Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFJ8_LEIMA

TriTrypDb:

LmjF.35.3740 , LMJLV39_350045000 , LMJSD75_350044400

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	260	262	PF00675	0.543
CLV_NRD_NRD_1	288	290	PF00675	0.579
CLV_NRD_NRD_1	77	79	PF00675	0.477
CLV_NRD_NRD_1	88	90	PF00675	0.492
CLV_NRD_NRD_1	92	94	PF00675	0.528
CLV_NRD_NRD_1	95	97	PF00675	0.466
CLV_PCSK_FUR_1	89	93	PF00082	0.541
CLV_PCSK_KEX2_1	260	262	PF00082	0.541
CLV_PCSK_KEX2_1	288	290	PF00082	0.486
CLV_PCSK_KEX2_1	76	78	PF00082	0.479
CLV_PCSK_KEX2_1	88	90	PF00082	0.459
CLV_PCSK_KEX2_1	91	93	PF00082	0.480
CLV_PCSK_KEX2_1	95	97	PF00082	0.415
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.522
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.386
CLV_PCSK_PC7_1	284	290	PF00082	0.602
CLV_PCSK_PC7_1	88	94	PF00082	0.551
CLV_PCSK_SKI1_1	78	82	PF00082	0.490
CLV_PCSK_SKI1_1	96	100	PF00082	0.437
DEG_APCC_DBOX_1	260	268	PF00400	0.525
DEG_SCF_FBW7_1	56	63	PF00400	0.642
DEG_SCF_FBW7_2	337	342	PF00400	0.569
DEG_SPOP_SBC_1	22	26	PF00917	0.470
DOC_CDC14_PxL_1	192	200	PF14671	0.466
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.522
DOC_PP1_RVXF_1	186	193	PF00149	0.386
DOC_PP2B_LxvP_1	245	248	PF13499	0.532
DOC_PP2B_LxvP_1	358	361	PF13499	0.471
DOC_PP4_FxxP_1	172	175	PF00568	0.421
DOC_PP4_FxxP_1	376	379	PF00568	0.420
DOC_USP7_MATH_1	221	225	PF00917	0.697
DOC_USP7_MATH_1	306	310	PF00917	0.677
DOC_USP7_MATH_1	35	39	PF00917	0.512
DOC_USP7_UBL2_3	57	61	PF12436	0.608
DOC_WW_Pin1_4	238	243	PF00397	0.460
DOC_WW_Pin1_4	308	313	PF00397	0.639
DOC_WW_Pin1_4	335	340	PF00397	0.539
DOC_WW_Pin1_4	375	380	PF00397	0.446
DOC_WW_Pin1_4	56	61	PF00397	0.640
LIG_14-3-3_CanoR_1	132	142	PF00244	0.565
LIG_14-3-3_CanoR_1	253	259	PF00244	0.490
LIG_14-3-3_CanoR_1	365	371	PF00244	0.495
LIG_14-3-3_CanoR_1	42	47	PF00244	0.560
LIG_Actin_WH2_2	103	119	PF00022	0.417
LIG_APCC_ABBAyCdc20_2	188	194	PF00400	0.381
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_BIR_III_1	1	5	PF00653	0.461
LIG_BIR_III_3	1	5	PF00653	0.461
LIG_deltaCOP1_diTrp_1	270	276	PF00928	0.613
LIG_DLG_GKlike_1	42	49	PF00625	0.615
LIG_FHA_1	133	139	PF00498	0.541
LIG_FHA_1	319	325	PF00498	0.453
LIG_FHA_1	61	67	PF00498	0.642
LIG_FHA_2	367	373	PF00498	0.527
LIG_HCF-1_HBM_1	13	16	PF13415	0.472
LIG_Integrin_isoDGR_2	103	105	PF01839	0.517
LIG_LIR_Apic_2	170	175	PF02991	0.444
LIG_LIR_Apic_2	200	205	PF02991	0.450
LIG_LIR_Apic_2	373	379	PF02991	0.421
LIG_LIR_Gen_1	13	23	PF02991	0.431
LIG_LIR_Gen_1	45	52	PF02991	0.568
LIG_LIR_Nem_3	13	19	PF02991	0.422
LIG_LIR_Nem_3	270	276	PF02991	0.598
LIG_LIR_Nem_3	40	46	PF02991	0.542
LIG_PCNA_PIPBox_1	67	76	PF02747	0.541
LIG_PCNA_yPIPBox_3	152	166	PF02747	0.472
LIG_SH2_CRK	16	20	PF00017	0.395
LIG_SH2_CRK	202	206	PF00017	0.439
LIG_SH2_CRK	208	212	PF00017	0.411
