LeishMANIAdb
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Glycosomal membrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glycosomal membrane protein
Gene product:
Gim5A protein, putative
Species:
Leishmania major
UniProt:
E9AFJ4_LEIMA
TriTrypDb:
LmjF.35.3700 , LMJLV39_350044600 , LMJSD75_350044000
Length:
225

Annotations

LeishMANIAdb annotations

Publication identifier(s): 11260462
A known glcosomal (peroxisomal) kinetoplastid protein. Known to be a dimeric, essential component of glycosomes (PMID: 11260462). Localization: Peroxisomal (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 2
GO:0020015 glycosome 7 2
GO:0042579 microbody 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 4
GO:0016020 membrane 2 2

Expansion

Sequence features

E9AFJ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFJ4

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 17
GO:0009987 cellular process 1 17
GO:0016043 cellular component organization 3 17
GO:0016559 peroxisome fission 6 17
GO:0048285 organelle fission 5 17
GO:0071840 cellular component organization or biogenesis 2 17
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 50 54 PF00656 0.340
CLV_PCSK_KEX2_1 155 157 PF00082 0.369
CLV_PCSK_PC1ET2_1 155 157 PF00082 0.336
CLV_PCSK_SKI1_1 212 216 PF00082 0.539
CLV_PCSK_SKI1_1 43 47 PF00082 0.560
CLV_PCSK_SKI1_1 56 60 PF00082 0.530
DEG_APCC_DBOX_1 211 219 PF00400 0.377
DOC_CYCLIN_RxL_1 200 210 PF00134 0.435
DOC_MAPK_gen_1 15 24 PF00069 0.351
DOC_MAPK_gen_1 78 85 PF00069 0.340
DOC_MAPK_MEF2A_6 56 65 PF00069 0.327
DOC_MAPK_RevD_3 133 147 PF00069 0.270
DOC_PP2B_LxvP_1 199 202 PF13499 0.498
DOC_WW_Pin1_4 147 152 PF00397 0.591
LIG_14-3-3_CanoR_1 156 164 PF00244 0.615
LIG_BIR_II_1 1 5 PF00653 0.441
LIG_BRCT_BRCA1_1 91 95 PF00533 0.354
LIG_FHA_1 103 109 PF00498 0.354
LIG_FHA_1 130 136 PF00498 0.362
LIG_FHA_1 159 165 PF00498 0.490
LIG_FHA_1 194 200 PF00498 0.466
LIG_FHA_2 148 154 PF00498 0.625
LIG_LIR_Nem_3 127 133 PF02991 0.503
LIG_LIR_Nem_3 53 58 PF02991 0.325
LIG_LIR_Nem_3 92 97 PF02991 0.459
LIG_MLH1_MIPbox_1 91 95 PF16413 0.340
LIG_PALB2_WD40_1 125 133 PF16756 0.450
LIG_PCNA_yPIPBox_3 203 215 PF02747 0.425
LIG_Pex14_2 95 99 PF04695 0.362
LIG_SH2_CRK 131 135 PF00017 0.330
LIG_SH2_CRK 55 59 PF00017 0.343
LIG_SH2_STAP1 131 135 PF00017 0.365
LIG_SH2_STAT5 131 134 PF00017 0.382
LIG_SH2_STAT5 142 145 PF00017 0.589
LIG_SH2_STAT5 8 11 PF00017 0.361
LIG_SH3_3 183 189 PF00018 0.450
LIG_SUMO_SIM_anti_2 59 65 PF11976 0.318
LIG_TRAF2_1 150 153 PF00917 0.561
LIG_UBA3_1 168 177 PF00899 0.348
LIG_UBA3_1 64 70 PF00899 0.362
MOD_CK1_1 44 50 PF00069 0.397
MOD_CK1_1 69 75 PF00069 0.331
MOD_CK2_1 147 153 PF00069 0.632
MOD_GlcNHglycan 1 4 PF01048 0.649
MOD_GlcNHglycan 184 189 PF01048 0.681
MOD_GSK3_1 102 109 PF00069 0.462
MOD_GSK3_1 37 44 PF00069 0.326
MOD_N-GLC_1 207 212 PF02516 0.639
MOD_NEK2_1 102 107 PF00069 0.384
MOD_NEK2_1 158 163 PF00069 0.421
MOD_NEK2_1 168 173 PF00069 0.376
MOD_NEK2_1 193 198 PF00069 0.413
MOD_NEK2_1 207 212 PF00069 0.364
MOD_NEK2_1 217 222 PF00069 0.393
MOD_NEK2_1 41 46 PF00069 0.316
MOD_Plk_1 102 108 PF00069 0.326
MOD_Plk_1 207 213 PF00069 0.465
MOD_Plk_4 129 135 PF00069 0.370
MOD_ProDKin_1 147 153 PF00069 0.591
TRG_ENDOCYTIC_2 131 134 PF00928 0.364
TRG_ENDOCYTIC_2 55 58 PF00928 0.343

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJQ7 Leptomonas seymouri 76% 100%
A0A1X0P585 Trypanosomatidae 25% 91%
A0A1X0P5I2 Trypanosomatidae 53% 91%
A0A3Q8IVG4 Leishmania donovani 99% 100%
A0A3R7K892 Trypanosoma rangeli 23% 91%
A0A3R7MWK0 Trypanosoma rangeli 51% 92%
A0A3S7X9W6 Leishmania donovani 26% 89%
A4HN40 Leishmania braziliensis 26% 89%
A4HN41 Leishmania braziliensis 92% 100%
A4IBQ8 Leishmania infantum 26% 89%
A4IBQ9 Leishmania infantum 99% 100%
C9ZYW5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 93%
C9ZYW6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 93%
E9AFJ3 Leishmania major 27% 100%
E9B6P7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 89%
E9B6P8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BTC6 Trypanosoma cruzi 54% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS