Reverse transcriptase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein, putative

Species:

Leishmania major

UniProt:

E9AFH4_LEIMA

TriTrypDb:

LmjF.35.3500 , LMJLV39_350042400 , LMJSD75_350041900

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFH4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.630
CLV_NRD_NRD_1	55	57	PF00675	0.626
CLV_PCSK_SKI1_1	107	111	PF00082	0.478
CLV_PCSK_SKI1_1	191	195	PF00082	0.631
CLV_PCSK_SKI1_1	96	100	PF00082	0.571
DOC_MAPK_MEF2A_6	107	115	PF00069	0.595
DOC_PP2B_LxvP_1	154	157	PF13499	0.636
DOC_USP7_MATH_1	30	34	PF00917	0.724
DOC_USP7_MATH_1	42	46	PF00917	0.654
DOC_WW_Pin1_4	87	92	PF00397	0.634
LIG_14-3-3_CanoR_1	102	107	PF00244	0.568
LIG_14-3-3_CanoR_1	31	38	PF00244	0.821
LIG_BIR_III_4	34	38	PF00653	0.731
LIG_EVH1_1	154	158	PF00568	0.647
LIG_FHA_1	108	114	PF00498	0.599
LIG_FHA_1	133	139	PF00498	0.698
LIG_FHA_1	149	155	PF00498	0.627
LIG_FHA_1	196	202	PF00498	0.710
LIG_FHA_2	125	131	PF00498	0.760
LIG_FHA_2	177	183	PF00498	0.710
LIG_FHA_2	45	51	PF00498	0.694
LIG_GBD_Chelix_1	184	192	PF00786	0.560
LIG_LIR_Gen_1	110	117	PF02991	0.612
LIG_LIR_Gen_1	59	70	PF02991	0.619
LIG_LIR_Nem_3	110	115	PF02991	0.610
LIG_LIR_Nem_3	207	212	PF02991	0.648
LIG_LIR_Nem_3	59	65	PF02991	0.595
LIG_SH2_CRK	62	66	PF00017	0.740
LIG_SH2_GRB2like	62	65	PF00017	0.733
LIG_SH2_PTP2	112	115	PF00017	0.620
LIG_SH2_SRC	112	115	PF00017	0.620
LIG_SH2_STAT5	112	115	PF00017	0.595
LIG_SH2_STAT5	166	169	PF00017	0.639
LIG_SH3_1	152	158	PF00018	0.647
LIG_SH3_3	139	145	PF00018	0.626
LIG_SH3_3	152	158	PF00018	0.636
LIG_SH3_CIN85_PxpxPR_1	26	31	PF14604	0.688
LIG_TYR_ITSM	108	115	PF00017	0.601
MOD_CK1_1	132	138	PF00069	0.639
MOD_CK1_1	160	166	PF00069	0.655
MOD_CK2_1	124	130	PF00069	0.752
MOD_CK2_1	176	182	PF00069	0.712
MOD_CK2_1	44	50	PF00069	0.677
MOD_GlcNHglycan	162	165	PF01048	0.610
MOD_GlcNHglycan	204	207	PF01048	0.516
MOD_GlcNHglycan	26	29	PF01048	0.780
MOD_GSK3_1	132	139	PF00069	0.669
MOD_GSK3_1	191	198	PF00069	0.653
MOD_GSK3_1	81	88	PF00069	0.668
MOD_N-GLC_2	6	8	PF02516	0.539
MOD_PKA_2	132	138	PF00069	0.660
MOD_PKA_2	202	208	PF00069	0.520
MOD_PKA_2	30	36	PF00069	0.767
MOD_Plk_2-3	136	142	PF00069	0.662
MOD_Plk_4	107	113	PF00069	0.530
MOD_ProDKin_1	87	93	PF00069	0.626
TRG_DiLeu_BaEn_1	95	100	PF01217	0.569
TRG_ENDOCYTIC_2	112	115	PF00928	0.620
TRG_ENDOCYTIC_2	62	65	PF00928	0.603
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9N1	Leptomonas seymouri	56%	70%
A0A3Q8II84	Leishmania donovani	93%	100%
A4HN19	Leishmania braziliensis	74%	71%
A4IBP0	Leishmania infantum	92%	95%
E9B6M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	71%