Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFI9_LEIMA

TriTrypDb:

LmjF.35.3650 , LMJLV39_350044000 , LMJSD75_350043500

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.680
CLV_C14_Caspase3-7	237	241	PF00656	0.684
CLV_C14_Caspase3-7	620	624	PF00656	0.705
CLV_C14_Caspase3-7	696	700	PF00656	0.821
CLV_C14_Caspase3-7	754	758	PF00656	0.588
CLV_NRD_NRD_1	316	318	PF00675	0.842
CLV_NRD_NRD_1	362	364	PF00675	0.663
CLV_NRD_NRD_1	511	513	PF00675	0.843
CLV_NRD_NRD_1	606	608	PF00675	0.820
CLV_NRD_NRD_1	621	623	PF00675	0.611
CLV_NRD_NRD_1	648	650	PF00675	0.745
CLV_NRD_NRD_1	739	741	PF00675	0.603
CLV_PCSK_FUR_1	619	623	PF00082	0.653
CLV_PCSK_KEX2_1	316	318	PF00082	0.699
CLV_PCSK_KEX2_1	362	364	PF00082	0.654
CLV_PCSK_KEX2_1	511	513	PF00082	0.843
CLV_PCSK_KEX2_1	606	608	PF00082	0.820
CLV_PCSK_KEX2_1	621	623	PF00082	0.611
CLV_PCSK_KEX2_1	647	649	PF00082	0.759
CLV_PCSK_KEX2_1	842	844	PF00082	0.731
CLV_PCSK_PC1ET2_1	842	844	PF00082	0.731
CLV_PCSK_PC7_1	617	623	PF00082	0.653
CLV_PCSK_PC7_1	643	649	PF00082	0.818
CLV_PCSK_SKI1_1	180	184	PF00082	0.724
CLV_PCSK_SKI1_1	512	516	PF00082	0.837
DEG_APCC_DBOX_1	489	497	PF00400	0.736
DEG_APCC_DBOX_1	85	93	PF00400	0.487
DEG_COP1_1	462	472	PF00400	0.647
DEG_Nend_Nbox_1	1	3	PF02207	0.488
DEG_SPOP_SBC_1	325	329	PF00917	0.675
DEG_SPOP_SBC_1	340	344	PF00917	0.526
DEG_SPOP_SBC_1	474	478	PF00917	0.786
DEG_SPOP_SBC_1	550	554	PF00917	0.819
DOC_CKS1_1	183	188	PF01111	0.798
DOC_CKS1_1	460	465	PF01111	0.597
DOC_CYCLIN_RxL_1	177	188	PF00134	0.729
DOC_CYCLIN_RxL_1	94	105	PF00134	0.585
DOC_CYCLIN_yCln2_LP_2	354	360	PF00134	0.817
DOC_CYCLIN_yCln2_LP_2	684	690	PF00134	0.755
DOC_MAPK_JIP1_4	228	234	PF00069	0.631
DOC_MAPK_MEF2A_6	485	493	PF00069	0.767
DOC_MAPK_MEF2A_6	791	800	PF00069	0.773
DOC_PP1_RVXF_1	178	185	PF00149	0.731
DOC_PP2B_LxvP_1	101	104	PF13499	0.579
DOC_PP2B_LxvP_1	161	164	PF13499	0.643
DOC_PP2B_LxvP_1	354	357	PF13499	0.666
DOC_PP4_FxxP_1	460	463	PF00568	0.596
DOC_PP4_FxxP_1	90	93	PF00568	0.649
DOC_USP7_MATH_1	136	140	PF00917	0.757
DOC_USP7_MATH_1	166	170	PF00917	0.680
DOC_USP7_MATH_1	294	298	PF00917	0.791
DOC_USP7_MATH_1	340	344	PF00917	0.697
DOC_USP7_MATH_1	358	362	PF00917	0.620
DOC_USP7_MATH_1	385	389	PF00917	0.664
DOC_USP7_MATH_1	415	419	PF00917	0.688
DOC_USP7_MATH_1	474	478	PF00917	0.806
DOC_USP7_MATH_1	519	523	PF00917	0.814
DOC_USP7_MATH_1	529	533	PF00917	0.638
DOC_USP7_MATH_1	540	544	PF00917	0.573
DOC_USP7_MATH_1	558	562	PF00917	0.710
