Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFJ5_LEIMA

TriTrypDb:

LmjF.35.3710 , LMJLV39_350044700 , LMJSD75_350044100

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AFJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFJ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.496
CLV_NRD_NRD_1	129	131	PF00675	0.609
CLV_NRD_NRD_1	77	79	PF00675	0.670
CLV_PCSK_FUR_1	75	79	PF00082	0.599
CLV_PCSK_KEX2_1	129	131	PF00082	0.586
CLV_PCSK_KEX2_1	77	79	PF00082	0.707
CLV_PCSK_SKI1_1	117	121	PF00082	0.671
CLV_PCSK_SKI1_1	205	209	PF00082	0.390
CLV_PCSK_SKI1_1	274	278	PF00082	0.567
CLV_PCSK_SKI1_1	282	286	PF00082	0.353
DEG_MDM2_SWIB_1	235	243	PF02201	0.587
DEG_SCF_TRCP1_1	59	65	PF00400	0.491
DOC_ANK_TNKS_1	76	83	PF00023	0.448
DOC_CKS1_1	275	280	PF01111	0.388
DOC_MAPK_gen_1	139	147	PF00069	0.402
DOC_PP1_RVXF_1	144	150	PF00149	0.358
DOC_USP7_MATH_1	115	119	PF00917	0.440
DOC_USP7_MATH_1	21	25	PF00917	0.551
DOC_USP7_MATH_1	267	271	PF00917	0.211
DOC_USP7_MATH_1	322	326	PF00917	0.732
DOC_USP7_MATH_1	331	335	PF00917	0.601
DOC_USP7_UBL2_3	189	193	PF12436	0.520
DOC_WW_Pin1_4	17	22	PF00397	0.527
DOC_WW_Pin1_4	242	247	PF00397	0.596
DOC_WW_Pin1_4	274	279	PF00397	0.376
LIG_14-3-3_CanoR_1	166	175	PF00244	0.289
LIG_14-3-3_CanoR_1	282	288	PF00244	0.493
LIG_14-3-3_CanoR_1	83	88	PF00244	0.475
LIG_BIR_III_2	330	334	PF00653	0.643
LIG_BIR_III_4	26	30	PF00653	0.547
LIG_BRCT_BRCA1_1	200	204	PF00533	0.518
LIG_deltaCOP1_diTrp_1	317	323	PF00928	0.576
LIG_FHA_1	178	184	PF00498	0.614
LIG_FHA_1	206	212	PF00498	0.533
LIG_FHA_1	310	316	PF00498	0.601
LIG_FHA_1	84	90	PF00498	0.418
LIG_FHA_2	49	55	PF00498	0.522
LIG_LIR_Apic_2	317	322	PF02991	0.567
LIG_LIR_Gen_1	188	199	PF02991	0.523
LIG_LIR_Gen_1	232	243	PF02991	0.626
LIG_LIR_Gen_1	249	258	PF02991	0.374
LIG_LIR_Gen_1	43	50	PF02991	0.436
LIG_LIR_Gen_1	65	73	PF02991	0.435
LIG_LIR_Nem_3	188	194	PF02991	0.526
LIG_LIR_Nem_3	201	207	PF02991	0.504
LIG_LIR_Nem_3	232	238	PF02991	0.599
LIG_LIR_Nem_3	249	254	PF02991	0.419
LIG_LIR_Nem_3	270	276	PF02991	0.440
LIG_LIR_Nem_3	3	7	PF02991	0.472
LIG_LIR_Nem_3	43	49	PF02991	0.522
LIG_NRBOX	233	239	PF00104	0.541
LIG_Pex14_2	235	239	PF04695	0.574
LIG_Pex14_2	99	103	PF04695	0.430
LIG_SH2_CRK	191	195	PF00017	0.555
LIG_SH2_CRK	273	277	PF00017	0.357
LIG_SH2_GRB2like	125	128	PF00017	0.393
LIG_SH2_SRC	123	126	PF00017	0.453
LIG_SH2_STAT3	307	310	PF00017	0.568
LIG_SH2_STAT5	163	166	PF00017	0.270
LIG_SH2_STAT5	182	185	PF00017	0.517
LIG_SH2_STAT5	268	271	PF00017	0.404
LIG_SH2_STAT5	298	301	PF00017	0.401
LIG_SH3_3	240	246	PF00018	0.602
LIG_SUMO_SIM_par_1	283	289	PF11976	0.366
LIG_WRC_WIRS_1	268	273	PF05994	0.278
LIG_WRPW_2	304	307	PF00400	0.544
LIG_WRPW_2	320	323	PF00400	0.558
MOD_CDC14_SPxK_1	245	248	PF00782	0.578
MOD_CDK_SPxK_1	242	248	PF00069	0.588
MOD_CK1_1	22	28	PF00069	0.537
MOD_CK1_1	257	263	PF00069	0.335
MOD_CK1_1	286	292	PF00069	0.368
MOD_CK2_1	94	100	PF00069	0.345
MOD_CMANNOS	149	152	PF00535	0.526
MOD_CMANNOS	320	323	PF00535	0.376
MOD_GlcNHglycan	239	242	PF01048	0.429
MOD_GlcNHglycan	259	262	PF01048	0.223
MOD_GlcNHglycan	290	293	PF01048	0.483
MOD_GlcNHglycan	59	62	PF01048	0.723
MOD_GSK3_1	17	24	PF00069	0.529
MOD_GSK3_1	183	190	PF00069	0.612
MOD_GSK3_1	237	244	PF00069	0.611
MOD_GSK3_1	253	260	PF00069	0.424
MOD_GSK3_1	36	43	PF00069	0.347
MOD_N-GLC_1	254	259	PF02516	0.335
MOD_NEK2_1	187	192	PF00069	0.568
MOD_NEK2_1	219	224	PF00069	0.594
MOD_NEK2_1	254	259	PF00069	0.435
MOD_NEK2_1	285	290	PF00069	0.426
MOD_NEK2_1	36	41	PF00069	0.565
MOD_NEK2_1	94	99	PF00069	0.502
MOD_PIKK_1	62	68	PF00454	0.494
MOD_PKA_2	82	88	PF00069	0.497
MOD_Plk_1	187	193	PF00069	0.593
MOD_Plk_1	254	260	PF00069	0.339
MOD_Plk_2-3	42	48	PF00069	0.464
MOD_Plk_2-3	88	94	PF00069	0.422
MOD_ProDKin_1	17	23	PF00069	0.525
MOD_ProDKin_1	242	248	PF00069	0.588
MOD_ProDKin_1	274	280	PF00069	0.372
MOD_SUMO_rev_2	25	35	PF00179	0.496
TRG_ENDOCYTIC_2	184	187	PF00928	0.513
TRG_ENDOCYTIC_2	191	194	PF00928	0.524
TRG_ENDOCYTIC_2	268	271	PF00928	0.404
TRG_ENDOCYTIC_2	273	276	PF00928	0.408
TRG_ENDOCYTIC_2	64	67	PF00928	0.452
TRG_ER_diArg_1	129	131	PF00400	0.403
TRG_ER_diArg_1	336	339	PF00400	0.558
TRG_ER_diArg_1	75	78	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB50	Leptomonas seymouri	59%	99%
A0A1X0P6A1	Trypanosomatidae	41%	100%
A0A3S7X9N6	Leishmania donovani	99%	100%
A0A422MTB0	Trypanosoma rangeli	41%	100%
A4HN42	Leishmania braziliensis	86%	100%
A4IBR0	Leishmania infantum	99%	100%
C9ZYW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B6P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5C2T1	Trypanosoma cruzi	41%	100%