Glycosomal membrane protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gim5A protein, putative

Species:

Leishmania major

UniProt:

E9AFJ4_LEIMA

TriTrypDb:

LmjF.35.3700 , LMJLV39_350044600 , LMJSD75_350044000

Length:

225

Annotations

LeishMANIAdb annotations

Publication identifier(s): 11260462
A known glcosomal (peroxisomal) kinetoplastid protein. Known to be a dimeric, essential component of glycosomes (PMID: 11260462). Localization: Peroxisomal (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

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Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0016020	membrane	2	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	4

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Expansion

Sequence features

E9AFJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFJ4

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	17
GO:0009987	cellular process	1	17
GO:0016043	cellular component organization	3	17
GO:0016559	peroxisome fission	6	17
GO:0048285	organelle fission	5	17
GO:0071840	cellular component organization or biogenesis	2	17

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	50	54	PF00656	0.340
CLV_PCSK_KEX2_1	155	157	PF00082	0.369
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.336
CLV_PCSK_SKI1_1	212	216	PF00082	0.539
CLV_PCSK_SKI1_1	43	47	PF00082	0.560
CLV_PCSK_SKI1_1	56	60	PF00082	0.530
DEG_APCC_DBOX_1	211	219	PF00400	0.377
DOC_CYCLIN_RxL_1	200	210	PF00134	0.435
DOC_MAPK_gen_1	15	24	PF00069	0.351
DOC_MAPK_gen_1	78	85	PF00069	0.340

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJQ7	Leptomonas seymouri	76%	100%
A0A1X0P585	Trypanosomatidae	25%	91%
A0A1X0P5I2	Trypanosomatidae	53%	91%
A0A3Q8IVG4	Leishmania donovani	99%	100%
A0A3R7K892	Trypanosoma rangeli	23%	91%
A0A3R7MWK0	Trypanosoma rangeli	51%	92%
A0A3S7X9W6	Leishmania donovani	26%	89%
A4HN40	Leishmania braziliensis	26%	89%
A4HN41	Leishmania braziliensis	92%	100%
A4IBQ8	Leishmania infantum	26%	89%

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