DOC_USP7_MATH_1	57	61	PF00917	0.683
DOC_USP7_MATH_1	611	615	PF00917	0.695
DOC_USP7_MATH_1	656	660	PF00917	0.646
DOC_USP7_MATH_1	67	71	PF00917	0.491
DOC_USP7_MATH_1	693	697	PF00917	0.821
DOC_USP7_MATH_1	743	747	PF00917	0.787
DOC_USP7_MATH_1	828	832	PF00917	0.722
DOC_WW_Pin1_4	182	187	PF00397	0.801
DOC_WW_Pin1_4	206	211	PF00397	0.808
DOC_WW_Pin1_4	300	305	PF00397	0.792
DOC_WW_Pin1_4	336	341	PF00397	0.678
DOC_WW_Pin1_4	407	412	PF00397	0.827
DOC_WW_Pin1_4	418	423	PF00397	0.650
DOC_WW_Pin1_4	424	429	PF00397	0.549
DOC_WW_Pin1_4	44	49	PF00397	0.706
DOC_WW_Pin1_4	459	464	PF00397	0.616
DOC_WW_Pin1_4	485	490	PF00397	0.699
DOC_WW_Pin1_4	503	508	PF00397	0.733
DOC_WW_Pin1_4	536	541	PF00397	0.657
DOC_WW_Pin1_4	562	567	PF00397	0.818
DOC_WW_Pin1_4	569	574	PF00397	0.682
DOC_WW_Pin1_4	586	591	PF00397	0.586
DOC_WW_Pin1_4	599	604	PF00397	0.627
DOC_WW_Pin1_4	624	629	PF00397	0.857
DOC_WW_Pin1_4	689	694	PF00397	0.808
LIG_14-3-3_CanoR_1	118	125	PF00244	0.615
LIG_14-3-3_CanoR_1	202	210	PF00244	0.797
LIG_14-3-3_CanoR_1	221	229	PF00244	0.564
LIG_14-3-3_CanoR_1	324	333	PF00244	0.831
LIG_14-3-3_CanoR_1	383	388	PF00244	0.644
LIG_14-3-3_CanoR_1	475	481	PF00244	0.811
LIG_14-3-3_CanoR_1	511	517	PF00244	0.785
LIG_14-3-3_CanoR_1	54	64	PF00244	0.705
LIG_14-3-3_CanoR_1	647	655	PF00244	0.736
LIG_14-3-3_CanoR_1	689	693	PF00244	0.804
LIG_14-3-3_CanoR_1	843	849	PF00244	0.727
LIG_Actin_WH2_2	112	130	PF00022	0.546
LIG_Clathr_ClatBox_1	72	76	PF01394	0.570
LIG_CSL_BTD_1	455	458	PF09270	0.803
LIG_FHA_1	220	226	PF00498	0.627
LIG_FHA_1	269	275	PF00498	0.622
LIG_FHA_1	28	34	PF00498	0.722
LIG_FHA_1	283	289	PF00498	0.582
LIG_FHA_1	326	332	PF00498	0.831
LIG_FHA_1	342	348	PF00498	0.558
LIG_FHA_1	382	388	PF00498	0.668
LIG_FHA_1	393	399	PF00498	0.667
LIG_FHA_1	45	51	PF00498	0.484
LIG_FHA_1	463	469	PF00498	0.799
LIG_FHA_1	477	483	PF00498	0.609
LIG_FHA_1	587	593	PF00498	0.770
LIG_FHA_1	640	646	PF00498	0.778
LIG_FHA_1	819	825	PF00498	0.530
LIG_FHA_1	93	99	PF00498	0.595
LIG_FHA_2	711	717	PF00498	0.691
LIG_FHA_2	830	836	PF00498	0.667
LIG_LIR_Apic_2	88	93	PF02991	0.633
LIG_LIR_Gen_1	10	19	PF02991	0.602
LIG_LIR_Gen_1	708	719	PF02991	0.683
LIG_LIR_Nem_3	110	116	PF02991	0.356
LIG_LIR_Nem_3	38	42	PF02991	0.716
LIG_LIR_Nem_3	542	548	PF02991	0.816
LIG_LIR_Nem_3	708	714	PF02991	0.680
LIG_LIR_Nem_3	806	811	PF02991	0.719
LIG_LIR_Nem_3	95	99	PF02991	0.579
LIG_LYPXL_yS_3	39	42	PF13949	0.716
LIG_MYND_1	590	594	PF01753	0.621
