Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFG5_LEIMA

TriTrypDb:

LmjF.35.3410 , LMJLV39_350041500 , LMJSD75_350041000

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.614
CLV_NRD_NRD_1	109	111	PF00675	0.722
CLV_NRD_NRD_1	11	13	PF00675	0.633
CLV_NRD_NRD_1	397	399	PF00675	0.407
CLV_NRD_NRD_1	479	481	PF00675	0.457
CLV_NRD_NRD_1	590	592	PF00675	0.491
CLV_NRD_NRD_1	634	636	PF00675	0.690
CLV_PCSK_FUR_1	394	398	PF00082	0.425
CLV_PCSK_FUR_1	588	592	PF00082	0.552
CLV_PCSK_KEX2_1	109	111	PF00082	0.726
CLV_PCSK_KEX2_1	11	13	PF00082	0.633
CLV_PCSK_KEX2_1	396	398	PF00082	0.422
CLV_PCSK_KEX2_1	399	401	PF00082	0.383
CLV_PCSK_KEX2_1	479	481	PF00082	0.457
CLV_PCSK_KEX2_1	590	592	PF00082	0.456
CLV_PCSK_KEX2_1	634	636	PF00082	0.654
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.392
CLV_PCSK_SKI1_1	533	537	PF00082	0.329
CLV_PCSK_SKI1_1	591	595	PF00082	0.474
CLV_PCSK_SKI1_1	74	78	PF00082	0.372
DEG_APCC_DBOX_1	462	470	PF00400	0.497
DEG_APCC_DBOX_1	530	538	PF00400	0.383
DEG_MDM2_SWIB_1	599	607	PF02201	0.488
DOC_CDC14_PxL_1	296	304	PF14671	0.339
DOC_CDC14_PxL_1	523	531	PF14671	0.521
DOC_CYCLIN_yCln2_LP_2	285	288	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.294
DOC_MAPK_gen_1	588	597	PF00069	0.442
DOC_PP1_RVXF_1	10	17	PF00149	0.558
DOC_PP2B_LxvP_1	284	287	PF13499	0.466
DOC_PP2B_LxvP_1	297	300	PF13499	0.319
DOC_PP4_FxxP_1	121	124	PF00568	0.680
DOC_PP4_FxxP_1	360	363	PF00568	0.462
DOC_PP4_FxxP_1	593	596	PF00568	0.424
DOC_USP7_MATH_1	122	126	PF00917	0.660
DOC_USP7_MATH_1	133	137	PF00917	0.670
DOC_USP7_MATH_1	203	207	PF00917	0.662
DOC_USP7_MATH_1	326	330	PF00917	0.745
DOC_USP7_MATH_1	487	491	PF00917	0.604
DOC_USP7_MATH_1	571	575	PF00917	0.619
DOC_USP7_MATH_1	619	623	PF00917	0.591
DOC_USP7_UBL2_3	606	610	PF12436	0.519
DOC_USP7_UBL2_3	613	617	PF12436	0.560
DOC_WW_Pin1_4	123	128	PF00397	0.553
DOC_WW_Pin1_4	16	21	PF00397	0.594
DOC_WW_Pin1_4	183	188	PF00397	0.563
DOC_WW_Pin1_4	2	7	PF00397	0.577
DOC_WW_Pin1_4	240	245	PF00397	0.687
DOC_WW_Pin1_4	27	32	PF00397	0.520
DOC_WW_Pin1_4	338	343	PF00397	0.542
DOC_WW_Pin1_4	410	415	PF00397	0.368
DOC_WW_Pin1_4	556	561	PF00397	0.545
DOC_WW_Pin1_4	567	572	PF00397	0.752
LIG_14-3-3_CanoR_1	190	196	PF00244	0.506
LIG_14-3-3_CanoR_1	26	31	PF00244	0.586
LIG_14-3-3_CanoR_1	384	391	PF00244	0.524
LIG_14-3-3_CanoR_1	533	538	PF00244	0.429
LIG_Actin_WH2_2	418	434	PF00022	0.423
LIG_APCC_ABBA_1	545	550	PF00400	0.503
LIG_BIR_III_2	339	343	PF00653	0.535
LIG_CtBP_PxDLS_1	362	366	PF00389	0.406
LIG_EH1_1	534	542	PF00400	0.435
LIG_FHA_1	213	219	PF00498	0.479
LIG_FHA_1	268	274	PF00498	0.555
LIG_FHA_1	27	33	PF00498	0.538
LIG_FHA_1	281	287	PF00498	0.466
LIG_FHA_1	455	461	PF00498	0.464
LIG_FHA_2	165	171	PF00498	0.539
