Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFH9_LEIMA

TriTrypDb:

LmjF.35.3550 , LMJLV39_350042900 , LMJSD75_350042400

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.651
CLV_C14_Caspase3-7	527	531	PF00656	0.674
CLV_C14_Caspase3-7	736	740	PF00656	0.722
CLV_NRD_NRD_1	186	188	PF00675	0.563
CLV_NRD_NRD_1	300	302	PF00675	0.551
CLV_NRD_NRD_1	412	414	PF00675	0.695
CLV_NRD_NRD_1	8	10	PF00675	0.565
CLV_PCSK_KEX2_1	175	177	PF00082	0.648
CLV_PCSK_KEX2_1	186	188	PF00082	0.532
CLV_PCSK_KEX2_1	300	302	PF00082	0.551
CLV_PCSK_KEX2_1	412	414	PF00082	0.708
CLV_PCSK_KEX2_1	8	10	PF00082	0.565
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.648
CLV_PCSK_SKI1_1	130	134	PF00082	0.670
CLV_PCSK_SKI1_1	172	176	PF00082	0.538
CLV_PCSK_SKI1_1	745	749	PF00082	0.704
DEG_APCC_DBOX_1	97	105	PF00400	0.660
DEG_SCF_FBW7_1	495	502	PF00400	0.814
DEG_SPOP_SBC_1	601	605	PF00917	0.696
DOC_CKS1_1	686	691	PF01111	0.719
DOC_CYCLIN_RxL_1	81	94	PF00134	0.604
DOC_MAPK_DCC_7	602	611	PF00069	0.574
DOC_MAPK_gen_1	369	378	PF00069	0.646
DOC_MAPK_MEF2A_6	602	611	PF00069	0.718
DOC_SPAK_OSR1_1	13	17	PF12202	0.421
DOC_USP7_MATH_1	320	324	PF00917	0.678
DOC_USP7_MATH_1	337	341	PF00917	0.635
DOC_USP7_MATH_1	429	433	PF00917	0.555
DOC_USP7_MATH_1	451	455	PF00917	0.692
DOC_USP7_MATH_1	467	471	PF00917	0.675
DOC_USP7_MATH_1	493	497	PF00917	0.740
DOC_USP7_MATH_1	499	503	PF00917	0.808
DOC_USP7_MATH_1	512	516	PF00917	0.594
DOC_USP7_MATH_1	528	532	PF00917	0.737
DOC_USP7_MATH_1	536	540	PF00917	0.715
DOC_USP7_MATH_1	596	600	PF00917	0.754
DOC_USP7_MATH_1	607	611	PF00917	0.643
DOC_USP7_MATH_1	621	625	PF00917	0.710
DOC_USP7_MATH_1	636	640	PF00917	0.796
DOC_USP7_MATH_1	654	658	PF00917	0.552
DOC_USP7_MATH_1	673	677	PF00917	0.700
DOC_USP7_MATH_1	692	696	PF00917	0.721
DOC_USP7_MATH_1	70	74	PF00917	0.707
DOC_USP7_MATH_1	713	717	PF00917	0.768
DOC_USP7_MATH_1	731	735	PF00917	0.583
DOC_WW_Pin1_4	333	338	PF00397	0.645
DOC_WW_Pin1_4	344	349	PF00397	0.571
DOC_WW_Pin1_4	495	500	PF00397	0.777
DOC_WW_Pin1_4	501	506	PF00397	0.729
DOC_WW_Pin1_4	680	685	PF00397	0.768
DOC_WW_Pin1_4	688	693	PF00397	0.688
DOC_WW_Pin1_4	697	702	PF00397	0.643
DOC_WW_Pin1_4	724	729	PF00397	0.790
LIG_14-3-3_CanoR_1	13	17	PF00244	0.568
LIG_14-3-3_CanoR_1	234	243	PF00244	0.571
LIG_14-3-3_CanoR_1	292	298	PF00244	0.631
LIG_14-3-3_CanoR_1	311	316	PF00244	0.593
LIG_14-3-3_CanoR_1	352	360	PF00244	0.614
LIG_14-3-3_CanoR_1	602	607	PF00244	0.688
LIG_14-3-3_CanoR_1	653	659	PF00244	0.793
LIG_Actin_WH2_2	106	123	PF00022	0.650
LIG_Actin_WH2_2	171	188	PF00022	0.634
LIG_Actin_WH2_2	18	33	PF00022	0.561
