SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFK7_LEIMA

TriTrypDb:

LmjF.35.3830 , LMJLV39_350046000 , LMJSD75_350045300

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.414
CLV_NRD_NRD_1	170	172	PF00675	0.269
CLV_NRD_NRD_1	197	199	PF00675	0.364
CLV_PCSK_KEX2_1	170	172	PF00082	0.269
CLV_PCSK_KEX2_1	197	199	PF00082	0.325
CLV_PCSK_SKI1_1	102	106	PF00082	0.337
DOC_CYCLIN_RxL_1	99	106	PF00134	0.562
DOC_MAPK_DCC_7	30	38	PF00069	0.438
DOC_MAPK_FxFP_2	282	285	PF00069	0.411
DOC_MAPK_gen_1	170	176	PF00069	0.476
DOC_MAPK_gen_1	23	33	PF00069	0.442
DOC_PP1_RVXF_1	10	17	PF00149	0.439
DOC_PP4_FxxP_1	282	285	PF00568	0.419
DOC_USP7_MATH_1	182	186	PF00917	0.571
DOC_USP7_MATH_1	285	289	PF00917	0.465
DOC_USP7_MATH_1	292	296	PF00917	0.598
DOC_USP7_MATH_1	57	61	PF00917	0.566
DOC_WW_Pin1_4	190	195	PF00397	0.460
DOC_WW_Pin1_4	213	218	PF00397	0.487
DOC_WW_Pin1_4	31	36	PF00397	0.432
LIG_14-3-3_CanoR_1	110	116	PF00244	0.498
LIG_Actin_WH2_2	57	75	PF00022	0.501
LIG_BIR_III_4	181	185	PF00653	0.414
LIG_BRCT_BRCA1_1	92	96	PF00533	0.487
LIG_FHA_1	16	22	PF00498	0.404
LIG_FHA_1	39	45	PF00498	0.487
LIG_FHA_1	56	62	PF00498	0.487
LIG_FHA_1	99	105	PF00498	0.524
LIG_FHA_2	112	118	PF00498	0.498
LIG_LIR_Apic_2	142	146	PF02991	0.537
LIG_LIR_Apic_2	279	285	PF02991	0.482
LIG_LIR_Gen_1	114	123	PF02991	0.480
LIG_LIR_Gen_1	18	27	PF02991	0.414
LIG_LIR_Gen_1	46	57	PF02991	0.492
LIG_LIR_Gen_1	93	100	PF02991	0.489
LIG_LIR_Nem_3	114	118	PF02991	0.480
LIG_LIR_Nem_3	279	284	PF02991	0.451
LIG_LIR_Nem_3	46	52	PF02991	0.480
LIG_LIR_Nem_3	93	99	PF02991	0.498
LIG_LYPXL_yS_3	284	287	PF13949	0.486
LIG_PCNA_yPIPBox_3	197	207	PF02747	0.548
LIG_PCNA_yPIPBox_3	5	17	PF02747	0.570
LIG_Pex14_2	158	162	PF04695	0.476
LIG_Pex14_2	278	282	PF04695	0.384
LIG_SH2_GRB2like	270	273	PF00017	0.416
LIG_SH2_SRC	115	118	PF00017	0.476
LIG_SH2_STAT3	189	192	PF00017	0.553
LIG_SH2_STAT5	115	118	PF00017	0.476
LIG_SH2_STAT5	166	169	PF00017	0.476
LIG_SH2_STAT5	189	192	PF00017	0.562
LIG_SH2_STAT5	248	251	PF00017	0.476
LIG_SH2_STAT5	270	273	PF00017	0.416
LIG_SH3_3	117	123	PF00018	0.523
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.487
LIG_SUMO_SIM_anti_2	48	54	PF11976	0.487
LIG_SUMO_SIM_par_1	60	67	PF11976	0.497
LIG_TRAF2_1	226	229	PF00917	0.557
LIG_UBA3_1	230	239	PF00899	0.344
MOD_CDK_SPxxK_3	190	197	PF00069	0.281
MOD_CK1_1	180	186	PF00069	0.418
MOD_CK1_1	60	66	PF00069	0.347
MOD_GlcNHglycan	181	185	PF01048	0.341
MOD_GlcNHglycan	293	297	PF01048	0.592
MOD_GlcNHglycan	299	302	PF01048	0.575
MOD_GlcNHglycan	74	77	PF01048	0.483
MOD_GSK3_1	176	183	PF00069	0.336
MOD_GSK3_1	292	299	PF00069	0.675
MOD_N-GLC_1	285	290	PF02516	0.463
MOD_PIKK_1	285	291	PF00454	0.473
MOD_PIKK_1	55	61	PF00454	0.428
MOD_PKA_2	90	96	PF00069	0.449
MOD_Plk_1	285	291	PF00069	0.521
MOD_Plk_4	111	117	PF00069	0.428
MOD_Plk_4	57	63	PF00069	0.344
MOD_ProDKin_1	190	196	PF00069	0.306
MOD_ProDKin_1	213	219	PF00069	0.344
MOD_ProDKin_1	31	37	PF00069	0.425
TRG_DiLeu_BaEn_2	244	250	PF01217	0.413
TRG_ENDOCYTIC_2	115	118	PF00928	0.320
TRG_ENDOCYTIC_2	166	169	PF00928	0.328
TRG_ENDOCYTIC_2	248	251	PF00928	0.328
TRG_ENDOCYTIC_2	270	273	PF00928	0.416
TRG_ENDOCYTIC_2	284	287	PF00928	0.411
TRG_ER_diArg_1	169	171	PF00400	0.319
TRG_NES_CRM1_1	42	56	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I289	Leptomonas seymouri	81%	100%
A0A0S4J0X3	Bodo saltans	50%	96%
A0A1X0P6M3	Trypanosomatidae	65%	100%
A0A3R7KQI7	Trypanosoma rangeli	68%	100%
A0A3S7X9T6	Leishmania donovani	96%	100%
A4HN54	Leishmania braziliensis	83%	100%
A4IBS1	Leishmania infantum	96%	100%
C9ZYV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B6R1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BXZ4	Trypanosoma cruzi	67%	100%