucei	25%	100%
Q9YER0	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	30%	100%
Q9YES4	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	32%	100%
Q9Z2U1	Mus musculus	24%	100%
V5B1X4	Trypanosoma cruzi	24%	100%
V5BCU3	Trypanosoma cruzi	83%	87%
V5BHX1	Trypanosoma cruzi	31%	89%
V5BLX4	Trypanosoma cruzi	24%	100%
V5BU39	Trypanosoma cruzi	28%	82%