tRNA N(3)-methylcytidine methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AFI4_LEIMA

TriTrypDb:

LmjF.35.3600 , LMJLV39_350043500 , LMJSD75_350043000

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFI4

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	13
GO:0006139	nucleobase-containing compound metabolic process	3	13
GO:0006725	cellular aromatic compound metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009451	RNA modification	5	13
GO:0009987	cellular process	1	13
GO:0016070	RNA metabolic process	5	13
GO:0032259	methylation	2	13
GO:0034641	cellular nitrogen compound metabolic process	3	13

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008168	methyltransferase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016741	transferase activity, transferring one-carbon groups	3	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.293
CLV_NRD_NRD_1	263	265	PF00675	0.335
CLV_NRD_NRD_1	28	30	PF00675	0.642
CLV_NRD_NRD_1	289	291	PF00675	0.406
CLV_NRD_NRD_1	298	300	PF00675	0.381
CLV_NRD_NRD_1	353	355	PF00675	0.444
CLV_NRD_NRD_1	362	364	PF00675	0.366
CLV_NRD_NRD_1	380	382	PF00675	0.643
CLV_PCSK_KEX2_1	172	174	PF00082	0.381
CLV_PCSK_KEX2_1	263	265	PF00082	0.321

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J3	Leptomonas seymouri	65%	100%
A0A0N1I1R8	Leptomonas seymouri	26%	100%
A0A0S4ISJ6	Bodo saltans	25%	88%
A0A0S4KFU5	Bodo saltans	34%	100%
A0A1X0NXB7	Trypanosomatidae	26%	100%
A0A1X0P5J2	Trypanosomatidae	44%	100%
A0A3Q8IDT0	Leishmania donovani	24%	100%
A0A3R7M2M3	Trypanosoma rangeli	44%	100%
A0A3S7X9Q3	Leishmania donovani	93%	100%
A0A422MZQ7	Trypanosoma rangeli	29%	100%

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