Enriched_in_surface-labeled_proteome_protein_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enriched in surface-labeled proteome protein 9, putative

Species:

Leishmania major

UniProt:

E9AFK1_LEIMA

TriTrypDb:

LmjF.35.3770 , LMJLV39_350045300 , LMJSD75_350044700

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 4
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005768	endosome	7	2
GO:0016020	membrane	2	8
GO:0020023	kinetoplast	2	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AFK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	384	386	PF00675	0.697
CLV_NRD_NRD_1	547	549	PF00675	0.696
CLV_PCSK_KEX2_1	396	398	PF00082	0.531
CLV_PCSK_KEX2_1	547	549	PF00082	0.696
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.493
CLV_PCSK_SKI1_1	386	390	PF00082	0.677
CLV_PCSK_SKI1_1	500	504	PF00082	0.544
CLV_PCSK_SKI1_1	574	578	PF00082	0.663
DEG_COP1_1	298	307	PF00400	0.309
DEG_SPOP_SBC_1	186	190	PF00917	0.339
DEG_SPOP_SBC_1	280	284	PF00917	0.525
DEG_SPOP_SBC_1	456	460	PF00917	0.336
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	176	182	PF00134	0.434
DOC_MAPK_gen_1	252	261	PF00069	0.461
DOC_MAPK_MEF2A_6	255	263	PF00069	0.450
DOC_MAPK_MEF2A_6	82	89	PF00069	0.339
DOC_MAPK_NFAT4_5	82	90	PF00069	0.329
DOC_PP1_RVXF_1	443	449	PF00149	0.309
DOC_PP2B_LxvP_1	167	170	PF13499	0.319
DOC_PP2B_LxvP_1	176	179	PF13499	0.362
DOC_PP4_FxxP_1	371	374	PF00568	0.416
DOC_SPAK_OSR1_1	69	73	PF12202	0.324
DOC_USP7_MATH_1	148	152	PF00917	0.353
DOC_USP7_MATH_1	273	277	PF00917	0.554
DOC_USP7_MATH_1	372	376	PF00917	0.380
DOC_WW_Pin1_4	139	144	PF00397	0.330
DOC_WW_Pin1_4	200	205	PF00397	0.353
DOC_WW_Pin1_4	313	318	PF00397	0.479
DOC_WW_Pin1_4	413	418	PF00397	0.431
LIG_14-3-3_CanoR_1	141	150	PF00244	0.362
LIG_14-3-3_CanoR_1	3	13	PF00244	0.635
LIG_14-3-3_CanoR_1	326	332	PF00244	0.404
LIG_14-3-3_CanoR_1	337	341	PF00244	0.340
LIG_14-3-3_CanoR_1	407	413	PF00244	0.372
LIG_14-3-3_CanoR_1	445	449	PF00244	0.309
LIG_14-3-3_CanoR_1	478	482	PF00244	0.376
LIG_14-3-3_CanoR_1	62	72	PF00244	0.425
LIG_APCC_ABBA_1	85	90	PF00400	0.399
LIG_BRCT_BRCA1_1	338	342	PF00533	0.425
LIG_Clathr_ClatBox_1	197	201	PF01394	0.453
LIG_Clathr_ClatBox_1	42	46	PF01394	0.367
LIG_deltaCOP1_diTrp_1	355	361	PF00928	0.396
LIG_FHA_1	10	16	PF00498	0.282
LIG_FHA_1	450	456	PF00498	0.388
LIG_FHA_1	538	544	PF00498	0.323
LIG_FHA_1	575	581	PF00498	0.401
LIG_FHA_1	634	640	PF00498	0.797
LIG_FHA_1	98	104	PF00498	0.387
