Membrane transporter protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane transporter protein, putative

Species:

Leishmania major

UniProt:

E9AFI7_LEIMA

TriTrypDb:

LmjF.35.3630 , LMJLV39_350043800 , LMJSD75_350043300

Length:

610

Annotations

LeishMANIAdb annotations

SLC47 family transporter, with potential detoxification functions

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	30
GO:0110165	cellular anatomical entity	1	30

Expansion

Sequence features

E9AFI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFI7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	13
GO:0009987	cellular process	1	13
GO:0042908	xenobiotic transport	4	13
GO:0046618	xenobiotic export from cell	3	13
GO:0051179	localization	1	13
GO:0051234	establishment of localization	2	13
GO:0055085	transmembrane transport	2	13
GO:0140115	export across plasma membrane	3	13
GO:0140352	export from cell	2	13
GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	4	13

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	30
GO:0015291	secondary active transmembrane transporter activity	4	30
GO:0015297	antiporter activity	5	30
GO:0022804	active transmembrane transporter activity	3	30
GO:0022857	transmembrane transporter activity	2	30
GO:0042910	xenobiotic transmembrane transporter activity	3	30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	436	440	PF00656	0.326
CLV_C14_Caspase3-7	5	9	PF00656	0.714
CLV_C14_Caspase3-7	55	59	PF00656	0.747
CLV_NRD_NRD_1	400	402	PF00675	0.256
CLV_NRD_NRD_1	47	49	PF00675	0.401
CLV_NRD_NRD_1	584	586	PF00675	0.544
CLV_PCSK_KEX2_1	154	156	PF00082	0.445
CLV_PCSK_KEX2_1	400	402	PF00082	0.227
CLV_PCSK_KEX2_1	47	49	PF00082	0.401
CLV_PCSK_KEX2_1	584	586	PF00082	0.550
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.445
CLV_PCSK_SKI1_1	328	332	PF00082	0.383
CLV_PCSK_SKI1_1	395	399	PF00082	0.229
CLV_PCSK_SKI1_1	401	405	PF00082	0.236
CLV_PCSK_SKI1_1	530	534	PF00082	0.300
CLV_PCSK_SKI1_1	77	81	PF00082	0.258
DEG_COP1_1	591	601	PF00400	0.585
DEG_SCF_FBW7_1	590	595	PF00400	0.532
DOC_CKS1_1	519	524	PF01111	0.422
DOC_CYCLIN_RxL_1	103	111	PF00134	0.170
DOC_CYCLIN_yCln2_LP_2	252	258	PF00134	0.460
DOC_CYCLIN_yCln2_LP_2	423	429	PF00134	0.208
DOC_CYCLIN_yCln2_LP_2	82	88	PF00134	0.359
DOC_MAPK_gen_1	400	407	PF00069	0.432
DOC_MAPK_HePTP_8	397	409	PF00069	0.458
DOC_MAPK_MEF2A_6	187	194	PF00069	0.401
DOC_MAPK_MEF2A_6	400	409	PF00069	0.464
DOC_MAPK_MEF2A_6	446	453	PF00069	0.306
DOC_MAPK_MEF2A_6	476	484	PF00069	0.420
DOC_MAPK_NFAT4_5	187	195	PF00069	0.423
DOC_PIKK_1	10	18	PF02985	0.577
DOC_PP1_RVXF_1	307	313	PF00149	0.627
DOC_PP1_RVXF_1	398	405	PF00149	0.534
DOC_PP1_RVXF_1	528	535	PF00149	0.476
DOC_PP4_FxxP_1	232	235	PF00568	0.308
DOC_USP7_MATH_1	213	217	PF00917	0.333
DOC_USP7_MATH_1	330	334	PF00917	0.273
DOC_USP7_MATH_1	348	352	PF00917	0.227
DOC_USP7_MATH_1	374	378	PF00917	0.286
DOC_USP7_MATH_1	41	45	PF00917	0.666
DOC_USP7_MATH_1	571	575	PF00917	0.692
DOC_USP7_UBL2_3	502	506	PF12436	0.362
DOC_WW_Pin1_4	280	285	PF00397	0.254
DOC_WW_Pin1_4	50	55	PF00397	0.738
DOC_WW_Pin1_4	518	523	PF00397	0.422
DOC_WW_Pin1_4	574	579	PF00397	0.703
DOC_WW_Pin1_4	586	591	PF00397	0.679
LIG_14-3-3_CanoR_1	165	171	PF00244	0.652
LIG_14-3-3_CanoR_1	245	252	PF00244	0.480
LIG_Actin_WH2_2	287	305	PF00022	0.341
LIG_AP2alpha_1	457	461	PF02296	0.422
LIG_APCC_ABBA_1	537	542	PF00400	0.578
LIG_BIR_II_1	1	5	PF00653	0.752
LIG_BRCT_BRCA1_1	142	146	PF00533	0.456
LIG_CaM_IQ_9	237	252	PF13499	0.332
LIG_Clathr_ClatBox_1	107	111	PF01394	0.212
LIG_FHA_1	175	181	PF00498	0.503
LIG_FHA_1	251	257	PF00498	0.428
LIG_FHA_1	290	296	PF00498	0.310
LIG_FHA_1	361	367	PF00498	0.212
LIG_FHA_1	413	419	PF00498	0.276
LIG_FHA_1	542	548	PF00498	0.714
LIG_FHA_1	555	561	PF00498	0.698
LIG_FHA_1	593	599	PF00498	0.660
LIG_FHA_1	70	76	PF00498	0.495
LIG_FHA_2	159	165	PF00498	0.516
LIG_FHA_2	166	172	PF00498	0.521
LIG_FHA_2	303	309	PF00498	0.586
LIG_FHA_2	353	359	PF00498	0.234
LIG_FHA_2	55	61	PF00498	0.672
LIG_GBD_Chelix_1	294	302	PF00786	0.208
LIG_LIR_Gen_1	339	349	PF02991	0.214
LIG_LIR_Gen_1	447	458	PF02991	0.319
LIG_LIR_Gen_1	483	493	PF02991	0.389
LIG_LIR_Gen_1	494	503	PF02991	0.389
LIG_LIR_Gen_1	521	532	PF02991	0.305
LIG_LIR_Nem_3	143	149	PF02991	0.463
LIG_LIR_Nem_3	339	344	PF02991	0.233
LIG_LIR_Nem_3	483	489	PF02991	0.389
LIG_LIR_Nem_3	494	498	PF02991	0.350
LIG_LIR_Nem_3	521	527	PF02991	0.328
LIG_NRBOX	419	425	PF00104	0.324
LIG_PCNA_PIPBox_1	73	82	PF02747	0.465
LIG_Pex14_1	509	513	PF04695	0.341
LIG_Pex14_2	201	205	PF04695	0.389
LIG_Pex14_2	274	278	PF04695	0.328
LIG_Pex14_2	369	373	PF04695	0.281
LIG_Pex14_2	427	431	PF04695	0.312
LIG_Pex14_2	457	461	PF04695	0.400
LIG_Pex14_2	495	499	PF04695	0.258
LIG_PTB_Apo_2	14	21	PF02174	0.713
LIG_REV1ctd_RIR_1	496	506	PF16727	0.380
LIG_SH2_PTP2	524	527	PF00017	0.264
LIG_SH2_SRC	524	527	PF00017	0.363
LIG_SH2_SRC	6	9	PF00017	0.571
LIG_SH2_STAP1	184	188	PF00017	0.386
LIG_SH2_STAP1	362	366	PF00017	0.334
LIG_SH2_STAT3	247	250	PF00017	0.427
LIG_SH2_STAT5	222	225	PF00017	0.253
LIG_SH2_STAT5	301	304	PF00017	0.356
LIG_SH2_STAT5	362	365	PF00017	0.307
LIG_SH2_STAT5	450	453	PF00017	0.299
LIG_SH2_STAT5	524	527	PF00017	0.261
LIG_SH2_STAT5	531	534	PF00017	0.466
LIG_SH2_STAT5	6	9	PF00017	0.530
LIG_SH3_3	169	175	PF00018	0.501
LIG_SH3_3	262	268	PF00018	0.278
LIG_SH3_3	423	429	PF00018	0.251
LIG_SH3_3	448	454	PF00018	0.208
LIG_SH3_3	486	492	PF00018	0.267
LIG_SH3_3	516	522	PF00018	0.300
LIG_SH3_3	561	567	PF00018	0.652
LIG_SH3_3	572	578	PF00018	0.561
LIG_SH3_3	584	590	PF00018	0.524
LIG_SH3_3	593	599	PF00018	0.569
LIG_Sin3_3	206	213	PF02671	0.193
LIG_SUMO_SIM_anti_2	189	194	PF11976	0.361
LIG_SUMO_SIM_anti_2	377	384	PF11976	0.345
LIG_SUMO_SIM_anti_2	415	420	PF11976	0.282
LIG_SUMO_SIM_anti_2	514	521	PF11976	0.406
LIG_SUMO_SIM_par_1	256	262	PF11976	0.413
LIG_SUMO_SIM_par_1	84	90	PF11976	0.268
LIG_UBA3_1	269	276	PF00899	0.344
LIG_UBA3_1	528	533	PF00899	0.491
LIG_WRC_WIRS_1	428	433	PF05994	0.315
MOD_CK1_1	19	25	PF00069	0.735
MOD_CK1_1	2	8	PF00069	0.726
MOD_CK1_1	574	580	PF00069	0.721
MOD_CK2_1	158	164	PF00069	0.514
MOD_CK2_1	165	171	PF00069	0.521
MOD_CK2_1	352	358	PF00069	0.232
MOD_CK2_1	54	60	PF00069	0.707
MOD_CK2_1	600	606	PF00069	0.724
MOD_CMANNOS	226	229	PF00535	0.422
MOD_CMANNOS	312	315	PF00535	0.295
MOD_GlcNHglycan	215	218	PF01048	0.404
MOD_GlcNHglycan	26	29	PF01048	0.371
MOD_GlcNHglycan	261	264	PF01048	0.369
MOD_GlcNHglycan	350	353	PF01048	0.394
MOD_GlcNHglycan	376	379	PF01048	0.280
MOD_GlcNHglycan	66	69	PF01048	0.393
MOD_GSK3_1	19	26	PF00069	0.736
MOD_GSK3_1	2	9	PF00069	0.723
MOD_GSK3_1	348	355	PF00069	0.254
MOD_GSK3_1	50	57	PF00069	0.750
MOD_GSK3_1	554	561	PF00069	0.694
MOD_GSK3_1	588	595	PF00069	0.655
MOD_GSK3_1	64	71	PF00069	0.569
MOD_N-GLC_1	123	128	PF02516	0.253
MOD_N-GLC_1	16	21	PF02516	0.508
MOD_NEK2_1	142	147	PF00069	0.399
MOD_NEK2_1	302	307	PF00069	0.356
MOD_NEK2_1	380	385	PF00069	0.318
MOD_NEK2_1	461	466	PF00069	0.332
MOD_NEK2_1	86	91	PF00069	0.281
MOD_PKA_2	186	192	PF00069	0.492
MOD_PKA_2	302	308	PF00069	0.411
MOD_PKB_1	556	564	PF00069	0.563
MOD_Plk_1	16	22	PF00069	0.698
MOD_Plk_1	541	547	PF00069	0.682
MOD_Plk_1	68	74	PF00069	0.521
MOD_Plk_2-3	69	75	PF00069	0.547
MOD_Plk_4	137	143	PF00069	0.263
MOD_Plk_4	186	192	PF00069	0.468
MOD_Plk_4	2	8	PF00069	0.540
MOD_Plk_4	322	328	PF00069	0.503
MOD_Plk_4	381	387	PF00069	0.251
MOD_Plk_4	427	433	PF00069	0.257
MOD_Plk_4	461	467	PF00069	0.250
MOD_Plk_4	491	497	PF00069	0.320
MOD_ProDKin_1	280	286	PF00069	0.242
MOD_ProDKin_1	50	56	PF00069	0.739
MOD_ProDKin_1	518	524	PF00069	0.422
MOD_ProDKin_1	574	580	PF00069	0.703
MOD_ProDKin_1	586	592	PF00069	0.679
MOD_SUMO_for_1	532	535	PF00179	0.555
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.170
TRG_DiLeu_LyEn_5	393	398	PF01217	0.434
TRG_ENDOCYTIC_2	445	448	PF00928	0.229
TRG_ENDOCYTIC_2	450	453	PF00928	0.258
TRG_ENDOCYTIC_2	455	458	PF00928	0.273
TRG_ENDOCYTIC_2	524	527	PF00928	0.267
TRG_ER_diArg_1	400	402	PF00400	0.433
TRG_ER_diArg_1	47	49	PF00400	0.611
TRG_ER_diArg_1	583	585	PF00400	0.756
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I213	Leptomonas seymouri	68%	98%
A0A0N1I703	Leptomonas seymouri	23%	67%
A0A0N1IJ56	Leptomonas seymouri	41%	86%
A0A0N1ILQ1	Leptomonas seymouri	22%	100%
A0A0S4IHH9	Bodo saltans	34%	100%
A0A0S4INI5	Bodo saltans	38%	100%
A0A0S4JEP9	Bodo saltans	22%	100%
A0A0S4JTQ3	Bodo saltans	25%	100%
A0A0S4JV01	Bodo saltans	22%	100%
A0A0S4JV08	Bodo saltans	23%	100%
A0A0S4JVA6	Bodo saltans	24%	83%
A0A0S4JZ61	Bodo saltans	22%	90%
A0A1X0NM81	Trypanosomatidae	21%	100%
A0A1X0NU76	Trypanosomatidae	43%	100%
A0A1X0P579	Trypanosomatidae	52%	100%
A0A1X0P5F0	Trypanosomatidae	38%	100%
A0A1X0P8J4	Trypanosomatidae	20%	100%
A0A3Q8ID83	Leishmania donovani	23%	69%
A0A3Q8IGH9	Leishmania donovani	41%	87%
A0A3Q8II95	Leishmania donovani	93%	98%
A0A3R7M3E2	Trypanosoma rangeli	43%	100%
A0A3R7NUJ8	Trypanosoma rangeli	50%	100%
A0A422NN08	Trypanosoma rangeli	21%	73%
A0A422NR58	Trypanosoma rangeli	37%	100%
A1L1P9	Danio rerio	27%	100%
A4HN33	Leishmania braziliensis	73%	98%
A4HN34	Leishmania braziliensis	76%	100%
A4IBQ2	Leishmania infantum	93%	98%
A4IIS8	Xenopus tropicalis	26%	100%
A7KAU2	Oryctolagus cuniculus	27%	100%
A7KAU3	Oryctolagus cuniculus	27%	100%
C9ZP79	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZP80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZQ36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZYX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZYX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZYY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZYY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AD56	Leishmania major	23%	68%
E9AFI2	Leishmania major	40%	100%
E9AHF1	Leishmania infantum	23%	69%
E9AHW7	Leishmania infantum	41%	87%
E9AYY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	69%
E9B6N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	94%
E9B6P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%
F4HPH2	Arabidopsis thaliana	23%	100%
F4HQ05	Arabidopsis thaliana	24%	100%
F4HZH9	Arabidopsis thaliana	24%	100%
F4I4Q3	Arabidopsis thaliana	24%	100%
F4IHU9	Arabidopsis thaliana	26%	100%
F4JH46	Arabidopsis thaliana	23%	100%
F4JTB3	Arabidopsis thaliana	21%	100%
O49660	Arabidopsis thaliana	21%	100%
O82752	Arabidopsis thaliana	24%	100%
P38767	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P45272	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	23%	100%
Q05497	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	88%
Q10085	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q1PDX9	Arabidopsis thaliana	23%	100%
Q1PFG9	Arabidopsis thaliana	26%	100%
Q38956	Arabidopsis thaliana	24%	100%
Q3V050	Mus musculus	27%	100%
Q5I0E9	Rattus norvegicus	26%	100%
Q5R7E4	Pongo abelii	25%	100%
Q5RFD2	Pongo abelii	27%	100%
Q65SY9	Mannheimia succiniciproducens (strain MBEL55E)	25%	100%
Q6NB79	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	25%	100%
Q86VL8	Homo sapiens	26%	100%
Q89W72	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	25%	100%
Q8GXM8	Arabidopsis thaliana	26%	100%
Q8K0H1	Mus musculus	25%	100%
Q8L731	Arabidopsis thaliana	25%	100%
Q8RWF5	Arabidopsis thaliana	24%	100%
Q8VYL8	Arabidopsis thaliana	23%	100%
Q8W488	Arabidopsis thaliana	23%	100%
Q940N9	Arabidopsis thaliana	22%	100%
Q94AL1	Arabidopsis thaliana	23%	100%
Q96FL8	Homo sapiens	26%	100%
Q98D15	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	24%	100%
Q9C994	Arabidopsis thaliana	23%	100%
Q9C9M8	Arabidopsis thaliana	24%	100%
Q9C9U1	Arabidopsis thaliana	25%	100%
Q9FH21	Arabidopsis thaliana	22%	100%
Q9FHB6	Arabidopsis thaliana	26%	100%
Q9FJ87	Arabidopsis thaliana	24%	100%
Q9FKQ1	Arabidopsis thaliana	24%	100%
Q9FNC1	Arabidopsis thaliana	22%	100%
Q9LE20	Arabidopsis thaliana	24%	100%
Q9LPV4	Arabidopsis thaliana	24%	100%
Q9LS19	Arabidopsis thaliana	25%	100%
Q9LUH2	Arabidopsis thaliana	23%	100%
Q9LUH3	Arabidopsis thaliana	24%	100%
Q9LVD9	Arabidopsis thaliana	22%	100%
Q9LYT3	Arabidopsis thaliana	24%	100%
Q9SIA1	Arabidopsis thaliana	25%	100%
Q9SIA3	Arabidopsis thaliana	25%	100%
Q9SIA4	Arabidopsis thaliana	25%	100%
Q9SIA5	Arabidopsis thaliana	24%	100%
Q9SLV0	Arabidopsis thaliana	24%	100%
Q9SX83	Arabidopsis thaliana	23%	100%
Q9SZE2	Arabidopsis thaliana	23%	100%
Q9USK3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9UT92	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9ZVH5	Arabidopsis thaliana	22%	100%
V5BE59	Trypanosoma cruzi	22%	75%
V5BJE3	Trypanosoma cruzi	40%	100%
V5C2T9	Trypanosoma cruzi	51%	100%