LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AFK6_LEIMA
TriTrypDb:
LmjF.35.3820 * , LMJLV39_350045900 * , LMJSD75_350045200 *
Length:
320

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFK6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFK6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 110 112 PF00675 0.372
CLV_NRD_NRD_1 22 24 PF00675 0.481
CLV_NRD_NRD_1 243 245 PF00675 0.661
CLV_NRD_NRD_1 263 265 PF00675 0.666
CLV_PCSK_FUR_1 108 112 PF00082 0.343
CLV_PCSK_FUR_1 20 24 PF00082 0.545
CLV_PCSK_FUR_1 269 273 PF00082 0.515
CLV_PCSK_KEX2_1 110 112 PF00082 0.410
CLV_PCSK_KEX2_1 22 24 PF00082 0.475
CLV_PCSK_KEX2_1 227 229 PF00082 0.666
CLV_PCSK_KEX2_1 242 244 PF00082 0.501
CLV_PCSK_KEX2_1 271 273 PF00082 0.599
CLV_PCSK_KEX2_1 310 312 PF00082 0.447
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.601
CLV_PCSK_PC1ET2_1 271 273 PF00082 0.509
CLV_PCSK_PC1ET2_1 310 312 PF00082 0.529
CLV_PCSK_PC7_1 18 24 PF00082 0.498
CLV_PCSK_PC7_1 267 273 PF00082 0.473
CLV_PCSK_SKI1_1 282 286 PF00082 0.467
CLV_PCSK_SKI1_1 297 301 PF00082 0.400
CLV_PCSK_SKI1_1 92 96 PF00082 0.477
DEG_APCC_DBOX_1 266 274 PF00400 0.469
DOC_CDC14_PxL_1 29 37 PF14671 0.524
DOC_CKS1_1 160 165 PF01111 0.557
DOC_CYCLIN_RxL_1 108 121 PF00134 0.425
DOC_MAPK_gen_1 108 117 PF00069 0.473
DOC_MAPK_gen_1 269 279 PF00069 0.485
DOC_MAPK_gen_1 297 307 PF00069 0.557
DOC_MAPK_MEF2A_6 167 176 PF00069 0.500
DOC_USP7_MATH_1 202 206 PF00917 0.481
DOC_USP7_MATH_1 233 237 PF00917 0.642
DOC_USP7_MATH_1 253 257 PF00917 0.537
DOC_USP7_MATH_1 69 73 PF00917 0.448
DOC_USP7_UBL2_3 306 310 PF12436 0.470
DOC_WW_Pin1_4 159 164 PF00397 0.562
DOC_WW_Pin1_4 227 232 PF00397 0.608
LIG_14-3-3_CanoR_1 201 211 PF00244 0.567
LIG_14-3-3_CanoR_1 282 291 PF00244 0.527
LIG_Actin_WH2_2 102 120 PF00022 0.511
LIG_Actin_WH2_2 130 145 PF00022 0.407
LIG_Actin_WH2_2 292 308 PF00022 0.541
LIG_APCC_ABBAyCdc20_2 255 261 PF00400 0.520
LIG_BIR_II_1 1 5 PF00653 0.523
LIG_BIR_III_1 1 5 PF00653 0.457
LIG_BIR_III_3 1 5 PF00653 0.457
LIG_BRCT_BRCA1_1 255 259 PF00533 0.530
LIG_FHA_1 152 158 PF00498 0.599
LIG_FHA_1 171 177 PF00498 0.508
LIG_FHA_1 208 214 PF00498 0.490
LIG_FHA_1 246 252 PF00498 0.635
LIG_FHA_1 283 289 PF00498 0.526
LIG_FHA_2 182 188 PF00498 0.510
LIG_FHA_2 4 10 PF00498 0.448
LIG_LIR_Nem_3 128 133 PF02991 0.534
LIG_SH2_CRK 36 40 PF00017 0.506
