Putative DNA-repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-repair protein, putative

Species:

Leishmania major

UniProt:

E9AFG9_LEIMA

TriTrypDb:

LmjF.35.3450 , LMJLV39_350041900 , LMJSD75_350041400

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000109	nucleotide-excision repair complex	3	2
GO:0000111	nucleotide-excision repair factor 2 complex	4	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0071942	XPC complex	4	2
GO:0110165	cellular anatomical entity	1	11
GO:0140513	nuclear protein-containing complex	2	2
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9

Expansion

Sequence features

E9AFG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFG9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006289	nucleotide-excision repair	6	11
GO:0006298	mismatch repair	6	2
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003684	damaged DNA binding	5	11
GO:0003697	single-stranded DNA binding	5	2
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.768
CLV_C14_Caspase3-7	434	438	PF00656	0.640
CLV_NRD_NRD_1	159	161	PF00675	0.591
CLV_NRD_NRD_1	245	247	PF00675	0.670
CLV_NRD_NRD_1	415	417	PF00675	0.553
CLV_NRD_NRD_1	429	431	PF00675	0.451
CLV_NRD_NRD_1	534	536	PF00675	0.327
CLV_NRD_NRD_1	741	743	PF00675	0.283
CLV_NRD_NRD_1	757	759	PF00675	0.286
CLV_NRD_NRD_1	763	765	PF00675	0.276
CLV_NRD_NRD_1	803	805	PF00675	0.362
CLV_PCSK_FUR_1	427	431	PF00082	0.573
CLV_PCSK_KEX2_1	158	160	PF00082	0.599
CLV_PCSK_KEX2_1	209	211	PF00082	0.739
CLV_PCSK_KEX2_1	415	417	PF00082	0.550
CLV_PCSK_KEX2_1	429	431	PF00082	0.449
CLV_PCSK_KEX2_1	449	451	PF00082	0.358
CLV_PCSK_KEX2_1	534	536	PF00082	0.320
CLV_PCSK_KEX2_1	641	643	PF00082	0.282
CLV_PCSK_KEX2_1	741	743	PF00082	0.292
CLV_PCSK_KEX2_1	756	758	PF00082	0.253
CLV_PCSK_KEX2_1	763	765	PF00082	0.284
CLV_PCSK_KEX2_1	802	804	PF00082	0.360
CLV_PCSK_KEX2_1	822	824	PF00082	0.229
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.663
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.746
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.527
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.362
CLV_PCSK_PC1ET2_1	641	643	PF00082	0.282
CLV_PCSK_PC1ET2_1	802	804	PF00082	0.353
CLV_PCSK_PC1ET2_1	822	824	PF00082	0.229
CLV_PCSK_PC7_1	637	643	PF00082	0.330
CLV_PCSK_SKI1_1	152	156	PF00082	0.648
CLV_PCSK_SKI1_1	17	21	PF00082	0.735
CLV_PCSK_SKI1_1	195	199	PF00082	0.565
CLV_PCSK_SKI1_1	60	64	PF00082	0.757