LIG_NRBOX	369	375	PF00104	0.805
LIG_Pex14_1	113	117	PF04695	0.522
LIG_Pex14_1	456	460	PF04695	0.606
LIG_RPA_C_Fungi	610	622	PF08784	0.648
LIG_RPA_C_Fungi	644	656	PF08784	0.762
LIG_SH2_CRK	598	602	PF00017	0.814
LIG_SH2_CRK	66	70	PF00017	0.609
LIG_SH2_CRK	96	100	PF00017	0.577
LIG_SH2_NCK_1	66	70	PF00017	0.609
LIG_SH2_PTP2	709	712	PF00017	0.676
LIG_SH2_SRC	545	548	PF00017	0.821
LIG_SH2_SRC	666	669	PF00017	0.590
LIG_SH2_STAT5	100	103	PF00017	0.572
LIG_SH2_STAT5	26	29	PF00017	0.733
LIG_SH2_STAT5	580	583	PF00017	0.773
LIG_SH2_STAT5	661	664	PF00017	0.794
LIG_SH2_STAT5	709	712	PF00017	0.676
LIG_SH2_STAT5	777	780	PF00017	0.684
LIG_SH2_STAT5	837	840	PF00017	0.716
LIG_SH2_STAT5	844	847	PF00017	0.608
LIG_SH3_2	307	312	PF14604	0.687
LIG_SH3_3	10	16	PF00018	0.661
LIG_SH3_3	183	189	PF00018	0.664
LIG_SH3_3	245	251	PF00018	0.606
LIG_SH3_3	301	307	PF00018	0.710
LIG_SH3_3	330	336	PF00018	0.826
LIG_SH3_3	483	489	PF00018	0.766
LIG_SH3_3	665	671	PF00018	0.635
LIG_SH3_3	687	693	PF00018	0.785
LIG_SH3_3	717	723	PF00018	0.671
LIG_SUMO_SIM_anti_2	794	801	PF11976	0.772
LIG_SUMO_SIM_par_1	70	76	PF11976	0.527
LIG_TYR_ITIM	596	601	PF00017	0.807
LIG_TYR_ITIM	64	69	PF00017	0.571
LIG_WRC_WIRS_1	763	768	PF05994	0.689
LIG_WW_3	303	307	PF00397	0.734
LIG_WW_3	500	504	PF00397	0.818
MOD_CDC14_SPxK_1	303	306	PF00782	0.788
MOD_CDK_SPK_2	418	423	PF00069	0.779
MOD_CDK_SPK_2	485	490	PF00069	0.611
MOD_CDK_SPK_2	590	595	PF00069	0.776
MOD_CDK_SPK_2	689	694	PF00069	0.808
MOD_CDK_SPxK_1	300	306	PF00069	0.794
MOD_CDK_SPxxK_3	418	425	PF00069	0.628
MOD_CDK_SPxxK_3	562	569	PF00069	0.819
MOD_CDK_SPxxK_3	599	606	PF00069	0.808
MOD_CK1_1	17	23	PF00069	0.673
MOD_CK1_1	173	179	PF00069	0.610
MOD_CK1_1	188	194	PF00069	0.707
MOD_CK1_1	206	212	PF00069	0.561
MOD_CK1_1	25	31	PF00069	0.680
MOD_CK1_1	272	278	PF00069	0.615
MOD_CK1_1	297	303	PF00069	0.816
MOD_CK1_1	329	335	PF00069	0.772
MOD_CK1_1	339	345	PF00069	0.685
MOD_CK1_1	386	392	PF00069	0.729
MOD_CK1_1	394	400	PF00069	0.644
MOD_CK1_1	410	416	PF00069	0.678
MOD_CK1_1	418	424	PF00069	0.698
MOD_CK1_1	539	545	PF00069	0.799
MOD_CK1_1	55	61	PF00069	0.711
MOD_CK1_1	561	567	PF00069	0.820
MOD_CK1_1	572	578	PF00069	0.599
MOD_CK1_1	624	630	PF00069	0.855
MOD_CK1_1	651	657	PF00069	0.808
MOD_CK1_1	692	698	PF00069	0.668
MOD_CK2_1	208	214	PF00069	0.820
MOD_CK2_1	418	424	PF00069	0.750
MOD_CK2_1	540	546	PF00069	0.759
MOD_CK2_1	68	74	PF00069	0.536
MOD_CK2_1	710	716	PF00069	0.686
