Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AFH7_LEIMA

TriTrypDb:

LmjF.35.3530 , LMJLV39_350042700 , LMJSD75_350042200

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFH7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.690
CLV_C14_Caspase3-7	295	299	PF00656	0.501
CLV_C14_Caspase3-7	346	350	PF00656	0.551
CLV_C14_Caspase3-7	351	355	PF00656	0.478
CLV_PCSK_SKI1_1	130	134	PF00082	0.580
DEG_SCF_FBW7_1	5	10	PF00400	0.495
DOC_CYCLIN_yCln2_LP_2	370	376	PF00134	0.608
DOC_MAPK_gen_1	171	180	PF00069	0.461
DOC_MAPK_MEF2A_6	160	169	PF00069	0.559
DOC_MAPK_MEF2A_6	171	180	PF00069	0.506
DOC_PP1_RVXF_1	142	148	PF00149	0.664
DOC_PP1_SILK_1	254	259	PF00149	0.579
DOC_USP7_MATH_1	214	218	PF00917	0.617
DOC_USP7_MATH_1	223	227	PF00917	0.518
DOC_USP7_MATH_1	319	323	PF00917	0.469
DOC_USP7_MATH_1	93	97	PF00917	0.650
DOC_USP7_UBL2_3	65	69	PF12436	0.670
DOC_WW_Pin1_4	219	224	PF00397	0.680
DOC_WW_Pin1_4	3	8	PF00397	0.503
LIG_14-3-3_CanoR_1	345	353	PF00244	0.549
LIG_Actin_WH2_2	131	148	PF00022	0.540
LIG_Actin_WH2_2	245	260	PF00022	0.576
LIG_APCC_ABBA_1	124	129	PF00400	0.530
LIG_BIR_III_4	79	83	PF00653	0.686
LIG_CaM_NSCaTE_8	253	260	PF13499	0.571
LIG_deltaCOP1_diTrp_1	100	109	PF00928	0.572
LIG_deltaCOP1_diTrp_1	333	337	PF00928	0.565
LIG_eIF4E_1	235	241	PF01652	0.555
LIG_EVH1_1	275	279	PF00568	0.531
LIG_FHA_1	164	170	PF00498	0.664
LIG_FHA_1	39	45	PF00498	0.521
LIG_FHA_1	4	10	PF00498	0.663
LIG_FHA_2	109	115	PF00498	0.451
LIG_FHA_2	227	233	PF00498	0.594
LIG_FHA_2	304	310	PF00498	0.608
LIG_FHA_2	344	350	PF00498	0.606
LIG_FHA_2	92	98	PF00498	0.716
LIG_GBD_Chelix_1	137	145	PF00786	0.582
LIG_LIR_Apic_2	25	31	PF02991	0.617
LIG_LIR_Gen_1	200	211	PF02991	0.515
LIG_LIR_Gen_1	250	260	PF02991	0.577
LIG_LIR_Gen_1	334	343	PF02991	0.656
LIG_LIR_Gen_1	364	374	PF02991	0.509
LIG_LIR_Gen_1	72	81	PF02991	0.514
LIG_LIR_Nem_3	200	206	PF02991	0.675
LIG_LIR_Nem_3	232	238	PF02991	0.597
LIG_LIR_Nem_3	250	256	PF02991	0.456
LIG_LIR_Nem_3	334	340	PF02991	0.651
LIG_LIR_Nem_3	364	370	PF02991	0.500
LIG_LIR_Nem_3	375	381	PF02991	0.536
LIG_LIR_Nem_3	72	76	PF02991	0.526
LIG_NRBOX	356	362	PF00104	0.449
LIG_Rb_LxCxE_1	287	309	PF01857	0.622
LIG_Rb_pABgroove_1	197	205	PF01858	0.514
LIG_SH2_CRK	73	77	PF00017	0.517
LIG_SH2_NCK_1	28	32	PF00017	0.546
LIG_SH2_SRC	28	31	PF00017	0.619
LIG_SH2_SRC	313	316	PF00017	0.546
LIG_SH2_STAP1	313	317	PF00017	0.536
LIG_SH2_STAP1	374	378	PF00017	0.532
LIG_SH2_STAP1	73	77	PF00017	0.517
LIG_SH2_STAT5	244	247	PF00017	0.514
LIG_SH2_STAT5	374	377	PF00017	0.530
LIG_SH3_3	173	179	PF00018	0.499
