CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO, N-terminal domain/CRAL/TRIO domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AFI0_LEIMA

TriTrypDb:

LmjF.35.3560 , LMJLV39_350043000 , LMJSD75_350042500

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFI0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005319	lipid transporter activity	2	2
GO:0005548	phospholipid transporter activity	3	2
GO:0008526	phosphatidylinositol transfer activity	5	2
GO:0120013	lipid transfer activity	3	2
GO:0120014	phospholipid transfer activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.512
CLV_NRD_NRD_1	178	180	PF00675	0.326
CLV_NRD_NRD_1	328	330	PF00675	0.575
CLV_NRD_NRD_1	363	365	PF00675	0.672
CLV_NRD_NRD_1	83	85	PF00675	0.538
CLV_PCSK_KEX2_1	356	358	PF00082	0.573
CLV_PCSK_KEX2_1	363	365	PF00082	0.472
CLV_PCSK_KEX2_1	83	85	PF00082	0.542
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.573
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.429
CLV_PCSK_SKI1_1	111	115	PF00082	0.365
CLV_PCSK_SKI1_1	256	260	PF00082	0.384
CLV_PCSK_SKI1_1	345	349	PF00082	0.592
DEG_MDM2_SWIB_1	251	259	PF02201	0.307
DOC_CKS1_1	309	314	PF01111	0.518
DOC_MAPK_FxFP_2	38	41	PF00069	0.401
DOC_MAPK_gen_1	329	335	PF00069	0.461
DOC_MAPK_MEF2A_6	220	227	PF00069	0.408
DOC_PP1_RVXF_1	164	171	PF00149	0.287
DOC_PP1_RVXF_1	267	273	PF00149	0.289
DOC_PP2B_LxvP_1	257	260	PF13499	0.408
DOC_PP2B_LxvP_1	31	34	PF13499	0.534
DOC_PP4_FxxP_1	38	41	PF00568	0.403
DOC_PP4_FxxP_1	47	50	PF00568	0.439
DOC_USP7_MATH_1	15	19	PF00917	0.712
DOC_USP7_MATH_1	277	281	PF00917	0.502
DOC_USP7_MATH_1	94	98	PF00917	0.496
DOC_USP7_MATH_2	2	8	PF00917	0.637
DOC_USP7_UBL2_3	330	334	PF12436	0.617
DOC_USP7_UBL2_3	341	345	PF12436	0.562
DOC_USP7_UBL2_3	355	359	PF12436	0.632
DOC_WW_Pin1_4	13	18	PF00397	0.641
DOC_WW_Pin1_4	178	183	PF00397	0.297
DOC_WW_Pin1_4	308	313	PF00397	0.546
LIG_14-3-3_CanoR_1	111	120	PF00244	0.361
LIG_deltaCOP1_diTrp_1	202	210	PF00928	0.287
LIG_EVH1_2	247	251	PF00568	0.332
LIG_FHA_1	309	315	PF00498	0.506
LIG_FHA_2	135	141	PF00498	0.483
LIG_FHA_2	14	20	PF00498	0.675
LIG_FHA_2	206	212	PF00498	0.304
LIG_FHA_2	266	272	PF00498	0.384
LIG_LIR_Apic_2	304	309	PF02991	0.581
LIG_LIR_Apic_2	36	41	PF02991	0.419
LIG_LIR_Apic_2	45	50	PF02991	0.512
LIG_LIR_Gen_1	105	115	PF02991	0.273
LIG_LIR_Gen_1	122	131	PF02991	0.310
LIG_LIR_Gen_1	189	198	PF02991	0.302
LIG_LIR_Gen_1	202	210	PF02991	0.259
LIG_LIR_Gen_1	211	221	PF02991	0.262
LIG_LIR_Nem_3	105	110	PF02991	0.273
