ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFJ7_LEIMA

TriTrypDb:

LmjF.35.3730 , LMJLV39_350044900 , LMJSD75_350044300

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFJ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.599
CLV_NRD_NRD_1	164	166	PF00675	0.548
CLV_NRD_NRD_1	171	173	PF00675	0.549
CLV_NRD_NRD_1	23	25	PF00675	0.544
CLV_NRD_NRD_1	254	256	PF00675	0.553
CLV_NRD_NRD_1	282	284	PF00675	0.593
CLV_NRD_NRD_1	3	5	PF00675	0.504
CLV_NRD_NRD_1	400	402	PF00675	0.505
CLV_NRD_NRD_1	423	425	PF00675	0.420
CLV_NRD_NRD_1	437	439	PF00675	0.477
CLV_NRD_NRD_1	52	54	PF00675	0.443
CLV_PCSK_FUR_1	252	256	PF00082	0.625
CLV_PCSK_FUR_1	280	284	PF00082	0.479
CLV_PCSK_KEX2_1	131	133	PF00082	0.631
CLV_PCSK_KEX2_1	164	166	PF00082	0.540
CLV_PCSK_KEX2_1	171	173	PF00082	0.569
CLV_PCSK_KEX2_1	254	256	PF00082	0.568
CLV_PCSK_KEX2_1	282	284	PF00082	0.593
CLV_PCSK_KEX2_1	286	288	PF00082	0.498
CLV_PCSK_KEX2_1	3	5	PF00082	0.504
CLV_PCSK_KEX2_1	400	402	PF00082	0.505
CLV_PCSK_KEX2_1	423	425	PF00082	0.412
CLV_PCSK_KEX2_1	436	438	PF00082	0.485
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.454
CLV_PCSK_PC7_1	127	133	PF00082	0.654
CLV_PCSK_PC7_1	250	256	PF00082	0.621
CLV_PCSK_PC7_1	282	288	PF00082	0.353
CLV_PCSK_SKI1_1	127	131	PF00082	0.643
CLV_PCSK_SKI1_1	132	136	PF00082	0.662
CLV_PCSK_SKI1_1	172	176	PF00082	0.583
CLV_PCSK_SKI1_1	221	225	PF00082	0.608
CLV_PCSK_SKI1_1	24	28	PF00082	0.596
CLV_PCSK_SKI1_1	287	291	PF00082	0.353
CLV_PCSK_SKI1_1	316	320	PF00082	0.488
CLV_PCSK_SKI1_1	347	351	PF00082	0.512
CLV_PCSK_SKI1_1	35	39	PF00082	0.447
CLV_PCSK_SKI1_1	448	452	PF00082	0.553
CLV_PCSK_SKI1_1	62	66	PF00082	0.606
CLV_PCSK_SKI1_1	70	74	PF00082	0.646
DEG_APCC_DBOX_1	126	134	PF00400	0.638
DEG_APCC_DBOX_1	23	31	PF00400	0.591
DEG_APCC_DBOX_1	257	265	PF00400	0.615
DEG_Nend_UBRbox_3	1	3	PF02207	0.627
DOC_CYCLIN_RxL_1	280	291	PF00134	0.593
DOC_MAPK_gen_1	280	290	PF00069	0.511
DOC_MAPK_gen_1	3	9	PF00069	0.579
DOC_MAPK_gen_1	320	330	PF00069	0.541
DOC_MAPK_gen_1	452	461	PF00069	0.687
DOC_MAPK_MEF2A_6	208	215	PF00069	0.629
DOC_MAPK_MEF2A_6	323	330	PF00069	0.606
DOC_MAPK_MEF2A_6	454	463	PF00069	0.703
DOC_PP1_RVXF_1	411	417	PF00149	0.608
DOC_USP7_MATH_1	111	115	PF00917	0.677
DOC_USP7_MATH_1	192	196	PF00917	0.642
DOC_WW_Pin1_4	453	458	PF00397	0.692
LIG_14-3-3_CanoR_1	138	146	PF00244	0.613
LIG_14-3-3_CanoR_1	164	173	PF00244	0.444
LIG_14-3-3_CanoR_1	299	309	PF00244	0.455
LIG_14-3-3_CanoR_1	323	329	PF00244	0.511
LIG_14-3-3_CanoR_1	4	10	PF00244	0.509
LIG_14-3-3_CanoR_1	436	441	PF00244	0.520
LIG_14-3-3_CanoR_1	62	67	PF00244	0.618
LIG_BRCT_BRCA1_1	41	45	PF00533	0.615
LIG_FHA_1	114	120	PF00498	0.689
LIG_FHA_1	325	331	PF00498	0.598
LIG_FHA_1	352	358	PF00498	0.607
LIG_FHA_1	390	396	PF00498	0.626
LIG_FHA_1	9	15	PF00498	0.535