LIG_BIR_II_1	1	5	PF00653	0.714
LIG_BRCT_BRCA1_1	430	434	PF00533	0.713
LIG_BRCT_BRCA1_1	520	524	PF00533	0.724
LIG_DLG_GKlike_1	412	419	PF00625	0.717
LIG_FHA_1	13	19	PF00498	0.657
LIG_FHA_1	280	286	PF00498	0.536
LIG_FHA_1	646	652	PF00498	0.746
LIG_FHA_2	161	167	PF00498	0.547
LIG_FHA_2	33	39	PF00498	0.675
LIG_GBD_Chelix_1	260	268	PF00786	0.408
LIG_LIR_Gen_1	223	232	PF02991	0.509
LIG_LIR_Gen_1	415	422	PF02991	0.724
LIG_LIR_Gen_1	431	441	PF02991	0.515
LIG_LIR_Nem_3	223	228	PF02991	0.455
LIG_LIR_Nem_3	415	419	PF02991	0.722
LIG_LIR_Nem_3	584	590	PF02991	0.578
LIG_MYND_1	495	499	PF01753	0.599
LIG_PCNA_yPIPBox_3	17	29	PF02747	0.519
LIG_Rb_LxCxE_1	439	454	PF01857	0.664
LIG_SH2_NCK_1	726	730	PF00017	0.818
LIG_SH2_STAT5	4	7	PF00017	0.680
LIG_SH2_STAT5	696	699	PF00017	0.728
LIG_SH2_STAT5	726	729	PF00017	0.727
LIG_SH3_3	64	70	PF00018	0.659
LIG_SH3_3	648	654	PF00018	0.796
LIG_SH3_3	683	689	PF00018	0.828
LIG_SUMO_SIM_anti_2	464	471	PF11976	0.653
LIG_SUMO_SIM_par_1	116	123	PF11976	0.650
LIG_TRAF2_1	123	126	PF00917	0.490
LIG_TRAF2_1	159	162	PF00917	0.673
LIG_TRAF2_2	728	733	PF00917	0.824
MOD_CK1_1	291	297	PF00069	0.569
MOD_CK1_1	314	320	PF00069	0.724
MOD_CK1_1	323	329	PF00069	0.649
MOD_CK1_1	333	339	PF00069	0.699
MOD_CK1_1	417	423	PF00069	0.792
MOD_CK1_1	504	510	PF00069	0.825
MOD_CK1_1	515	521	PF00069	0.655
MOD_CK1_1	632	638	PF00069	0.823
MOD_CK1_1	695	701	PF00069	0.789
MOD_CK1_1	94	100	PF00069	0.562
MOD_CK2_1	120	126	PF00069	0.573
MOD_CK2_1	32	38	PF00069	0.670
MOD_CK2_1	39	45	PF00069	0.595
MOD_CK2_1	602	608	PF00069	0.629
MOD_CK2_1	654	660	PF00069	0.677
MOD_CK2_1	662	668	PF00069	0.600
MOD_CK2_1	731	737	PF00069	0.722
MOD_GlcNHglycan	122	125	PF01048	0.400
MOD_GlcNHglycan	156	159	PF01048	0.540
MOD_GlcNHglycan	40	44	PF01048	0.615
MOD_GlcNHglycan	431	434	PF01048	0.738
MOD_GlcNHglycan	444	448	PF01048	0.535
MOD_GlcNHglycan	453	456	PF01048	0.768
MOD_GlcNHglycan	470	473	PF01048	0.636
MOD_GlcNHglycan	485	488	PF01048	0.676
MOD_GlcNHglycan	501	504	PF01048	0.623
MOD_GlcNHglycan	506	509	PF01048	0.748
MOD_GlcNHglycan	542	545	PF01048	0.746
MOD_GlcNHglycan	598	601	PF01048	0.745
MOD_GlcNHglycan	634	637	PF01048	0.814
MOD_GlcNHglycan	640	643	PF01048	0.760
MOD_GlcNHglycan	675	678	PF01048	0.802
MOD_GlcNHglycan	711	714	PF01048	0.772
MOD_GlcNHglycan	72	75	PF01048	0.756
MOD_GlcNHglycan	745	748	PF01048	0.703
MOD_GSK3_1	116	123	PF00069	0.411
MOD_GSK3_1	310	317	PF00069	0.592
MOD_GSK3_1	333	340	PF00069	0.547
MOD_GSK3_1	376	383	PF00069	0.648
MOD_GSK3_1	387	394	PF00069	0.768
MOD_GSK3_1	408	415	PF00069	0.702
MOD_GSK3_1	495	502	PF00069	0.814
MOD_GSK3_1	512	519	PF00069	0.604
