FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania major

UniProt:

E9AFH6_LEIMA

TriTrypDb:

LmjF.35.3520 , LMJLV39_350042600 , LMJSD75_350042100

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFH6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.736
CLV_NRD_NRD_1	203	205	PF00675	0.568
CLV_NRD_NRD_1	439	441	PF00675	0.433
CLV_NRD_NRD_1	467	469	PF00675	0.710
CLV_NRD_NRD_1	559	561	PF00675	0.519
CLV_NRD_NRD_1	82	84	PF00675	0.666
CLV_PCSK_FUR_1	115	119	PF00082	0.587
CLV_PCSK_KEX2_1	111	113	PF00082	0.824
CLV_PCSK_KEX2_1	117	119	PF00082	0.724
CLV_PCSK_KEX2_1	203	205	PF00082	0.568
CLV_PCSK_KEX2_1	439	441	PF00082	0.433
CLV_PCSK_KEX2_1	466	468	PF00082	0.683
CLV_PCSK_KEX2_1	559	561	PF00082	0.519
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.824
CLV_PCSK_PC7_1	462	468	PF00082	0.394
CLV_PCSK_SKI1_1	227	231	PF00082	0.564
CLV_PCSK_SKI1_1	350	354	PF00082	0.356
CLV_PCSK_SKI1_1	440	444	PF00082	0.433
CLV_PCSK_SKI1_1	84	88	PF00082	0.693
DEG_APCC_DBOX_1	349	357	PF00400	0.354
DEG_APCC_DBOX_1	559	567	PF00400	0.443
DEG_SPOP_SBC_1	182	186	PF00917	0.574
DOC_CYCLIN_RxL_1	31	39	PF00134	0.578
DOC_CYCLIN_RxL_1	345	357	PF00134	0.296
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.578
DOC_MAPK_gen_1	436	444	PF00069	0.530
DOC_MAPK_MEF2A_6	287	296	PF00069	0.561
DOC_MAPK_MEF2A_6	381	390	PF00069	0.433
DOC_MAPK_MEF2A_6	523	531	PF00069	0.598
DOC_PP1_RVXF_1	348	355	PF00149	0.296
DOC_PP1_RVXF_1	551	558	PF00149	0.508
DOC_PP2B_LxvP_1	22	25	PF13499	0.582
DOC_PP2B_PxIxI_1	383	389	PF00149	0.530
DOC_USP7_MATH_1	116	120	PF00917	0.720
DOC_USP7_MATH_1	123	127	PF00917	0.741
DOC_USP7_MATH_1	153	157	PF00917	0.645
DOC_USP7_MATH_1	3	7	PF00917	0.661
DOC_USP7_MATH_1	395	399	PF00917	0.569
DOC_USP7_MATH_1	455	459	PF00917	0.433
DOC_USP7_MATH_1	502	506	PF00917	0.670
DOC_USP7_UBL2_3	339	343	PF12436	0.530
DOC_WW_Pin1_4	162	167	PF00397	0.621
DOC_WW_Pin1_4	176	181	PF00397	0.621
DOC_WW_Pin1_4	198	203	PF00397	0.617
DOC_WW_Pin1_4	222	227	PF00397	0.695
DOC_WW_Pin1_4	268	273	PF00397	0.463
DOC_WW_Pin1_4	418	423	PF00397	0.437
DOC_WW_Pin1_4	42	47	PF00397	0.692
LIG_14-3-3_CanoR_1	125	130	PF00244	0.687
LIG_14-3-3_CanoR_1	144	149	PF00244	0.494
LIG_14-3-3_CanoR_1	227	233	PF00244	0.628
LIG_14-3-3_CanoR_1	478	487	PF00244	0.599
LIG_14-3-3_CanoR_1	540	548	PF00244	0.499
LIG_14-3-3_CanoR_1	568	578	PF00244	0.539
LIG_Clathr_ClatBox_1	353	357	PF01394	0.491
LIG_DLG_GKlike_1	125	132	PF00625	0.739
LIG_FHA_1	183	189	PF00498	0.597
LIG_FHA_1	21	27	PF00498	0.730
LIG_FHA_1	291	297	PF00498	0.501
LIG_FHA_1	439	445	PF00498	0.467