MOD_CK2_1	829	835	PF00069	0.669
MOD_Cter_Amidation	314	317	PF01082	0.847
MOD_Cter_Amidation	645	648	PF01082	0.812
MOD_DYRK1A_RPxSP_1	485	489	PF00069	0.608
MOD_DYRK1A_RPxSP_1	689	693	PF00069	0.804
MOD_GlcNHglycan	104	107	PF01048	0.573
MOD_GlcNHglycan	145	148	PF01048	0.729
MOD_GlcNHglycan	171	175	PF01048	0.616
MOD_GlcNHglycan	210	213	PF01048	0.822
MOD_GlcNHglycan	251	254	PF01048	0.634
MOD_GlcNHglycan	279	282	PF01048	0.670
MOD_GlcNHglycan	296	299	PF01048	0.576
MOD_GlcNHglycan	313	316	PF01048	0.609
MOD_GlcNHglycan	328	331	PF01048	0.592
MOD_GlcNHglycan	349	352	PF01048	0.797
MOD_GlcNHglycan	375	378	PF01048	0.702
MOD_GlcNHglycan	398	401	PF01048	0.638
MOD_GlcNHglycan	417	420	PF01048	0.683
MOD_GlcNHglycan	438	441	PF01048	0.825
MOD_GlcNHglycan	450	453	PF01048	0.615
MOD_GlcNHglycan	542	545	PF01048	0.768
MOD_GlcNHglycan	55	58	PF01048	0.715
MOD_GlcNHglycan	560	563	PF01048	0.579
MOD_GlcNHglycan	574	577	PF01048	0.549
MOD_GlcNHglycan	59	62	PF01048	0.658
MOD_GlcNHglycan	623	626	PF01048	0.863
MOD_GlcNHglycan	629	632	PF01048	0.749
MOD_GlcNHglycan	744	748	PF01048	0.784
MOD_GlcNHglycan	753	756	PF01048	0.657
MOD_GSK3_1	166	173	PF00069	0.743
MOD_GSK3_1	184	191	PF00069	0.570
MOD_GSK3_1	215	222	PF00069	0.688
MOD_GSK3_1	22	29	PF00069	0.727
MOD_GSK3_1	234	241	PF00069	0.666
MOD_GSK3_1	266	273	PF00069	0.799
MOD_GSK3_1	294	301	PF00069	0.806
MOD_GSK3_1	325	332	PF00069	0.765
MOD_GSK3_1	336	343	PF00069	0.675
MOD_GSK3_1	375	382	PF00069	0.691
MOD_GSK3_1	388	395	PF00069	0.608
MOD_GSK3_1	432	439	PF00069	0.634
MOD_GSK3_1	49	56	PF00069	0.694
MOD_GSK3_1	503	510	PF00069	0.845
MOD_GSK3_1	530	537	PF00069	0.741
MOD_GSK3_1	549	556	PF00069	0.561
MOD_GSK3_1	558	565	PF00069	0.677
MOD_GSK3_1	586	593	PF00069	0.769
MOD_GSK3_1	611	618	PF00069	0.846
MOD_GSK3_1	688	695	PF00069	0.650
MOD_GSK3_1	751	758	PF00069	0.795
MOD_N-GLC_1	347	352	PF02516	0.817
MOD_N-GLC_1	448	453	PF02516	0.611
MOD_N-GLC_1	829	834	PF02516	0.665
MOD_NEK2_1	127	132	PF00069	0.624
MOD_NEK2_1	157	162	PF00069	0.667
MOD_NEK2_1	205	210	PF00069	0.771
MOD_NEK2_1	22	27	PF00069	0.621
MOD_NEK2_1	220	225	PF00069	0.621
MOD_NEK2_1	234	239	PF00069	0.610
MOD_NEK2_1	331	336	PF00069	0.826
MOD_NEK2_1	373	378	PF00069	0.601
MOD_NEK2_1	436	441	PF00069	0.677
MOD_NEK2_1	448	453	PF00069	0.556
MOD_NEK2_1	641	646	PF00069	0.628
MOD_NEK2_1	826	831	PF00069	0.572
MOD_NEK2_1	9	14	PF00069	0.595
MOD_NEK2_1	99	104	PF00069	0.517
MOD_NEK2_2	844	849	PF00069	0.725
MOD_PIKK_1	166	172	PF00454	0.735