LIG_SH2_SRC 138 141 PF00017 0.384
LIG_SH2_STAP1 138 142 PF00017 0.382
LIG_SH3_3 157 163 PF00018 0.556
LIG_SUMO_SIM_anti_2 209 216 PF11976 0.486
LIG_SUMO_SIM_par_1 170 178 PF11976 0.506
MOD_CK1_1 159 165 PF00069 0.640
MOD_CK1_1 181 187 PF00069 0.615
MOD_CK2_1 152 158 PF00069 0.718
MOD_CK2_1 181 187 PF00069 0.565
MOD_CK2_1 3 9 PF00069 0.618
MOD_GlcNHglycan 154 157 PF01048 0.690
MOD_GlcNHglycan 204 207 PF01048 0.513
MOD_GlcNHglycan 234 238 PF01048 0.704
MOD_GlcNHglycan 245 251 PF01048 0.551
MOD_GlcNHglycan 301 305 PF01048 0.437
MOD_GSK3_1 113 120 PF00069 0.468
MOD_GSK3_1 152 159 PF00069 0.550
MOD_GSK3_1 170 177 PF00069 0.666
MOD_GSK3_1 178 185 PF00069 0.642
MOD_GSK3_1 209 216 PF00069 0.521
MOD_GSK3_1 219 226 PF00069 0.574
MOD_GSK3_1 282 289 PF00069 0.410
MOD_NEK2_1 174 179 PF00069 0.589
MOD_NEK2_1 207 212 PF00069 0.567
MOD_NEK2_1 213 218 PF00069 0.531
MOD_NEK2_1 53 58 PF00069 0.435
MOD_NEK2_2 138 143 PF00069 0.430
MOD_PIKK_1 282 288 PF00454 0.551
MOD_PKA_2 117 123 PF00069 0.580
MOD_PKA_2 202 208 PF00069 0.566
MOD_PKA_2 263 269 PF00069 0.635
MOD_PKA_2 286 292 PF00069 0.421
MOD_Plk_1 113 119 PF00069 0.470
MOD_Plk_1 138 144 PF00069 0.425
MOD_Plk_1 170 176 PF00069 0.771
MOD_Plk_1 300 306 PF00069 0.421
MOD_Plk_4 156 162 PF00069 0.623
MOD_Plk_4 209 215 PF00069 0.492
MOD_ProDKin_1 159 165 PF00069 0.563
MOD_ProDKin_1 227 233 PF00069 0.606
TRG_DiLeu_BaEn_1 209 214 PF01217 0.492
TRG_DiLeu_BaEn_4 97 103 PF01217 0.460
TRG_DiLeu_BaLyEn_6 279 284 PF01217 0.584
TRG_ENDOCYTIC_2 130 133 PF00928 0.532
TRG_ENDOCYTIC_2 36 39 PF00928 0.509
TRG_ER_diArg_1 108 111 PF00400 0.375
TRG_ER_diArg_1 20 23 PF00400 0.478
TRG_ER_diArg_1 242 244 PF00400 0.697
TRG_ER_diArg_1 255 258 PF00400 0.601
TRG_ER_diArg_1 267 270 PF00400 0.538
TRG_NES_CRM1_1 189 200 PF08389 0.377
TRG_Pf-PMV_PEXEL_1 100 105 PF00026 0.412
TRG_Pf-PMV_PEXEL_1 27 31 PF00026 0.536
TRG_Pf-PMV_PEXEL_1 282 286 PF00026 0.428

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3I4 Leptomonas seymouri 37% 93%
A0A1X0P5H2 Trypanosomatidae 27% 89%
A0A3Q8IIM5 Leishmania donovani 92% 100%
A0A3R7NA43 Trypanosoma rangeli 27% 88%
A4HN53 Leishmania braziliensis 74% 92%
A4IBS0 Leishmania infantum 92% 100%
E9B6R0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 94%
V5C2S8 Trypanosoma cruzi 28% 88%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS