Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFG7_LEIMA

TriTrypDb:

LmjF.35.3430 , LMJLV39_350041700 , LMJSD75_350041200

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFG7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	489	493	PF00656	0.639
CLV_C14_Caspase3-7	539	543	PF00656	0.472
CLV_C14_Caspase3-7	81	85	PF00656	0.594
CLV_NRD_NRD_1	165	167	PF00675	0.450
CLV_NRD_NRD_1	248	250	PF00675	0.560
CLV_NRD_NRD_1	516	518	PF00675	0.659
CLV_NRD_NRD_1	534	536	PF00675	0.379
CLV_PCSK_KEX2_1	164	166	PF00082	0.522
CLV_PCSK_KEX2_1	240	242	PF00082	0.563
CLV_PCSK_KEX2_1	248	250	PF00082	0.612
CLV_PCSK_KEX2_1	516	518	PF00082	0.659
CLV_PCSK_KEX2_1	534	536	PF00082	0.379
CLV_PCSK_KEX2_1	56	58	PF00082	0.494
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.522
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.622
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.494
CLV_PCSK_SKI1_1	353	357	PF00082	0.557
CLV_PCSK_SKI1_1	402	406	PF00082	0.524
CLV_PCSK_SKI1_1	486	490	PF00082	0.663
DEG_APCC_DBOX_1	362	370	PF00400	0.411
DEG_Nend_UBRbox_3	1	3	PF02207	0.642
DOC_CDC14_PxL_1	322	330	PF14671	0.375
DOC_CYCLIN_yCln2_LP_2	257	263	PF00134	0.538
DOC_MAPK_gen_1	133	141	PF00069	0.537
DOC_MAPK_gen_1	213	221	PF00069	0.558
DOC_MAPK_gen_1	525	533	PF00069	0.504
DOC_MAPK_gen_1	534	540	PF00069	0.475
DOC_MAPK_gen_1	99	108	PF00069	0.414
DOC_MAPK_MEF2A_6	102	110	PF00069	0.429
DOC_MAPK_MEF2A_6	357	366	PF00069	0.509
DOC_MIT_MIM_1	152	161	PF04212	0.411
DOC_PP1_RVXF_1	218	224	PF00149	0.507
DOC_PP1_SILK_1	359	364	PF00149	0.515
DOC_USP7_MATH_1	181	185	PF00917	0.654
DOC_USP7_MATH_1	244	248	PF00917	0.588
DOC_USP7_MATH_1	274	278	PF00917	0.394
DOC_USP7_MATH_1	36	40	PF00917	0.622
DOC_USP7_MATH_1	392	396	PF00917	0.524
DOC_USP7_MATH_1	543	547	PF00917	0.532
DOC_USP7_MATH_1	553	557	PF00917	0.513
DOC_USP7_UBL2_3	390	394	PF12436	0.422
DOC_WW_Pin1_4	397	402	PF00397	0.539
DOC_WW_Pin1_4	509	514	PF00397	0.664
LIG_14-3-3_CanoR_1	165	170	PF00244	0.532
LIG_14-3-3_CanoR_1	220	224	PF00244	0.539
LIG_14-3-3_CanoR_1	314	318	PF00244	0.627
LIG_14-3-3_CanoR_1	363	367	PF00244	0.425
LIG_14-3-3_CanoR_1	453	457	PF00244	0.445
LIG_BRCT_BRCA1_1	50	54	PF00533	0.500
LIG_BRCT_BRCA1_1	545	549	PF00533	0.378
LIG_BRCT_BRCA1_2	50	56	PF00533	0.492
LIG_deltaCOP1_diTrp_1	479	484	PF00928	0.474
LIG_EH1_1	378	386	PF00400	0.418
LIG_eIF4E_1	323	329	PF01652	0.424
LIG_eIF4E_1	331	337	PF01652	0.361
LIG_FHA_1	209	215	PF00498	0.516
LIG_FHA_1	252	258	PF00498	0.609
LIG_FHA_1	263	269	PF00498	0.488
LIG_FHA_1	356	362	PF00498	0.484
LIG_FHA_1	398	404	PF00498	0.584
LIG_FHA_1	467	473	PF00498	0.427
LIG_FHA_1	483	489	PF00498	0.579
LIG_FHA_1	91	97	PF00498	0.533
LIG_FHA_1	99	105	PF00498	0.401
LIG_FHA_2	122	128	PF00498	0.451
LIG_FHA_2	487	493	PF00498	0.634
LIG_FHA_2	6	12	PF00498	0.572
LIG_LIR_Gen_1	222	231	PF02991	0.555
LIG_LIR_Gen_1	25	33	PF02991	0.501
LIG_LIR_Gen_1	456	466	PF02991	0.466
LIG_LIR_Gen_1	479	488	PF02991	0.594
LIG_LIR_Nem_3	222	226	PF02991	0.553
LIG_LIR_Nem_3	25	30	PF02991	0.584
LIG_LIR_Nem_3	319	325	PF02991	0.419
LIG_LIR_Nem_3	4	9	PF02991	0.580
LIG_LIR_Nem_3	456	462	PF02991	0.465
LIG_LIR_Nem_3	479	483	PF02991	0.607
LIG_NRBOX	267	273	PF00104	0.518
LIG_NRBOX	365	371	PF00104	0.404
LIG_PDZ_Wminus1_1	584	586	PF00595	0.540
LIG_SH2_CRK	307	311	PF00017	0.427
LIG_SH2_SRC	323	326	PF00017	0.466
LIG_SH2_STAP1	15	19	PF00017	0.504
LIG_SH2_STAP1	331	335	PF00017	0.455
LIG_SH2_STAP1	91	95	PF00017	0.444
LIG_SH2_STAT5	137	140	PF00017	0.538
LIG_SH2_STAT5	323	326	PF00017	0.398
LIG_SH2_STAT5	572	575	PF00017	0.467
LIG_SH2_STAT5	577	580	PF00017	0.410
LIG_SH3_3	164	170	PF00018	0.502
LIG_SH3_3	18	24	PF00018	0.535
LIG_SH3_3	409	415	PF00018	0.577
LIG_SH3_3	430	436	PF00018	0.711
LIG_SH3_3	462	468	PF00018	0.430
LIG_SH3_3	55	61	PF00018	0.576
LIG_SUMO_SIM_anti_2	18	23	PF11976	0.570
LIG_SUMO_SIM_par_1	121	128	PF11976	0.492
LIG_SUMO_SIM_par_1	259	265	PF11976	0.583
LIG_SUMO_SIM_par_1	293	298	PF11976	0.384
LIG_SUMO_SIM_par_1	460	467	PF11976	0.432
LIG_TRFH_1	278	282	PF08558	0.550
LIG_TRFH_1	322	326	PF08558	0.398
LIG_TYR_ITIM	305	310	PF00017	0.414
LIG_WRC_WIRS_1	275	280	PF05994	0.414
LIG_WRC_WIRS_1	537	542	PF05994	0.488
MOD_CDK_SPK_2	397	402	PF00069	0.608
MOD_CDK_SPxxK_3	509	516	PF00069	0.645
MOD_CK1_1	25	31	PF00069	0.566
MOD_CK1_1	32	38	PF00069	0.606
MOD_CK1_1	39	45	PF00069	0.465
MOD_CK1_1	395	401	PF00069	0.550
MOD_CK1_1	48	54	PF00069	0.502
MOD_CK1_1	512	518	PF00069	0.729
MOD_CK2_1	121	127	PF00069	0.472
MOD_CK2_1	146	152	PF00069	0.490
MOD_CK2_1	23	29	PF00069	0.588
MOD_CK2_1	313	319	PF00069	0.524
MOD_CK2_1	5	11	PF00069	0.509
MOD_GlcNHglycan	118	121	PF01048	0.461
MOD_GlcNHglycan	242	245	PF01048	0.694
MOD_GlcNHglycan	290	293	PF01048	0.515
MOD_GlcNHglycan	33	37	PF01048	0.598
MOD_GlcNHglycan	344	347	PF01048	0.561
MOD_GlcNHglycan	371	374	PF01048	0.453
MOD_GlcNHglycan	390	393	PF01048	0.351
MOD_GlcNHglycan	395	398	PF01048	0.530
MOD_GlcNHglycan	406	409	PF01048	0.531
MOD_GlcNHglycan	446	449	PF01048	0.602
MOD_GlcNHglycan	499	502	PF01048	0.641
MOD_GlcNHglycan	555	558	PF01048	0.551
MOD_GlcNHglycan	578	581	PF01048	0.368
MOD_GSK3_1	181	188	PF00069	0.553
MOD_GSK3_1	227	234	PF00069	0.614
MOD_GSK3_1	240	247	PF00069	0.496
MOD_GSK3_1	249	256	PF00069	0.583
MOD_GSK3_1	25	32	PF00069	0.427
MOD_GSK3_1	308	315	PF00069	0.480