CLV_PCSK_SKI1_1	659	663	PF00082	0.409
CLV_PCSK_SKI1_1	741	745	PF00082	0.362
CLV_Separin_Metazoa	560	564	PF03568	0.586
DEG_APCC_DBOX_1	414	422	PF00400	0.770
DEG_SPOP_SBC_1	289	293	PF00917	0.574
DEG_SPOP_SBC_1	571	575	PF00917	0.530
DEG_SPOP_SBC_1	86	90	PF00917	0.538
DOC_CYCLIN_yCln2_LP_2	346	352	PF00134	0.400
DOC_MAPK_gen_1	415	423	PF00069	0.744
DOC_MAPK_gen_1	641	648	PF00069	0.482
DOC_MAPK_gen_1	738	747	PF00069	0.482
DOC_MAPK_HePTP_8	262	274	PF00069	0.403
DOC_MAPK_MEF2A_6	195	202	PF00069	0.354
DOC_MAPK_MEF2A_6	265	274	PF00069	0.397
DOC_MAPK_MEF2A_6	738	747	PF00069	0.482
DOC_MAPK_NFAT4_5	195	203	PF00069	0.377
DOC_PP1_RVXF_1	180	186	PF00149	0.379
DOC_PP1_RVXF_1	742	748	PF00149	0.534
DOC_PP2B_LxvP_1	286	289	PF13499	0.487
DOC_PP2B_LxvP_1	344	347	PF13499	0.395
DOC_PP4_FxxP_1	680	683	PF00568	0.642
DOC_USP7_MATH_1	113	117	PF00917	0.573
DOC_USP7_MATH_1	132	136	PF00917	0.573
DOC_USP7_MATH_1	208	212	PF00917	0.568
DOC_USP7_MATH_1	289	293	PF00917	0.559
DOC_USP7_MATH_1	494	498	PF00917	0.530
DOC_USP7_MATH_1	571	575	PF00917	0.562
DOC_USP7_MATH_1	644	648	PF00917	0.607
DOC_USP7_MATH_1	681	685	PF00917	0.628
DOC_WW_Pin1_4	41	46	PF00397	0.573
DOC_WW_Pin1_4	516	521	PF00397	0.506
LIG_14-3-3_CanoR_1	159	167	PF00244	0.445
LIG_14-3-3_CanoR_1	337	344	PF00244	0.471
LIG_14-3-3_CanoR_1	563	567	PF00244	0.544
LIG_14-3-3_CanoR_1	586	592	PF00244	0.553
LIG_14-3-3_CanoR_1	659	669	PF00244	0.602
LIG_14-3-3_CanoR_1	689	694	PF00244	0.607
LIG_14-3-3_CanoR_1	713	717	PF00244	0.561
LIG_Actin_WH2_2	641	658	PF00022	0.548
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_BIR_III_2	517	521	PF00653	0.562
LIG_BIR_III_4	437	441	PF00653	0.646
LIG_BRCT_BRCA1_1	352	356	PF00533	0.415
LIG_BRCT_BRCA1_1	676	680	PF00533	0.604
LIG_Clathr_ClatBox_1	106	110	PF01394	0.573
LIG_deltaCOP1_diTrp_1	480	489	PF00928	0.496
LIG_FHA_1	14	20	PF00498	0.587
LIG_FHA_1	230	236	PF00498	0.408
LIG_FHA_1	505	511	PF00498	0.496
LIG_FHA_1	553	559	PF00498	0.569
LIG_FHA_1	563	569	PF00498	0.550
LIG_FHA_1	571	577	PF00498	0.350
LIG_FHA_1	777	783	PF00498	0.544
LIG_FHA_2	18	24	PF00498	0.582
LIG_FHA_2	274	280	PF00498	0.362
LIG_FHA_2	375	381	PF00498	0.728
LIG_FHA_2	610	616	PF00498	0.419
LIG_FHA_2	699	705	PF00498	0.668
LIG_FHA_2	88	94	PF00498	0.587
LIG_GBD_Chelix_1	175	183	PF00786	0.629
LIG_LIR_Apic_2	316	321	PF02991	0.435
LIG_LIR_Apic_2	677	683	PF02991	0.646
LIG_LIR_Gen_1	122	129	PF02991	0.583
LIG_LIR_Gen_1	142	149	PF02991	0.410
