Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFH3_LEIMA

TriTrypDb:

LmjF.35.3490 , LMJLV39_350042300 , LMJSD75_350041800

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFH3

PDB structure(s): 7ane_q

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.489
CLV_C14_Caspase3-7	207	211	PF00656	0.407
CLV_C14_Caspase3-7	246	250	PF00656	0.659
CLV_C14_Caspase3-7	337	341	PF00656	0.566
CLV_NRD_NRD_1	102	104	PF00675	0.515
CLV_NRD_NRD_1	26	28	PF00675	0.431
CLV_NRD_NRD_1	268	270	PF00675	0.633
CLV_NRD_NRD_1	286	288	PF00675	0.400
CLV_NRD_NRD_1	302	304	PF00675	0.657
CLV_NRD_NRD_1	324	326	PF00675	0.615
CLV_NRD_NRD_1	57	59	PF00675	0.366
CLV_NRD_NRD_1	9	11	PF00675	0.466
CLV_NRD_NRD_1	99	101	PF00675	0.528
CLV_PCSK_FUR_1	100	104	PF00082	0.514
CLV_PCSK_KEX2_1	101	103	PF00082	0.437
CLV_PCSK_KEX2_1	26	28	PF00082	0.431
CLV_PCSK_KEX2_1	286	288	PF00082	0.499
CLV_PCSK_KEX2_1	302	304	PF00082	0.657
CLV_PCSK_KEX2_1	323	325	PF00082	0.617
CLV_PCSK_KEX2_1	362	364	PF00082	0.609
CLV_PCSK_KEX2_1	62	64	PF00082	0.373
CLV_PCSK_KEX2_1	9	11	PF00082	0.466
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.437
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.614
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.609
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.386
CLV_PCSK_PC7_1	282	288	PF00082	0.485
CLV_PCSK_PC7_1	58	64	PF00082	0.367
CLV_PCSK_SKI1_1	112	116	PF00082	0.427
CLV_PCSK_SKI1_1	129	133	PF00082	0.317
CLV_PCSK_SKI1_1	26	30	PF00082	0.403
CLV_PCSK_SKI1_1	298	302	PF00082	0.587
CLV_PCSK_SKI1_1	349	353	PF00082	0.557
DOC_CKS1_1	31	36	PF01111	0.376
DOC_CYCLIN_RxL_1	112	125	PF00134	0.404
DOC_MAPK_gen_1	116	122	PF00069	0.402
DOC_PP4_FxxP_1	301	304	PF00568	0.601
DOC_PP4_FxxP_1	31	34	PF00568	0.382
DOC_USP7_MATH_1	152	156	PF00917	0.346
DOC_USP7_MATH_1	19	23	PF00917	0.444
DOC_USP7_MATH_1	245	249	PF00917	0.651
DOC_USP7_UBL2_3	294	298	PF12436	0.567
DOC_USP7_UBL2_3	345	349	PF12436	0.710
DOC_WW_Pin1_4	30	35	PF00397	0.391
DOC_WW_Pin1_4	309	314	PF00397	0.730
DOC_WW_Pin1_4	317	322	PF00397	0.627
DOC_WW_Pin1_4	385	390	PF00397	0.664
LIG_14-3-3_CanoR_1	137	145	PF00244	0.361
LIG_14-3-3_CanoR_1	400	407	PF00244	0.631
LIG_FHA_1	27	33	PF00498	0.402
LIG_FHA_1	401	407	PF00498	0.673
LIG_FHA_2	212	218	PF00498	0.576
LIG_FHA_2	272	278	PF00498	0.612
LIG_LIR_Apic_2	214	219	PF02991	0.597
LIG_LIR_Apic_2	29	34	PF02991	0.382
LIG_LIR_Apic_2	299	304	PF02991	0.645
LIG_LIR_Gen_1	51	61	PF02991	0.369
LIG_LIR_Nem_3	44	49	PF02991	0.364
LIG_LIR_Nem_3	51	57	PF02991	0.371
LIG_MYND_3	183	187	PF01753	0.440
LIG_MYND_3	379	383	PF01753	0.652
LIG_PDZ_Class_3	421	426	PF00595	0.610
LIG_Pex14_1	65	69	PF04695	0.356
LIG_SH2_CRK	16	20	PF00017	0.417
LIG_SH2_GRB2like	15	18	PF00017	0.429
LIG_SH2_NCK_1	135	139	PF00017	0.351
LIG_SH2_NCK_1	16	20	PF00017	0.402
LIG_SH2_NCK_1	216	220	PF00017	0.541
LIG_SH2_STAT3	150	153	PF00017	0.437
LIG_SH2_STAT3	61	64	PF00017	0.370
