PEROXIDASE_4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxidase, putative

Species:

Leishmania major

UniProt:

E9AFH0_LEIMA

TriTrypDb:

LmjF.35.3460 , LMJLV39_350042000 , LMJSD75_350041500

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	7
GO:0016020	membrane	2	5

Expansion

Sequence features

E9AFH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFH0

Function

Biological processes
Term	Name	Level	Count
GO:0000302	response to reactive oxygen species	4	2
GO:0006950	response to stress	2	10
GO:0006979	response to oxidative stress	3	10
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	10
GO:0033554	cellular response to stress	3	10
GO:0034599	cellular response to oxidative stress	4	10
GO:0042221	response to chemical	2	10
GO:0042743	hydrogen peroxide metabolic process	4	2
GO:0042744	hydrogen peroxide catabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0050896	response to stimulus	1	10
GO:0051716	cellular response to stimulus	2	10
GO:0062197	cellular response to chemical stress	4	10
GO:0070887	cellular response to chemical stimulus	3	10
GO:0072593	reactive oxygen species metabolic process	3	2
GO:1901700	response to oxygen-containing compound	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004601	peroxidase activity	2	10
GO:0005488	binding	1	10
GO:0016209	antioxidant activity	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	10
GO:0020037	heme binding	4	10
GO:0046906	tetrapyrrole binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0140825	lactoperoxidase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.525
CLV_NRD_NRD_1	147	149	PF00675	0.349
CLV_NRD_NRD_1	197	199	PF00675	0.630
CLV_NRD_NRD_1	229	231	PF00675	0.546
CLV_PCSK_KEX2_1	104	106	PF00082	0.331
CLV_PCSK_KEX2_1	146	148	PF00082	0.333
CLV_PCSK_KEX2_1	229	231	PF00082	0.539
CLV_PCSK_KEX2_1	246	248	PF00082	0.621
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.348
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.454
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.705
CLV_PCSK_SKI1_1	104	108	PF00082	0.328
CLV_PCSK_SKI1_1	211	215	PF00082	0.571
CLV_PCSK_SKI1_1	82	86	PF00082	0.440
CLV_PCSK_SKI1_1	98	102	PF00082	0.207
DEG_Nend_Nbox_1	1	3	PF02207	0.553
DOC_ANK_TNKS_1	147	154	PF00023	0.413
DOC_CYCLIN_yClb1_LxF_4	339	345	PF00134	0.521
DOC_MAPK_gen_1	207	215	PF00069	0.530
DOC_PP1_RVXF_1	123	130	PF00149	0.328
DOC_PP4_FxxP_1	14	17	PF00568	0.415
DOC_PP4_FxxP_1	159	162	PF00568	0.340
DOC_USP7_MATH_1	237	241	PF00917	0.642
DOC_USP7_MATH_1	346	350	PF00917	0.497
DOC_USP7_MATH_2	311	317	PF00917	0.501
DOC_USP7_UBL2_3	142	146	PF12436	0.393
DOC_WW_Pin1_4	9	14	PF00397	0.440
LIG_14-3-3_CanoR_1	109	115	PF00244	0.440
LIG_14-3-3_CanoR_1	211	216	PF00244	0.653
LIG_14-3-3_CanoR_1	247	253	PF00244	0.735
LIG_14-3-3_CanoR_1	304	310	PF00244	0.698
LIG_AP2alpha_2	217	219	PF02296	0.572
