Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFI8_LEIMA

TriTrypDb:

LmjF.35.3640 , LMJLV39_350043900 , LMJSD75_350043400

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.498
CLV_C14_Caspase3-7	30	34	PF00656	0.459
CLV_NRD_NRD_1	126	128	PF00675	0.472
CLV_NRD_NRD_1	195	197	PF00675	0.628
CLV_PCSK_KEX2_1	126	128	PF00082	0.498
CLV_PCSK_KEX2_1	194	196	PF00082	0.635
DOC_MAPK_gen_1	194	200	PF00069	0.552
DOC_MAPK_MEF2A_6	50	59	PF00069	0.512
DOC_PP2B_LxvP_1	113	116	PF13499	0.546
DOC_USP7_MATH_1	49	53	PF00917	0.668
DOC_WW_Pin1_4	140	145	PF00397	0.583
LIG_14-3-3_CanoR_1	105	111	PF00244	0.556
LIG_14-3-3_CanoR_1	153	162	PF00244	0.703
LIG_14-3-3_CanoR_1	18	23	PF00244	0.461
LIG_14-3-3_CanoR_1	25	30	PF00244	0.548
LIG_14-3-3_CanoR_1	38	47	PF00244	0.450
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_EH1_1	16	24	PF00400	0.446
LIG_eIF4E_1	17	23	PF01652	0.463
LIG_FHA_1	3	9	PF00498	0.505
LIG_FHA_1	39	45	PF00498	0.406
LIG_FHA_1	83	89	PF00498	0.651
LIG_PTAP_UEV_1	143	148	PF05743	0.534
LIG_SH3_3	141	147	PF00018	0.565
LIG_SUMO_SIM_anti_2	169	176	PF11976	0.633
LIG_SUMO_SIM_par_1	196	201	PF11976	0.476
LIG_TRAF2_1	119	122	PF00917	0.453
MOD_CK1_1	140	146	PF00069	0.534
MOD_CK1_1	2	8	PF00069	0.599
MOD_CK1_1	68	74	PF00069	0.775
MOD_CK2_1	69	75	PF00069	0.659
MOD_GlcNHglycan	139	142	PF01048	0.628
MOD_GlcNHglycan	144	147	PF01048	0.658
MOD_GlcNHglycan	67	70	PF01048	0.688
MOD_GlcNHglycan	71	74	PF01048	0.705
MOD_GSK3_1	33	40	PF00069	0.637
MOD_GSK3_1	65	72	PF00069	0.718
MOD_GSK3_1	82	89	PF00069	0.640
MOD_N-GLC_1	69	74	PF02516	0.490
MOD_NEK2_1	37	42	PF00069	0.644
MOD_NEK2_1	86	91	PF00069	0.484
MOD_PKA_2	2	8	PF00069	0.639
MOD_PKA_2	37	43	PF00069	0.574
MOD_PKA_2	49	55	PF00069	0.582
MOD_Plk_1	75	81	PF00069	0.665
MOD_Plk_2-3	183	189	PF00069	0.682
MOD_Plk_2-3	75	81	PF00069	0.608
MOD_Plk_4	18	24	PF00069	0.454
MOD_Plk_4	86	92	PF00069	0.468
MOD_ProDKin_1	140	146	PF00069	0.588
TRG_ER_diArg_1	194	196	PF00400	0.683
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI1	Leptomonas seymouri	46%	91%
A0A1X0P5H7	Trypanosomatidae	34%	100%
A0A3Q8IMQ4	Leishmania donovani	88%	99%
A0A422NR35	Trypanosoma rangeli	38%	100%
A4HN35	Leishmania braziliensis	71%	100%
A4IBQ3	Leishmania infantum	89%	99%
C9ZYX2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	79%
E9B6P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BD49	Trypanosoma cruzi	34%	100%