LeishMANIAdb
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Peroxisomal membrane protein PMP34

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Peroxisomal membrane protein PMP34
Gene product:
Peroxisomal biogenesis factor 11 (PEX11), putative
Species:
Leishmania major
UniProt:
E9AFJ3_LEIMA
TriTrypDb:
LmjF.35.3690 , LMJLV39_350044500 , LMJSD75_350043900
Length:
253

Annotations

LeishMANIAdb annotations

Publication identifier(s): 11260462
A known glcosomal (peroxisomal) kinetoplastid protein. Known to be a dimeric, essential component of glycosomes (PMID: 11260462). Localization: Peroxisomal (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 20
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 3
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9AFJ3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFJ3

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 18
GO:0009987 cellular process 1 18
GO:0016043 cellular component organization 3 18
GO:0016559 peroxisome fission 6 18
GO:0048285 organelle fission 5 18
GO:0071840 cellular component organization or biogenesis 2 18
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 177 179 PF00675 0.295
CLV_PCSK_KEX2_1 131 133 PF00082 0.384
CLV_PCSK_KEX2_1 177 179 PF00082 0.298
CLV_PCSK_PC1ET2_1 131 133 PF00082 0.384
CLV_PCSK_SKI1_1 137 141 PF00082 0.413
CLV_PCSK_SKI1_1 178 182 PF00082 0.280
CLV_PCSK_SKI1_1 64 68 PF00082 0.469
DOC_CDC14_PxL_1 73 81 PF14671 0.359
DOC_CKS1_1 232 237 PF01111 0.409
DOC_CYCLIN_yCln2_LP_2 224 230 PF00134 0.348
DOC_CYCLIN_yCln2_LP_2 37 43 PF00134 0.315
DOC_MAPK_gen_1 131 141 PF00069 0.301
DOC_MAPK_gen_1 174 183 PF00069 0.543
DOC_MAPK_gen_1 23 32 PF00069 0.491
DOC_PP1_RVXF_1 133 139 PF00149 0.359
DOC_PP2B_LxvP_1 224 227 PF13499 0.447
DOC_PP2B_LxvP_1 229 232 PF13499 0.465
DOC_PP2B_LxvP_1 37 40 PF13499 0.256
DOC_USP7_MATH_1 211 215 PF00917 0.387
DOC_USP7_MATH_1 87 91 PF00917 0.303
DOC_WW_Pin1_4 231 236 PF00397 0.390
DOC_WW_Pin1_4 77 82 PF00397 0.260
LIG_14-3-3_CanoR_1 148 154 PF00244 0.427
LIG_14-3-3_CanoR_1 25 30 PF00244 0.470
LIG_14-3-3_CanoR_1 68 75 PF00244 0.264
LIG_14-3-3_CanoR_1 9 17 PF00244 0.565
LIG_Actin_WH2_2 142 159 PF00022 0.404
LIG_Actin_WH2_2 184 200 PF00022 0.367
LIG_BRCT_BRCA1_1 102 106 PF00533 0.299
LIG_FHA_1 106 112 PF00498 0.299
LIG_FHA_1 5 11 PF00498 0.557
LIG_LIR_Gen_1 104 112 PF02991 0.357
LIG_LIR_Gen_1 152 161 PF02991 0.572
LIG_LIR_Gen_1 70 79 PF02991 0.230
LIG_LIR_LC3C_4 70 75 PF02991 0.361
LIG_LIR_Nem_3 103 109 PF02991 0.373
LIG_LIR_Nem_3 11 16 PF02991 0.493
LIG_LIR_Nem_3 152 156 PF02991 0.570
LIG_LIR_Nem_3 158 164 PF02991 0.555
LIG_LIR_Nem_3 70 75 PF02991 0.251
LIG_MYND_1 77 81 PF01753 0.349
LIG_PDZ_Class_1 248 253 PF00595 0.425
LIG_Pex14_2 106 110 PF04695 0.309