LIG_SH3_3	204	210	PF00018	0.525
LIG_SH3_3	270	276	PF00018	0.565
LIG_SUMO_SIM_anti_2	338	344	PF11976	0.571
LIG_TRAF2_1	229	232	PF00917	0.599
LIG_TYR_ITIM	71	76	PF00017	0.513
LIG_UBA3_1	202	208	PF00899	0.582
LIG_WRC_WIRS_1	285	290	PF05994	0.457
LIG_WRC_WIRS_1	48	53	PF05994	0.625
LIG_WW_2	276	279	PF00397	0.526
MOD_CK1_1	218	224	PF00069	0.678
MOD_CK1_1	226	232	PF00069	0.518
MOD_CK1_1	3	9	PF00069	0.537
MOD_CK1_1	355	361	PF00069	0.443
MOD_CK1_1	37	43	PF00069	0.599
MOD_CK1_1	54	60	PF00069	0.496
MOD_CK1_1	64	70	PF00069	0.682
MOD_CK2_1	226	232	PF00069	0.608
MOD_CK2_1	290	296	PF00069	0.673
MOD_CK2_1	303	309	PF00069	0.511
MOD_CK2_1	7	13	PF00069	0.590
MOD_GlcNHglycan	223	226	PF01048	0.580
MOD_GlcNHglycan	270	273	PF01048	0.527
MOD_GlcNHglycan	303	306	PF01048	0.646
MOD_GlcNHglycan	321	324	PF01048	0.516
MOD_GlcNHglycan	346	349	PF01048	0.545
MOD_GlcNHglycan	357	360	PF01048	0.458
MOD_GlcNHglycan	56	59	PF01048	0.573
MOD_GlcNHglycan	83	87	PF01048	0.613
MOD_GlcNHglycan	9	12	PF01048	0.577
MOD_GSK3_1	182	189	PF00069	0.647
MOD_GSK3_1	214	221	PF00069	0.675
MOD_GSK3_1	248	255	PF00069	0.678
MOD_GSK3_1	3	10	PF00069	0.668
MOD_GSK3_1	34	41	PF00069	0.658
MOD_GSK3_1	344	351	PF00069	0.546
MOD_GSK3_1	47	54	PF00069	0.575
MOD_GSK3_1	61	68	PF00069	0.585
MOD_N-GLC_1	52	57	PF02516	0.482
MOD_N-GLC_2	99	101	PF02516	0.605
MOD_NEK2_1	1	6	PF00069	0.622
MOD_NEK2_1	128	133	PF00069	0.507
MOD_NEK2_1	137	142	PF00069	0.537
MOD_NEK2_1	284	289	PF00069	0.454
MOD_NEK2_1	343	348	PF00069	0.616
MOD_NEK2_1	353	358	PF00069	0.448
MOD_NEK2_1	47	52	PF00069	0.584
MOD_PKA_2	182	188	PF00069	0.538
MOD_PKA_2	344	350	PF00069	0.544
MOD_PKB_1	329	337	PF00069	0.511
MOD_Plk_1	128	134	PF00069	0.502
MOD_Plk_1	348	354	PF00069	0.565
MOD_Plk_1	38	44	PF00069	0.548
MOD_Plk_4	248	254	PF00069	0.575
MOD_Plk_4	331	337	PF00069	0.487
MOD_Plk_4	348	354	PF00069	0.508
MOD_Plk_4	71	77	PF00069	0.588
MOD_ProDKin_1	219	225	PF00069	0.677
MOD_ProDKin_1	3	9	PF00069	0.502
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.475
TRG_ENDOCYTIC_2	235	238	PF00928	0.488
TRG_ENDOCYTIC_2	313	316	PF00928	0.621
TRG_ENDOCYTIC_2	366	369	PF00928	0.550
TRG_ENDOCYTIC_2	374	377	PF00928	0.491
TRG_ENDOCYTIC_2	73	76	PF00928	0.518
TRG_ER_diArg_1	144	147	PF00400	0.669
TRG_NES_CRM1_1	32	45	PF08389	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P5	Leptomonas seymouri	39%	81%
A0A3S7X9Q8	Leishmania donovani	90%	90%
A4HN22	Leishmania braziliensis	74%	96%
A4IBP6	Leishmania infantum	90%	90%
E9B6N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	90%