MOD_PIKK_1	17	23	PF00454	0.598
MOD_PIKK_1	203	209	PF00454	0.761
MOD_PIKK_1	220	226	PF00454	0.543
MOD_PIKK_1	476	482	PF00454	0.686
MOD_PIKK_1	816	822	PF00454	0.519
MOD_PK_1	383	389	PF00069	0.675
MOD_PKA_1	621	627	PF00069	0.659
MOD_PKA_1	648	654	PF00069	0.761
MOD_PKA_2	117	123	PF00069	0.498
MOD_PKA_2	127	133	PF00069	0.601
MOD_PKA_2	195	201	PF00069	0.804
MOD_PKA_2	220	226	PF00069	0.827
MOD_PKA_2	323	329	PF00069	0.697
MOD_PKA_2	474	480	PF00069	0.788
MOD_PKA_2	53	59	PF00069	0.713
MOD_PKA_2	621	627	PF00069	0.704
MOD_PKA_2	648	654	PF00069	0.682
MOD_PKA_2	688	694	PF00069	0.799
MOD_PKA_2	787	793	PF00069	0.769
MOD_PKB_1	503	511	PF00069	0.744
MOD_PKB_1	619	627	PF00069	0.857
MOD_PKB_1	647	655	PF00069	0.762
MOD_PKB_1	807	815	PF00069	0.706
MOD_Plk_1	22	28	PF00069	0.572
MOD_Plk_1	550	556	PF00069	0.820
MOD_Plk_1	732	738	PF00069	0.538
MOD_Plk_1	9	15	PF00069	0.623
MOD_Plk_4	157	163	PF00069	0.632
MOD_Plk_4	46	52	PF00069	0.687
MOD_Plk_4	672	678	PF00069	0.783
MOD_Plk_4	68	74	PF00069	0.586
MOD_Plk_4	705	711	PF00069	0.708
MOD_Plk_4	732	738	PF00069	0.538
MOD_ProDKin_1	182	188	PF00069	0.800
MOD_ProDKin_1	206	212	PF00069	0.811
MOD_ProDKin_1	300	306	PF00069	0.794
MOD_ProDKin_1	336	342	PF00069	0.678
MOD_ProDKin_1	407	413	PF00069	0.828
MOD_ProDKin_1	418	424	PF00069	0.649
MOD_ProDKin_1	44	50	PF00069	0.704
MOD_ProDKin_1	459	465	PF00069	0.618
MOD_ProDKin_1	485	491	PF00069	0.702
MOD_ProDKin_1	503	509	PF00069	0.733
MOD_ProDKin_1	536	542	PF00069	0.657
MOD_ProDKin_1	562	568	PF00069	0.818
MOD_ProDKin_1	569	575	PF00069	0.680
MOD_ProDKin_1	586	592	PF00069	0.588
MOD_ProDKin_1	599	605	PF00069	0.626
MOD_ProDKin_1	624	630	PF00069	0.855
MOD_ProDKin_1	689	695	PF00069	0.807
TRG_DiLeu_BaEn_1	794	799	PF01217	0.778
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.787
TRG_DiLeu_BaLyEn_6	793	798	PF01217	0.785
TRG_ENDOCYTIC_2	39	42	PF00928	0.716
TRG_ENDOCYTIC_2	545	548	PF00928	0.821
TRG_ENDOCYTIC_2	598	601	PF00928	0.814
TRG_ENDOCYTIC_2	66	69	PF00928	0.607
TRG_ENDOCYTIC_2	709	712	PF00928	0.676
TRG_ENDOCYTIC_2	96	99	PF00928	0.572
TRG_ER_diArg_1	362	364	PF00400	0.659
TRG_ER_diArg_1	502	505	PF00400	0.687
TRG_ER_diArg_1	605	607	PF00400	0.814
TRG_ER_diArg_1	647	649	PF00400	0.709
TRG_ER_diArg_1	658	661	PF00400	0.544
TRG_ER_diArg_1	83	86	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIL4	Leishmania donovani	85%	99%
A4IBQ4	Leishmania infantum	84%	100%
E9B6P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%