LIG_Pex14_2 138 142 PF04695 0.397
LIG_SH2_CRK 161 165 PF00017 0.467
LIG_SH2_CRK 194 198 PF00017 0.476
LIG_SH2_CRK 63 67 PF00017 0.282
LIG_SH2_STAT5 153 156 PF00017 0.525
LIG_SH2_STAT5 16 19 PF00017 0.499
LIG_SH2_STAT5 194 197 PF00017 0.441
LIG_SH2_STAT5 207 210 PF00017 0.317
LIG_SH3_3 199 205 PF00018 0.420
LIG_SH3_3 229 235 PF00018 0.431
LIG_SH3_3 71 77 PF00018 0.359
LIG_SUMO_SIM_par_1 227 234 PF11976 0.308
LIG_UBA3_1 94 100 PF00899 0.380
MOD_Cter_Amidation 129 132 PF01082 0.501
MOD_GlcNHglycan 199 202 PF01048 0.672
MOD_GlcNHglycan 208 211 PF01048 0.580
MOD_GlcNHglycan 213 216 PF01048 0.573
MOD_GlcNHglycan 48 52 PF01048 0.511
MOD_GlcNHglycan 81 84 PF01048 0.517
MOD_GlcNHglycan 85 88 PF01048 0.509
MOD_GSK3_1 101 108 PF00069 0.368
MOD_GSK3_1 192 199 PF00069 0.455
MOD_GSK3_1 4 11 PF00069 0.603
MOD_GSK3_1 47 54 PF00069 0.262
MOD_GSK3_1 79 86 PF00069 0.309
MOD_LATS_1 62 68 PF00433 0.268
MOD_N-GLC_1 18 23 PF02516 0.280
MOD_NEK2_1 141 146 PF00069 0.413
MOD_NEK2_1 149 154 PF00069 0.308
MOD_NEK2_1 155 160 PF00069 0.529
MOD_NEK2_1 192 197 PF00069 0.313
MOD_NEK2_1 241 246 PF00069 0.328
MOD_NEK2_1 248 253 PF00069 0.362
MOD_NEK2_2 105 110 PF00069 0.357
MOD_PIKK_1 4 10 PF00454 0.680
MOD_PIKK_1 67 73 PF00454 0.359
MOD_PK_1 25 31 PF00069 0.559
MOD_PKA_2 67 73 PF00069 0.264
MOD_PKA_2 8 14 PF00069 0.659
MOD_PKB_1 23 31 PF00069 0.559
MOD_Plk_4 149 155 PF00069 0.361
MOD_Plk_4 187 193 PF00069 0.341
MOD_Plk_4 25 31 PF00069 0.497
MOD_Plk_4 52 58 PF00069 0.314
MOD_ProDKin_1 231 237 PF00069 0.414
MOD_ProDKin_1 77 83 PF00069 0.260
MOD_SUMO_rev_2 166 173 PF00179 0.481
TRG_DiLeu_BaLyEn_6 224 229 PF01217 0.303
TRG_ENDOCYTIC_2 153 156 PF00928 0.516
TRG_ENDOCYTIC_2 161 164 PF00928 0.481
TRG_ENDOCYTIC_2 194 197 PF00928 0.438
TRG_ENDOCYTIC_2 63 66 PF00928 0.282
TRG_ER_diArg_1 135 138 PF00400 0.359

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4J0 Leptomonas seymouri 71% 100%
A0A0N1IJQ7 Leptomonas seymouri 28% 100%
A0A1X0P585 Trypanosomatidae 28% 100%
A0A1X0P5I2 Trypanosomatidae 29% 100%
A0A3Q8IVG4 Leishmania donovani 27% 100%
A0A3R7K892 Trypanosoma rangeli 27% 100%
A0A3R7MWK0 Trypanosoma rangeli 26% 100%
A0A3S7X9W6 Leishmania donovani 93% 100%
A4HN40 Leishmania braziliensis 82% 100%
A4HN41 Leishmania braziliensis 26% 100%
A4IBQ8 Leishmania infantum 94% 100%
A4IBQ9 Leishmania infantum 27% 100%
C9ZYW5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZYW6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZYW7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
E9AFJ4 Leishmania major 27% 100%
E9B6P7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9B6P8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
V5BTC6 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS