Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFH2_LEIMA

TriTrypDb:

LmjF.35.3480 , LMJLV39_350042200 , LMJSD75_350041700

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	414	418	PF00656	0.510
CLV_NRD_NRD_1	190	192	PF00675	0.754
CLV_NRD_NRD_1	225	227	PF00675	0.685
CLV_NRD_NRD_1	437	439	PF00675	0.810
CLV_PCSK_FUR_1	188	192	PF00082	0.748
CLV_PCSK_FUR_1	440	444	PF00082	0.638
CLV_PCSK_KEX2_1	11	13	PF00082	0.444
CLV_PCSK_KEX2_1	190	192	PF00082	0.758
CLV_PCSK_KEX2_1	225	227	PF00082	0.685
CLV_PCSK_KEX2_1	439	441	PF00082	0.744
CLV_PCSK_KEX2_1	442	444	PF00082	0.711
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.444
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.744
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.711
CLV_PCSK_PC7_1	438	444	PF00082	0.633
CLV_PCSK_SKI1_1	325	329	PF00082	0.681
CLV_PCSK_SKI1_1	376	380	PF00082	0.601
CLV_PCSK_SKI1_1	705	709	PF00082	0.781
DEG_SCF_FBW7_1	379	385	PF00400	0.578
DEG_SCF_FBW7_1	579	586	PF00400	0.775
DEG_SIAH_1	145	153	PF03145	0.803
DEG_SPOP_SBC_1	280	284	PF00917	0.646
DEG_SPOP_SBC_1	482	486	PF00917	0.727
DEG_SPOP_SBC_1	549	553	PF00917	0.805
DOC_CKS1_1	379	384	PF01111	0.535
DOC_CKS1_1	446	451	PF01111	0.721
DOC_CKS1_1	515	520	PF01111	0.788
DOC_CKS1_1	584	589	PF01111	0.771
DOC_CKS1_1	683	688	PF01111	0.743
DOC_CKS1_1	701	706	PF01111	0.677
DOC_CYCLIN_yCln2_LP_2	720	726	PF00134	0.776
DOC_MAPK_DCC_7	147	155	PF00069	0.679
DOC_MAPK_HePTP_8	29	41	PF00069	0.597
DOC_MAPK_MEF2A_6	175	183	PF00069	0.655
DOC_MAPK_MEF2A_6	299	307	PF00069	0.467
DOC_MAPK_MEF2A_6	32	41	PF00069	0.541
DOC_PP1_RVXF_1	30	37	PF00149	0.607
DOC_PP2B_LxvP_1	341	344	PF13499	0.503
DOC_PP2B_LxvP_1	671	674	PF13499	0.782
DOC_PP2B_LxvP_1	689	692	PF13499	0.625
DOC_PP2B_LxvP_1	720	723	PF13499	0.753
DOC_PP4_FxxP_1	603	606	PF00568	0.726
DOC_USP7_MATH_1	146	150	PF00917	0.796
DOC_USP7_MATH_1	163	167	PF00917	0.737
DOC_USP7_MATH_1	213	217	PF00917	0.830
DOC_USP7_MATH_1	232	236	PF00917	0.582
DOC_USP7_MATH_1	275	279	PF00917	0.676
DOC_USP7_MATH_1	345	349	PF00917	0.544
DOC_USP7_MATH_1	382	386	PF00917	0.627
DOC_USP7_MATH_1	423	427	PF00917	0.692
DOC_USP7_MATH_1	482	486	PF00917	0.690
DOC_USP7_MATH_1	541	545	PF00917	0.730
DOC_USP7_MATH_1	550	554	PF00917	0.814
DOC_USP7_MATH_1	573	577	PF00917	0.753
DOC_USP7_MATH_1	587	591	PF00917	0.619
DOC_USP7_MATH_1	596	600	PF00917	0.728
DOC_USP7_MATH_1	643	647	PF00917	0.718
DOC_USP7_UBL2_3	273	277	PF12436	0.734
DOC_WW_Pin1_4	148	153	PF00397	0.794
DOC_WW_Pin1_4	267	272	PF00397	0.537
DOC_WW_Pin1_4	312	317	PF00397	0.624
DOC_WW_Pin1_4	378	383	PF00397	0.480
DOC_WW_Pin1_4	445	450	PF00397	0.725
DOC_WW_Pin1_4	455	460	PF00397	0.581
DOC_WW_Pin1_4	501	506	PF00397	0.765
DOC_WW_Pin1_4	514	519	PF00397	0.763
DOC_WW_Pin1_4	521	526	PF00397	0.818
DOC_WW_Pin1_4	539	544	PF00397	0.671
DOC_WW_Pin1_4	555	560	PF00397	0.726
DOC_WW_Pin1_4	579	584	PF00397	0.754
DOC_WW_Pin1_4	592	597	PF00397	0.657
DOC_WW_Pin1_4	614	619	PF00397	0.698
DOC_WW_Pin1_4	633	638	PF00397	0.794
DOC_WW_Pin1_4	682	687	PF00397	0.715
DOC_WW_Pin1_4	694	699	PF00397	0.745
DOC_WW_Pin1_4	700	705	PF00397	0.788
LIG_14-3-3_CanoR_1	114	120	PF00244	0.401
LIG_14-3-3_CanoR_1	137	146	PF00244	0.585
LIG_14-3-3_CanoR_1	147	151	PF00244	0.676
LIG_14-3-3_CanoR_1	214	224	PF00244	0.749
LIG_14-3-3_CanoR_1	443	449	PF00244	0.773
LIG_14-3-3_CanoR_1	470	474	PF00244	0.747
LIG_14-3-3_CanoR_1	480	487	PF00244	0.692
LIG_14-3-3_CanoR_1	63	72	PF00244	0.603
LIG_14-3-3_CanoR_1	94	98	PF00244	0.581
LIG_BIR_III_2	162	166	PF00653	0.701
LIG_BRCT_BRCA1_1	457	461	PF00533	0.787
LIG_BRCT_BRCA1_1	653	657	PF00533	0.817
LIG_EH1_1	291	299	PF00400	0.462
LIG_eIF4E_1	14	20	PF01652	0.496
LIG_FHA_1	24	30	PF00498	0.480
LIG_FHA_1	281	287	PF00498	0.600
LIG_FHA_1	403	409	PF00498	0.486
LIG_FHA_1	51	57	PF00498	0.468
LIG_FHA_1	633	639	PF00498	0.664
LIG_FHA_1	701	707	PF00498	0.662
LIG_FHA_2	194	200	PF00498	0.688
LIG_FHA_2	321	327	PF00498	0.690
LIG_FXI_DFP_1	33	37	PF00024	0.535
LIG_LIR_Apic_2	601	606	PF02991	0.766
LIG_LIR_Apic_2	625	631	PF02991	0.710
LIG_LIR_Gen_1	128	139	PF02991	0.495
LIG_LIR_Gen_1	30	41	PF02991	0.475
LIG_LIR_Gen_1	369	378	PF02991	0.517
LIG_LIR_Nem_3	115	119	PF02991	0.565
LIG_LIR_Nem_3	30	36	PF02991	0.454
LIG_LIR_Nem_3	369	373	PF02991	0.517
LIG_LIR_Nem_3	458	464	PF02991	0.639
LIG_LIR_Nem_3	472	476	PF02991	0.713
LIG_MYND_1	669	673	PF01753	0.784
LIG_NRBOX	236	242	PF00104	0.593
LIG_PTAP_UEV_1	605	610	PF05743	0.570
LIG_PTB_Apo_2	669	676	PF02174	0.567
LIG_PTB_Phospho_1	669	675	PF10480	0.567
LIG_SH2_CRK	355	359	PF00017	0.455
LIG_SH2_CRK	370	374	PF00017	0.489
LIG_SH2_CRK	628	632	PF00017	0.672
LIG_SH2_NCK_1	243	247	PF00017	0.486
LIG_SH2_NCK_1	545	549	PF00017	0.830
LIG_SH2_NCK_1	570	574	PF00017	0.764
LIG_SH2_SRC	119	122	PF00017	0.588
LIG_SH2_SRC	46	49	PF00017	0.570
LIG_SH2_SRC	628	631	PF00017	0.562
LIG_SH2_STAP1	116	120	PF00017	0.621
LIG_SH2_STAP1	243	247	PF00017	0.486
LIG_SH2_STAP1	355	359	PF00017	0.509
LIG_SH2_STAP1	545	549	PF00017	0.590
LIG_SH2_STAP1	570	574	PF00017	0.764
LIG_SH2_STAT3	247	250	PF00017	0.523
LIG_SH2_STAT3	359	362	PF00017	0.509
LIG_SH2_STAT5	119	122	PF00017	0.494
LIG_SH2_STAT5	177	180	PF00017	0.646
LIG_SH2_STAT5	352	355	PF00017	0.456
LIG_SH2_STAT5	393	396	PF00017	0.611
LIG_SH2_STAT5	570	573	PF00017	0.838
LIG_SH2_STAT5	675	678	PF00017	0.718
LIG_SH3_2	192	197	PF14604	0.739
LIG_SH3_2	559	564	PF14604	0.578
LIG_SH3_3	152	158	PF00018	0.716
LIG_SH3_3	189	195	PF00018	0.734
LIG_SH3_3	313	319	PF00018	0.648
LIG_SH3_3	37	43	PF00018	0.461
LIG_SH3_3	425	431	PF00018	0.709
LIG_SH3_3	503	509	PF00018	0.736
LIG_SH3_3	512	518	PF00018	0.782
LIG_SH3_3	519	525	PF00018	0.666
LIG_SH3_3	535	541	PF00018	0.778
LIG_SH3_3	553	559	PF00018	0.610
LIG_SH3_3	562	568	PF00018	0.788
LIG_SH3_3	569	575	PF00018	0.608
LIG_SH3_3	603	609	PF00018	0.751
LIG_SH3_3	667	673	PF00018	0.719
LIG_SH3_3	676	682	PF00018	0.679
LIG_SH3_3	685	691	PF00018	0.544
LIG_SH3_3	693	699	PF00018	0.697
LIG_SH3_3	708	714	PF00018	0.581
LIG_SH3_3	723	729	PF00018	0.681
LIG_SH3_3	97	103	PF00018	0.588
LIG_SH3_CIN85_PxpxPR_1	725	730	PF14604	0.655
LIG_SUMO_SIM_par_1	25	30	PF11976	0.526
LIG_SUMO_SIM_par_1	635	642	PF11976	0.573
LIG_TRFH_1	14	18	PF08558	0.493
LIG_TYR_ITIM	353	358	PF00017	0.437
LIG_TYR_ITIM	368	373	PF00017	0.478
LIG_WRC_WIRS_1	473	478	PF05994	0.796
LIG_WRC_WIRS_1	600	605	PF05994	0.731
LIG_WW_1	567	570	PF00397	0.737
LIG_WW_2	559	562	PF00397	0.671
LIG_WW_3	222	226	PF00397	0.837
LIG_WW_3	317	321	PF00397	0.676
MOD_CDK_SPK_2	455	460	PF00069	0.553
MOD_CDK_SPK_2	700	705	PF00069	0.570
MOD_CDK_SPxK_1	267	273	PF00069	0.664
MOD_CDK_SPxK_1	583	589	PF00069	0.749
MOD_CDK_SPxK_1	684	690	PF00069	0.575
MOD_CK1_1	193	199	PF00069	0.744
MOD_CK1_1	22	28	PF00069	0.534
MOD_CK1_1	284	290	PF00069	0.630
MOD_CK1_1	445	451	PF00069	0.767
MOD_CK1_1	469	475	PF00069	0.703
MOD_CK1_1	478	484	PF00069	0.665
MOD_CK1_1	485	491	PF00069	0.592
MOD_CK1_1	599	605	PF00069	0.743
MOD_CK1_1	636	642	PF00069	0.784
MOD_CK2_1	193	199	PF00069	0.768
MOD_CK2_1	248	254	PF00069	0.544
MOD_CK2_1	320	326	PF00069	0.726
MOD_GlcNHglycan	22	25	PF01048	0.513
MOD_GlcNHglycan	276	280	PF01048	0.674
MOD_GlcNHglycan	480	483	PF01048	0.698
MOD_GlcNHglycan	545	548	PF01048	0.590
MOD_GlcNHglycan	575	578	PF01048	0.826
MOD_GlcNHglycan	603	606	PF01048	0.768
MOD_GlcNHglycan	692	695	PF01048	0.764
MOD_GSK3_1	19	26	PF00069	0.443
MOD_GSK3_1	228	235	PF00069	0.645
MOD_GSK3_1	248	255	PF00069	0.390
MOD_GSK3_1	275	282	PF00069	0.697
MOD_GSK3_1	378	385	PF00069	0.580
MOD_GSK3_1	412	419	PF00069	0.501
MOD_GSK3_1	438	445	PF00069	0.734
MOD_GSK3_1	455	462	PF00069	0.698
MOD_GSK3_1	471	478	PF00069	0.660
MOD_GSK3_1	481	488	PF00069	0.627
MOD_GSK3_1	539	546	PF00069	0.760
MOD_GSK3_1	551	558	PF00069	0.828
MOD_GSK3_1	573	580	PF00069	0.732
MOD_GSK3_1	583	590	PF00069	0.675
MOD_GSK3_1	592	599	PF00069	0.544
MOD_GSK3_1	632	639	PF00069	0.656
MOD_GSK3_1	649	656	PF00069	0.803
MOD_GSK3_1	690	697	PF00069	0.775
MOD_N-GLC_1	122	127	PF02516	0.344
MOD_N-GLC_1	366	371	PF02516	0.496
MOD_N-GLC_1	532	537	PF02516	0.738
MOD_N-GLC_2	55	57	PF02516	0.552
MOD_NEK2_1	19	24	PF00069	0.501
MOD_NEK2_1	252	257	PF00069	0.498
MOD_NEK2_1	411	416	PF00069	0.623
MOD_NEK2_1	476	481	PF00069	0.723
MOD_NEK2_1	487	492	PF00069	0.644
MOD_NEK2_1	644	649	PF00069	0.706
MOD_PIKK_1	137	143	PF00454	0.613
MOD_PIKK_1	190	196	PF00454	0.828
MOD_PIKK_1	442	448	PF00454	0.775
MOD_PIKK_1	533	539	PF00454	0.756
MOD_PIKK_1	551	557	PF00454	0.835
MOD_PIKK_1	587	593	PF00454	0.778
MOD_PIKK_1	607	613	PF00454	0.584
MOD_PIKK_1	705	711	PF00454	0.718
MOD_PKA_1	190	196	PF00069	0.781
MOD_PKA_1	438	444	PF00069	0.740
MOD_PKA_2	146	152	PF00069	0.674
MOD_PKA_2	190	196	PF00069	0.731
MOD_PKA_2	213	219	PF00069	0.751
MOD_PKA_2	284	290	PF00069	0.612
MOD_PKA_2	442	448	PF00069	0.782
MOD_PKA_2	469	475	PF00069	0.735
MOD_PKA_2	62	68	PF00069	0.532
MOD_PKA_2	93	99	PF00069	0.568
MOD_PKB_1	188	196	PF00069	0.824
MOD_Plk_1	232	238	PF00069	0.560
MOD_Plk_1	366	372	PF00069	0.492
MOD_Plk_4	115	121	PF00069	0.456
MOD_Plk_4	233	239	PF00069	0.509
MOD_Plk_4	293	299	PF00069	0.570
MOD_Plk_4	366	372	PF00069	0.492
MOD_Plk_4	423	429	PF00069	0.696
MOD_Plk_4	68	74	PF00069	0.431
MOD_ProDKin_1	148	154	PF00069	0.698
MOD_ProDKin_1	267	273	PF00069	0.549
MOD_ProDKin_1	312	318	PF00069	0.633
MOD_ProDKin_1	378	384	PF00069	0.489
MOD_ProDKin_1	445	451	PF00069	0.725
MOD_ProDKin_1	455	461	PF00069	0.581
MOD_ProDKin_1	501	507	PF00069	0.768
MOD_ProDKin_1	514	520	PF00069	0.761
MOD_ProDKin_1	521	527	PF00069	0.820
MOD_ProDKin_1	539	545	PF00069	0.675
MOD_ProDKin_1	555	561	PF00069	0.730
MOD_ProDKin_1	579	585	PF00069	0.752
MOD_ProDKin_1	592	598	PF00069	0.658
MOD_ProDKin_1	614	620	PF00069	0.697
MOD_ProDKin_1	633	639	PF00069	0.792
MOD_ProDKin_1	682	688	PF00069	0.717
MOD_ProDKin_1	694	700	PF00069	0.746
MOD_SUMO_rev_2	324	330	PF00179	0.686
TRG_DiLeu_BaEn_1	233	238	PF01217	0.648
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.600
TRG_ENDOCYTIC_2	131	134	PF00928	0.459
TRG_ENDOCYTIC_2	355	358	PF00928	0.447
TRG_ENDOCYTIC_2	370	373	PF00928	0.491
TRG_ENDOCYTIC_2	473	476	PF00928	0.798
TRG_ER_diArg_1	188	191	PF00400	0.747
TRG_ER_diArg_1	224	226	PF00400	0.732
TRG_NLS_MonoExtC_3	437	442	PF00514	0.738
TRG_NLS_MonoExtN_4	436	443	PF00514	0.739
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHM5	Leptomonas seymouri	54%	99%
A0A1X0P647	Trypanosomatidae	35%	100%
A0A3S5H801	Leishmania donovani	92%	100%
A4HN17	Leishmania braziliensis	72%	99%
A4IBN8	Leishmania infantum	92%	100%
E9B6M7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%