LIG_FHA_2	386	392	PF00498	0.541
LIG_FHA_2	90	96	PF00498	0.672
LIG_LIR_Nem_3	245	249	PF02991	0.555
LIG_LIR_Nem_3	32	37	PF02991	0.640
LIG_PDZ_Class_2	458	463	PF00595	0.707
LIG_Pex14_1	60	64	PF04695	0.608
LIG_RPA_C_Fungi	227	239	PF08784	0.612
LIG_SH2_SRC	265	268	PF00017	0.598
LIG_SH2_STAP1	265	269	PF00017	0.578
LIG_SH2_STAT3	154	157	PF00017	0.616
LIG_SH2_STAT5	154	157	PF00017	0.595
LIG_SH2_STAT5	384	387	PF00017	0.640
LIG_SH3_3	439	445	PF00018	0.657
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.651
MOD_CK1_1	324	330	PF00069	0.590
MOD_CK1_1	8	14	PF00069	0.556
MOD_CK2_1	177	183	PF00069	0.642
MOD_CK2_1	385	391	PF00069	0.519
MOD_CK2_1	89	95	PF00069	0.673
MOD_GlcNHglycan	113	116	PF01048	0.686
MOD_GlcNHglycan	199	202	PF01048	0.703
MOD_GlcNHglycan	228	231	PF01048	0.616
MOD_GSK3_1	111	118	PF00069	0.676
MOD_GSK3_1	324	331	PF00069	0.619
MOD_GSK3_1	385	392	PF00069	0.629
MOD_GSK3_1	448	455	PF00069	0.643
MOD_GSK3_1	5	12	PF00069	0.562
MOD_NEK2_1	20	25	PF00069	0.566
MOD_NEK2_1	288	293	PF00069	0.566
MOD_NEK2_1	321	326	PF00069	0.532
MOD_NEK2_1	357	362	PF00069	0.553
MOD_NEK2_1	80	85	PF00069	0.641
MOD_NEK2_1	9	14	PF00069	0.558
MOD_PKA_1	436	442	PF00069	0.513
MOD_PKA_2	324	330	PF00069	0.568
MOD_PKA_2	351	357	PF00069	0.606
MOD_PKA_2	425	431	PF00069	0.531
MOD_PKA_2	436	442	PF00069	0.453
MOD_PKA_2	5	11	PF00069	0.550
MOD_PKB_1	343	351	PF00069	0.367
MOD_Plk_1	345	351	PF00069	0.538
MOD_Plk_4	115	121	PF00069	0.689
MOD_Plk_4	457	463	PF00069	0.704
MOD_Plk_4	5	11	PF00069	0.509
MOD_Plk_4	89	95	PF00069	0.674
MOD_ProDKin_1	453	459	PF00069	0.697
TRG_DiLeu_BaEn_1	102	107	PF01217	0.648
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.634
TRG_ENDOCYTIC_2	265	268	PF00928	0.598
TRG_ER_diArg_1	130	132	PF00400	0.599
TRG_ER_diArg_1	137	140	PF00400	0.563
TRG_ER_diArg_1	164	166	PF00400	0.567
TRG_ER_diArg_1	171	173	PF00400	0.566
TRG_ER_diArg_1	179	182	PF00400	0.641
TRG_ER_diArg_1	249	252	PF00400	0.519
TRG_ER_diArg_1	280	283	PF00400	0.571
TRG_ER_diArg_1	285	288	PF00400	0.495
TRG_ER_diArg_1	3	5	PF00400	0.564
TRG_ER_diArg_1	322	325	PF00400	0.545
TRG_ER_diArg_1	399	401	PF00400	0.522
TRG_ER_diArg_1	411	414	PF00400	0.508
TRG_ER_diArg_1	422	424	PF00400	0.422
TRG_ER_diArg_1	435	438	PF00400	0.477
TRG_ER_diArg_1	84	87	PF00400	0.635
TRG_NLS_MonoExtN_4	282	289	PF00514	0.440
TRG_Pf-PMV_PEXEL_1	171	176	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	438	443	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	448	453	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IQ74	Bodo saltans	26%	72%
A0A1X0P570	Trypanosomatidae	26%	82%
A0A3Q8IJQ1	Leishmania donovani	91%	100%
A0A422MYK4	Trypanosoma rangeli	28%	78%
A4IBR2	Leishmania infantum	90%	100%
C9ZYW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	69%
V5DUN3	Trypanosoma cruzi	28%	78%