Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFK5_LEIMA

TriTrypDb:

LmjF.35.3810 , LMJLV39_350045800 , LMJSD75_350045100

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AFK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.478
CLV_NRD_NRD_1	106	108	PF00675	0.585
CLV_NRD_NRD_1	115	117	PF00675	0.591
CLV_NRD_NRD_1	144	146	PF00675	0.688
CLV_NRD_NRD_1	34	36	PF00675	0.417
CLV_PCSK_KEX2_1	106	108	PF00082	0.585
CLV_PCSK_KEX2_1	144	146	PF00082	0.688
CLV_PCSK_KEX2_1	34	36	PF00082	0.403
CLV_PCSK_KEX2_1	7	9	PF00082	0.365
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.365
CLV_PCSK_SKI1_1	7	11	PF00082	0.412
DOC_MAPK_gen_1	129	139	PF00069	0.372
DOC_MAPK_gen_1	47	57	PF00069	0.491
DOC_MAPK_MEF2A_6	50	59	PF00069	0.245
DOC_PP1_RVXF_1	105	112	PF00149	0.390
DOC_PP4_FxxP_1	27	30	PF00568	0.597
LIG_14-3-3_CanoR_1	37	46	PF00244	0.680
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_deltaCOP1_diTrp_1	110	118	PF00928	0.397
LIG_eIF4E_1	51	57	PF01652	0.262
LIG_FHA_2	119	125	PF00498	0.397
LIG_FHA_2	62	68	PF00498	0.378
LIG_HP1_1	58	62	PF01393	0.235
LIG_LIR_Gen_1	133	139	PF02991	0.375
LIG_LIR_Gen_1	74	85	PF02991	0.363
LIG_LIR_Nem_3	133	137	PF02991	0.374
LIG_LIR_Nem_3	41	46	PF02991	0.564
LIG_LIR_Nem_3	74	80	PF02991	0.403
LIG_OCRL_FandH_1	76	88	PF00620	0.345
LIG_Pex14_1	48	52	PF04695	0.262
LIG_Pex14_2	27	31	PF04695	0.598
LIG_PTB_Apo_2	96	103	PF02174	0.387
LIG_SH2_STAT5	51	54	PF00017	0.326
LIG_TRAF2_1	30	33	PF00917	0.583
LIG_TYR_ITIM	49	54	PF00017	0.281
MOD_CK1_1	42	48	PF00069	0.585
MOD_CK2_1	124	130	PF00069	0.370
MOD_CK2_1	61	67	PF00069	0.378
MOD_GSK3_1	120	127	PF00069	0.357
MOD_GSK3_1	38	45	PF00069	0.596
MOD_GSK3_1	61	68	PF00069	0.378
MOD_PKA_2	105	111	PF00069	0.405
MOD_PKA_2	118	124	PF00069	0.377
MOD_PKA_2	14	20	PF00069	0.569
MOD_PKA_2	33	39	PF00069	0.730
MOD_Plk_2-3	105	111	PF00069	0.437
MOD_Plk_2-3	124	130	PF00069	0.309
MOD_Plk_4	61	67	PF00069	0.414
MOD_SUMO_for_1	9	12	PF00179	0.571
MOD_SUMO_rev_2	104	113	PF00179	0.415
TRG_ENDOCYTIC_2	46	49	PF00928	0.556
TRG_ENDOCYTIC_2	51	54	PF00928	0.248
TRG_ER_diArg_1	34	37	PF00400	0.626
TRG_NLS_MonoExtC_3	6	12	PF00514	0.630
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X2	Leptomonas seymouri	89%	100%
A0A0S4J4A6	Bodo saltans	77%	96%
A0A1X0P575	Trypanosomatidae	85%	99%
A0A3Q8IMS0	Leishmania donovani	98%	100%
A0A3R7M4Q6	Trypanosoma rangeli	77%	99%
A4HN52	Leishmania braziliensis	97%	100%
A4IBR9	Leishmania infantum	98%	100%
C9ZYV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	84%	75%
E9B6Q9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%