LIG_LIR_Gen_1	169	179	PF02991	0.392
LIG_LIR_Gen_1	221	231	PF02991	0.406
LIG_LIR_Gen_1	32	42	PF02991	0.507
LIG_LIR_Gen_1	353	363	PF02991	0.369
LIG_LIR_Gen_1	475	484	PF02991	0.488
LIG_LIR_Gen_1	487	494	PF02991	0.466
LIG_LIR_Gen_1	714	725	PF02991	0.482
LIG_LIR_Gen_1	789	795	PF02991	0.624
LIG_LIR_LC3C_4	366	371	PF02991	0.408
LIG_LIR_Nem_3	122	126	PF02991	0.586
LIG_LIR_Nem_3	169	175	PF02991	0.400
LIG_LIR_Nem_3	221	227	PF02991	0.388
LIG_LIR_Nem_3	279	283	PF02991	0.433
LIG_LIR_Nem_3	32	37	PF02991	0.505
LIG_LIR_Nem_3	353	359	PF02991	0.389
LIG_LIR_Nem_3	475	481	PF02991	0.483
LIG_LIR_Nem_3	487	492	PF02991	0.457
LIG_LIR_Nem_3	692	698	PF02991	0.612
LIG_LIR_Nem_3	714	720	PF02991	0.482
LIG_LIR_Nem_3	789	794	PF02991	0.559
LIG_MYND_1	248	252	PF01753	0.366
LIG_NBox_RRM_1	226	236	PF00076	0.441
LIG_NRBOX	170	176	PF00104	0.401
LIG_Pex14_1	502	506	PF04695	0.496
LIG_Pex14_2	352	356	PF04695	0.408
LIG_SH2_CRK	669	673	PF00017	0.587
LIG_SH2_NCK_1	304	308	PF00017	0.530
LIG_SH2_NCK_1	526	530	PF00017	0.496
LIG_SH2_PTP2	224	227	PF00017	0.448
LIG_SH2_PTP2	717	720	PF00017	0.482
LIG_SH2_SRC	530	533	PF00017	0.553
LIG_SH2_STAP1	145	149	PF00017	0.385
LIG_SH2_STAP1	506	510	PF00017	0.482
LIG_SH2_STAP1	526	530	PF00017	0.496
LIG_SH2_STAP1	593	597	PF00017	0.496
LIG_SH2_STAP1	788	792	PF00017	0.583
LIG_SH2_STAT5	224	227	PF00017	0.448
LIG_SH2_STAT5	280	283	PF00017	0.374
LIG_SH2_STAT5	304	307	PF00017	0.505
LIG_SH2_STAT5	351	354	PF00017	0.378
LIG_SH2_STAT5	506	509	PF00017	0.498
LIG_SH2_STAT5	522	525	PF00017	0.482
LIG_SH2_STAT5	610	613	PF00017	0.534
LIG_SH2_STAT5	717	720	PF00017	0.482
LIG_SH3_3	126	132	PF00018	0.518
LIG_SH3_3	318	324	PF00018	0.431
LIG_SH3_3	34	40	PF00018	0.511
LIG_SH3_3	565	571	PF00018	0.586
LIG_SH3_3	668	674	PF00018	0.572
LIG_SH3_3	691	697	PF00018	0.580
LIG_SH3_3	7	13	PF00018	0.573
LIG_SH3_3	703	709	PF00018	0.612
LIG_SUMO_SIM_anti_2	778	786	PF11976	0.586
LIG_SUMO_SIM_par_1	104	112	PF11976	0.518
LIG_SUMO_SIM_par_1	419	425	PF11976	0.735
LIG_SUMO_SIM_par_1	505	511	PF11976	0.586
LIG_SUMO_SIM_par_1	643	650	PF11976	0.575
LIG_TRAF2_1	787	790	PF00917	0.569
LIG_UBA3_1	273	282	PF00899	0.439
LIG_UBA3_1	818	822	PF00899	0.541
MOD_CDC14_SPxK_1	44	47	PF00782	0.681
MOD_CDK_SPK_2	516	521	PF00069	0.355
MOD_CDK_SPxK_1	41	47	PF00069	0.683
MOD_CDK_SPxxK_3	41	48	PF00069	0.684
MOD_CK1_1	108	114	PF00069	0.542
MOD_CK1_1	316	322	PF00069	0.552
MOD_CK1_1	410	416	PF00069	0.553
MOD_CK1_1	433	439	PF00069	0.725
MOD_CK1_1	488	494	PF00069	0.403