LIG_FHA_1	502	508	PF00498	0.768
LIG_FHA_1	524	530	PF00498	0.593
LIG_FHA_1	54	60	PF00498	0.748
LIG_FHA_1	87	93	PF00498	0.678
LIG_FHA_2	138	144	PF00498	0.577
LIG_FHA_2	233	239	PF00498	0.745
LIG_FHA_2	495	501	PF00498	0.692
LIG_FHA_2	71	77	PF00498	0.581
LIG_LIR_Gen_1	349	359	PF02991	0.530
LIG_LIR_Gen_1	515	525	PF02991	0.560
LIG_LIR_Nem_3	103	108	PF02991	0.654
LIG_LIR_Nem_3	335	341	PF02991	0.462
LIG_LIR_Nem_3	349	354	PF02991	0.366
LIG_LIR_Nem_3	357	362	PF02991	0.398
LIG_LIR_Nem_3	382	386	PF02991	0.368
LIG_LIR_Nem_3	515	521	PF02991	0.573
LIG_MYND_1	162	166	PF01753	0.673
LIG_MYND_1	46	50	PF01753	0.669
LIG_PCNA_TLS_4	345	352	PF02747	0.530
LIG_PCNA_yPIPBox_3	439	453	PF02747	0.530
LIG_PTB_Apo_2	272	279	PF02174	0.631
LIG_PTB_Apo_2	99	106	PF02174	0.632
LIG_PTB_Phospho_1	99	105	PF10480	0.634
LIG_SH2_CRK	105	109	PF00017	0.679
LIG_SH2_CRK	456	460	PF00017	0.530
LIG_SH2_STAP1	371	375	PF00017	0.530
LIG_SH2_STAP1	427	431	PF00017	0.433
LIG_SH2_STAT5	281	284	PF00017	0.475
LIG_SH3_3	22	28	PF00018	0.797
LIG_SH3_3	449	455	PF00018	0.530
LIG_SUMO_SIM_anti_2	126	134	PF11976	0.698
LIG_SUMO_SIM_par_1	292	297	PF11976	0.530
LIG_SUMO_SIM_par_1	440	445	PF11976	0.530
LIG_TRAF2_1	234	237	PF00917	0.657
LIG_WRC_WIRS_1	547	552	PF05994	0.570
MOD_CDC14_SPxK_1	165	168	PF00782	0.717
MOD_CDK_SPK_2	198	203	PF00069	0.670
MOD_CDK_SPK_2	222	227	PF00069	0.597
MOD_CDK_SPxK_1	162	168	PF00069	0.623
MOD_CDK_SPxK_1	198	204	PF00069	0.561
MOD_CK1_1	15	21	PF00069	0.766
MOD_CK1_1	216	222	PF00069	0.701
MOD_CK1_1	332	338	PF00069	0.433
MOD_CK1_1	393	399	PF00069	0.787
MOD_CK1_1	494	500	PF00069	0.705
MOD_CK1_1	570	576	PF00069	0.562
MOD_CK2_1	232	238	PF00069	0.756
MOD_CK2_1	494	500	PF00069	0.773
MOD_CK2_1	539	545	PF00069	0.603
MOD_Cter_Amidation	109	112	PF01082	0.822
MOD_GlcNHglycan	108	111	PF01048	0.737
MOD_GlcNHglycan	120	123	PF01048	0.578
MOD_GlcNHglycan	146	149	PF01048	0.676
MOD_GlcNHglycan	17	20	PF01048	0.723
MOD_GlcNHglycan	174	177	PF01048	0.681
MOD_GlcNHglycan	334	337	PF01048	0.504
MOD_GlcNHglycan	393	396	PF01048	0.757
MOD_GlcNHglycan	397	400	PF01048	0.766
MOD_GlcNHglycan	493	496	PF01048	0.776
MOD_GlcNHglycan	572	575	PF01048	0.561
MOD_GSK3_1	153	160	PF00069	0.700
MOD_GSK3_1	172	179	PF00069	0.511
MOD_GSK3_1	192	199	PF00069	0.703
MOD_GSK3_1	228	235	PF00069	0.663
MOD_GSK3_1	298	305	PF00069	0.407
MOD_GSK3_1	3	10	PF00069	0.802
MOD_GSK3_1	328	335	PF00069	0.394
MOD_GSK3_1	391	398	PF00069	0.582
MOD_GSK3_1	487	494	PF00069	0.659
MOD_GSK3_1	551	558	PF00069	0.371
MOD_GSK3_1	71	78	PF00069	0.653
MOD_N-GLC_1	268	273	PF02516	0.586