MOD_GSK3_1	34	41	PF00069	0.681
MOD_GSK3_1	353	360	PF00069	0.634
MOD_GSK3_1	365	372	PF00069	0.381
MOD_GSK3_1	388	395	PF00069	0.521
MOD_GSK3_1	431	438	PF00069	0.598
MOD_GSK3_1	44	51	PF00069	0.523
MOD_GSK3_1	482	489	PF00069	0.609
MOD_GSK3_1	5	12	PF00069	0.590
MOD_GSK3_1	553	560	PF00069	0.522
MOD_GSK3_1	61	68	PF00069	0.392
MOD_GSK3_1	73	80	PF00069	0.549
MOD_LATS_1	351	357	PF00433	0.564
MOD_N-GLC_1	116	121	PF02516	0.439
MOD_NEK2_1	115	120	PF00069	0.522
MOD_NEK2_1	146	151	PF00069	0.501
MOD_NEK2_1	171	176	PF00069	0.650
MOD_NEK2_1	180	185	PF00069	0.525
MOD_NEK2_1	208	213	PF00069	0.503
MOD_NEK2_1	295	300	PF00069	0.458
MOD_NEK2_1	342	347	PF00069	0.457
MOD_NEK2_1	355	360	PF00069	0.621
MOD_NEK2_1	362	367	PF00069	0.397
MOD_NEK2_1	369	374	PF00069	0.354
MOD_NEK2_1	43	48	PF00069	0.655
MOD_NEK2_1	573	578	PF00069	0.497
MOD_NEK2_2	274	279	PF00069	0.398
MOD_PIKK_1	165	171	PF00454	0.590
MOD_PIKK_1	208	214	PF00454	0.479
MOD_PIKK_1	295	301	PF00454	0.598
MOD_PIKK_1	355	361	PF00454	0.488
MOD_PIKK_1	519	525	PF00454	0.642
MOD_PIKK_1	61	67	PF00454	0.504
MOD_PK_1	357	363	PF00069	0.481
MOD_PK_1	525	531	PF00069	0.440
MOD_PKA_1	165	171	PF00069	0.484
MOD_PKA_1	240	246	PF00069	0.623
MOD_PKA_2	165	171	PF00069	0.479
MOD_PKA_2	219	225	PF00069	0.586
MOD_PKA_2	240	246	PF00069	0.656
MOD_PKA_2	313	319	PF00069	0.530
MOD_PKA_2	362	368	PF00069	0.422
MOD_PKA_2	452	458	PF00069	0.518
MOD_PKA_2	9	15	PF00069	0.565
MOD_PKA_2	98	104	PF00069	0.426
MOD_PKB_1	517	525	PF00069	0.569
MOD_Plk_1	146	152	PF00069	0.482
MOD_Plk_2-3	5	11	PF00069	0.578
MOD_Plk_2-3	536	542	PF00069	0.494
MOD_Plk_4	185	191	PF00069	0.615
MOD_Plk_4	313	319	PF00069	0.524
MOD_Plk_4	357	363	PF00069	0.503
MOD_Plk_4	365	371	PF00069	0.412
MOD_Plk_4	536	542	PF00069	0.569
MOD_Plk_4	573	579	PF00069	0.502
MOD_Plk_4	9	15	PF00069	0.565
MOD_ProDKin_1	397	403	PF00069	0.539
MOD_ProDKin_1	509	515	PF00069	0.664
MOD_SUMO_rev_2	382	391	PF00179	0.440
TRG_DiLeu_BaEn_1	18	23	PF01217	0.532
TRG_DiLeu_BaEn_2	535	541	PF01217	0.498
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.399
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.497
TRG_ENDOCYTIC_2	307	310	PF00928	0.420
TRG_ENDOCYTIC_2	322	325	PF00928	0.399
TRG_ENDOCYTIC_2	377	380	PF00928	0.424
TRG_ER_diArg_1	165	167	PF00400	0.523
TRG_ER_diArg_1	278	281	PF00400	0.585
TRG_ER_diArg_1	516	519	PF00400	0.592
TRG_ER_diArg_1	533	535	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V6	Leptomonas seymouri	34%	99%
A0A3Q8IVE9	Leishmania donovani	89%	100%
A4HN10	Leishmania braziliensis	69%	100%
A4IBN3	Leishmania infantum	90%	100%
E9B6M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%