MOD_CK1_1	497	503	PF00069	0.376
MOD_CK1_1	524	530	PF00069	0.415
MOD_CK1_1	647	653	PF00069	0.468
MOD_CK1_1	660	666	PF00069	0.502
MOD_CK2_1	208	214	PF00069	0.756
MOD_CK2_1	290	296	PF00069	0.740
MOD_CK2_1	306	312	PF00069	0.626
MOD_CK2_1	374	380	PF00069	0.663
MOD_CK2_1	419	425	PF00069	0.703
MOD_CK2_1	87	93	PF00069	0.777
MOD_Cter_Amidation	532	535	PF01082	0.447
MOD_GlcNHglycan	214	219	PF01048	0.719
MOD_GlcNHglycan	221	224	PF01048	0.612
MOD_GlcNHglycan	266	269	PF01048	0.443
MOD_GlcNHglycan	292	295	PF01048	0.764
MOD_GlcNHglycan	309	312	PF01048	0.727
MOD_GlcNHglycan	338	341	PF01048	0.648
MOD_GlcNHglycan	437	441	PF01048	0.714
MOD_GlcNHglycan	453	456	PF01048	0.308
MOD_GlcNHglycan	482	485	PF01048	0.480
MOD_GlcNHglycan	5	8	PF01048	0.722
MOD_GlcNHglycan	510	513	PF01048	0.400
MOD_GlcNHglycan	53	56	PF01048	0.666
MOD_GlcNHglycan	642	645	PF01048	0.355
MOD_GlcNHglycan	98	101	PF01048	0.703
MOD_GSK3_1	13	20	PF00069	0.787
MOD_GSK3_1	214	221	PF00069	0.726
MOD_GSK3_1	237	244	PF00069	0.550
MOD_GSK3_1	302	309	PF00069	0.526
MOD_GSK3_1	407	414	PF00069	0.645
MOD_GSK3_1	49	56	PF00069	0.680
MOD_GSK3_1	502	509	PF00069	0.384
MOD_GSK3_1	521	528	PF00069	0.150
MOD_GSK3_1	552	559	PF00069	0.454
MOD_GSK3_1	587	594	PF00069	0.613
MOD_GSK3_1	626	633	PF00069	0.335
MOD_GSK3_1	640	647	PF00069	0.335
MOD_GSK3_1	77	84	PF00069	0.763
MOD_N-GLC_1	17	22	PF02516	0.782
MOD_N-GLC_1	263	268	PF02516	0.413
MOD_N-GLC_1	395	400	PF02516	0.790
MOD_N-GLC_1	627	632	PF02516	0.372
MOD_NEK2_1	200	205	PF00069	0.615
MOD_NEK2_1	273	278	PF00069	0.467
MOD_NEK2_1	3	8	PF00069	0.732
MOD_NEK2_1	326	331	PF00069	0.515
MOD_NEK2_1	350	355	PF00069	0.417
MOD_NEK2_1	374	379	PF00069	0.637
MOD_NEK2_1	508	513	PF00069	0.447
MOD_NEK2_1	562	567	PF00069	0.480
MOD_NEK2_2	185	190	PF00069	0.561
MOD_NEK2_2	363	368	PF00069	0.480
MOD_NEK2_2	644	649	PF00069	0.478
MOD_NEK2_2	78	83	PF00069	0.701
MOD_PIKK_1	374	380	PF00454	0.600
MOD_PIKK_1	689	695	PF00454	0.576
MOD_PIKK_1	729	735	PF00454	0.445
MOD_PK_1	419	425	PF00069	0.767
MOD_PKA_1	158	164	PF00069	0.572
MOD_PKA_1	246	252	PF00069	0.550
MOD_PKA_1	430	436	PF00069	0.791
MOD_PKA_1	756	762	PF00069	0.391
MOD_PKA_2	132	138	PF00069	0.719
MOD_PKA_2	158	164	PF00069	0.480
MOD_PKA_2	185	191	PF00069	0.501
MOD_PKA_2	336	342	PF00069	0.608
MOD_PKA_2	451	457	PF00069	0.463
MOD_PKA_2	485	491	PF00069	0.378
MOD_PKA_2	562	568	PF00069	0.447
MOD_PKA_2	582	588	PF00069	0.480
MOD_PKA_2	712	718	PF00069	0.422