LIG_LIR_Nem_3	122	127	PF02991	0.291
LIG_LIR_Nem_3	189	193	PF02991	0.309
LIG_LIR_Nem_3	202	207	PF02991	0.261
LIG_LIR_Nem_3	208	213	PF02991	0.206
LIG_LIR_Nem_3	252	258	PF02991	0.296
LIG_LIR_Nem_3	283	288	PF02991	0.354
LIG_MYND_1	286	290	PF01753	0.477
LIG_Pex14_2	251	255	PF04695	0.272
LIG_Pex14_2	285	289	PF04695	0.341
LIG_SH2_CRK	306	310	PF00017	0.606
LIG_SH2_NCK_1	306	310	PF00017	0.606
LIG_SH2_STAT5	112	115	PF00017	0.287
LIG_SH2_STAT5	296	299	PF00017	0.387
LIG_SH2_STAT5	51	54	PF00017	0.520
LIG_SH3_1	306	312	PF00018	0.609
LIG_SH3_3	306	312	PF00018	0.495
LIG_TRAF2_1	55	58	PF00917	0.438
LIG_UBA3_1	196	203	PF00899	0.209
LIG_UBA3_1	250	256	PF00899	0.376
LIG_WRC_WIRS_1	187	192	PF05994	0.344
MOD_CDC14_SPxK_1	181	184	PF00782	0.297
MOD_CDK_SPxK_1	178	184	PF00069	0.297
MOD_CK1_1	7	13	PF00069	0.735
MOD_CK2_1	122	128	PF00069	0.443
MOD_CK2_1	134	140	PF00069	0.398
MOD_CK2_1	205	211	PF00069	0.304
MOD_CK2_1	265	271	PF00069	0.408
MOD_CK2_1	277	283	PF00069	0.502
MOD_CK2_1	51	57	PF00069	0.464
MOD_CK2_1	94	100	PF00069	0.272
MOD_GlcNHglycan	9	12	PF01048	0.742
MOD_GSK3_1	134	141	PF00069	0.459
MOD_GSK3_1	205	212	PF00069	0.285
MOD_GSK3_1	277	284	PF00069	0.516
MOD_GSK3_1	291	298	PF00069	0.306
MOD_GSK3_1	5	12	PF00069	0.715
MOD_NEK2_1	127	132	PF00069	0.337
MOD_NEK2_1	169	174	PF00069	0.416
MOD_NEK2_1	186	191	PF00069	0.403
MOD_NEK2_1	9	14	PF00069	0.703
MOD_PIKK_1	291	297	PF00454	0.406
MOD_Plk_1	127	133	PF00069	0.320
MOD_Plk_1	5	11	PF00069	0.644
MOD_Plk_2-3	122	128	PF00069	0.326
MOD_Plk_4	94	100	PF00069	0.209
MOD_ProDKin_1	13	19	PF00069	0.639
MOD_ProDKin_1	178	184	PF00069	0.297
MOD_ProDKin_1	308	314	PF00069	0.537
MOD_SUMO_rev_2	172	182	PF00179	0.408
MOD_SUMO_rev_2	214	222	PF00179	0.408
MOD_SUMO_rev_2	338	347	PF00179	0.574
MOD_SUMO_rev_2	87	92	PF00179	0.483
MOD_SUMO_rev_2	97	104	PF00179	0.289
TRG_ENDOCYTIC_2	213	216	PF00928	0.307
TRG_ER_diArg_1	363	366	PF00400	0.550
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHG0	Leptomonas seymouri	73%	97%
A0A0S4IKI1	Bodo saltans	47%	100%
A0A1X0P588	Trypanosomatidae	53%	100%
A0A3Q8IJP6	Leishmania donovani	96%	100%
A0A3R7L5B2	Trypanosoma rangeli	53%	100%
A4HN25	Leishmania braziliensis	80%	100%
A4IBP3	Leishmania infantum	96%	100%
C9ZYY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B6N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P46250	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	100%
Q55CU8	Dictyostelium discoideum	23%	100%
V5BCV8	Trypanosoma cruzi	54%	100%