LIG_FHA_2	192	198	PF00498	0.501
LIG_FHA_2	205	211	PF00498	0.668
LIG_FHA_2	266	272	PF00498	0.490
LIG_FHA_2	309	315	PF00498	0.504
LIG_FHA_2	493	499	PF00498	0.480
LIG_FHA_2	534	540	PF00498	0.547
LIG_GBD_Chelix_1	421	429	PF00786	0.403
LIG_HCF-1_HBM_1	219	222	PF13415	0.436
LIG_LIR_Apic_2	120	124	PF02991	0.671
LIG_LIR_Apic_2	156	160	PF02991	0.326
LIG_LIR_Apic_2	304	310	PF02991	0.490
LIG_LIR_Apic_2	357	363	PF02991	0.379
LIG_LIR_Apic_2	592	596	PF02991	0.468
LIG_LIR_Gen_1	219	230	PF02991	0.487
LIG_LIR_Gen_1	291	301	PF02991	0.468
LIG_LIR_Gen_1	349	356	PF02991	0.421
LIG_LIR_Gen_1	46	53	PF02991	0.396
LIG_LIR_Nem_3	219	225	PF02991	0.439
LIG_LIR_Nem_3	257	261	PF02991	0.367
LIG_LIR_Nem_3	291	296	PF02991	0.455
LIG_LIR_Nem_3	349	354	PF02991	0.421
LIG_LIR_Nem_3	46	50	PF02991	0.450
LIG_MAD2	179	187	PF02301	0.440
LIG_NRBOX	72	78	PF00104	0.336
LIG_PCNA_yPIPBox_3	531	545	PF02747	0.433
LIG_Pex14_2	593	597	PF04695	0.461
LIG_Pex14_2	599	603	PF04695	0.480
LIG_SH2_CRK	307	311	PF00017	0.463
LIG_SH2_NCK_1	307	311	PF00017	0.463
LIG_SH2_PTP2	222	225	PF00017	0.424
LIG_SH2_STAP1	119	123	PF00017	0.499
LIG_SH2_STAP1	80	84	PF00017	0.492
LIG_SH2_STAT3	611	614	PF00017	0.538
LIG_SH2_STAT5	157	160	PF00017	0.510
LIG_SH2_STAT5	222	225	PF00017	0.464
LIG_SH2_STAT5	351	354	PF00017	0.411
LIG_SH2_STAT5	408	411	PF00017	0.417
LIG_SH2_STAT5	415	418	PF00017	0.330
LIG_SH2_STAT5	611	614	PF00017	0.538
LIG_SH3_1	521	527	PF00018	0.474
LIG_SH3_3	121	127	PF00018	0.663
LIG_SH3_3	238	244	PF00018	0.598
LIG_SH3_3	521	527	PF00018	0.530
LIG_SH3_3	62	68	PF00018	0.599
LIG_SUMO_SIM_anti_2	543	548	PF11976	0.408
LIG_SUMO_SIM_anti_2	550	557	PF11976	0.373
LIG_SxIP_EBH_1	43	55	PF03271	0.412
LIG_TRAF2_1	368	371	PF00917	0.469
LIG_TRAF2_1	495	498	PF00917	0.434
LIG_TRFH_1	426	430	PF08558	0.424
LIG_WRC_WIRS_1	39	44	PF05994	0.298
MOD_CDK_SPxxK_3	183	190	PF00069	0.472
MOD_CDK_SPxxK_3	240	247	PF00069	0.606
MOD_CK1_1	125	131	PF00069	0.676
MOD_CK1_1	18	24	PF00069	0.657
MOD_CK1_1	204	210	PF00069	0.678
MOD_CK1_1	243	249	PF00069	0.681
MOD_CK1_1	25	31	PF00069	0.566
MOD_CK1_1	490	496	PF00069	0.426
MOD_CK1_1	505	511	PF00069	0.348
MOD_CK1_1	561	567	PF00069	0.652
MOD_CK1_1	570	576	PF00069	0.627
MOD_CK1_1	629	635	PF00069	0.614
MOD_CK1_1	75	81	PF00069	0.424
MOD_CK2_1	164	170	PF00069	0.500
MOD_CK2_1	191	197	PF00069	0.421
MOD_CK2_1	205	211	PF00069	0.552
MOD_CK2_1	265	271	PF00069	0.481
MOD_CK2_1	492	498	PF00069	0.446
MOD_Cter_Amidation	588	591	PF01082	0.528
MOD_GlcNHglycan	103	106	PF01048	0.640
MOD_GlcNHglycan	127	130	PF01048	0.728
MOD_GlcNHglycan	207	210	PF01048	0.596
MOD_GlcNHglycan	274	277	PF01048	0.428
MOD_GlcNHglycan	297	300	PF01048	0.357
MOD_GlcNHglycan	314	317	PF01048	0.568
MOD_GlcNHglycan	324	327	PF01048	0.682