LIG_FHA_2	504	510	PF00498	0.407
LIG_GBD_Chelix_1	132	140	PF00786	0.495
LIG_LIR_Apic_2	296	302	PF02991	0.425
LIG_LIR_Apic_2	369	374	PF02991	0.402
LIG_LIR_Apic_2	550	554	PF02991	0.369
LIG_LIR_Gen_1	224	232	PF02991	0.362
LIG_LIR_Gen_1	309	318	PF02991	0.363
LIG_LIR_Gen_1	358	367	PF02991	0.424
LIG_LIR_Gen_1	471	481	PF02991	0.337
LIG_LIR_Gen_1	532	539	PF02991	0.386
LIG_LIR_Nem_3	172	176	PF02991	0.374
LIG_LIR_Nem_3	224	228	PF02991	0.318
LIG_LIR_Nem_3	309	315	PF02991	0.339
LIG_LIR_Nem_3	319	325	PF02991	0.386
LIG_LIR_Nem_3	328	332	PF02991	0.400
LIG_LIR_Nem_3	471	476	PF02991	0.336
LIG_LIR_Nem_3	532	536	PF02991	0.332
LIG_LIR_Nem_3	540	545	PF02991	0.288
LIG_LIR_Nem_3	81	87	PF02991	0.385
LIG_LYPXL_yS_3	149	152	PF13949	0.315
LIG_NRBOX	18	24	PF00104	0.370
LIG_Pex14_2	223	227	PF04695	0.370
LIG_Pex14_2	308	312	PF04695	0.326
LIG_PTB_Apo_2	217	224	PF02174	0.360
LIG_SH2_CRK	173	177	PF00017	0.429
LIG_SH2_CRK	299	303	PF00017	0.344
LIG_SH2_CRK	402	406	PF00017	0.317
LIG_SH2_CRK	473	477	PF00017	0.378
LIG_SH2_CRK	533	537	PF00017	0.338
LIG_SH2_CRK	551	555	PF00017	0.484
LIG_SH2_CRK	573	577	PF00017	0.425
LIG_SH2_GRB2like	102	105	PF00017	0.361
LIG_SH2_NCK_1	299	303	PF00017	0.355
LIG_SH2_NCK_1	402	406	PF00017	0.344
LIG_SH2_NCK_1	551	555	PF00017	0.484
LIG_SH2_SRC	102	105	PF00017	0.361
LIG_SH2_SRC	551	554	PF00017	0.302
LIG_SH2_STAP1	165	169	PF00017	0.364
LIG_SH2_STAP1	329	333	PF00017	0.325
LIG_SH2_STAP1	357	361	PF00017	0.366
LIG_SH2_STAP1	402	406	PF00017	0.372
LIG_SH2_STAP1	473	477	PF00017	0.334
LIG_SH2_STAP1	527	531	PF00017	0.422
LIG_SH2_STAP1	533	537	PF00017	0.328
LIG_SH2_STAT3	161	164	PF00017	0.331
LIG_SH2_STAT5	102	105	PF00017	0.306
LIG_SH2_STAT5	299	302	PF00017	0.396
LIG_SH2_STAT5	387	390	PF00017	0.355
LIG_SH2_STAT5	525	528	PF00017	0.394
LIG_SH2_STAT5	533	536	PF00017	0.299
LIG_SH2_STAT5	545	548	PF00017	0.303
LIG_SH2_STAT5	84	87	PF00017	0.378
LIG_SH2_STAT5	88	91	PF00017	0.328
LIG_SH2_STAT5	97	100	PF00017	0.303
LIG_SH3_1	299	305	PF00018	0.349
LIG_SH3_2	495	500	PF14604	0.336
LIG_SH3_3	256	262	PF00018	0.459
LIG_SH3_3	299	305	PF00018	0.342
LIG_SH3_3	311	317	PF00018	0.301
LIG_SH3_3	414	420	PF00018	0.378
LIG_SH3_3	492	498	PF00018	0.389
LIG_SH3_3	597	603	PF00018	0.327
LIG_SH3_3	644	650	PF00018	0.620
LIG_SH3_3	80	86	PF00018	0.401
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.357
LIG_SUMO_SIM_anti_2	44	49	PF11976	0.359
LIG_SUMO_SIM_anti_2	586	593	PF11976	0.356