MOD_N-GLC_1	95	100	PF02516	0.771
MOD_N-GLC_2	41	43	PF02516	0.680
MOD_N-GLC_2	448	450	PF02516	0.394
MOD_NEK2_1	100	105	PF00069	0.691
MOD_NEK2_1	196	201	PF00069	0.661
MOD_NEK2_1	228	233	PF00069	0.558
MOD_NEK2_1	298	303	PF00069	0.530
MOD_NEK2_1	30	35	PF00069	0.712
MOD_NEK2_1	36	41	PF00069	0.649
MOD_NEK2_1	364	369	PF00069	0.530
MOD_NEK2_1	390	395	PF00069	0.640
MOD_NEK2_1	438	443	PF00069	0.530
MOD_NEK2_1	479	484	PF00069	0.655
MOD_NEK2_1	487	492	PF00069	0.633
MOD_NEK2_1	511	516	PF00069	0.686
MOD_NEK2_1	551	556	PF00069	0.594
MOD_NEK2_1	59	64	PF00069	0.756
MOD_NEK2_2	455	460	PF00069	0.433
MOD_PIKK_1	281	287	PF00454	0.401
MOD_PIKK_1	399	405	PF00454	0.703
MOD_PIKK_1	479	485	PF00454	0.598
MOD_PIKK_1	539	545	PF00454	0.506
MOD_PIKK_1	59	65	PF00454	0.692
MOD_PKA_1	117	123	PF00069	0.673
MOD_PKA_1	203	209	PF00069	0.570
MOD_PKA_2	116	122	PF00069	0.691
MOD_PKA_2	124	130	PF00069	0.747
MOD_PKA_2	143	149	PF00069	0.499
MOD_PKA_2	203	209	PF00069	0.614
MOD_PKA_2	290	296	PF00069	0.413
MOD_PKA_2	438	444	PF00069	0.530
MOD_PKA_2	479	485	PF00069	0.598
MOD_PKA_2	539	545	PF00069	0.506
MOD_PKA_2	567	573	PF00069	0.513
MOD_PKB_1	115	123	PF00069	0.721
MOD_Plk_1	219	225	PF00069	0.566
MOD_Plk_1	298	304	PF00069	0.407
MOD_Plk_1	502	508	PF00069	0.695
MOD_Plk_1	523	529	PF00069	0.600
MOD_Plk_1	75	81	PF00069	0.809
MOD_Plk_1	95	101	PF00069	0.676
MOD_Plk_4	228	234	PF00069	0.744
MOD_Plk_4	290	296	PF00069	0.501
MOD_Plk_4	298	304	PF00069	0.362
MOD_Plk_4	371	377	PF00069	0.296
MOD_Plk_4	523	529	PF00069	0.600
MOD_Plk_4	546	552	PF00069	0.576
MOD_Plk_4	95	101	PF00069	0.579
MOD_ProDKin_1	162	168	PF00069	0.623
MOD_ProDKin_1	176	182	PF00069	0.622
MOD_ProDKin_1	198	204	PF00069	0.617
MOD_ProDKin_1	222	228	PF00069	0.696
MOD_ProDKin_1	268	274	PF00069	0.468
MOD_ProDKin_1	418	424	PF00069	0.437
MOD_ProDKin_1	42	48	PF00069	0.692
TRG_DiLeu_BaEn_1	524	529	PF01217	0.588
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.633
TRG_ENDOCYTIC_2	105	108	PF00928	0.625
TRG_ENDOCYTIC_2	338	341	PF00928	0.530
TRG_ENDOCYTIC_2	456	459	PF00928	0.530
TRG_ENDOCYTIC_2	518	521	PF00928	0.540
TRG_ER_diArg_1	115	118	PF00400	0.590
TRG_ER_diArg_1	202	204	PF00400	0.559
TRG_ER_diArg_1	438	440	PF00400	0.433
TRG_ER_diArg_1	466	468	PF00400	0.644
TRG_ER_diArg_1	478	481	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.703
TRG_Pf-PMV_PEXEL_1	377	382	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIK2	Leishmania donovani	88%	100%
A4HN21	Leishmania braziliensis	59%	100%
A4IBP7	Leishmania infantum	88%	100%
E9B6N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%