MOD_PKA_2	756	762	PF00069	0.373
MOD_Plk_1	316	322	PF00069	0.577
MOD_Plk_1	627	633	PF00069	0.260
MOD_Plk_2-3	105	111	PF00069	0.540
MOD_Plk_2-3	407	413	PF00069	0.653
MOD_Plk_4	167	173	PF00069	0.501
MOD_Plk_4	419	425	PF00069	0.665
MOD_Plk_4	485	491	PF00069	0.359
MOD_Plk_4	497	503	PF00069	0.294
MOD_Plk_4	53	59	PF00069	0.721
MOD_Plk_4	587	593	PF00069	0.513
MOD_Plk_4	682	688	PF00069	0.538
MOD_Plk_4	712	718	PF00069	0.408
MOD_Plk_4	766	772	PF00069	0.398
MOD_ProDKin_1	41	47	PF00069	0.743
MOD_ProDKin_1	516	522	PF00069	0.368
MOD_SUMO_for_1	102	105	PF00179	0.629
MOD_SUMO_for_1	281	284	PF00179	0.575
MOD_SUMO_for_1	71	74	PF00179	0.751
MOD_SUMO_for_1	82	85	PF00179	0.752
MOD_SUMO_rev_2	460	469	PF00179	0.443
TRG_DiLeu_BaEn_1	150	155	PF01217	0.504
TRG_DiLeu_BaEn_1	53	58	PF01217	0.612
TRG_DiLeu_BaEn_1	657	662	PF01217	0.554
TRG_DiLeu_BaEn_1	790	795	PF01217	0.532
TRG_DiLeu_BaEn_2	484	490	PF01217	0.447
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.487
TRG_DiLeu_BaLyEn_6	814	819	PF01217	0.491
TRG_ENDOCYTIC_2	145	148	PF00928	0.506
TRG_ENDOCYTIC_2	224	227	PF00928	0.496
TRG_ENDOCYTIC_2	280	283	PF00928	0.480
TRG_ENDOCYTIC_2	351	354	PF00928	0.355
TRG_ENDOCYTIC_2	669	672	PF00928	0.455
TRG_ENDOCYTIC_2	717	720	PF00928	0.335
TRG_ER_diArg_1	138	141	PF00400	0.635
TRG_ER_diArg_1	179	182	PF00400	0.460
TRG_ER_diArg_1	415	417	PF00400	0.709
TRG_ER_diArg_1	450	453	PF00400	0.488
TRG_ER_diArg_1	534	536	PF00400	0.398
TRG_ER_diArg_1	648	651	PF00400	0.419
TRG_ER_diArg_1	741	743	PF00400	0.355
TRG_ER_diArg_1	756	758	PF00400	0.355
TRG_ER_diArg_1	803	806	PF00400	0.466
TRG_NES_CRM1_1	735	746	PF08389	0.447
TRG_NLS_MonoExtC_3	208	214	PF00514	0.744
TRG_NLS_MonoExtC_3	448	453	PF00514	0.434
TRG_NLS_MonoExtC_3	801	806	PF00514	0.432
TRG_NLS_MonoExtN_4	206	213	PF00514	0.757
TRG_NLS_MonoExtN_4	446	453	PF00514	0.442
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.724
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	543	548	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	659	664	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G5	Leptomonas seymouri	66%	95%
A0A0S4IKI4	Bodo saltans	34%	93%
A0A1X0P5A4	Trypanosomatidae	40%	100%
A0A3Q8IJN2	Leishmania donovani	93%	100%
A0A3R7KHS6	Trypanosoma rangeli	43%	100%
A4HN12	Leishmania braziliensis	81%	100%
A4IBN5	Leishmania infantum	93%	100%
C9ZYZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B6M4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%