KH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-rRNA-processing protein PNO1, putative

Species:

Leishmania major

UniProt:

E9AFH8_LEIMA

TriTrypDb:

LmjF.35.3540 , LMJLV39_350042800 , LMJSD75_350042300

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	3
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AFH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFH8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.675
CLV_C14_Caspase3-7	113	117	PF00656	0.417
CLV_PCSK_SKI1_1	34	38	PF00082	0.438
CLV_PCSK_SKI1_1	95	99	PF00082	0.468
DEG_SCF_FBW7_2	53	59	PF00400	0.392
DEG_SPOP_SBC_1	80	84	PF00917	0.600
DOC_CKS1_1	53	58	PF01111	0.386
DOC_MAPK_gen_1	47	53	PF00069	0.437
DOC_USP7_MATH_1	7	11	PF00917	0.677
DOC_USP7_MATH_1	80	84	PF00917	0.640
DOC_USP7_MATH_1	91	95	PF00917	0.600
DOC_WW_Pin1_4	198	203	PF00397	0.420
DOC_WW_Pin1_4	52	57	PF00397	0.407
DOC_WW_Pin1_4	76	81	PF00397	0.644
LIG_Actin_WH2_2	62	79	PF00022	0.550
LIG_BIR_II_1	1	5	PF00653	0.530
LIG_Clathr_ClatBox_1	120	124	PF01394	0.452
LIG_FHA_1	167	173	PF00498	0.408
LIG_FHA_1	182	188	PF00498	0.400
LIG_FHA_1	22	28	PF00498	0.561
LIG_FHA_1	31	37	PF00498	0.476
LIG_FHA_1	53	59	PF00498	0.439
LIG_FHA_1	69	75	PF00498	0.421
LIG_KLC1_Yacidic_2	124	129	PF13176	0.447
LIG_LIR_Nem_3	52	57	PF02991	0.401
LIG_Pex14_1	50	54	PF04695	0.403
LIG_SH2_CRK	207	211	PF00017	0.441
LIG_SH2_CRK	54	58	PF00017	0.383
LIG_SH2_SRC	127	130	PF00017	0.438
LIG_SH2_STAT5	127	130	PF00017	0.438
LIG_SH2_STAT5	161	164	PF00017	0.430
LIG_SH2_STAT5	207	210	PF00017	0.451
LIG_SH2_STAT5	54	57	PF00017	0.388
LIG_SH3_3	50	56	PF00018	0.501
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.450
MOD_CDK_SPxxK_3	198	205	PF00069	0.409
MOD_CK1_1	79	85	PF00069	0.650
MOD_CK2_1	80	86	PF00069	0.665
MOD_GlcNHglycan	152	155	PF01048	0.410
MOD_GlcNHglycan	88	92	PF01048	0.631
MOD_GSK3_1	152	159	PF00069	0.418
MOD_GSK3_1	75	82	PF00069	0.510
MOD_GSK3_1	87	94	PF00069	0.618
MOD_N-GLC_1	143	148	PF02516	0.440
MOD_N-GLC_1	164	169	PF02516	0.411
MOD_NEK2_1	181	186	PF00069	0.407
MOD_PIKK_1	181	187	PF00454	0.397
MOD_PK_1	70	76	PF00069	0.520
MOD_PKA_2	150	156	PF00069	0.427
MOD_PKA_2	30	36	PF00069	0.491
MOD_ProDKin_1	198	204	PF00069	0.418
MOD_ProDKin_1	52	58	PF00069	0.405
MOD_ProDKin_1	76	82	PF00069	0.647
MOD_SUMO_rev_2	10	20	PF00179	0.599
MOD_SUMO_rev_2	129	136	PF00179	0.434
TRG_ENDOCYTIC_2	207	210	PF00928	0.451
TRG_ENDOCYTIC_2	54	57	PF00928	0.384
TRG_ER_diArg_1	168	171	PF00400	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGS8	Leptomonas seymouri	87%	100%
A0A0S4IKD6	Bodo saltans	76%	100%
A0A1X0P5I9	Trypanosomatidae	76%	100%
A0A3Q8IVF4	Leishmania donovani	96%	100%
A0A422NR21	Trypanosoma rangeli	84%	100%
A4HN23	Leishmania braziliensis	97%	100%
A4IBP5	Leishmania infantum	97%	100%
A7RP64	Nematostella vectensis	55%	93%
C9ZYY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9B6N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
G0S3T2	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	48%	85%
O14044	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	92%
O18216	Caenorhabditis elegans	48%	80%
P0CO46	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	48%	83%
P0CO47	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	48%	83%
Q0UWT7	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	51%	84%
Q1DQZ5	Coccidioides immitis (strain RS)	53%	87%
Q29IG6	Drosophila pseudoobscura pseudoobscura	48%	93%
Q2UMG1	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	53%	85%
Q4IN63	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	52%	87%
Q4PMC9	Ixodes scapularis	47%	94%
Q4WNG7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	52%	88%
Q54K66	Dictyostelium discoideum	54%	92%
Q5ACM4	Candida albicans (strain SC5314 / ATCC MYA-2876)	52%	80%
Q5B0Z5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	51%	86%
Q5F414	Gallus gallus	56%	91%
Q626C1	Caenorhabditis briggsae	46%	80%
Q6BJ75	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	50%	87%
Q6C7G0	Yarrowia lipolytica (strain CLIB 122 / E 150)	52%	86%
Q6CUA5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	51%	81%
Q6DDB9	Xenopus tropicalis	55%	94%
Q6FMB3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	52%	85%
Q6VBQ6	Oryzias latipes	53%	91%
Q6VBQ8	Rattus norvegicus	51%	89%
Q6VEU3	Danio rerio	52%	88%
Q753C6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	50%	83%
Q7YRD0	Bos taurus	52%	88%
Q8AVH4	Xenopus laevis	55%	94%
Q99216	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	81%
Q9CPS7	Mus musculus	51%	89%
Q9NRX1	Homo sapiens	52%	88%
Q9VR89	Drosophila melanogaster	51%	92%
V5BY96	Trypanosoma cruzi	76%	100%