LIG_SUMO_SIM_par_1	11	16	PF11976	0.411
LIG_SUMO_SIM_par_1	18	24	PF11976	0.354
LIG_SUMO_SIM_par_1	203	208	PF11976	0.377
LIG_TYR_ITIM	400	405	PF00017	0.314
LIG_WRC_WIRS_1	222	227	PF05994	0.354
LIG_WRC_WIRS_1	539	544	PF05994	0.288
LIG_WRC_WIRS_1	566	571	PF05994	0.394
MOD_CK1_1	123	129	PF00069	0.431
MOD_CK1_1	135	141	PF00069	0.336
MOD_CK1_1	142	148	PF00069	0.331
MOD_CK1_1	230	236	PF00069	0.444
MOD_CK1_1	238	244	PF00069	0.406
MOD_CK1_1	276	282	PF00069	0.531
MOD_CK1_1	284	290	PF00069	0.528
MOD_CK1_1	336	342	PF00069	0.320
MOD_CK1_1	408	414	PF00069	0.434
MOD_CK1_1	460	466	PF00069	0.531
MOD_CK1_1	468	474	PF00069	0.459
MOD_CK1_1	55	61	PF00069	0.403
MOD_CK1_1	565	571	PF00069	0.407
MOD_CK1_1	63	69	PF00069	0.335
MOD_CK1_1	75	81	PF00069	0.370
MOD_CK2_1	109	115	PF00069	0.395
MOD_CK2_1	123	129	PF00069	0.376
MOD_CK2_1	280	286	PF00069	0.598
MOD_CK2_1	313	319	PF00069	0.300
MOD_CK2_1	75	81	PF00069	0.385
MOD_GlcNHglycan	144	147	PF01048	0.566
MOD_GlcNHglycan	161	164	PF01048	0.509
MOD_GlcNHglycan	289	292	PF01048	0.798
MOD_GlcNHglycan	29	32	PF01048	0.438
MOD_GlcNHglycan	374	377	PF01048	0.595
MOD_GlcNHglycan	407	410	PF01048	0.608
MOD_GlcNHglycan	467	470	PF01048	0.639
MOD_GlcNHglycan	50	53	PF01048	0.571
MOD_GlcNHglycan	6	9	PF01048	0.522
MOD_GlcNHglycan	626	629	PF01048	0.436
MOD_GlcNHglycan	65	68	PF01048	0.485
MOD_GlcNHglycan	74	77	PF01048	0.588
MOD_GSK3_1	120	127	PF00069	0.395
MOD_GSK3_1	135	142	PF00069	0.325
MOD_GSK3_1	165	172	PF00069	0.461
MOD_GSK3_1	196	203	PF00069	0.453
MOD_GSK3_1	209	216	PF00069	0.421
MOD_GSK3_1	223	230	PF00069	0.293
MOD_GSK3_1	23	30	PF00069	0.302
MOD_GSK3_1	231	238	PF00069	0.368
MOD_GSK3_1	239	246	PF00069	0.351
MOD_GSK3_1	269	276	PF00069	0.541
MOD_GSK3_1	280	287	PF00069	0.501
MOD_GSK3_1	289	296	PF00069	0.534
MOD_GSK3_1	362	369	PF00069	0.385
MOD_GSK3_1	4	11	PF00069	0.733
MOD_GSK3_1	456	463	PF00069	0.364
MOD_GSK3_1	465	472	PF00069	0.422
MOD_GSK3_1	48	55	PF00069	0.433
MOD_GSK3_1	579	586	PF00069	0.359
MOD_GSK3_1	624	631	PF00069	0.613
MOD_GSK3_1	68	75	PF00069	0.258
MOD_N-GLC_1	103	108	PF02516	0.634
MOD_N-GLC_1	109	114	PF02516	0.622
MOD_N-GLC_1	159	164	PF02516	0.569
MOD_N-GLC_1	230	235	PF02516	0.610
MOD_N-GLC_1	244	249	PF02516	0.625
MOD_N-GLC_1	425	430	PF02516	0.601
MOD_N-GLC_1	60	65	PF02516	0.608
MOD_N-GLC_1	628	633	PF02516	0.444
MOD_N-GLC_1	72	77	PF02516	0.624
MOD_N-GLC_2	219	221	PF02516	0.549
MOD_N-GLC_2	393	395	PF02516	0.543
MOD_NEK2_1	1	6	PF00069	0.660
MOD_NEK2_1	13	18	PF00069	0.253