LIG_APCC_ABBA_1	216	221	PF00400	0.564
LIG_APCC_ABBAyCdc20_2	90	96	PF00400	0.413
LIG_BIR_III_4	242	246	PF00653	0.497
LIG_BRCT_BRCA1_1	176	180	PF00533	0.434
LIG_deltaCOP1_diTrp_1	185	194	PF00928	0.371
LIG_FHA_1	79	85	PF00498	0.371
LIG_FHA_2	135	141	PF00498	0.328
LIG_FHA_2	166	172	PF00498	0.440
LIG_FHA_2	212	218	PF00498	0.607
LIG_FHA_2	44	50	PF00498	0.440
LIG_LIR_Apic_2	12	17	PF02991	0.414
LIG_LIR_Apic_2	156	162	PF02991	0.323
LIG_LIR_Apic_2	185	191	PF02991	0.467
LIG_LIR_Gen_1	177	186	PF02991	0.331
LIG_LIR_Gen_1	343	353	PF02991	0.499
LIG_LIR_Gen_1	49	59	PF02991	0.328
LIG_LIR_Nem_3	177	183	PF02991	0.331
LIG_LIR_Nem_3	343	348	PF02991	0.375
LIG_LIR_Nem_3	46	50	PF02991	0.339
LIG_MLH1_MIPbox_1	176	180	PF16413	0.440
LIG_Pex14_1	333	337	PF04695	0.385
LIG_Pex14_2	47	51	PF04695	0.440
LIG_SH2_CRK	345	349	PF00017	0.495
LIG_SH2_NCK_1	345	349	PF00017	0.495
LIG_SH2_STAT3	224	227	PF00017	0.670
LIG_SH2_STAT5	173	176	PF00017	0.325
LIG_SH2_STAT5	179	182	PF00017	0.312
LIG_SH2_STAT5	45	48	PF00017	0.440
LIG_SH3_3	148	154	PF00018	0.312
LIG_SH3_4	142	149	PF00018	0.467
LIG_SUMO_SIM_anti_2	321	327	PF11976	0.467
LIG_TRAF2_1	137	140	PF00917	0.347
MOD_CK1_1	220	226	PF00069	0.677
MOD_CK1_1	284	290	PF00069	0.762
MOD_CK2_1	134	140	PF00069	0.328
MOD_CK2_1	152	158	PF00069	0.328
MOD_CK2_1	285	291	PF00069	0.709
MOD_Cter_Amidation	196	199	PF01082	0.491
MOD_Cter_Amidation	244	247	PF01082	0.517
MOD_GlcNHglycan	256	259	PF01048	0.732
MOD_GlcNHglycan	265	269	PF01048	0.531
MOD_GlcNHglycan	277	280	PF01048	0.596
MOD_GSK3_1	161	168	PF00069	0.473
MOD_GSK3_1	275	282	PF00069	0.715
MOD_GSK3_1	5	12	PF00069	0.416
MOD_N-GLC_1	254	259	PF02516	0.773
MOD_N-GLC_1	279	284	PF02516	0.775
MOD_N-GLC_2	124	126	PF02516	0.467
MOD_NEK2_1	7	12	PF00069	0.470
MOD_PIKK_1	223	229	PF00454	0.692
MOD_PIKK_1	7	13	PF00454	0.459
MOD_PKA_2	237	243	PF00069	0.609
MOD_PKB_1	209	217	PF00069	0.569
MOD_Plk_1	220	226	PF00069	0.670
MOD_Plk_4	211	217	PF00069	0.655
MOD_ProDKin_1	9	15	PF00069	0.435
MOD_SUMO_rev_2	139	143	PF00179	0.347
TRG_DiLeu_BaEn_1	178	183	PF01217	0.328
TRG_DiLeu_BaEn_3	26	32	PF01217	0.438
TRG_ENDOCYTIC_2	179	182	PF00928	0.328
TRG_ENDOCYTIC_2	345	348	PF00928	0.380
TRG_ER_diArg_1	147	149	PF00400	0.337
TRG_ER_diArg_1	229	232	PF00400	0.540
TRG_ER_diArg_1	261	264	PF00400	0.785
TRG_ER_diArg_1	70	73	PF00400	0.350
TRG_NLS_MonoExtN_4	143	150	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.220
TRG_Pf-PMV_PEXEL_1	90	95	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF6	Leptomonas seymouri	69%	79%
A0A1X0P5A0	Trypanosomatidae	49%	80%
A0A3Q8IJA1	Leishmania donovani	94%	100%
A0A422NR12	Trypanosoma rangeli	50%	81%
A4IBN6	Leishmania infantum	93%	100%
C9ZYZ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	81%
E9B6M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5C2U7	Trypanosoma cruzi	51%	81%