Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AFG6_LEIMA

TriTrypDb:

LmjF.35.3420 , LMJLV39_350041600 , LMJSD75_350041100

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.587
CLV_NRD_NRD_1	124	126	PF00675	0.521
CLV_PCSK_KEX2_1	114	116	PF00082	0.594
CLV_PCSK_KEX2_1	124	126	PF00082	0.521
CLV_PCSK_PC7_1	120	126	PF00082	0.509
DEG_Nend_UBRbox_1	1	4	PF02207	0.609
DEG_SPOP_SBC_1	54	58	PF00917	0.618
DOC_PP4_FxxP_1	10	13	PF00568	0.567
DOC_PP4_FxxP_1	75	78	PF00568	0.655
DOC_USP7_MATH_1	43	47	PF00917	0.672
DOC_USP7_MATH_1	54	58	PF00917	0.675
DOC_USP7_MATH_1	6	10	PF00917	0.639
DOC_USP7_MATH_1	97	101	PF00917	0.674
DOC_WW_Pin1_4	56	61	PF00397	0.640
DOC_WW_Pin1_4	85	90	PF00397	0.752
LIG_14-3-3_CanoR_1	165	174	PF00244	0.494
LIG_14-3-3_CanoR_1	2	10	PF00244	0.562
LIG_14-3-3_CanoR_1	91	97	PF00244	0.717
LIG_BRCT_BRCA1_1	35	39	PF00533	0.577
LIG_BRCT_BRCA1_1	71	75	PF00533	0.659
LIG_Clathr_ClatBox_1	178	182	PF01394	0.525
LIG_FHA_1	93	99	PF00498	0.733
LIG_FHA_2	78	84	PF00498	0.768
LIG_FHA_2	99	105	PF00498	0.596
LIG_LIR_Apic_2	72	78	PF02991	0.720
LIG_LIR_Apic_2	9	13	PF02991	0.632
LIG_LIR_Gen_1	140	151	PF02991	0.479
LIG_LIR_Nem_3	140	146	PF02991	0.471
LIG_Pex14_2	10	14	PF04695	0.566
LIG_SH3_3	59	65	PF00018	0.614
LIG_SH3_3	68	74	PF00018	0.555
LIG_SH3_3	84	90	PF00018	0.578
LIG_TRAF2_1	180	183	PF00917	0.619
LIG_WW_3	88	92	PF00397	0.625
MOD_CDK_SPxK_1	85	91	PF00069	0.622
MOD_CK1_1	100	106	PF00069	0.575
MOD_CK2_1	132	138	PF00069	0.409
MOD_CK2_1	177	183	PF00069	0.531
MOD_CK2_1	77	83	PF00069	0.761
MOD_GSK3_1	142	149	PF00069	0.394
MOD_GSK3_1	173	180	PF00069	0.531
MOD_GSK3_1	69	76	PF00069	0.628
MOD_N-GLC_1	54	59	PF02516	0.619
MOD_NEK2_1	1	6	PF00069	0.664
MOD_NEK2_1	14	19	PF00069	0.518
MOD_NEK2_1	33	38	PF00069	0.526
MOD_NEK2_2	6	11	PF00069	0.639
MOD_PIKK_1	144	150	PF00454	0.523
MOD_PIKK_1	33	39	PF00454	0.598
MOD_PKA_2	1	7	PF00069	0.571
MOD_PKA_2	110	116	PF00069	0.541
MOD_Plk_1	137	143	PF00069	0.378
MOD_Plk_4	137	143	PF00069	0.471
MOD_Plk_4	173	179	PF00069	0.512
MOD_ProDKin_1	56	62	PF00069	0.641
MOD_ProDKin_1	85	91	PF00069	0.755
TRG_ER_diArg_1	109	112	PF00400	0.640
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G4	Leptomonas seymouri	27%	99%
A0A3Q8IIJ1	Leishmania donovani	89%	100%
A4HN09	Leishmania braziliensis	71%	100%
A4IBN2	Leishmania infantum	90%	100%
E9B6M1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%