MOD_GSK3_1	536	543	PF00069	0.598
MOD_GSK3_1	592	599	PF00069	0.784
MOD_GSK3_1	607	614	PF00069	0.809
MOD_GSK3_1	630	637	PF00069	0.732
MOD_GSK3_1	654	661	PF00069	0.673
MOD_GSK3_1	688	695	PF00069	0.769
MOD_GSK3_1	705	712	PF00069	0.798
MOD_GSK3_1	713	720	PF00069	0.726
MOD_GSK3_1	96	103	PF00069	0.528
MOD_LATS_1	627	633	PF00433	0.732
MOD_N-GLC_1	331	336	PF02516	0.678
MOD_N-GLC_1	420	425	PF02516	0.667
MOD_N-GLC_1	458	463	PF02516	0.665
MOD_N-GLC_1	629	634	PF02516	0.758
MOD_N-GLC_1	731	736	PF02516	0.645
MOD_NEK2_1	267	272	PF00069	0.544
MOD_NEK2_1	29	34	PF00069	0.568
MOD_NEK2_1	353	358	PF00069	0.666
MOD_NEK2_1	376	381	PF00069	0.463
MOD_NEK2_1	39	44	PF00069	0.603
MOD_NEK2_1	468	473	PF00069	0.699
MOD_NEK2_1	517	522	PF00069	0.812
MOD_NEK2_1	705	710	PF00069	0.774
MOD_NEK2_1	84	89	PF00069	0.567
MOD_NEK2_2	391	396	PF00069	0.754
MOD_PIKK_1	160	166	PF00454	0.661
MOD_PIKK_1	279	285	PF00454	0.410
MOD_PIKK_1	611	617	PF00454	0.805
MOD_PIKK_1	91	97	PF00454	0.563
MOD_PKA_1	412	418	PF00069	0.703
MOD_PKA_2	12	18	PF00069	0.656
MOD_PKA_2	120	126	PF00069	0.585
MOD_PKA_2	208	214	PF00069	0.566
MOD_PKA_2	235	241	PF00069	0.562
MOD_PKA_2	291	297	PF00069	0.629
MOD_PKA_2	310	316	PF00069	0.591
MOD_PKA_2	351	357	PF00069	0.552
MOD_PKA_2	379	385	PF00069	0.639
MOD_PKA_2	412	418	PF00069	0.735
MOD_PKA_2	601	607	PF00069	0.689
MOD_PKB_1	234	242	PF00069	0.560
MOD_Plk_1	399	405	PF00069	0.693
MOD_Plk_1	607	613	PF00069	0.712
MOD_Plk_1	645	651	PF00069	0.725
MOD_Plk_1	91	97	PF00069	0.563
MOD_Plk_2-3	662	668	PF00069	0.732
MOD_Plk_2-3	733	739	PF00069	0.814
MOD_Plk_4	100	106	PF00069	0.557
MOD_Plk_4	314	320	PF00069	0.558
MOD_Plk_4	337	343	PF00069	0.765
MOD_Plk_4	399	405	PF00069	0.740
MOD_Plk_4	436	442	PF00069	0.557
MOD_Plk_4	645	651	PF00069	0.798
MOD_Plk_4	692	698	PF00069	0.721
MOD_ProDKin_1	333	339	PF00069	0.643
MOD_ProDKin_1	344	350	PF00069	0.568
MOD_ProDKin_1	495	501	PF00069	0.781
MOD_ProDKin_1	680	686	PF00069	0.768
MOD_ProDKin_1	688	694	PF00069	0.690
MOD_ProDKin_1	697	703	PF00069	0.641
MOD_ProDKin_1	724	730	PF00069	0.792
MOD_SUMO_for_1	132	135	PF00179	0.668
MOD_SUMO_rev_2	704	710	PF00179	0.774
TRG_DiLeu_BaEn_1	24	29	PF01217	0.546
TRG_DiLeu_BaEn_1	281	286	PF01217	0.652
TRG_ENDOCYTIC_2	416	419	PF00928	0.724
TRG_ER_diArg_1	127	130	PF00400	0.658
TRG_ER_diArg_1	185	187	PF00400	0.528
TRG_ER_diArg_1	412	414	PF00400	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I179	Leptomonas seymouri	40%	96%
A0A3Q8IFD3	Leishmania donovani	88%	100%
A4HN24	Leishmania braziliensis	64%	100%
A4IBP4	Leishmania infantum	88%	100%
E9B6N4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%