MOD_NEK2_1	132	137	PF00069	0.320
MOD_NEK2_1	187	192	PF00069	0.351
MOD_NEK2_1	223	228	PF00069	0.365
MOD_NEK2_1	23	28	PF00069	0.241
MOD_NEK2_1	318	323	PF00069	0.350
MOD_NEK2_1	335	340	PF00069	0.264
MOD_NEK2_1	455	460	PF00069	0.358
MOD_NEK2_1	479	484	PF00069	0.388
MOD_NEK2_1	590	595	PF00069	0.406
MOD_NEK2_1	624	629	PF00069	0.607
MOD_NEK2_1	68	73	PF00069	0.346
MOD_NEK2_2	327	332	PF00069	0.371
MOD_NEK2_2	425	430	PF00069	0.401
MOD_PIKK_1	187	193	PF00454	0.351
MOD_PKA_2	2	8	PF00069	0.715
MOD_PKA_2	276	282	PF00069	0.479
MOD_PKA_2	325	331	PF00069	0.445
MOD_PKA_2	336	342	PF00069	0.388
MOD_PKA_2	444	450	PF00069	0.347
MOD_PKA_2	477	483	PF00069	0.377
MOD_PKA_2	68	74	PF00069	0.489
MOD_Plk_1	165	171	PF00069	0.351
MOD_Plk_1	230	236	PF00069	0.425
MOD_Plk_1	244	250	PF00069	0.407
MOD_Plk_1	297	303	PF00069	0.403
MOD_Plk_1	318	324	PF00069	0.365
MOD_Plk_1	425	431	PF00069	0.399
MOD_Plk_1	456	462	PF00069	0.478
MOD_Plk_1	463	469	PF00069	0.460
MOD_Plk_1	531	537	PF00069	0.352
MOD_Plk_1	60	66	PF00069	0.396
MOD_Plk_4	132	138	PF00069	0.389
MOD_Plk_4	148	154	PF00069	0.348
MOD_Plk_4	15	21	PF00069	0.368
MOD_Plk_4	276	282	PF00069	0.490
MOD_Plk_4	318	324	PF00069	0.352
MOD_Plk_4	327	333	PF00069	0.298
MOD_Plk_4	362	368	PF00069	0.339
MOD_Plk_4	408	414	PF00069	0.335
MOD_Plk_4	419	425	PF00069	0.315
MOD_Plk_4	444	450	PF00069	0.353
MOD_Plk_4	457	463	PF00069	0.413
MOD_Plk_4	531	537	PF00069	0.386
MOD_Plk_4	538	544	PF00069	0.343
MOD_Plk_4	55	61	PF00069	0.384
MOD_Plk_4	579	585	PF00069	0.378
MOD_ProDKin_1	139	145	PF00069	0.332
MOD_ProDKin_1	200	206	PF00069	0.347
MOD_ProDKin_1	313	319	PF00069	0.482
MOD_ProDKin_1	413	419	PF00069	0.432
MOD_SUMO_for_1	641	644	PF00179	0.673
TRG_DiLeu_BaEn_2	537	543	PF01217	0.304
TRG_ENDOCYTIC_2	149	152	PF00928	0.361
TRG_ENDOCYTIC_2	173	176	PF00928	0.354
TRG_ENDOCYTIC_2	332	335	PF00928	0.465
TRG_ENDOCYTIC_2	402	405	PF00928	0.363
TRG_ENDOCYTIC_2	473	476	PF00928	0.385
TRG_ENDOCYTIC_2	533	536	PF00928	0.318
TRG_ENDOCYTIC_2	573	576	PF00928	0.425
TRG_ENDOCYTIC_2	84	87	PF00928	0.297
TRG_ER_diArg_1	546	548	PF00400	0.470
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH70	Leptomonas seymouri	44%	100%
A0A1X0NCX6	Trypanosomatidae	30%	100%
A0A3S5H803	Leishmania donovani	88%	100%
A4HN48	Leishmania braziliensis	61%	100%
A4IBR6	Leishmania infantum	87%	100%
C9ZYV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B6Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%