MOD_GlcNHglycan	386	389	PF01048	0.573
MOD_GlcNHglycan	437	440	PF01048	0.447
MOD_GSK3_1	133	140	PF00069	0.672
MOD_GSK3_1	14	21	PF00069	0.554
MOD_GSK3_1	2	9	PF00069	0.687
MOD_GSK3_1	201	208	PF00069	0.592
MOD_GSK3_1	22	29	PF00069	0.532
MOD_GSK3_1	308	315	PF00069	0.542
MOD_GSK3_1	322	329	PF00069	0.614
MOD_GSK3_1	338	345	PF00069	0.734
MOD_GSK3_1	515	522	PF00069	0.574
MOD_GSK3_1	556	563	PF00069	0.651
MOD_GSK3_1	566	573	PF00069	0.607
MOD_GSK3_1	605	612	PF00069	0.418
MOD_LATS_1	24	30	PF00433	0.471
MOD_N-GLC_1	454	459	PF02516	0.435
MOD_NEK2_1	1	6	PF00069	0.501
MOD_NEK2_1	164	169	PF00069	0.507
MOD_NEK2_1	346	351	PF00069	0.564
MOD_NEK2_1	440	445	PF00069	0.507
MOD_NEK2_1	565	570	PF00069	0.701
MOD_NEK2_2	191	196	PF00069	0.397
MOD_NEK2_2	6	11	PF00069	0.578
MOD_NEK2_2	619	624	PF00069	0.591
MOD_PK_1	137	143	PF00069	0.532
MOD_PK_1	369	375	PF00069	0.343
MOD_PK_1	558	564	PF00069	0.466
MOD_PKA_2	101	107	PF00069	0.663
MOD_PKA_2	25	31	PF00069	0.469
MOD_PKB_1	531	539	PF00069	0.347
MOD_PKB_1	624	632	PF00069	0.644
MOD_Plk_1	212	218	PF00069	0.478
MOD_Plk_1	369	375	PF00069	0.557
MOD_Plk_1	37	43	PF00069	0.331
MOD_Plk_4	153	159	PF00069	0.358
MOD_Plk_4	280	286	PF00069	0.465
MOD_Plk_4	346	352	PF00069	0.469
MOD_Plk_4	369	375	PF00069	0.476
MOD_Plk_4	38	44	PF00069	0.336
MOD_ProDKin_1	123	129	PF00069	0.554
MOD_ProDKin_1	16	22	PF00069	0.595
MOD_ProDKin_1	183	189	PF00069	0.560
MOD_ProDKin_1	2	8	PF00069	0.580
MOD_ProDKin_1	240	246	PF00069	0.685
MOD_ProDKin_1	27	33	PF00069	0.508
MOD_ProDKin_1	338	344	PF00069	0.538
MOD_ProDKin_1	410	416	PF00069	0.363
MOD_ProDKin_1	556	562	PF00069	0.538
MOD_ProDKin_1	567	573	PF00069	0.747
MOD_SUMO_rev_2	82	89	PF00179	0.521
TRG_DiLeu_BaEn_1	280	285	PF01217	0.437
TRG_DiLeu_BaEn_2	37	43	PF01217	0.380
TRG_ENDOCYTIC_2	222	225	PF00928	0.434
TRG_ENDOCYTIC_2	351	354	PF00928	0.411
TRG_ER_diArg_1	10	12	PF00400	0.627
TRG_ER_diArg_1	176	179	PF00400	0.541
TRG_ER_diArg_1	394	397	PF00400	0.503
TRG_ER_diArg_1	478	480	PF00400	0.452
TRG_ER_diArg_1	587	590	PF00400	0.523
TRG_ER_diArg_1	623	626	PF00400	0.635
TRG_ER_diArg_1	634	636	PF00400	0.638
TRG_ER_diArg_1	95	98	PF00400	0.389
TRG_ER_diArg_1	99	102	PF00400	0.523
TRG_NLS_MonoCore_2	397	402	PF00514	0.415
TRG_NLS_MonoExtN_4	396	403	PF00514	0.400
TRG_Pf-PMV_PEXEL_1	400	405	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUU2	Leptomonas seymouri	52%	100%
A0A1X0P6R1	Trypanosomatidae	29%	100%
A0A3Q8IMM0	Leishmania donovani	93%	89%
A0A3R7L599	Trypanosoma rangeli	30%	100%
A4HN08	Leishmania braziliensis	82%	100%
A4IBN1	Leishmania infantum	94%	89%
C9ZZ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B6M0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BY91	Trypanosoma cruzi	31%	100%