LIG_SH2_NCK_1	16	20	PF00017	0.500
LIG_SH2_SRC	16	19	PF00017	0.516
LIG_SH2_SRC	263	266	PF00017	0.579
LIG_SH2_STAT5	240	243	PF00017	0.468
LIG_SH2_STAT5	263	266	PF00017	0.455
LIG_SH2_STAT5	79	82	PF00017	0.485
LIG_SH3_3	183	189	PF00018	0.436
LIG_SH3_3	272	278	PF00018	0.522
LIG_SH3_3	294	300	PF00018	0.441
LIG_SH3_3	309	315	PF00018	0.658
LIG_SH3_3	321	327	PF00018	0.294
LIG_SH3_3	377	383	PF00018	0.391
LIG_SH3_4	174	181	PF00018	0.518
LIG_SUMO_SIM_anti_2	321	326	PF11976	0.418
LIG_SUMO_SIM_par_1	320	326	PF11976	0.425
LIG_TYR_ITIM	206	211	PF00017	0.543
LIG_UBA3_1	70	76	PF00899	0.629
LIG_WRC_WIRS_1	43	48	PF05994	0.614
LIG_WRPW_2	273	276	PF00400	0.658
LIG_WW_1	383	386	PF00397	0.439
MOD_CDK_SPK_2	56	61	PF00069	0.640
MOD_CK2_1	23	29	PF00069	0.477
MOD_CK2_1	366	372	PF00069	0.449
MOD_GlcNHglycan	32	35	PF01048	0.519
MOD_GSK3_1	128	135	PF00069	0.577
MOD_GSK3_1	236	243	PF00069	0.477
MOD_GSK3_1	51	58	PF00069	0.571
MOD_N-GLC_1	335	340	PF02516	0.418
MOD_NEK2_1	23	28	PF00069	0.547
MOD_NEK2_1	252	257	PF00069	0.452
MOD_NEK2_1	292	297	PF00069	0.448
MOD_NEK2_1	36	41	PF00069	0.445
MOD_NEK2_1	55	60	PF00069	0.677
MOD_NEK2_2	134	139	PF00069	0.514
MOD_NEK2_2	263	268	PF00069	0.577
MOD_PIKK_1	174	180	PF00454	0.515
MOD_PIKK_1	252	258	PF00454	0.469
MOD_PKA_2	116	122	PF00069	0.491
MOD_PKA_2	221	227	PF00069	0.667
MOD_PKA_2	252	258	PF00069	0.488
MOD_Plk_1	228	234	PF00069	0.585
MOD_Plk_1	292	298	PF00069	0.448
MOD_Plk_4	23	29	PF00069	0.451
MOD_Plk_4	231	237	PF00069	0.376
MOD_Plk_4	292	298	PF00069	0.448
MOD_Plk_4	318	324	PF00069	0.396
MOD_Plk_4	359	365	PF00069	0.408
MOD_Plk_4	51	57	PF00069	0.542
MOD_ProDKin_1	238	244	PF00069	0.467
MOD_ProDKin_1	308	314	PF00069	0.630
MOD_ProDKin_1	335	341	PF00069	0.540
MOD_ProDKin_1	375	381	PF00069	0.439
MOD_ProDKin_1	56	62	PF00069	0.642
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.493
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.488
TRG_ENDOCYTIC_2	16	19	PF00928	0.375
TRG_ENDOCYTIC_2	208	211	PF00928	0.543
TRG_ENDOCYTIC_2	84	87	PF00928	0.595
TRG_ER_diArg_1	259	261	PF00400	0.525
TRG_ER_diArg_1	287	289	PF00400	0.602
TRG_ER_diArg_1	77	79	PF00400	0.527
TRG_ER_diArg_1	87	89	PF00400	0.503
TRG_ER_diArg_1	92	95	PF00400	0.489
TRG_NLS_Bipartite_1	76	95	PF00514	0.529
TRG_NLS_MonoExtC_3	90	95	PF00514	0.582
TRG_NLS_MonoExtN_4	88	95	PF00514	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF2	Leptomonas seymouri	70%	100%
A0A0S4J0E9	Bodo saltans	31%	96%
A0A1X0P564	Trypanosomatidae	46%	100%
A0A3Q8IJC4	Leishmania donovani	97%	100%
A0A3R7R9I8	Trypanosoma rangeli	47%	100%
A4HN45	Leishmania braziliensis	87%	100%
A4IBR3	Leishmania infantum	96%	100%
C9ZYW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B6Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BCU7	Trypanosoma cruzi	47%	100%