LIG_SH2_STAT5	150	153	PF00017	0.402
LIG_SH2_STAT5	167	170	PF00017	0.390
LIG_SH2_STAT5	289	292	PF00017	0.512
LIG_SH2_STAT5	76	79	PF00017	0.370
LIG_TRAF2_1	155	158	PF00917	0.470
LIG_TRAF2_1	235	238	PF00917	0.532
LIG_TRAF2_1	274	277	PF00917	0.594
LIG_TRAF2_1	278	281	PF00917	0.655
LIG_TRAF2_1	334	337	PF00917	0.558
LIG_WRC_WIRS_1	66	71	PF05994	0.357
MOD_CDK_SPxK_1	30	36	PF00069	0.385
MOD_CDK_SPxK_1	317	323	PF00069	0.639
MOD_CDK_SPxxK_3	317	324	PF00069	0.634
MOD_CK1_1	381	387	PF00069	0.686
MOD_CK2_1	152	158	PF00069	0.479
MOD_CK2_1	17	23	PF00069	0.479
MOD_CK2_1	211	217	PF00069	0.554
MOD_CK2_1	232	238	PF00069	0.541
MOD_CK2_1	271	277	PF00069	0.622
MOD_Cter_Amidation	24	27	PF01082	0.451
MOD_GlcNHglycan	234	237	PF01048	0.480
MOD_GlcNHglycan	262	265	PF01048	0.687
MOD_GlcNHglycan	314	317	PF01048	0.631
MOD_GlcNHglycan	4	7	PF01048	0.710
MOD_GlcNHglycan	84	87	PF01048	0.509
MOD_GSK3_1	199	206	PF00069	0.532
MOD_GSK3_1	245	252	PF00069	0.517
MOD_GSK3_1	26	33	PF00069	0.392
MOD_GSK3_1	271	278	PF00069	0.494
MOD_GSK3_1	292	299	PF00069	0.537
MOD_GSK3_1	305	312	PF00069	0.561
MOD_GSK3_1	381	388	PF00069	0.664
MOD_LATS_1	24	30	PF00433	0.428
MOD_N-GLC_1	80	85	PF02516	0.366
MOD_NEK2_1	1	6	PF00069	0.570
MOD_NEK2_1	232	237	PF00069	0.485
MOD_NEK2_2	211	216	PF00069	0.595
MOD_NEK2_2	296	301	PF00069	0.591
MOD_NEK2_2	65	70	PF00069	0.358
MOD_PIKK_1	102	108	PF00454	0.530
MOD_PKA_1	102	108	PF00069	0.530
MOD_PKA_1	26	32	PF00069	0.411
MOD_PKA_1	324	330	PF00069	0.664
MOD_PKA_2	102	108	PF00069	0.530
MOD_PKA_2	136	142	PF00069	0.354
MOD_PKA_2	26	32	PF00069	0.539
MOD_PKA_2	324	330	PF00069	0.676
MOD_PKB_1	100	108	PF00069	0.515
MOD_PKB_1	303	311	PF00069	0.622
MOD_Plk_1	353	359	PF00069	0.622
MOD_Plk_4	211	217	PF00069	0.568
MOD_Plk_4	296	302	PF00069	0.631
MOD_ProDKin_1	30	36	PF00069	0.385
MOD_ProDKin_1	309	315	PF00069	0.732
MOD_ProDKin_1	317	323	PF00069	0.625
MOD_ProDKin_1	385	391	PF00069	0.662
MOD_SUMO_for_1	351	354	PF00179	0.591
MOD_SUMO_rev_2	220	230	PF00179	0.621
TRG_ENDOCYTIC_2	15	18	PF00928	0.429
TRG_ER_diArg_1	100	103	PF00400	0.516
TRG_ER_diArg_1	241	244	PF00400	0.566
TRG_ER_diArg_1	26	28	PF00400	0.533
TRG_ER_diArg_1	301	303	PF00400	0.670
TRG_ER_diArg_1	370	373	PF00400	0.578
TRG_NLS_Bipartite_1	100	120	PF00514	0.434
TRG_NLS_MonoCore_2	322	327	PF00514	0.628
TRG_NLS_MonoExtC_3	115	121	PF00514	0.409
TRG_NLS_MonoExtC_3	324	330	PF00514	0.545
TRG_NLS_MonoExtN_4	321	327	PF00514	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P6	Leptomonas seymouri	78%	100%
A0A0S4IKL5	Bodo saltans	51%	91%
A0A1X0P5A6	Trypanosomatidae	61%	96%
A0A3Q8IPV2	Leishmania donovani	97%	100%
A0A3R7NKQ1	Trypanosoma rangeli	61%	97%
A4HN18	Leishmania braziliensis	92%	100%
A4IBN9	Leishmania infantum	97%	100%
C9ZYZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	97%
E9B6M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BY99	Trypanosoma cruzi	60%	96%